Bolus-only bivalirudin for carotid endarterectomy in a patient with heparin-induced thrombocytopenia
(Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - January 12, 2024 Category: Anesthesiology Source Type: research
Bivalirudin Stability in Citrated Plasma and Citrated Whole Blood
Arch Pathol Lab Med. 2024 Jan 1;148(1):11-12. doi: 10.5858/arpa.2023-0117-LE.NO ABSTRACTPMID:38157869 | DOI:10.5858/arpa.2023-0117-LE (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - December 29, 2023 Category: Laboratory Medicine Authors: Karen Bruzdoski Vadim Kostousov Jun Teruya Source Type: research
Bivalirudin Stability in Citrated Plasma and Citrated Whole Blood
Arch Pathol Lab Med. 2024 Jan 1;148(1):11-12. doi: 10.5858/arpa.2023-0117-LE.NO ABSTRACTPMID:38157869 | DOI:10.5858/arpa.2023-0117-LE (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - December 29, 2023 Category: Laboratory Medicine Authors: Karen Bruzdoski Vadim Kostousov Jun Teruya Source Type: research
Bivalirudin Stability in Citrated Plasma and Citrated Whole Blood
Arch Pathol Lab Med. 2024 Jan 1;148(1):11-12. doi: 10.5858/arpa.2023-0117-LE.NO ABSTRACTPMID:38157869 | DOI:10.5858/arpa.2023-0117-LE (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - December 29, 2023 Category: Laboratory Medicine Authors: Karen Bruzdoski Vadim Kostousov Jun Teruya Source Type: research
Direct Thrombin Inhibitors Fail to Reverse the Negative Effects of Heparin on Lung Growth and Function after Murine Left Pneumonectomy
Am J Physiol Lung Cell Mol Physiol. 2023 Dec 19. doi: 10.1152/ajplung.00096.2023. Online ahead of print.ABSTRACTNeonates with congenital diaphragmatic hernia (CDH) frequently require cardiopulmonary bypass and systemic anticoagulation. We previously demonstrated that even subtherapeutic heparin impairs lung growth and function in a murine model of compensatory lung growth. The direct thrombin inhibitors (DTIs) bivalirudin and argatroban preserved growth in this model. While DTIs are increasingly used for systemic anticoagulation clinically, CDH patients may still receive heparin. In this experiment, lung endothelial cell p...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - December 19, 2023 Category: Cytology Authors: Savas T Tsikis Thomas I Hirsch Timothy Klouda Scott C Fligor Amy Pan Malachi M Joiner Sarah Z Wang Mikayla Quigley Angela Devietro Paul D Mitchell Hiroko Kishikawa Ke Yuan Mark Puder Source Type: research
Direct Thrombin Inhibitors Fail to Reverse the Negative Effects of Heparin on Lung Growth and Function after Murine Left Pneumonectomy
Am J Physiol Lung Cell Mol Physiol. 2023 Dec 19. doi: 10.1152/ajplung.00096.2023. Online ahead of print.ABSTRACTNeonates with congenital diaphragmatic hernia (CDH) frequently require cardiopulmonary bypass and systemic anticoagulation. We previously demonstrated that even subtherapeutic heparin impairs lung growth and function in a murine model of compensatory lung growth. The direct thrombin inhibitors (DTIs) bivalirudin and argatroban preserved growth in this model. While DTIs are increasingly used for systemic anticoagulation clinically, CDH patients may still receive heparin. In this experiment, lung endothelial cell p...
