PAR4 Antagonism in Patients With Coronary Artery Disease Receiving Antiplatelet Therapies
CONCLUSIONS: PAR4 antagonism has additive antithrombotic effects when used in addition to ticagrelor, aspirin, or their combination, in patients with stable coronary heart disease.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT05093790.PMID:38357820 | DOI:10.1161/ATVBAHA.123.320448 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Jennifer Nash Mohammed N Meah Beth Whittington Samuel Debono Jennifer Raftis Mark R Miller Andrew Sorbie Nicholas L Mills Josselin Nespoux Lorraine Bruce Rodger Duffin Neeraj Dhaun Mairi Brittan Longfei Chao Samira Merali Minji Kim Zhaoqing Wang Yue Zhang Source Type: research

Microvascular Network Remodeling in the Ischemic Mouse Brain Defined by Light Sheet Microscopy
CONCLUSIONS: Utilizing light sheet microscopy together with automated image analysis, we characterized microvascular remodeling post-ischemia in unprecedented detail. This technology will significantly advance our understanding of microvascular restorative processes and pave the way for novel treatment developments in the stroke field.PMID:38357819 | DOI:10.1161/ATVBAHA.123.320339 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Nina Hagemann Yachao Qi Ayan Mohamud Yusuf AnRan Li Anthony Squire Tobias Tertel Bernd Giebel Peter Ludewig Philippa Spangenberg Jianxu Chen Axel Mosig Matthias Gunzer Dirk M Hermann Source Type: research

Lymphangiogenesis in Rheumatic Heart Valve Disease: A New Factor in the Pathogenic Conundrum
Arterioscler Thromb Vasc Biol. 2024 Feb 15. doi: 10.1161/ATVBAHA.124.320708. Online ahead of print.NO ABSTRACTPMID:38357818 | DOI:10.1161/ATVBAHA.124.320708 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Adrien Lupieri Livia S A Passos Robert A Levine Victor Nizet Elena Aikawa Source Type: research

Valvular Prostaglandins Are Elevated in Severe Human Aortic Valve Stenosis
CONCLUSIONS: Our comprehensive analysis of oxylipins in the human AV identified the inflammatory and osteogenic regulating prostanoids to be positively correlated with AVS severity. This elucidation of prostanoid dysregulation warrants further research into COX inhibition to mitigate AVS.PMID:38357817 | DOI:10.1161/ATVBAHA.123.320001 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Lucien G J Cayer Arun Surendran Tobias Karakach Harold M Aukema Amir Ravandi Source Type: research

Single-Cell Transcriptome Reveals Potential Mechanisms for Coronary Artery Lesions in Kawasaki Disease
CONCLUSIONS: Collectively, this study provides a comprehensive understanding of the roles of various immune cells and inflammatory cytokine storms in the development of CALs in KD and offers a valuable resource for identifying novel therapeutic targets for patients with KD with CALs.PMID:38357816 | DOI:10.1161/ATVBAHA.123.320188 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Yeshi Chen Minna Yang Mingming Zhang Hongmao Wang Yang Zheng Rui Sun Xiaohui Li Source Type: research

Single-Cell Transcriptome Reveals Potential Mechanisms for Coronary Artery Lesions in Kawasaki Disease
CONCLUSIONS: Collectively, this study provides a comprehensive understanding of the roles of various immune cells and inflammatory cytokine storms in the development of CALs in KD and offers a valuable resource for identifying novel therapeutic targets for patients with KD with CALs.PMID:38357816 | DOI:10.1161/ATVBAHA.123.320188 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Yeshi Chen Minna Yang Mingming Zhang Hongmao Wang Yang Zheng Rui Sun Xiaohui Li Source Type: research

Valvular Prostaglandins Are Elevated in Severe Human Aortic Valve Stenosis
CONCLUSIONS: Our comprehensive analysis of oxylipins in the human AV identified the inflammatory and osteogenic regulating prostanoids to be positively correlated with AVS severity. This elucidation of prostanoid dysregulation warrants further research into COX inhibition to mitigate AVS.PMID:38357817 | DOI:10.1161/ATVBAHA.123.320001 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Lucien G J Cayer Arun Surendran Tobias Karakach Harold M Aukema Amir Ravandi Source Type: research

Lymphangiogenesis in Rheumatic Heart Valve Disease: A New Factor in the Pathogenic Conundrum
Arterioscler Thromb Vasc Biol. 2024 Feb 15. doi: 10.1161/ATVBAHA.124.320708. Online ahead of print.NO ABSTRACTPMID:38357818 | DOI:10.1161/ATVBAHA.124.320708 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Adrien Lupieri Livia S A Passos Robert A Levine Victor Nizet Elena Aikawa Source Type: research

