HMGB2 Release Promotes Pulmonary Hypertension and Predicts Severity and Mortality of Patients With Pulmonary Arterial Hypertension
CONCLUSIONS: Our findings indicate that targeting HMGB2 might be a novel therapeutic strategy for treating PH. Serum HMGB2 levels could serve as a novel biomarker for diagnosing PA hypertension and determining its prognosis.PMID:38572649 | DOI:10.1161/ATVBAHA.123.319916 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 4, 2024 Category: Cardiology Authors: Deping Kong Jing Liu Junmi Lu Cheng Zeng Hao Chen Zhenzhen Duan Ke Yu Xialei Zheng Pu Zou Liufang Zhou Yicheng Lv Qingye Zeng Lin Lu Jiang Li Yuhu He Source Type: research

Hemodynamics and Wall Mechanics of Vascular Graft Failure
Arterioscler Thromb Vasc Biol. 2024 Apr 4. doi: 10.1161/ATVBAHA.123.318239. Online ahead of print.ABSTRACTBlood vessels are subjected to complex biomechanical loads, primarily from pressure-driven blood flow. Abnormal loading associated with vascular grafts, arising from altered hemodynamics or wall mechanics, can cause acute and progressive vascular failure and end-organ dysfunction. Perturbations to mechanobiological stimuli experienced by vascular cells contribute to remodeling of the vascular wall via activation of mechanosensitive signaling pathways and subsequent changes in gene expression and associated turnover of ...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 4, 2024 Category: Cardiology Authors: Jason M Szafron Elbert E Heng Jack Boyd Jay D Humphrey Alison L Marsden Source Type: research

Virus-Specific T Cells in the Atheroma Crime Scene: Guilty Accomplices or Innocent Bystanders?
Arterioscler Thromb Vasc Biol. 2024 Apr 4. doi: 10.1161/ATVBAHA.124.320932. Online ahead of print.NO ABSTRACTPMID:38572645 | DOI:10.1161/ATVBAHA.124.320932 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 4, 2024 Category: Cardiology Authors: Anton Gister å Source Type: research

Angiotensinogen as a Therapeutic Target for Cardiovascular and Metabolic Diseases
Arterioscler Thromb Vasc Biol. 2024 Apr 4. doi: 10.1161/ATVBAHA.124.318374. Online ahead of print.ABSTRACTAGT (angiotensinogen) is the unique precursor for the generation of all the peptides of the renin-angiotensin system, but it has received relatively scant attention compared to many other renin-angiotensin system components. Focus on AGT has increased recently, particularly with the evolution of drugs to target the synthesis of the protein. AGT is a noninhibitory serpin that has several conserved domains in addition to the angiotensin II sequences at the N terminus. Increased study is needed on the structure-function r...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 4, 2024 Category: Cardiology Authors: Alan Daugherty Hisashi Sawada Mary B Sheppard Hong S Lu Source Type: research

Glycoursodeoxycholic Acid Alleviates Arterial Thrombosis via Suppressing Diacylglycerol Kinases Activity in Platelet
CONCLUSIONS: Our study implicated that GUDCA reduces platelet hyperreactivity and improves thrombotic propensity by inhibiting DGKs activity, which is a potentially effective prophylactic approach and promising therapeutic agent for arterial thrombotic events.PMID:38572646 | DOI:10.1161/ATVBAHA.124.320728 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 4, 2024 Category: Cardiology Authors: Wenchao Yang Ruijia Feng Guiyan Peng Zhecun Wang Meifeng Cen Yexiang Jing Weiqi Feng Ting Long Yunchong Liu Zilun Li Kan Huang Guangqi Chang Source Type: research

