Statin administration ameliorates ischemia-induced overactive bladder with improvement of blood flow and anti-inflammatory effects in rats
CONCLUSIONS: The present results suggest that statins are effective in OAB caused by arteriosclerosis and ischemia. The mechanism of their effects involves improved bladder blood flow and decreased bladder inflammation.PMID:38426742 | DOI:10.1002/nau.25433 (Source: Atherosclerosis)
Source: Atherosclerosis - March 1, 2024 Category: Cardiology Authors: Yuichi Ishizuka Yohei Satake Shingo Kimura Shinichi Yamashita Naoki Kawamorita Akihiro Ito Source Type: research

Salidroside promotes pro-angiogenesis and repair of blood brain barrier via Notch/ITGB1 signal path in CSVD Model
CONCLUSION: The aforementioned findings demonstrated that SAL could protect BBB integrity through Notch-ITGB1 signaling path in CSVD, which indicated that SAL could be a potential medicine candidate for CSVD treatment.PMID:38417575 | DOI:10.1016/j.jare.2024.02.019 (Source: Cell Research)
Source: Cell Research - February 28, 2024 Category: Cytology Authors: Tu Zhilan Zhang Zengyu Jin Pengpeng Yang Hualan Li Chao Xi Yan Guo Zimin Hou Shuangxing Li Weiwei Source Type: research

CircHAT1 regulates the proliferation and phenotype switch of vascular smooth muscle cells in lower extremity arteriosclerosis obliterans through targeting SFRS1
This study aimed to decipher the mechanism of circular ribonucleic acids (circRNAs) in lower extremity arteriosclerosis obliterans (LEASO). First, bioinformatics analysis was performed for screening significantly down-regulated cardiac specific circRNA-circHAT1 in LEASO. The expression of circHAT1 in LEASO clinical samples was detected by quantitative real-time polymerase chain reaction (qRT-PCR). The protein expression of splicing factor arginine/serine-rich 1 (SFRS1), α-smooth muscle actin (α-SMA), Calponin (CNN1), cyclin D1 (CNND1) and smooth muscle myosin heavy chain 11 (SMHC) in vascular smooth muscle cells (VSMCs) ...
Source: Molecular and Cellular Biochemistry - February 27, 2024 Category: Biochemistry Authors: Xian-Ying Huang Fang-Yong Fu Kai Qian Qiao-Li Feng Sai Cao Wei-Yu Wu Yuan-Lin Luo Wei-Jie Chen Zhi Zhang Shui-Chuan Huang Source Type: research

CircHAT1 regulates the proliferation and phenotype switch of vascular smooth muscle cells in lower extremity arteriosclerosis obliterans through targeting SFRS1
This study aimed to decipher the mechanism of circular ribonucleic acids (circRNAs) in lower extremity arteriosclerosis obliterans (LEASO). First, bioinformatics analysis was performed for screening significantly down-regulated cardiac specific circRNA-circHAT1 in LEASO. The expression of circHAT1 in LEASO clinical samples was detected by quantitative real-time polymerase chain reaction (qRT-PCR). The protein expression of splicing factor arginine/serine-rich 1 (SFRS1), α-smooth muscle actin (α-SMA), Calponin (CNN1), cyclin D1 (CNND1) and smooth muscle myosin heavy chain 11 (SMHC) in vascular smooth muscle cells (VSMCs) ...
Source: Molecular and Cellular Biochemistry - February 27, 2024 Category: Biochemistry Authors: Xian-Ying Huang Fang-Yong Fu Kai Qian Qiao-Li Feng Sai Cao Wei-Yu Wu Yuan-Lin Luo Wei-Jie Chen Zhi Zhang Shui-Chuan Huang Source Type: research

CircHAT1 regulates the proliferation and phenotype switch of vascular smooth muscle cells in lower extremity arteriosclerosis obliterans through targeting SFRS1
This study aimed to decipher the mechanism of circular ribonucleic acids (circRNAs) in lower extremity arteriosclerosis obliterans (LEASO). First, bioinformatics analysis was performed for screening significantly down-regulated cardiac specific circRNA-circHAT1 in LEASO. The expression of circHAT1 in LEASO clinical samples was detected by quantitative real-time polymerase chain reaction (qRT-PCR). The protein expression of splicing factor arginine/serine-rich 1 (SFRS1), α-smooth muscle actin (α-SMA), Calponin (CNN1), cyclin D1 (CNND1) and smooth muscle myosin heavy chain 11 (SMHC) in vascular smooth muscle cells (VSMCs) ...
Source: Molecular and Cellular Biochemistry - February 27, 2024 Category: Biochemistry Authors: Xian-Ying Huang Fang-Yong Fu Kai Qian Qiao-Li Feng Sai Cao Wei-Yu Wu Yuan-Lin Luo Wei-Jie Chen Zhi Zhang Shui-Chuan Huang Source Type: research

Pathology-based brain arterial disease phenotypes and their radiographic correlates
CONCLUSIONS AND RESULTS: Arteriosclerosis refers to hardening of the arteries but does not specify the underlying etiology. Specific terms such as atherosclerosis, calcification, or non-atherosclerotic fibroplasia are preferred. Atherosclerosis is defined pathologically by an atheroma. Other brain arterial pathologies occur and should be distinguished from atherosclerosis given therapeutic implications. On brain imaging, intracranial arterial luminal stenosis is usually attributed to atherosclerosis in the presence of atherosclerotic risk factors but advanced high-resolution arterial wall imaging has the potential to more ...
Source: Atherosclerosis - February 23, 2024 Category: Cardiology Authors: Jose Gutierrez Daniel Bos Tanya N Turan Brian Hoh Saima Hilal Juan F Arenillas Julie A Schneider Marc Chimowitz Susan Morgello Source Type: research

The Pink Tax: Sex and Gender Disparities in Peripheral Artery Disease
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in women, accounting for nearly one of every three deaths in women in the US annually.1 Peripheral artery disease (PAD) is a significant marker of systemic arteriosclerosis associated with increased all-cause, cardiovascular (CV), and cerebrovascular mortality, but it remains largely underrecognized and undertreated among wom... (Source: Radcliffe Cardiology)
Source: Radcliffe Cardiology - February 23, 2024 Category: Cardiology Authors: dbarot525787 Source Type: research

Research development on gut microbiota and vulnerable atherosclerotic plaque
Heliyon. 2024 Feb 8;10(4):e25186. doi: 10.1016/j.heliyon.2024.e25186. eCollection 2024 Feb 29.ABSTRACTThe relationship between gut microbiota and its metabolites with cardiovascular disease (CVD) has been proven. In this review, we aim to conclude the potential mechanism of gut microbiota and its metabolites on inducing the formation of vulnerable atherosclerotic plaque, and to discuss the effect of intestinal metabolites, including trimethylamine-N-oxide (TMAO), lipopolysaccharide (LPS), phenylacetylglutamine (PAG), short-chain fatty acids (SCFAs) on plaque stability. Finally, we include the impact of gut microbiota and i...
Source: Atherosclerosis - February 22, 2024 Category: Cardiology Authors: Shujiao Zheng Zuheng Liu Haiyue Liu Jie Ying Lim Dolly Wong Hui Li Shaofeng Zhang Fang Luo Xiujing Wang Changqing Sun Rong Tang Wuyang Zheng Qiang Xie Source Type: research

TF-FVIIa PAR2- β-Arrestin in Mouse Signaling Sustains Organ Dysfunction in Coxsackievirus B3 Infection
CONCLUSIONS: These data provide insights into a TF-FVIIa signaling axis through PAR2-β-arrestin coupling that is a regulator of inflammation-triggered tissue repair and hemodynamic compromise in coxsackievirus B3 infection and can potentially be targeted with selective coagulation inhibitors.PMID:38385286 | DOI:10.1161/ATVBAHA.123.320157 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Meike Kespohl Carl Christoph Goetzke Nadine Althof Clara Bredow Nicolas Kelm Sandra Pinkert Thomas Bukur Valesca Bukur Kristin Grunz Dilraj Kaur Arnd Heuser Michael M ülleder Martina Sauter Karin Klingel Hartmut Weiler Nikolaus Berndt Matthias M Gaida Wo Source Type: research

Use of Genomics to Develop Novel Therapeutics and Personalize Hypertension Therapy
Arterioscler Thromb Vasc Biol. 2024 Feb 22. doi: 10.1161/ATVBAHA.123.319220. Online ahead of print.ABSTRACTHypertension is a prevalent public health problem, contributing to >10 million deaths annually. Though multiple therapeutics exist, many patients suffer from treatment-resistant hypertension or try several medications before achieving blood pressure control. Genomic advances offer mechanistic understanding of blood pressure variability, therapeutic targets, therapeutic response, and promise a stratified approach to treatment of primary hypertension. Cyclic guanosine monophosphate augmentation, aldosterone synthase ...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Emma F Magavern Vikas Kapil Manish Saxena Ajay Gupta Mark J Caulfield Source Type: research

