Role of Colchicine in Cardiovascular Disease Management
Arterioscler Thromb Vasc Biol. 2024 Mar 21. doi: 10.1161/ATVBAHA.124.319851. Online ahead of print.ABSTRACTColchicine-an anti-inflammatory alkaloid-has assumed an important role in the management of cardiovascular inflammation ≈3500 years after its first medicinal use in ancient Egypt. Primarily used in extremely high doses for the treatment of acute gout flares during the 20th century, research in the early 21st century demonstrated that low-dose colchicine effectively treats acute gout attacks, lowers the risk of recurrent pericarditis, and can even add to secondary prevention of major adverse cardiovascular events. As...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 21, 2024 Category: Cardiology Authors: Leo F Buckley Peter Libby Source Type: research

Monocyte-Mediated Thrombosis Linked to Circulating Tissue Factor and Immune Paralysis in COVID-19
CONCLUSIONS: Taken together, these observations further elucidate the pathological mechanisms that underlie immune dysfunction and coagulation abnormalities in COVID-19, contributing to our growing understanding of SARS-CoV-2 infections that could also be leveraged to develop novel diagnostic and therapeutic strategies.PMID:38511328 | DOI:10.1161/ATVBAHA.122.318721 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 21, 2024 Category: Cardiology Authors: Sascha N Goonewardena Qinzhong Chen Ashley M Tate Olga G Grushko Dilna Damodaran Pennelope Blakely Salim S Hayek David J Pinsky Robert S Rosenson Source Type: research

Virus-Associated CD8 < sup > + < /sup > T-Cells Are Not Activated Through Antigen-Mediated Interaction Inside Atherosclerotic Lesions
CONCLUSIONS: This study suggests that virus-specific CD8+ T-cells are tissue enriched in atherosclerotic lesions; however, their potential contribution to inflammation may involve antigen-independent mechanisms.PMID:38511327 | DOI:10.1161/ATVBAHA.123.320539 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 21, 2024 Category: Cardiology Authors: Maaike J M de Jong Frank H Schaftenaar Marie A C Depuydt Fernando Lozano Vigario George M C Janssen Judith A H M Peeters Lauren Goncalves Anouk Wezel Harm J Smeets Johan Kuiper Ilze Bot Peter van Veelen Bram Sl ütter Source Type: research

Significance of the total renal chronicity score in predicting renal outcome in PLA2R-associated membranous nephropathy
CONCLUSIONS: Renal chronicity is closely associated with renal outcomes in PLA2R-associated membranous nephropathy, and combining the KDIGO risk classification with chronicity scores may provide a more accurate prognostic prediction.PMID:38512370 | DOI:10.1007/s40620-024-01893-z (Source: Journal of Nephrology)
Source: Journal of Nephrology - March 21, 2024 Category: Urology & Nephrology Authors: Weifu Ren Jing Sun Lingyan Zhang Wei He Zhiyong Guo Qi Bian Source Type: research

Monocyte-Mediated Thrombosis Linked to Circulating Tissue Factor and Immune Paralysis in COVID-19
CONCLUSIONS: Taken together, these observations further elucidate the pathological mechanisms that underlie immune dysfunction and coagulation abnormalities in COVID-19, contributing to our growing understanding of SARS-CoV-2 infections that could also be leveraged to develop novel diagnostic and therapeutic strategies.PMID:38511328 | DOI:10.1161/ATVBAHA.122.318721 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 21, 2024 Category: Cardiology Authors: Sascha N Goonewardena Qinzhong Chen Ashley M Tate Olga G Grushko Dilna Damodaran Pennelope Blakely Salim S Hayek David J Pinsky Robert S Rosenson Source Type: research

Virus-Associated CD8 < sup > + < /sup > T-Cells Are Not Activated Through Antigen-Mediated Interaction Inside Atherosclerotic Lesions
CONCLUSIONS: This study suggests that virus-specific CD8+ T-cells are tissue enriched in atherosclerotic lesions; however, their potential contribution to inflammation may involve antigen-independent mechanisms.PMID:38511327 | DOI:10.1161/ATVBAHA.123.320539 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 21, 2024 Category: Cardiology Authors: Maaike J M de Jong Frank H Schaftenaar Marie A C Depuydt Fernando Lozano Vigario George M C Janssen Judith A H M Peeters Lauren Goncalves Anouk Wezel Harm J Smeets Johan Kuiper Ilze Bot Peter van Veelen Bram Sl ütter Source Type: research

Remnant Cholesterol, Not LDL Cholesterol, Explains Peripheral Artery Disease Risk Conferred by apoB: A Cohort Study
CONCLUSIONS: PAD risk conferred by elevated apoB-containing lipoproteins was explained mainly by elevated remnants, while myocardial infarction risk was explained by both elevated remnants and LDL.PMID:38511326 | DOI:10.1161/ATVBAHA.123.320175 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 21, 2024 Category: Cardiology Authors: Benjamin N Wadstr öm Kasper M Pedersen Anders B Wulff B ørge G Nordestgaard Source Type: research

Novel Angiogenesis Role of GLP-1(32-36) to Rescue Diabetic Ischemic Lower Limbs via GLP-1R-Dependent Glycolysis in Mice
CONCLUSIONS: Our study provides a novel mechanism with which GLP-1(32-36) acts in modulating metabolic reprogramming toward glycolytic flux in partnership with GLP-1R for improved angiogenesis in high glucose-exposed EPCs and T1DM murine models. We propose that GLP-1(32-36) could be used as a monotherapy or add-on therapy with existing treatments for peripheral artery disease.REGISTRATION: URL: www.ebi.ac.uk/metabolights/; Unique identifier: MTBLS9543.PMID:38511325 | DOI:10.1161/ATVBAHA.124.320714 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 21, 2024 Category: Cardiology Authors: Yikai Zhang Shengyao Wang Qiao Zhou Yi Xie Yepeng Hu Weihuan Fang Changxin Yang Zhe Wang Shu Ye Xinyi Wang Chao Zheng Source Type: research

Role of Colchicine in Cardiovascular Disease Management
Arterioscler Thromb Vasc Biol. 2024 Mar 21. doi: 10.1161/ATVBAHA.124.319851. Online ahead of print.ABSTRACTColchicine-an anti-inflammatory alkaloid-has assumed an important role in the management of cardiovascular inflammation ≈3500 years after its first medicinal use in ancient Egypt. Primarily used in extremely high doses for the treatment of acute gout flares during the 20th century, research in the early 21st century demonstrated that low-dose colchicine effectively treats acute gout attacks, lowers the risk of recurrent pericarditis, and can even add to secondary prevention of major adverse cardiovascular events. As...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 21, 2024 Category: Cardiology Authors: Leo F Buckley Peter Libby Source Type: research

Burden of intracranial artery calcification in white patients with ischemic stroke
CONCLUSION: IAC is seen in the majority of white ischemic stroke patients, aligning with findings from patient studies in other ethnicities. Furthermore, over half of patients with a stroke of undetermined etiology presented with IAC. Assessing IAC burden may help identify the cause in ischemic stroke of undetermined etiology, and could offer important prognostic information.PMID:38506452 | DOI:10.1177/23969873241239787 (Source: Atherosclerosis)
Source: Atherosclerosis - March 20, 2024 Category: Cardiology Authors: Bernhard P Berghout Robin Yr Camarasa Dianne Hk Van Dam-Nolen Aad van der Lugt Marleen de Bruijne Peter J Koudstaal M Kamran Ikram Daniel Bos Source Type: research

Burden of intracranial artery calcification in white patients with ischemic stroke
CONCLUSION: IAC is seen in the majority of white ischemic stroke patients, aligning with findings from patient studies in other ethnicities. Furthermore, over half of patients with a stroke of undetermined etiology presented with IAC. Assessing IAC burden may help identify the cause in ischemic stroke of undetermined etiology, and could offer important prognostic information.PMID:38506452 | DOI:10.1177/23969873241239787 (Source: Atherosclerosis)
Source: Atherosclerosis - March 20, 2024 Category: Cardiology Authors: Bernhard P Berghout Robin Yr Camarasa Dianne Hk Van Dam-Nolen Aad van der Lugt Marleen de Bruijne Peter J Koudstaal M Kamran Ikram Daniel Bos Source Type: research