Source: Am J Physiol Lung Ce... - December 19, 2023 Category: Respiratory Medicine Authors: Savas T Tsikis Thomas I Hirsch Timothy Klouda Scott C Fligor Amy Pan Malachi M Joiner Sarah Z Wang Mikayla Quigley Angela Devietro Paul D Mitchell Hiroko Kishikawa Ke Yuan Mark Puder Source Type: research
Direct Thrombin Inhibitors Fail to Reverse the Negative Effects of Heparin on Lung Growth and Function after Murine Left Pneumonectomy
Am J Physiol Lung Cell Mol Physiol. 2023 Dec 19. doi: 10.1152/ajplung.00096.2023. Online ahead of print.ABSTRACTNeonates with congenital diaphragmatic hernia (CDH) frequently require cardiopulmonary bypass and systemic anticoagulation. We previously demonstrated that even subtherapeutic heparin impairs lung growth and function in a murine model of compensatory lung growth. The direct thrombin inhibitors (DTIs) bivalirudin and argatroban preserved growth in this model. While DTIs are increasingly used for systemic anticoagulation clinically, CDH patients may still receive heparin. In this experiment, lung endothelial cell p...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - December 19, 2023 Category: Cytology Authors: Savas T Tsikis Thomas I Hirsch Timothy Klouda Scott C Fligor Amy Pan Malachi M Joiner Sarah Z Wang Mikayla Quigley Angela Devietro Paul D Mitchell Hiroko Kishikawa Ke Yuan Mark Puder Source Type: research
Direct Thrombin Inhibitors Fail to Reverse the Negative Effects of Heparin on Lung Growth and Function after Murine Left Pneumonectomy
Am J Physiol Lung Cell Mol Physiol. 2023 Dec 19. doi: 10.1152/ajplung.00096.2023. Online ahead of print.ABSTRACTNeonates with congenital diaphragmatic hernia (CDH) frequently require cardiopulmonary bypass and systemic anticoagulation. We previously demonstrated that even subtherapeutic heparin impairs lung growth and function in a murine model of compensatory lung growth. The direct thrombin inhibitors (DTIs) bivalirudin and argatroban preserved growth in this model. While DTIs are increasingly used for systemic anticoagulation clinically, CDH patients may still receive heparin. In this experiment, lung endothelial cell p...
Source: Am J Physiol Lung Ce... - December 19, 2023 Category: Respiratory Medicine Authors: Savas T Tsikis Thomas I Hirsch Timothy Klouda Scott C Fligor Amy Pan Malachi M Joiner Sarah Z Wang Mikayla Quigley Angela Devietro Paul D Mitchell Hiroko Kishikawa Ke Yuan Mark Puder Source Type: research
Direct Thrombin Inhibitors Fail to Reverse the Negative Effects of Heparin on Lung Growth and Function after Murine Left Pneumonectomy
Am J Physiol Lung Cell Mol Physiol. 2023 Dec 19. doi: 10.1152/ajplung.00096.2023. Online ahead of print.ABSTRACTNeonates with congenital diaphragmatic hernia (CDH) frequently require cardiopulmonary bypass and systemic anticoagulation. We previously demonstrated that even subtherapeutic heparin impairs lung growth and function in a murine model of compensatory lung growth. The direct thrombin inhibitors (DTIs) bivalirudin and argatroban preserved growth in this model. While DTIs are increasingly used for systemic anticoagulation clinically, CDH patients may still receive heparin. In this experiment, lung endothelial cell p...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - December 19, 2023 Category: Cytology Authors: Savas T Tsikis Thomas I Hirsch Timothy Klouda Scott C Fligor Amy Pan Malachi M Joiner Sarah Z Wang Mikayla Quigley Angela Devietro Paul D Mitchell Hiroko Kishikawa Ke Yuan Mark Puder Source Type: research
Direct Thrombin Inhibitors Fail to Reverse the Negative Effects of Heparin on Lung Growth and Function after Murine Left Pneumonectomy
Am J Physiol Lung Cell Mol Physiol. 2023 Dec 19. doi: 10.1152/ajplung.00096.2023. Online ahead of print.ABSTRACTNeonates with congenital diaphragmatic hernia (CDH) frequently require cardiopulmonary bypass and systemic anticoagulation. We previously demonstrated that even subtherapeutic heparin impairs lung growth and function in a murine model of compensatory lung growth. The direct thrombin inhibitors (DTIs) bivalirudin and argatroban preserved growth in this model. While DTIs are increasingly used for systemic anticoagulation clinically, CDH patients may still receive heparin. In this experiment, lung endothelial cell p...
Source: Am J Physiol Lung Ce... - December 19, 2023 Category: Respiratory Medicine Authors: Savas T Tsikis Thomas I Hirsch Timothy Klouda Scott C Fligor Amy Pan Malachi M Joiner Sarah Z Wang Mikayla Quigley Angela Devietro Paul D Mitchell Hiroko Kishikawa Ke Yuan Mark Puder Source Type: research
Direct Thrombin Inhibitors Fail to Reverse the Negative Effects of Heparin on Lung Growth and Function after Murine Left Pneumonectomy
Am J Physiol Lung Cell Mol Physiol. 2023 Dec 19. doi: 10.1152/ajplung.00096.2023. Online ahead of print.ABSTRACTNeonates with congenital diaphragmatic hernia (CDH) frequently require cardiopulmonary bypass and systemic anticoagulation. We previously demonstrated that even subtherapeutic heparin impairs lung growth and function in a murine model of compensatory lung growth. The direct thrombin inhibitors (DTIs) bivalirudin and argatroban preserved growth in this model. While DTIs are increasingly used for systemic anticoagulation clinically, CDH patients may still receive heparin. In this experiment, lung endothelial cell p...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - December 19, 2023 Category: Cytology Authors: Savas T Tsikis Thomas I Hirsch Timothy Klouda Scott C Fligor Amy Pan Malachi M Joiner Sarah Z Wang Mikayla Quigley Angela Devietro Paul D Mitchell Hiroko Kishikawa Ke Yuan Mark Puder Source Type: research
Direct Thrombin Inhibitors Fail to Reverse the Negative Effects of Heparin on Lung Growth and Function after Murine Left Pneumonectomy
Am J Physiol Lung Cell Mol Physiol. 2023 Dec 19. doi: 10.1152/ajplung.00096.2023. Online ahead of print.ABSTRACTNeonates with congenital diaphragmatic hernia (CDH) frequently require cardiopulmonary bypass and systemic anticoagulation. We previously demonstrated that even subtherapeutic heparin impairs lung growth and function in a murine model of compensatory lung growth. The direct thrombin inhibitors (DTIs) bivalirudin and argatroban preserved growth in this model. While DTIs are increasingly used for systemic anticoagulation clinically, CDH patients may still receive heparin. In this experiment, lung endothelial cell p...
Source: Am J Physiol Lung Ce... - December 19, 2023 Category: Respiratory Medicine Authors: Savas T Tsikis Thomas I Hirsch Timothy Klouda Scott C Fligor Amy Pan Malachi M Joiner Sarah Z Wang Mikayla Quigley Angela Devietro Paul D Mitchell Hiroko Kishikawa Ke Yuan Mark Puder Source Type: research
Direct Thrombin Inhibitors Fail to Reverse the Negative Effects of Heparin on Lung Growth and Function after Murine Left Pneumonectomy
Am J Physiol Lung Cell Mol Physiol. 2023 Dec 19. doi: 10.1152/ajplung.00096.2023. Online ahead of print.ABSTRACTNeonates with congenital diaphragmatic hernia (CDH) frequently require cardiopulmonary bypass and systemic anticoagulation. We previously demonstrated that even subtherapeutic heparin impairs lung growth and function in a murine model of compensatory lung growth. The direct thrombin inhibitors (DTIs) bivalirudin and argatroban preserved growth in this model. While DTIs are increasingly used for systemic anticoagulation clinically, CDH patients may still receive heparin. In this experiment, lung endothelial cell p...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - December 19, 2023 Category: Cytology Authors: Savas T Tsikis Thomas I Hirsch Timothy Klouda Scott C Fligor Amy Pan Malachi M Joiner Sarah Z Wang Mikayla Quigley Angela Devietro Paul D Mitchell Hiroko Kishikawa Ke Yuan Mark Puder Source Type: research
Direct Thrombin Inhibitors Fail to Reverse the Negative Effects of Heparin on Lung Growth and Function after Murine Left Pneumonectomy
Am J Physiol Lung Cell Mol Physiol. 2023 Dec 19. doi: 10.1152/ajplung.00096.2023. Online ahead of print.ABSTRACTNeonates with congenital diaphragmatic hernia (CDH) frequently require cardiopulmonary bypass and systemic anticoagulation. We previously demonstrated that even subtherapeutic heparin impairs lung growth and function in a murine model of compensatory lung growth. The direct thrombin inhibitors (DTIs) bivalirudin and argatroban preserved growth in this model. While DTIs are increasingly used for systemic anticoagulation clinically, CDH patients may still receive heparin. In this experiment, lung endothelial cell p...
Source: Am J Physiol Lung Ce... - December 19, 2023 Category: Respiratory Medicine Authors: Savas T Tsikis Thomas I Hirsch Timothy Klouda Scott C Fligor Amy Pan Malachi M Joiner Sarah Z Wang Mikayla Quigley Angela Devietro Paul D Mitchell Hiroko Kishikawa Ke Yuan Mark Puder Source Type: research