Microvascular Network Remodeling in the Ischemic Mouse Brain Defined by Light Sheet Microscopy
CONCLUSIONS: Utilizing light sheet microscopy together with automated image analysis, we characterized microvascular remodeling post-ischemia in unprecedented detail. This technology will significantly advance our understanding of microvascular restorative processes and pave the way for novel treatment developments in the stroke field.PMID:38357819 | DOI:10.1161/ATVBAHA.123.320339 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Nina Hagemann Yachao Qi Ayan Mohamud Yusuf AnRan Li Anthony Squire Tobias Tertel Bernd Giebel Peter Ludewig Philippa Spangenberg Jianxu Chen Axel Mosig Matthias Gunzer Dirk M Hermann Source Type: research

PAR4 Antagonism in Patients With Coronary Artery Disease Receiving Antiplatelet Therapies
CONCLUSIONS: PAR4 antagonism has additive antithrombotic effects when used in addition to ticagrelor, aspirin, or their combination, in patients with stable coronary heart disease.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT05093790.PMID:38357820 | DOI:10.1161/ATVBAHA.123.320448 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Jennifer Nash Mohammed N Meah Beth Whittington Samuel Debono Jennifer Raftis Mark R Miller Andrew Sorbie Nicholas L Mills Josselin Nespoux Lorraine Bruce Rodger Duffin Neeraj Dhaun Mairi Brittan Longfei Chao Samira Merali Minji Kim Zhaoqing Wang Yue Zhang Source Type: research

Single-Cell Transcriptome Reveals Potential Mechanisms for Coronary Artery Lesions in Kawasaki Disease
CONCLUSIONS: Collectively, this study provides a comprehensive understanding of the roles of various immune cells and inflammatory cytokine storms in the development of CALs in KD and offers a valuable resource for identifying novel therapeutic targets for patients with KD with CALs.PMID:38357816 | DOI:10.1161/ATVBAHA.123.320188 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Yeshi Chen Minna Yang Mingming Zhang Hongmao Wang Yang Zheng Rui Sun Xiaohui Li Source Type: research

Lymphangiogenesis in Rheumatic Heart Valve Disease: A New Factor in the Pathogenic Conundrum
Arterioscler Thromb Vasc Biol. 2024 Feb 15. doi: 10.1161/ATVBAHA.124.320708. Online ahead of print.NO ABSTRACTPMID:38357818 | DOI:10.1161/ATVBAHA.124.320708 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Adrien Lupieri Livia S A Passos Robert A Levine Victor Nizet Elena Aikawa Source Type: research

Valvular Prostaglandins Are Elevated in Severe Human Aortic Valve Stenosis
CONCLUSIONS: Our comprehensive analysis of oxylipins in the human AV identified the inflammatory and osteogenic regulating prostanoids to be positively correlated with AVS severity. This elucidation of prostanoid dysregulation warrants further research into COX inhibition to mitigate AVS.PMID:38357817 | DOI:10.1161/ATVBAHA.123.320001 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Lucien G J Cayer Arun Surendran Tobias Karakach Harold M Aukema Amir Ravandi Source Type: research

PAR4 Antagonism in Patients With Coronary Artery Disease Receiving Antiplatelet Therapies
CONCLUSIONS: PAR4 antagonism has additive antithrombotic effects when used in addition to ticagrelor, aspirin, or their combination, in patients with stable coronary heart disease.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT05093790.PMID:38357820 | DOI:10.1161/ATVBAHA.123.320448 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Jennifer Nash Mohammed N Meah Beth Whittington Samuel Debono Jennifer Raftis Mark R Miller Andrew Sorbie Nicholas L Mills Josselin Nespoux Lorraine Bruce Rodger Duffin Neeraj Dhaun Mairi Brittan Longfei Chao Samira Merali Minji Kim Zhaoqing Wang Yue Zhang Source Type: research

Microvascular Network Remodeling in the Ischemic Mouse Brain Defined by Light Sheet Microscopy
CONCLUSIONS: Utilizing light sheet microscopy together with automated image analysis, we characterized microvascular remodeling post-ischemia in unprecedented detail. This technology will significantly advance our understanding of microvascular restorative processes and pave the way for novel treatment developments in the stroke field.PMID:38357819 | DOI:10.1161/ATVBAHA.123.320339 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Nina Hagemann Yachao Qi Ayan Mohamud Yusuf AnRan Li Anthony Squire Tobias Tertel Bernd Giebel Peter Ludewig Philippa Spangenberg Jianxu Chen Axel Mosig Matthias Gunzer Dirk M Hermann Source Type: research