TF-FVIIa PAR2- β-Arrestin in Mouse Signaling Sustains Organ Dysfunction in Coxsackievirus B3 Infection
CONCLUSIONS: These data provide insights into a TF-FVIIa signaling axis through PAR2-β-arrestin coupling that is a regulator of inflammation-triggered tissue repair and hemodynamic compromise in coxsackievirus B3 infection and can potentially be targeted with selective coagulation inhibitors.PMID:38385286 | DOI:10.1161/ATVBAHA.123.320157 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Meike Kespohl Carl Christoph Goetzke Nadine Althof Clara Bredow Nicolas Kelm Sandra Pinkert Thomas Bukur Valesca Bukur Kristin Grunz Dilraj Kaur Arnd Heuser Michael M ülleder Martina Sauter Karin Klingel Hartmut Weiler Nikolaus Berndt Matthias M Gaida Wo Source Type: research

Use of Genomics to Develop Novel Therapeutics and Personalize Hypertension Therapy
Arterioscler Thromb Vasc Biol. 2024 Feb 22. doi: 10.1161/ATVBAHA.123.319220. Online ahead of print.ABSTRACTHypertension is a prevalent public health problem, contributing to >10 million deaths annually. Though multiple therapeutics exist, many patients suffer from treatment-resistant hypertension or try several medications before achieving blood pressure control. Genomic advances offer mechanistic understanding of blood pressure variability, therapeutic targets, therapeutic response, and promise a stratified approach to treatment of primary hypertension. Cyclic guanosine monophosphate augmentation, aldosterone synthase ...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Emma F Magavern Vikas Kapil Manish Saxena Ajay Gupta Mark J Caulfield Source Type: research

Differences in Cardiometabolic Proteins in Pregnancy Prioritize Relevant Targets of Preeclampsia
CONCLUSIONS: These results demonstrate the value of performing targeted proteomics using a panel of cardiovascular biomarkers to identify biomarkers relevant to preeclampsia pathophysiology and highlight the need for larger multiomic studies to define modifiable pathways of surveillance and intervention upstream to preeclampsia diagnosis.PMID:38385288 | DOI:10.1161/ATVBAHA.124.320737 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Kathryn J Lindley Andrew Perry Marni Jacobs Lauren Petty Kaushik Amancherla Shilin Zhao Claire Barker Victor G Davila-Roman Sadiya S Khan Sarah S Osmundson Kahraman Tanriverdi Jane E Freedman Jennifer Below Ravi V Shah Louise C Laurent Source Type: research

Inhibition of IL-1 Ameliorates Cardiac Dysfunction and Arrhythmias in a Murine Model of Kawasaki Disease
CONCLUSIONS: Our results characterize the electrophysiological abnormalities associated with L casei cell wall extract-induced KD and show that IL-1Ra is more effective in preventing KD-induced myocardial dysfunction and arrhythmias than anti-TNFα therapy. These findings support the advancement of clinical trials using IL-1Ra in patients with KD.PMID:38385289 | DOI:10.1161/ATVBAHA.123.320382 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Thassio Mesquita Yen-Nien Lin Shuang Chen Youngho Lee Rodrigo Miguel-Dos-Santos Asli E Atici Michael C Fishbein Magali Noval Rivas Moshe Arditi Eugenio Cingolani Source Type: research

< em > ANGPTL3 < /em > Downregulation Increases Intracellular Lipids by Reducing Energy Utilization
CONCLUSIONS: In conclusion, intracellular ANGPTL3 downregulation by silencing RNA led to an increase in triglycerides content due to a reduction in energy substrate utilization resembling a primary intracellular hepatocyte hypothyroidism.PMID:38385290 | DOI:10.1161/ATVBAHA.123.319789 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Grazia Pennisi Samantha Maurotti Ester Ciociola Oveis Jamialahmadi Giorgio Bertolazzi Angela Mirarchi Per-Olof Bergh Francesca Scionti Rosellina M Mancina Rocco Spagnuolo Claudio Tripodo Jan Boren Salvatore Petta Stefano Romeo Source Type: research

Reduced Monocyte and Neutrophil Infiltration and Activation by P-Selectin/CD62P Inhibition Enhances Thrombus Resolution
CONCLUSIONS: Inhibition of P-selectin-dependent activation of monocytes and neutrophils accelerates venous thrombosis resolution due to reduced infiltration and activation of innate immune cells at the site of thrombus formation, which prevents early thrombus stabilization and facilitates fibrinolysis.PMID:38385292 | DOI:10.1161/ATVBAHA.123.320016 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Julia B Kral-Pointner Patrick Haider Petra L Szabo Manuel Salzmann Mira Brekalo Karl H Schneider Waltraud C Schrottmaier Christoph Kaun Sonja Bleichert Attila Kiss Romana Sickha Christian Hengstenberg Kurt Huber Christine Brostjan Helga Bergmeister Alice Source Type: research