Single-Cell RNA Sequencing Reveals an Immune Landscape of CD4 < sup > + < /sup > T Cells in Coronary Culprit Plaques With Acute Coronary Syndrome in Humans
CONCLUSIONS: For the first time, we revealed single cell-level characteristics of CD4+ T cells in patients with ACS. CD4+ T cells could be therapeutic targets of ACS.REGISTRATION: URL: https://www.umin.ac.jp/ctr; Unique identifier: UMIN000040747.PMID:38572648 | DOI:10.1161/ATVBAHA.123.320409 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 4, 2024 Category: Cardiology Authors: Shintaro Takeda Takuo Emoto Tomoya Yamashita Hiroyuki Yamamoto Tomofumi Takaya Takahiro Sawada Takeshi Yoshida Masatoshi Inoue Yuya Suzuki Tomoyo Hamana Taishi Inoue Masayuki Taniguchi Naoto Sasaki Hiromasa Otake Takenao Ohkawa Tomoyuki Furuyashiki Hiroya Source Type: research

HMGB2 Release Promotes Pulmonary Hypertension and Predicts Severity and Mortality of Patients With Pulmonary Arterial Hypertension
CONCLUSIONS: Our findings indicate that targeting HMGB2 might be a novel therapeutic strategy for treating PH. Serum HMGB2 levels could serve as a novel biomarker for diagnosing PA hypertension and determining its prognosis.PMID:38572649 | DOI:10.1161/ATVBAHA.123.319916 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 4, 2024 Category: Cardiology Authors: Deping Kong Jing Liu Junmi Lu Cheng Zeng Hao Chen Zhenzhen Duan Ke Yu Xialei Zheng Pu Zou Liufang Zhou Yicheng Lv Qingye Zeng Lin Lu Jiang Li Yuhu He Source Type: research

Hemodynamics and Wall Mechanics of Vascular Graft Failure
Arterioscler Thromb Vasc Biol. 2024 Apr 4. doi: 10.1161/ATVBAHA.123.318239. Online ahead of print.ABSTRACTBlood vessels are subjected to complex biomechanical loads, primarily from pressure-driven blood flow. Abnormal loading associated with vascular grafts, arising from altered hemodynamics or wall mechanics, can cause acute and progressive vascular failure and end-organ dysfunction. Perturbations to mechanobiological stimuli experienced by vascular cells contribute to remodeling of the vascular wall via activation of mechanosensitive signaling pathways and subsequent changes in gene expression and associated turnover of ...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 4, 2024 Category: Cardiology Authors: Jason M Szafron Elbert E Heng Jack Boyd Jay D Humphrey Alison L Marsden Source Type: research

Single-Cell RNA Sequencing Reveals an Immune Landscape of CD4 < sup > + < /sup > T Cells in Coronary Culprit Plaques With Acute Coronary Syndrome in Humans
CONCLUSIONS: For the first time, we revealed single cell-level characteristics of CD4+ T cells in patients with ACS. CD4+ T cells could be therapeutic targets of ACS.REGISTRATION: URL: https://www.umin.ac.jp/ctr; Unique identifier: UMIN000040747.PMID:38572648 | DOI:10.1161/ATVBAHA.123.320409 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 4, 2024 Category: Cardiology Authors: Shintaro Takeda Takuo Emoto Tomoya Yamashita Hiroyuki Yamamoto Tomofumi Takaya Takahiro Sawada Takeshi Yoshida Masatoshi Inoue Yuya Suzuki Tomoyo Hamana Taishi Inoue Masayuki Taniguchi Naoto Sasaki Hiromasa Otake Takenao Ohkawa Tomoyuki Furuyashiki Hiroya Source Type: research

Angiotensinogen as a Therapeutic Target for Cardiovascular and Metabolic Diseases
Arterioscler Thromb Vasc Biol. 2024 Apr 4. doi: 10.1161/ATVBAHA.124.318374. Online ahead of print.ABSTRACTAGT (angiotensinogen) is the unique precursor for the generation of all the peptides of the renin-angiotensin system, but it has received relatively scant attention compared to many other renin-angiotensin system components. Focus on AGT has increased recently, particularly with the evolution of drugs to target the synthesis of the protein. AGT is a noninhibitory serpin that has several conserved domains in addition to the angiotensin II sequences at the N terminus. Increased study is needed on the structure-function r...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 4, 2024 Category: Cardiology Authors: Alan Daugherty Hisashi Sawada Mary B Sheppard Hong S Lu Source Type: research

