Fight Aging! Newsletter, September 25th 2023
In conclusion, this individual patient data meta-analysis of longitudinal cohort studies found that antihypertensive use was associated with decreased dementia risk compared with individuals with untreated hypertension through all ages in late life. Individuals with treated hypertension had no increased risk of dementia compared with healthy controls. « Back to Top Results from Human Clinical Trials Do Not Support Metformin as a Longevity Drug https://www.fightaging.org/archives/2023/09/results-from-human-clinical-trials-do-not-support-metformin-as-a-longevity-drug/ The SENS Research Fou...
Source: Fight Aging! - September 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Different Invasive Bacterial Species are Found in Alzheimer's Brains versus Normal Brains
Research into the effects of the human microbiome on health and aging has progressed quite rapidly in recent years. It now costs little to sequence a sample to determine the which bacterial species are present and in what proportions. With age, the intestinal barrier, blood vessels, and blood-brain barrier begin to leak, allowing greater passage of microbes into the body. Additionally, the immune system declines in function, reducing the ability to clear these microbes from tissues. In the case of patients with Alzheimer's disease, researchers are finding that the gut microbiome exhibits characteristic differences w...
Source: Fight Aging! - September 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Navigating chronic diseases and menopause: healthier habits for aging
An excerpt from The Menopause Menu. Whether it’s heart disease or cognitive decline, arthritis or diabetes, getting older is linked to an increased incidence of many different chronic diseases. The menopausal journey adds an extra layer of health risks to some of them but is also an opportunity to fine-tune healthy living goals in a Read more… Navigating chronic diseases and menopause: healthier habits for aging originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - September 12, 2023 Category: General Medicine Authors: Tags: Conditions OB/GYN Rheumatology Source Type: blogs

Fight Aging! Newsletter, September 4th 2023
In conclusion, although the contribution of CRF to GrimAgeAccel and FitAgeAccel is relatively low compared to lifestyle-related factors such as smoking, the results suggest that the maintenance of CRF is associated with delayed biological ageing in older men. « Back to Top Release of Acetylcholine is Necessary for the Aging Brain to Compensate for a Lack of Neurogenesis https://www.fightaging.org/archives/2023/09/release-of-acetylcholine-is-necessary-for-the-aging-brain-to-compensate-for-a-lack-of-neurogenesis/ Neurogenesis is the process by which new neurons are created by neural stem c...
Source: Fight Aging! - September 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Transferring the Naked Mole Rat Hyaluronan Synthase 2 Gene Into Mice Reduces Cancer Incidence, Extends Life
Naked mole rats live far longer than similarly sized mammals, and are near immune to cancer. One of the mechanisms of cancer resistance involves the production of a different form of high molecular weight hyaluronan, and much more of it, improving the anti-cancer mechanism of contact inhibition. In addition, other mechanisms derived from changes in hyaluronan may affect life span through improved cellular function, but this is less well explored. Researchers here take the naked mole-rat version of the gene for high molecular weight hyoluronan, hyaluronan synthase 2, and put it into mice. The result is less cancer, improved...
Source: Fight Aging! - August 31, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Consciously Exploring Your Relationship with Drugs
Humanity has a complex, long-term relationship with a wide variety of drugs. In this article let’s delve into your personal relationship with drugs, how you frame them, and how you might upgrade these relationships to be more conscious and aligned with your path of self-development. Let’s include common drug sources like coffee, tea, and chocolate too, so this will be very inclusive. My purpose here isn’t to encourage or discourage you from using any particular substances but rather to invite you to take a more conscious and honest look at your current frames, attitudes, biases, and behaviors, and dete...
Source: Steve Pavlina's Personal Development Blog - July 21, 2023 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Creating Reality Emotions Health Lifestyle Relationships Values Source Type: blogs

Pulmonary Arterial Hypertension: Unraveling Its Impact On Heart And Lungs
Conclusion Navigating the complexities of Pulmonary Arterial Hypertension (PAH) might seem daunting. However, with the right knowledge and proactive approach, it’s possible to manage the condition and maintain a good quality of life. PAH, a unique type of high blood pressure affecting the arteries in the lungs, can put extra strain on the heart. Over time, this can lead to heart failure. The condition’s root cause may vary, from genetic factors to other health issues like heart defects, liver disease, or autoimmune diseases. Remember, sometimes the cause remains unknown, resulting in idiopathic pulmonary ...
Source: The EMT Spot - July 19, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs

Preventive Medicine is the Key to Value-Based Care
The following is a guest article by Dr. Ed Cladera, Medical Director at AristaMD We’re amid a massive provider shortage, and it’s only getting worse. According to data from the Association of American Medical Colleges, the U.S. is on track to face a shortage of up to 124,000 physicians by 2034. As a result of being unable to access care, patients are pushing off routine health services. Neglected care comes with more complications down the line. Studies have shown that preventative care decreases the incidence of disease and patient mortality, resulting in better care outcomes. Preventive medicine proactively identifie...
Source: EMR and HIPAA - July 18, 2023 Category: Information Technology Authors: Guest Author Tags: Clinical Communication and Patient Experience Health IT Company Healthcare IT Hospital - Health System AristaMD Association of American Medical Colleges Decreasing Costs Ed Cladera MD Improving Outcomes Medicaid Medicare PCP Prev Source Type: blogs