Differences in Cardiometabolic Proteins in Pregnancy Prioritize Relevant Targets of Preeclampsia
CONCLUSIONS: These results demonstrate the value of performing targeted proteomics using a panel of cardiovascular biomarkers to identify biomarkers relevant to preeclampsia pathophysiology and highlight the need for larger multiomic studies to define modifiable pathways of surveillance and intervention upstream to preeclampsia diagnosis.PMID:38385288 | DOI:10.1161/ATVBAHA.124.320737 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Kathryn J Lindley Andrew Perry Marni Jacobs Lauren Petty Kaushik Amancherla Shilin Zhao Claire Barker Victor G Davila-Roman Sadiya S Khan Sarah S Osmundson Kahraman Tanriverdi Jane E Freedman Jennifer Below Ravi V Shah Louise C Laurent Source Type: research

Inhibition of IL-1 Ameliorates Cardiac Dysfunction and Arrhythmias in a Murine Model of Kawasaki Disease
CONCLUSIONS: Our results characterize the electrophysiological abnormalities associated with L casei cell wall extract-induced KD and show that IL-1Ra is more effective in preventing KD-induced myocardial dysfunction and arrhythmias than anti-TNFα therapy. These findings support the advancement of clinical trials using IL-1Ra in patients with KD.PMID:38385289 | DOI:10.1161/ATVBAHA.123.320382 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Thassio Mesquita Yen-Nien Lin Shuang Chen Youngho Lee Rodrigo Miguel-Dos-Santos Asli E Atici Michael C Fishbein Magali Noval Rivas Moshe Arditi Eugenio Cingolani Source Type: research

< em > ANGPTL3 < /em > Downregulation Increases Intracellular Lipids by Reducing Energy Utilization
CONCLUSIONS: In conclusion, intracellular ANGPTL3 downregulation by silencing RNA led to an increase in triglycerides content due to a reduction in energy substrate utilization resembling a primary intracellular hepatocyte hypothyroidism.PMID:38385290 | DOI:10.1161/ATVBAHA.123.319789 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Grazia Pennisi Samantha Maurotti Ester Ciociola Oveis Jamialahmadi Giorgio Bertolazzi Angela Mirarchi Per-Olof Bergh Francesca Scionti Rosellina M Mancina Rocco Spagnuolo Claudio Tripodo Jan Boren Salvatore Petta Stefano Romeo Source Type: research

High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis
CONCLUSIONS: Our multimodal atlas of cell populations within atherosclerosis provides novel insights into the diversity, phenotype, location, isolation, and clinical relevance of the unique cellular composition of human carotid atherosclerosis. These findings facilitate both the mapping of cardiovascular disease susceptibility loci to specific cell types and the identification of novel molecular and cellular therapeutic targets for the treatment of the disease.PMID:38385291 | DOI:10.1161/ATVBAHA.123.320524 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Alexander C Bashore Hanying Yan Chenyi Xue Lucie Y Zhu Eunyoung Kim Thomas Mawson Johana Coronel Allen Chung Nadja Sachs Sebastian Ho Leila S Ross Michael Kissner Emmanuelle Passegu é Robert C Bauer Lars Maegdefessel Mingyao Li Muredach P Reilly Source Type: research

Reduced Monocyte and Neutrophil Infiltration and Activation by P-Selectin/CD62P Inhibition Enhances Thrombus Resolution
CONCLUSIONS: Inhibition of P-selectin-dependent activation of monocytes and neutrophils accelerates venous thrombosis resolution due to reduced infiltration and activation of innate immune cells at the site of thrombus formation, which prevents early thrombus stabilization and facilitates fibrinolysis.PMID:38385292 | DOI:10.1161/ATVBAHA.123.320016 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Julia B Kral-Pointner Patrick Haider Petra L Szabo Manuel Salzmann Mira Brekalo Karl H Schneider Waltraud C Schrottmaier Christoph Kaun Sonja Bleichert Attila Kiss Romana Sickha Christian Hengstenberg Kurt Huber Christine Brostjan Helga Bergmeister Alice Source Type: research