Cognate antigen-independent differentiation of resident memory T cells in chronic kidney disease
In this study we subjected male C57BL/6J mice and OT-1 transgenic mice to five consecutive days of 2mg/kg Aristolochic acid (AA) injections i.p. to induce CKD or saline injections as a control. We evaluated their kidney immune profiles at two weeks, six weeks, and six months after treatment. We identified a substantial population of TRMs in the kidneys of mice with AA-induced CKD. Flow cytometry of injured kidneys showed T cells bearing TRM surface markers and single cell RNA sequencing revealed these cells as expressing well-known TRM transcription factors and receptors responsible for TRM differentiation and maintenance....
Source: American Journal of Physiology. Renal Physiology - March 7, 2024 Category: Physiology Authors: Kyle H Moore Elise N Erman Amie M Traylor Stephanie K Esman Yanlin Jiang Jennifer R LaFontaine Anna Zmijewska Yan Lu Reham H Soliman Anupam Agarwal James F George Source Type: research

Cognate antigen-independent differentiation of resident memory T cells in chronic kidney disease
In this study we subjected male C57BL/6J mice and OT-1 transgenic mice to five consecutive days of 2mg/kg Aristolochic acid (AA) injections i.p. to induce CKD or saline injections as a control. We evaluated their kidney immune profiles at two weeks, six weeks, and six months after treatment. We identified a substantial population of TRMs in the kidneys of mice with AA-induced CKD. Flow cytometry of injured kidneys showed T cells bearing TRM surface markers and single cell RNA sequencing revealed these cells as expressing well-known TRM transcription factors and receptors responsible for TRM differentiation and maintenance....
Source: Am J Physiol Renal P... - March 7, 2024 Category: Urology & Nephrology Authors: Kyle H Moore Elise N Erman Amie M Traylor Stephanie K Esman Yanlin Jiang Jennifer R LaFontaine Anna Zmijewska Yan Lu Reham H Soliman Anupam Agarwal James F George Source Type: research

Cognate antigen-independent differentiation of resident memory T cells in chronic kidney disease
In this study we subjected male C57BL/6J mice and OT-1 transgenic mice to five consecutive days of 2mg/kg Aristolochic acid (AA) injections i.p. to induce CKD or saline injections as a control. We evaluated their kidney immune profiles at two weeks, six weeks, and six months after treatment. We identified a substantial population of TRMs in the kidneys of mice with AA-induced CKD. Flow cytometry of injured kidneys showed T cells bearing TRM surface markers and single cell RNA sequencing revealed these cells as expressing well-known TRM transcription factors and receptors responsible for TRM differentiation and maintenance....
Source: American Journal of Physiology. Renal Physiology - March 7, 2024 Category: Physiology Authors: Kyle H Moore Elise N Erman Amie M Traylor Stephanie K Esman Yanlin Jiang Jennifer R LaFontaine Anna Zmijewska Yan Lu Reham H Soliman Anupam Agarwal James F George Source Type: research

Cognate antigen-independent differentiation of resident memory T cells in chronic kidney disease
In this study we subjected male C57BL/6J mice and OT-1 transgenic mice to five consecutive days of 2mg/kg Aristolochic acid (AA) injections i.p. to induce CKD or saline injections as a control. We evaluated their kidney immune profiles at two weeks, six weeks, and six months after treatment. We identified a substantial population of TRMs in the kidneys of mice with AA-induced CKD. Flow cytometry of injured kidneys showed T cells bearing TRM surface markers and single cell RNA sequencing revealed these cells as expressing well-known TRM transcription factors and receptors responsible for TRM differentiation and maintenance....
Source: Am J Physiol Renal P... - March 7, 2024 Category: Urology & Nephrology Authors: Kyle H Moore Elise N Erman Amie M Traylor Stephanie K Esman Yanlin Jiang Jennifer R LaFontaine Anna Zmijewska Yan Lu Reham H Soliman Anupam Agarwal James F George Source Type: research

Cognate antigen-independent differentiation of resident memory T cells in chronic kidney disease
In this study we subjected male C57BL/6J mice and OT-1 transgenic mice to five consecutive days of 2mg/kg Aristolochic acid (AA) injections i.p. to induce CKD or saline injections as a control. We evaluated their kidney immune profiles at two weeks, six weeks, and six months after treatment. We identified a substantial population of TRMs in the kidneys of mice with AA-induced CKD. Flow cytometry of injured kidneys showed T cells bearing TRM surface markers and single cell RNA sequencing revealed these cells as expressing well-known TRM transcription factors and receptors responsible for TRM differentiation and maintenance....
Source: American Journal of Physiology. Renal Physiology - March 7, 2024 Category: Physiology Authors: Kyle H Moore Elise N Erman Amie M Traylor Stephanie K Esman Yanlin Jiang Jennifer R LaFontaine Anna Zmijewska Yan Lu Reham H Soliman Anupam Agarwal James F George Source Type: research

Cognate antigen-independent differentiation of resident memory T cells in chronic kidney disease
In this study we subjected male C57BL/6J mice and OT-1 transgenic mice to five consecutive days of 2mg/kg Aristolochic acid (AA) injections i.p. to induce CKD or saline injections as a control. We evaluated their kidney immune profiles at two weeks, six weeks, and six months after treatment. We identified a substantial population of TRMs in the kidneys of mice with AA-induced CKD. Flow cytometry of injured kidneys showed T cells bearing TRM surface markers and single cell RNA sequencing revealed these cells as expressing well-known TRM transcription factors and receptors responsible for TRM differentiation and maintenance....
Source: Am J Physiol Renal P... - March 7, 2024 Category: Urology & Nephrology Authors: Kyle H Moore Elise N Erman Amie M Traylor Stephanie K Esman Yanlin Jiang Jennifer R LaFontaine Anna Zmijewska Yan Lu Reham H Soliman Anupam Agarwal James F George Source Type: research

Cognate antigen-independent differentiation of resident memory T cells in chronic kidney disease
In this study we subjected male C57BL/6J mice and OT-1 transgenic mice to five consecutive days of 2mg/kg Aristolochic acid (AA) injections i.p. to induce CKD or saline injections as a control. We evaluated their kidney immune profiles at two weeks, six weeks, and six months after treatment. We identified a substantial population of TRMs in the kidneys of mice with AA-induced CKD. Flow cytometry of injured kidneys showed T cells bearing TRM surface markers and single cell RNA sequencing revealed these cells as expressing well-known TRM transcription factors and receptors responsible for TRM differentiation and maintenance....
Source: American Journal of Physiology. Renal Physiology - March 7, 2024 Category: Physiology Authors: Kyle H Moore Elise N Erman Amie M Traylor Stephanie K Esman Yanlin Jiang Jennifer R LaFontaine Anna Zmijewska Yan Lu Reham H Soliman Anupam Agarwal James F George Source Type: research

Cognate antigen-independent differentiation of resident memory T cells in chronic kidney disease
In this study we subjected male C57BL/6J mice and OT-1 transgenic mice to five consecutive days of 2mg/kg Aristolochic acid (AA) injections i.p. to induce CKD or saline injections as a control. We evaluated their kidney immune profiles at two weeks, six weeks, and six months after treatment. We identified a substantial population of TRMs in the kidneys of mice with AA-induced CKD. Flow cytometry of injured kidneys showed T cells bearing TRM surface markers and single cell RNA sequencing revealed these cells as expressing well-known TRM transcription factors and receptors responsible for TRM differentiation and maintenance....
Source: Am J Physiol Renal P... - March 7, 2024 Category: Urology & Nephrology Authors: Kyle H Moore Elise N Erman Amie M Traylor Stephanie K Esman Yanlin Jiang Jennifer R LaFontaine Anna Zmijewska Yan Lu Reham H Soliman Anupam Agarwal James F George Source Type: research

Cognate antigen-independent differentiation of resident memory T cells in chronic kidney disease
In this study we subjected male C57BL/6J mice and OT-1 transgenic mice to five consecutive days of 2mg/kg Aristolochic acid (AA) injections i.p. to induce CKD or saline injections as a control. We evaluated their kidney immune profiles at two weeks, six weeks, and six months after treatment. We identified a substantial population of TRMs in the kidneys of mice with AA-induced CKD. Flow cytometry of injured kidneys showed T cells bearing TRM surface markers and single cell RNA sequencing revealed these cells as expressing well-known TRM transcription factors and receptors responsible for TRM differentiation and maintenance....
Source: American Journal of Physiology. Renal Physiology - March 7, 2024 Category: Physiology Authors: Kyle H Moore Elise N Erman Amie M Traylor Stephanie K Esman Yanlin Jiang Jennifer R LaFontaine Anna Zmijewska Yan Lu Reham H Soliman Anupam Agarwal James F George Source Type: research

Cognate antigen-independent differentiation of resident memory T cells in chronic kidney disease
In this study we subjected male C57BL/6J mice and OT-1 transgenic mice to five consecutive days of 2mg/kg Aristolochic acid (AA) injections i.p. to induce CKD or saline injections as a control. We evaluated their kidney immune profiles at two weeks, six weeks, and six months after treatment. We identified a substantial population of TRMs in the kidneys of mice with AA-induced CKD. Flow cytometry of injured kidneys showed T cells bearing TRM surface markers and single cell RNA sequencing revealed these cells as expressing well-known TRM transcription factors and receptors responsible for TRM differentiation and maintenance....
Source: Am J Physiol Renal P... - March 7, 2024 Category: Urology & Nephrology Authors: Kyle H Moore Elise N Erman Amie M Traylor Stephanie K Esman Yanlin Jiang Jennifer R LaFontaine Anna Zmijewska Yan Lu Reham H Soliman Anupam Agarwal James F George Source Type: research

Cognate antigen-independent differentiation of resident memory T cells in chronic kidney disease
In this study we subjected male C57BL/6J mice and OT-1 transgenic mice to five consecutive days of 2mg/kg Aristolochic acid (AA) injections i.p. to induce CKD or saline injections as a control. We evaluated their kidney immune profiles at two weeks, six weeks, and six months after treatment. We identified a substantial population of TRMs in the kidneys of mice with AA-induced CKD. Flow cytometry of injured kidneys showed T cells bearing TRM surface markers and single cell RNA sequencing revealed these cells as expressing well-known TRM transcription factors and receptors responsible for TRM differentiation and maintenance....
Source: American Journal of Physiology. Renal Physiology - March 7, 2024 Category: Physiology Authors: Kyle H Moore Elise N Erman Amie M Traylor Stephanie K Esman Yanlin Jiang Jennifer R LaFontaine Anna Zmijewska Yan Lu Reham H Soliman Anupam Agarwal James F George Source Type: research

Mitochondrial Uptake of Aristolactam I Plays a Critical Role in its Toxicity
In conclusion, this research reports the mitochondrial uptake of ALI and provides new insight on potential strategies for protection against AAI-induced nephrotoxicity.PMID:38428544 | DOI:10.1016/j.toxlet.2024.02.013 (Source: Toxicology Letters)
Source: Toxicology Letters - March 1, 2024 Category: Toxicology Authors: Yan Zhou Ruirui Cui Mingkang Zhang Fabing Tang Xiaohua Ma Xin'an Wu Source Type: research

Mitochondrial Uptake of Aristolactam I Plays a Critical Role in its Toxicity
In conclusion, this research reports the mitochondrial uptake of ALI and provides new insight on potential strategies for protection against AAI-induced nephrotoxicity.PMID:38428544 | DOI:10.1016/j.toxlet.2024.02.013 (Source: Toxicology Letters)
Source: Toxicology Letters - March 1, 2024 Category: Toxicology Authors: Yan Zhou Ruirui Cui Mingkang Zhang Fabing Tang Xiaohua Ma Xin'an Wu Source Type: research

Mitochondrial Uptake of Aristolactam I Plays a Critical Role in its Toxicity
In conclusion, this research reports the mitochondrial uptake of ALI and provides new insight on potential strategies for protection against AAI-induced nephrotoxicity.PMID:38428544 | DOI:10.1016/j.toxlet.2024.02.013 (Source: Toxicology Letters)
Source: Toxicology Letters - March 1, 2024 Category: Toxicology Authors: Yan Zhou Ruirui Cui Mingkang Zhang Fabing Tang Xiaohua Ma Xin'an Wu Source Type: research

GSE246803 Cognate antigen-independent differentiation of resident memory t cells in chronic kidney disease
In this study we identify a substantial population of TRMs in the kidneys of mice with aristolochic acid (AA)-induced CKD. Flow cytometry of injured kidneys showed T cells bearing TRM surface markers and single cell RNA sequencing revealed these cells as expressing well-known TRM transcription factors and receptors responsible for TRM differentiation and maintenance. While kidney TRMs expressed Cd44, a marker of antigen experience and T cell activation, their derivation was surprisingly independent of cognate antigen-T cell receptor interactions, as the kidneys of transgenic OT-1 mice still harbored considerable proportion...
Source: GEO: Gene Expression Omnibus - March 1, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research