Is it really depressing? Really living with chronic pain
Someone responded to my post Unpalatable truths about pain saying it was depressing. For a moment I thought – yeah, it is really. And then I reflected on my life living with, and working with people dealing daily with chronic, ongoing, persistent pain. It’s not inevitably miserable. Is there something wrong with me? This, of course, set me to thinking maybe my pain isn’t as intense as others. Well – how would I know? I can’t give my pain a number out of 10. It’s just there and I can’t remember a time without any pain, so I can’t compare a 0 = no pain at all with anything ...
Source: HealthSkills Weblog - June 18, 2023 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Clinical reasoning Pain conditions Psychology Research Resilience/Health Science in practice Wellness pain management Therapeutic approaches Source Type: blogs

Fight Aging! Newsletter, June 19th 2023
In conclusion, among Swedish middle-aged subjects, nearly two-thirds showed complete fatty degeneration of thymus on CT. Age-Related Dysfunction of Water Homeostasis https://www.fightaging.org/archives/2023/06/age-related-dysfunction-of-water-homeostasis/ Dehydration can be an issue in older people. As in every complex system in the body, the mechanisms by which hydration is regulated become dysfunctional with advancing age. Researchers here look at the brain region responsible for regulating some of the response to dehydration, cataloging altered gene expression in search of the more important mechan...
Source: Fight Aging! - June 18, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Notes from the 2023 Age-Related Disease Therapeutics Summit
The former Longevity Therapeutics conference series was renamed to the Age-Related Disease Therapeutics Summit and held its fifth event recently in San Francisco. It was a smaller meeting than in past years, perhaps a result of the recent downturn in the global financial and investment environment. Few investors were present. Nonetheless, one can usually learn something interesting from the presenting biotech founders and executives. I took a few notes while I was there to present on progress at Repair Biotechnologies, and they follow in the order of the conference program. Birget Schilling from the Buck Institute f...
Source: Fight Aging! - June 16, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs

Can You Practice Tai Chi With Hypertension?
Conclusions To sum up, there’s compelling evidence and substantial anecdotal support suggesting that Tai Chi can be a beneficial and safe practice for people with hypertension. However, always remember to consult with your healthcare provider before starting any new exercise regimen. Tai Chi embodies a perfect blend of gentle physical movement, mental focus, and calming breathwork. While it may not replace traditional hypertension treatments, it can certainly be a serene, therapeutic addition to an overall health strategy. Read also: Impact of Increased Exercise (Or No Exercise) On Blood Pressure ...
Source: The EMT Spot - June 13, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs

Humira Biosimilar Gross-to-Net Pricing Bubble Was Preceded by the Same Pricing Bubble Burst for Insulin Just Months Ago
Today ' s post is not about diabetes per se, although there IS a diabetes connection. But this morning, the big news was that a biosimilar of Abbvie ' s blockbuster anti-inflammatory biologic Humira will be sold byMark Cuban Cost Plus Drug Company (see the press release athttps://www.globenewswire.com/news-release/2023/06/01/2680351/33333/en/Mark-Cuban-Cost-Plus-Drug-Company-joins-forces-with-Coherus-to-make-YUSIMRY-a-HUMIRA-biosimilar-available-to-patients.html for more) at what amounts to an 85% discount to the innovator drug. Mark Cuban Cost Plus Drug Company announced the Humira biosimilar on social media today. See th...
Source: Scott's Web Log - June 1, 2023 Category: Endocrinology Tags: 2023 Abbvie Biosimilar drug discounts gross-to-net bubble Humira insulin Source Type: blogs

Laguna Health Closes $15M Series A to Usher in the Next Generation of Care Management
AI-powered contextual care innovator gives care managers intimate insights into individuals life circumstances, helping identify risk barriers, personalize care plans and improve care manager productivity Laguna-supported patients in hospital transitions and complex care settings see superior care plan adherence and outcomes, offering a beacon of light for payers and employers grappling with high-cost members Initial close of Series A fundraise heralds next generation of contextual care management, which goes beyond SDOH to consider behavioral, emotional, cultural, financial, and spiritual patient life context Laguna ...
Source: EMR and HIPAA - May 26, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT AI Care Management HC9 HC9 Ventures Health IT Funding Health IT Fundings Health IT Investment Laguna Laguna Health NLP Personalized Care Plans Richard Lungen Robby Peters ROI SDOH SemperVir Source Type: blogs

Can You Use Saunas With Hypertension?
Conclusion So, can you use saunas with hypertension? With the right precautions and guidance from a healthcare provider, it appears you can indeed enjoy the soothing warmth of a sauna. Regular sauna use might even provide certain health benefits. However, it’s vital to monitor your blood pressure regularly, stay well-hydrated, and pay close attention to how your body is reacting. Sauna bathing should be a stress-relieving, enjoyable experience. If it leads to discomfort or concern, it’s best to cool down and consult your healthcare provider. References Sauna bathing is associated with ...
Source: The EMT Spot - May 24, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs