Understanding the views of adult migrants around catch-up vaccination for missed routine immunisations to define strategies to improve coverage: A UK in-depth interview study
CONCLUSIONS: The major barrier to adult catch-up vaccination for missed routine immunisations and doses in migrant communities in the UK is the limited opportunities, recommendations or tailored vaccination information presented to migrants by health services. This could be improved with financial incentives for provision of catch-up vaccination in UK primary care, alongside training of healthcare professionals to support catch-up immunisation and raise awareness of existing guidelines. It will also be essential to address root causes of mistrust around vaccination, where it exists among migrants, by working closely with c...
Source: Vaccine - April 17, 2024 Category: Allergy & Immunology Authors: Anna Deal Alison F Crawshaw Maha Salloum Sally E Hayward Jessica Carter Felicity Knights Farah Seedat Oumnia Bouaddi Nuria Sanchez-Clemente Laura Muzinga Lutumba Lusau Mimi Kitoko Sarah Nkembi Caroline Hickey Sandra Mounier-Jack Azeem Majeed Sally Hargrea Source Type: research

Naja nigricincta nigricincta venom, a murine model. Evaluation of skeletal and cardio-myonecrosis, kidney injury and inflammatory response along with neutralisation efficacy by the SAIMR/SAVP - and EchiTAb-Plus-ICP polyvalent antivenoms
Toxicon. 2024 Apr 15:107719. doi: 10.1016/j.toxicon.2024.107719. Online ahead of print.ABSTRACTAfrican spitting cobra, Naja nigricincta nigricincta (Zebra snake), envenomation is an important cause of snakebite morbidity and mortality in Namibia. The snake is endemic to central and northern Namibia as well as southern Angola. The venom is mainly cytotoxic, resulting in aggressive dermo-necrosis and often accompanied by severe systemic complications. No specific antivenom exists. Rhabdomyolysis, systemic inflammatory response, haemostatic abnormalities, infective necrotising fasciitis as well as acute kidney failure have be...
Source: Toxicon - April 17, 2024 Category: Toxicology Authors: Esta L Saaiman Engelbrecht Vinny Naidoo Christo J Botha Source Type: research

Genes, Vol. 15, Pages 469: Genetic Modifiers of Sickle Cell Anemia Phenotype in a Cohort of Angolan Children
Miguel Brito The aim of this study was to identify genetic markers in the HBB Cluster; HBS1L-MYB intergenic region; and BCL11A, KLF1, FOX3, and ZBTB7A genes associated with the heterogeneous phenotypes of Sickle Cell Anemia (SCA) using next-generation sequencing, as well as to assess their influence and prevalence in an Angolan population. Hematological, biochemical, and clinical data were considered to determine patients’ severity phenotypes. Samples from 192 patients were sequenced, and 5,019,378 variants of high quality were registered. A catalog of candidate modifier genes that clustered in pathophy...
Source: Genes - April 8, 2024 Category: Genetics & Stem Cells Authors: Catarina Ginete Mariana Delgadinho Br ígida Santos Armandina Miranda Carina Silva Paulo Guerreiro Emile R. Chimusa Miguel Brito Tags: Article Source Type: research

Molecules, Vol. 29, Pages 1611: Antiprotozoal Activity of Plants Used in the Management of Sleeping Sickness in Angola and Bioactivity-Guided Fractionation of Brasenia schreberi J.F.Gmel and Nymphaea lotus L. Active against T. b. rhodesiense
Wolfender Pascal Mäser Folk medicine is widely used in Angola, even for human African trypanosomiasis (sleeping sickness) in spite of the fact that the reference treatment is available for free. Aiming to validate herbal remedies in use, we selected nine medicinal plants and assessed their antitrypanosomal activity. A total of 122 extracts were prepared using different plant parts and solvents. A total of 15 extracts from seven different plants exhibited in vitro activity (>70% at 20 µg/mL) against Trypanosoma brucei rhodesiense bloodstream forms. The dichloromethane extract of Nymphaea lotu...
Source: Molecules - April 3, 2024 Category: Chemistry Authors: Nina Vahekeni Th éo Brillatz Marjan Rahmaty Monica Cal Sonja Keller-Maerki Romina Rocchetti Marcel Kaiser Sibylle Sax Kevin Mattli Evelyn Wolfram Laurence Marcourt Emerson Ferreira Queiroz Jean-Luc Wolfender Pascal M äser Tags: Article Source Type: research

Molecular and entomological surveillance of malaria vectors in urban and rural communities of Benguela Province, Angola
This study aimed to clarify the information gaps concerning local Anop... (Source: Parasites and Vectors)
Source: Parasites and Vectors - March 6, 2024 Category: Microbiology Authors: Gon çalo Alves, Arlete Dina Troco, Gonçalo Seixas, Rebecca Pabst, Alfredo Francisco, Cani Pedro, Luzala Garcia, José Franco Martins and Sergio Lopes Tags: Research Source Type: research

Continuum of care for maternal and child health and child undernutrition in Angola
This study aimed to... (Source: BMC Public Health)
Source: BMC Public Health - March 4, 2024 Category: Consumer Health News Authors: Akiko Saito and Masahide Kondo Tags: Research Source Type: research

Therapeutic response to four artemisinin-based combination therapies in Angola, 2021
Antimicrob Agents Chemother. 2024 Feb 29:e0152523. doi: 10.1128/aac.01525-23. Online ahead of print.ABSTRACTMonitoring antimalarial efficacy is important to detect the emergence of parasite drug resistance. Angola conducts in vivo therapeutic efficacy studies (TESs) every 2 years in its fixed sentinel sites in Benguela, Lunda Sul, and Zaire provinces. Children with uncomplicated Plasmodium falciparum malaria were treated with artemether-lumefantrine (AL), artesunate-amodiaquine (ASAQ), dihydroartemisinin-piperaquine (DP), or artesunate-pyronaridine (ASPY) and followed for 28 (AL and ASAQ) or 42 days (DP and ASPY) to assess...
Source: Antimicrobial Agents and Chemotherapy - February 29, 2024 Category: Microbiology Authors: Pedro Rafael Dimbu Sarah Labuda Carolina Miguel Ferreira Felismina Caquece Kialanda Andr é Garcia Pembele Dilunvuidi Pode Maria Florinda Jo ão Venceslau Mambi Pelenda Benjamin Nieto Andrade Breanna Horton Culzean Kennedy Samaly S Svigel Zhiyong Zhou Joa Source Type: research

Tuberculosis contact tracing, Angola
CONCLUSION: Contact tracing increased the diagnosis of tuberculosis although engagement with the programme was low and loss to follow-up was high. Participation increased during community DOT. Community-based screening should be explored to improve participation and diagnosis.PMID:38420572 | PMC:PMC10898286 | DOI:10.2471/BLT.23.290068 (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - February 29, 2024 Category: International Medicine & Public Health Authors: Joan Mart ínez-Campreciós Eva Gil Sandra Aixut Milagros Moreno Adriano Zacarias Arlete Nindia Estevao Gabriel Juan Espinosa-Pereiro Adri án Sánchez-Montalvá Maria Luisa Aznar Israel Molina Source Type: research

Tuberculosis contact tracing, Angola
CONCLUSION: Contact tracing increased the diagnosis of tuberculosis although engagement with the programme was low and loss to follow-up was high. Participation increased during community DOT. Community-based screening should be explored to improve participation and diagnosis.PMID:38420572 | PMC:PMC10898286 | DOI:10.2471/BLT.23.290068 (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - February 29, 2024 Category: International Medicine & Public Health Authors: Joan Mart ínez-Campreciós Eva Gil Sandra Aixut Milagros Moreno Adriano Zacarias Arlete Nindia Estevao Gabriel Juan Espinosa-Pereiro Adri án Sánchez-Montalvá Maria Luisa Aznar Israel Molina Source Type: research

Tuberculosis contact tracing, Angola
CONCLUSION: Contact tracing increased the diagnosis of tuberculosis although engagement with the programme was low and loss to follow-up was high. Participation increased during community DOT. Community-based screening should be explored to improve participation and diagnosis.PMID:38420572 | PMC:PMC10898286 | DOI:10.2471/BLT.23.290068 (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - February 29, 2024 Category: International Medicine & Public Health Authors: Joan Mart ínez-Campreciós Eva Gil Sandra Aixut Milagros Moreno Adriano Zacarias Arlete Nindia Estevao Gabriel Juan Espinosa-Pereiro Adri án Sánchez-Montalvá Maria Luisa Aznar Israel Molina Source Type: research

Influence of cigarette smoking on the Index of Cardiac Electrophysiological Balance in apparently healthy Angolans
Conclusions: In summary, iCEB and iCEBc were significantly higher in habitual smokers than in nonsmokers, which represents an increased risk of ventricular arrhythmogenesis in healthy habitual smokers. To the best of our knowledge, this is the first study performed in Africa to evaluate iCEB in smokers, making this type of study very important in low- and middle-income countries in the context of epidemiological transition.PMID:38404660 | PMC:PMC10886906 | DOI:10.21542/gcsp.2024.5 (Source: Atherosclerosis)
Source: Atherosclerosis - February 26, 2024 Category: Cardiology Authors: Mauer A A Gon çalves Jo ão Mário Pedro Carina Silva Pedro Magalh ães Miguel Brito Source Type: research

Nutrition supplementation plus standard of care versus standard of care alone or standard of care plus unconditional cash transfer in the prevention of chronic malnutrition in Southern Angola: study protocol for the MuCCUA study, a cluster randomized controlled trial
Chronic malnutrition is a condition associated with negative impacts on physical and cognitive development. It is multi-causal and can start very early in life, already in utero, thus it is especially challeng... (Source: BMC Public Health)
Source: BMC Public Health - February 10, 2024 Category: Consumer Health News Authors: E Custodio, Z Herrador, E Trigo, M Romay-Barja, F Ramirez, I Aguado, E Iraizoz, A Silva-Gerardo, ML Faria, R Martin-Ca ñavate, T Marques, A Vargas, A Gómez and I Molina Tags: Study Protocol Source Type: research

Investigation of an airport-associated cluster of falciparum malaria in Frankfurt, Germany, 2022
We describe the clinical, epidemiological and environmental investigations of a cluster of airport malaria cases and measures taken in response. Three Frankfurt International Airport employees without travel histories to malaria-endemic areas were diagnosed with Plasmodium falciparum malaria in Germany in 2022. Two cases were diagnosed within 1 week, and the third one after 10 weeks. Two cases had severe disease, all three recovered fully. The cases worked in separate areas and no specific location for the transmissions could be identified. No additional cases were detected among airport employees. In June and July, direct...
Source: Euro Surveill - February 2, 2024 Category: Infectious Diseases Authors: Johanna Kessel Anna Rosanas-Urgell Tobias Dingwerth Udo Goetsch Jonas Haller Ralph Huits Johanna H Kattenberg Anna Meinecke Pieter Monsieurs Michael Sroka Torsten Witte Timo Wolf Source Type: research

Investigation of an airport-associated cluster of falciparum malaria in Frankfurt, Germany, 2022
We describe the clinical, epidemiological and environmental investigations of a cluster of airport malaria cases and measures taken in response. Three Frankfurt International Airport employees without travel histories to malaria-endemic areas were diagnosed withPlasmodium falciparum malaria in Germany in 2022. Two cases were diagnosed within 1 week, and the third one after 10 weeks. Two cases had severe disease, all three recovered fully. The cases worked in separate areas and no specific location for the transmissions could be identified. No additional cases were detected among airport employees. In June and J...
Source: Eurosurveillance - February 1, 2024 Category: Infectious Diseases Authors: Johanna Kessel, Anna Rosanas-Urgell, Tobias Dingwerth, Udo Goetsch, Jonas Haller, Ralph Huits, Johanna H Kattenberg, Anna Meinecke, Pieter Monsieurs, Michael Sroka, Torsten Witte and Timo Wolf Source Type: research

Multiple Gardner Syndrome Osteomas Mimicking Temporomandibular Ankylosis: Case Report
ConclusionsClassical surgical techniques are still very useful in some parts of the world that do not rely on modern technology. International collaboration through teledentistry, case review over the Internet, and humanitarian or educational missions are very helpful in low-income countries. (Source: Journal of Maxillofacial and Oral Surgery)
Source: Journal of Maxillofacial and Oral Surgery - February 1, 2024 Category: ENT & OMF Source Type: research