What is Ondine ’ s Curse?
Discussion
Congenital central hypoventilation syndrome (CCHS) is an autosomal dominant with variable inheritance genetic disease caused by mutation in the Paired Like Homeobox B2 (PHOX2B) gene on chromosome 4. There are two other genes which may also cause CCHS. CCHS affects the chemoreceptor afferent ventilation pathways and is a neural crest migration problem of the autonomic nervous system. The incidence is unknown but a prevalence of 1 in 200,000 live births has been reported. Obviously it is a rarer phenomenon because of the general lethality of the syndrome.
Patients usually present at birth or soon afterwards, but o...
Source: PediatricEducation.org - August 15, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Another Study Shows COVID's Danger to Pregnant Women
THURSDAY, Aug. 11, 2022 -- Pregnancy significantly increases the odds of devastating outcomes from COVID-19, a new study confirms.
Complications from the virus to pregnant women can include heart attack, arrhythmias, heart failure and long-haul... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - August 11, 2022 Category: General Medicine Source Type: news
Cardiogenic shock due to yew poisoning rescued by VA-ECMO: case report and literature review - Schreiber N, Manninger M, P ätzold S, Reisinger AC, Hatzl S, Hackl G, Högenauer C, Eller P.
Ingestion of leaves of the European yew tree (Taxus baccata) can result in fatal cardiac arrhythmias and acute cardiogenic shock. This cardiotoxicity derives from taxine alkaloids that block cardiac voltage-gated sodium and calcium channels. Prompt initiat... (Source: SafetyLit)
Source: SafetyLit - August 11, 2022 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
A case of arrhythmia caused by barium carbonate poisoning - Feng WL, Yin YJ, Liu ZY.
Barium carbonate poisoning is mostly caused by mistaken ingestion in clinical cases, and self-administration of poisoning is rare. In November 2020, Tianjin Occupational Disease Prevention Hospital admitted a patient with severe hypokalemia complicated wit... (Source: SafetyLit)
Source: SafetyLit - August 8, 2022 Category: International Medicine & Public Health Tags: Home and Consumer Product Safety Source Type: news
Axol Bioscience introduces CiPA-validated human stem cell-derived ventricular cardiomyocytes to help improve drug discovery
Axol Bioscience Ltd. (Axol), an established provider of iPSC-derived cells, media, and characterization services for life science discovery, today announced that its human induced pluripotent stem cell (iPSC)-derived ventricular cardiomyocytes have undergone comprehensive in vitro pro-arrhythmia assay (CiPA) validation. Using this assay, the cells were shown to be suitable for measuring cardiotoxicity, offering scientists a robust cardiac model for drug discovery and screening. (Source: The Scientist)
Source: The Scientist - August 2, 2022 Category: Science Tags: The Scientist The Marketplace Source Type: news
Arrhythmias (Abnormal Heart Rhythms)
Title: Arrhythmias (Abnormal Heart Rhythms)Category: Diseases and ConditionsCreated: 10/15/2007 12:00:00 AMLast Editorial Review: 7/28/2022 12:00:00 AM (Source: MedicineNet Heart General)
Source: MedicineNet Heart General - July 28, 2022 Category: Cardiology Source Type: news
Drug Repurposing Study Could Identify New Mesothelioma Treatments
The next breakthrough in the treatment of malignant mesothelioma may be quietly underway.
An international research team based at Temple University in Philadelphia recently identified four drug compounds – already being used safely for noncancerous conditions – that have shown impressive potential for treating mesothelioma. They were part of a novel drug repurposing project aimed at uncovering much-needed options for mesothelioma patients.
“Mesothelioma has shown resistance to all current treatments, including immunotherapy. Novel combinations are badly needed now,” Dr. Antonio Giordano, director of Sbarro He...
Source: Asbestos and Mesothelioma News - July 6, 2022 Category: Environmental Health Authors: Fran Mannino Tags: Clinical Trials/Research/Emerging Treatments Mesothelioma Source Type: news
Vanderbilt University Researchers Combine Genetic Data and EHR Records to Identify Undiagnosed Disease in Patients
Multi-university research group discovers that heart arrhythmia genes may be more common than previously thought For years, big data has been heralded as the key to unlocking the promise of personalized medicine. Now, researchers at Vanderbilt University are bringing that goal a step closer to reality by combining genetic testing data with data stored in […]
The post Vanderbilt University Researchers Combine Genetic Data and EHR Records to Identify Undiagnosed Disease in Patients appeared first on Dark Daily. (Source: Dark Daily)
Source: Dark Daily - July 6, 2022 Category: Laboratory Medicine Authors: Jillia Schlingman Tags: International Laboratory News Laboratory Pathology Laboratory Testing Molecular Diagnostics, Genetic Testing, Whole Gene Sequencing Amsterdam University Medical Centers anatomic pathology Arthur A.M. Wilde PhD big data Carlos G. Vanoye PhD Source Type: news
A case series of oleander poisoning: challenges faced by emergency physicians in developing countries - Mani UA, Kumar M, Abbas H, Gupta P.
OBJECTIVE: Through the reporting of this case series, we aim to establish whether a conservative approach, through managing arrhythmias and vital signs, can be reliably used as a treatment modality for oleander poisoning in developing countries. Methods: ... (Source: SafetyLit)
Source: SafetyLit - July 6, 2022 Category: International Medicine & Public Health Tags: Home and Consumer Product Safety Source Type: news
The Significance of Widely Split P Waves The Significance of Widely Split P Waves
This case highlights the need to be aware that the presence of widely split P waves on an ECG may proceed to more serious cardiac arrhythmias during an anesthetic procedure.Journal of Medical Case Reports (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 23, 2022 Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news
Unexplained Syncope in Young Man With Inherited Arrhythmia Disorder
(MedPage Today) -- Diagnosis of Brugada syndrome should be followed by genetic testing, authors urge (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - June 21, 2022 Category: Cardiology Source Type: news
Supplements warning: Four supplements that may cause ‘potentially fatal’ heart arrhythmias
MULTIVITAMINS are used by millions to help stave off deficiencies, but the pills aren't without flaws. Four supplements used widely to improve athletic and mental performance have been linked to the development of heart arrhythmias, according to health bodies. (Source: Daily Express - Health)
Source: Daily Express - Health - June 20, 2022 Category: Consumer Health News Source Type: news
Air Pollution Tied to Ventricular Arrhythmias in Those With ICDs Air Pollution Tied to Ventricular Arrhythmias in Those With ICDs
Researchers found that vulnerable patients with ICDs experienced more ventricular arrhythmias on days with higher levels of air pollution.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - June 14, 2022 Category: Cardiology Tags: Cardiology News Source Type: news
A rare case of metronidazole overdose causing ventricular fibrillation - Elgassim MAM, Saied ASS, Mustafa MA, Abdelrahman A, AlJaufi I, Salem W.
Ventricular fibrillation is not known as a complication of metronidazole poisoning. Although some arrhythmias have been reported as a complication of metronidazole intake while taking antiarrhythmic medications, most such arrhythmias are possibly related t... (Source: SafetyLit)
Source: SafetyLit - June 13, 2022 Category: International Medicine & Public Health Tags: Poisoning Source Type: news
New IMBRUVICA ® (ibrutinib) Data in Fixed-Duration Combination Regimen Presented at EHA 2022 Shows Deep, Durable Response at Three Years in Untreated Chronic Lymphocytic Leukemia
June 10, 2022 (VIENNA) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new and updated results from the Phase 2 CAPTIVATE study evaluating IMBRUVICA® (ibrutinib) in combination with venetoclax (I+V) as a potential fixed-duration (FD) treatment in adult patients with previously untreated chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). Updated data from the FD cohort with three years of follow-up shows that I+V continues to demonstrate deep and durable responses and clinically meaningful progression-free survival (PFS) and overall survival (OS) in the first-line tre...
Source: Johnson and Johnson - June 10, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news