SEA 2024 Standards for Global Control of Vascular Risk
Clin Investig Arterioscler. 2024 Mar 14:S0214-9168(24)00017-2. doi: 10.1016/j.arteri.2024.02.001. Online ahead of print.ABSTRACTOne of the objectives of the Spanish Society of Arteriosclerosis is to contribute to the knowledge, prevention and treatment of vascular diseases, which are the leading cause of death in Spain and entail a high degree of disability and health expenditure. Atherosclerosis is a multifactorial disease and its prevention requires a global approach that takes into account the associated risk factors. This document summarises the current evidence and includes recommendations for patients with establishe...
Source: Atherosclerosis - March 15, 2024 Category: Cardiology Authors: Jos é María Mostaza Xavier Pint ó Pedro Armario Luis Masana Jos é T Real Pedro Valdivielso Teresa Arrobas-Velilla Ram ón Baeza-Trinidad Pilar Calmarza Jes ús Cebollada Miguel Civera-Andr és Jos é I Cuende Melero Jos é L Díaz-Díaz Javier Esp íl Source Type: research

SEA 2024 Standards for Global Control of Vascular Risk
Clin Investig Arterioscler. 2024 Mar 14:S0214-9168(24)00017-2. doi: 10.1016/j.arteri.2024.02.001. Online ahead of print.ABSTRACTOne of the objectives of the Spanish Society of Arteriosclerosis is to contribute to the knowledge, prevention and treatment of vascular diseases, which are the leading cause of death in Spain and entail a high degree of disability and health expenditure. Atherosclerosis is a multifactorial disease and its prevention requires a global approach that takes into account the associated risk factors. This document summarises the current evidence and includes recommendations for patients with establishe...
Source: Atherosclerosis - March 15, 2024 Category: Cardiology Authors: Jos é María Mostaza Xavier Pint ó Pedro Armario Luis Masana Jos é T Real Pedro Valdivielso Teresa Arrobas-Velilla Ram ón Baeza-Trinidad Pilar Calmarza Jes ús Cebollada Miguel Civera-Andr és Jos é I Cuende Melero Jos é L Díaz-Díaz Javier Esp íl Source Type: research

Identification of New Markers of Angiogenic Sprouting Using Transcriptomics: New Role for RND3
CONCLUSIONS: Validation of multiple genes, including rounding 3, revealed a functional role for this gene signature early in the angiogenic process. This study expands the list of genes associated with the acquisition of a tip cell phenotype during endothelial cell sprout initiation.PMID:38482696 | DOI:10.1161/ATVBAHA.123.320599 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 14, 2024 Category: Cardiology Authors: Colette A Abbey Camille L Duran Zhishi Chen Yanping Chen Sukanya Roy Ashley Coffell Timothy M Sveeggen Sanjukta Chakraborty Gregg B Wells Jiang Chang Kayla J Bayless Source Type: research

Zebrafish ApoB-Containing Lipoprotein Metabolism: A Closer Look
Arterioscler Thromb Vasc Biol. 2024 Mar 14. doi: 10.1161/ATVBAHA.123.318287. Online ahead of print.ABSTRACTZebrafish have become a powerful model of mammalian lipoprotein metabolism and lipid cell biology. Most key proteins involved in lipid metabolism, including cholesteryl ester transfer protein, are conserved in zebrafish. Consequently, zebrafish exhibit a human-like lipoprotein profile. Zebrafish with mutations in genes linked to human metabolic diseases often mimic the human phenotype. Zebrafish larvae develop rapidly and externally around the maternally deposited yolk. Recent work revealed that any disturbance of lip...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 14, 2024 Category: Cardiology Authors: Tabea Moll Steven A Farber Source Type: research