Calcium Signaling in Airway Epithelial Cells: Current Understanding and Implications for Inflammatory Airway Disease
Arterioscler Thromb Vasc Biol. 2024 Feb 22. doi: 10.1161/ATVBAHA.123.318339. Online ahead of print.ABSTRACTAirway epithelial cells play an indispensable role in protecting the lung from inhaled pathogens and allergens by releasing an array of mediators that orchestrate inflammatory and immune responses when confronted with harmful environmental triggers. While this process is undoubtedly important for containing the effects of various harmful insults, dysregulation of the inflammatory response can cause lung diseases including asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis. A key cellular mechanism t...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Amit Jairaman Murali Prakriya Source Type: research

Tissue Factor and COVID-19 Associated Thrombosis
Arterioscler Thromb Vasc Biol. 2024 Mar;44(3):523-529. doi: 10.1161/ATVBAHA.123.320144. Epub 2024 Feb 21.ABSTRACTMicrobial infections activate the innate and adaptive immune systems.1 Pathogen-associated molecular patterns produced by microbes, such as double-stranded RNA, are detected by PRRs (pattern-recognition receptors), such as toll-like receptor 3, and this leads to the expression of interferons and cytokines.1,2.PMID:38381854 | DOI:10.1161/ATVBAHA.123.320144 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 21, 2024 Category: Cardiology Authors: Nigel Mackman Source Type: research

Correction to: Long Noncoding RNA Gpr137b-ps Promotes Advanced Atherosclerosis via the Regulation of Autophagy in Macrophages
Arterioscler Thromb Vasc Biol. 2024 Mar;44(3):e116. doi: 10.1161/ATV.0000000000000170. Epub 2024 Feb 21.NO ABSTRACTPMID:38381855 | DOI:10.1161/ATV.0000000000000170 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 21, 2024 Category: Cardiology Source Type: research

Incremental values of AOPP, IL-6, and GDF15 for identifying arteriosclerosis in patients with obstructive sleep apnea
ConclusionsThis study verified the independent and incremental value of GDF15 in identifying arteriosclerosis in OSA patients, surpassing clinical risk factors and other serum biomarkers such as AOPP and IL-6. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - February 20, 2024 Category: Research Source Type: research

PAR4 Antagonism in Patients With Coronary Artery Disease Receiving Antiplatelet Therapies
CONCLUSIONS: PAR4 antagonism has additive antithrombotic effects when used in addition to ticagrelor, aspirin, or their combination, in patients with stable coronary heart disease.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT05093790.PMID:38357820 | DOI:10.1161/ATVBAHA.123.320448 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Jennifer Nash Mohammed N Meah Beth Whittington Samuel Debono Jennifer Raftis Mark R Miller Andrew Sorbie Nicholas L Mills Josselin Nespoux Lorraine Bruce Rodger Duffin Neeraj Dhaun Mairi Brittan Longfei Chao Samira Merali Minji Kim Zhaoqing Wang Yue Zhang Source Type: research

Lymphangiogenesis in Rheumatic Heart Valve Disease: A New Factor in the Pathogenic Conundrum
Arterioscler Thromb Vasc Biol. 2024 Feb 15. doi: 10.1161/ATVBAHA.124.320708. Online ahead of print.NO ABSTRACTPMID:38357818 | DOI:10.1161/ATVBAHA.124.320708 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Adrien Lupieri Livia S A Passos Robert A Levine Victor Nizet Elena Aikawa Source Type: research

Single-Cell Transcriptome Reveals Potential Mechanisms for Coronary Artery Lesions in Kawasaki Disease
CONCLUSIONS: Collectively, this study provides a comprehensive understanding of the roles of various immune cells and inflammatory cytokine storms in the development of CALs in KD and offers a valuable resource for identifying novel therapeutic targets for patients with KD with CALs.PMID:38357816 | DOI:10.1161/ATVBAHA.123.320188 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Yeshi Chen Minna Yang Mingming Zhang Hongmao Wang Yang Zheng Rui Sun Xiaohui Li Source Type: research

Microvascular Network Remodeling in the Ischemic Mouse Brain Defined by Light Sheet Microscopy
CONCLUSIONS: Utilizing light sheet microscopy together with automated image analysis, we characterized microvascular remodeling post-ischemia in unprecedented detail. This technology will significantly advance our understanding of microvascular restorative processes and pave the way for novel treatment developments in the stroke field.PMID:38357819 | DOI:10.1161/ATVBAHA.123.320339 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Nina Hagemann Yachao Qi Ayan Mohamud Yusuf AnRan Li Anthony Squire Tobias Tertel Bernd Giebel Peter Ludewig Philippa Spangenberg Jianxu Chen Axel Mosig Matthias Gunzer Dirk M Hermann Source Type: research

Valvular Prostaglandins Are Elevated in Severe Human Aortic Valve Stenosis
CONCLUSIONS: Our comprehensive analysis of oxylipins in the human AV identified the inflammatory and osteogenic regulating prostanoids to be positively correlated with AVS severity. This elucidation of prostanoid dysregulation warrants further research into COX inhibition to mitigate AVS.PMID:38357817 | DOI:10.1161/ATVBAHA.123.320001 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 15, 2024 Category: Cardiology Authors: Lucien G J Cayer Arun Surendran Tobias Karakach Harold M Aukema Amir Ravandi Source Type: research