Virus-Specific T Cells in the Atheroma Crime Scene: Guilty Accomplices or Innocent Bystanders?
Arterioscler Thromb Vasc Biol. 2024 Apr 4. doi: 10.1161/ATVBAHA.124.320932. Online ahead of print.NO ABSTRACTPMID:38572645 | DOI:10.1161/ATVBAHA.124.320932 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 4, 2024 Category: Cardiology Authors: Anton Gister å Source Type: research

Glycoursodeoxycholic Acid Alleviates Arterial Thrombosis via Suppressing Diacylglycerol Kinases Activity in Platelet
CONCLUSIONS: Our study implicated that GUDCA reduces platelet hyperreactivity and improves thrombotic propensity by inhibiting DGKs activity, which is a potentially effective prophylactic approach and promising therapeutic agent for arterial thrombotic events.PMID:38572646 | DOI:10.1161/ATVBAHA.124.320728 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 4, 2024 Category: Cardiology Authors: Wenchao Yang Ruijia Feng Guiyan Peng Zhecun Wang Meifeng Cen Yexiang Jing Weiqi Feng Ting Long Yunchong Liu Zilun Li Kan Huang Guangqi Chang Source Type: research

HMGB2 Release Promotes Pulmonary Hypertension and Predicts Severity and Mortality of Patients With Pulmonary Arterial Hypertension
CONCLUSIONS: Our findings indicate that targeting HMGB2 might be a novel therapeutic strategy for treating PH. Serum HMGB2 levels could serve as a novel biomarker for diagnosing PA hypertension and determining its prognosis.PMID:38572649 | DOI:10.1161/ATVBAHA.123.319916 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 4, 2024 Category: Cardiology Authors: Deping Kong Jing Liu Junmi Lu Cheng Zeng Hao Chen Zhenzhen Duan Ke Yu Xialei Zheng Pu Zou Liufang Zhou Yicheng Lv Qingye Zeng Lin Lu Jiang Li Yuhu He Source Type: research

Hemodynamics and Wall Mechanics of Vascular Graft Failure
Arterioscler Thromb Vasc Biol. 2024 Apr 4. doi: 10.1161/ATVBAHA.123.318239. Online ahead of print.ABSTRACTBlood vessels are subjected to complex biomechanical loads, primarily from pressure-driven blood flow. Abnormal loading associated with vascular grafts, arising from altered hemodynamics or wall mechanics, can cause acute and progressive vascular failure and end-organ dysfunction. Perturbations to mechanobiological stimuli experienced by vascular cells contribute to remodeling of the vascular wall via activation of mechanosensitive signaling pathways and subsequent changes in gene expression and associated turnover of ...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 4, 2024 Category: Cardiology Authors: Jason M Szafron Elbert E Heng Jack Boyd Jay D Humphrey Alison L Marsden Source Type: research

Hemodynamics and Wall Mechanics of Vascular Graft Failure
Arterioscler Thromb Vasc Biol. 2024 Apr 4. doi: 10.1161/ATVBAHA.123.318239. Online ahead of print.ABSTRACTBlood vessels are subjected to complex biomechanical loads, primarily from pressure-driven blood flow. Abnormal loading associated with vascular grafts, arising from altered hemodynamics or wall mechanics, can cause acute and progressive vascular failure and end-organ dysfunction. Perturbations to mechanobiological stimuli experienced by vascular cells contribute to remodeling of the vascular wall via activation of mechanosensitive signaling pathways and subsequent changes in gene expression and associated turnover of ...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 4, 2024 Category: Cardiology Authors: Jason M Szafron Elbert E Heng Jack Boyd Jay D Humphrey Alison L Marsden Source Type: research