Oral iron supplementation: new formulations, old questions
Haematologica. 2024 Apr 11. doi: 10.3324/haematol.2024.284967. Online ahead of print.ABSTRACTIron deficiency anemia and pre-anemic iron deficiency are the most frequent pathologies. The first line of treatment involves oral iron supplementation. The simplest, least expensive, and most frequently prescribed drug is ferrous sulfate, while other ferrous salts and ferric complexes with polysaccharides or succinylated milk proteins are also widely used. In recent years, novel iron formulations have been developed, such as the lipophilic iron donor ferric maltol, or nanoparticle encapsulated sucrosomial® iron. Oral iron supplem...
Source: Haematologica - April 15, 2024 Category: Hematology Authors: Kostas Pantopoulos Source Type: research
Nephrology: What You May Have Missed in 2023
This article highlights a selection of important nephrology studies published in 2023 that have relevance for nonnephrologist physicians. Four studies examined progression of chronic kidney disease or cardiovascular disease with respect to finerenone use, magnesium supplementation, iron markers, and COVID-19. Two studies examined treatments to improve specific aspects of chronic kidney disease management, including daprodustat to address anemia and patiromer to address hyperphosphatemia. One study showed that acetazolamide added to loop diuretics increased diuresis in acute decompensated heart failure across a wide range o...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Ali A M AlHabobi Ashwaq M S Almutairi Danah A S Y Bohemid Ashwini R Sehgal Source Type: research
Effect of patient and wound characteristics on diabetic foot ulcer healing in phase 3 study of novel topical esmolol hydrochloride
ConclusionsNovel topical esmolol with SoC treatment exhibited significant DFU healing independent of patient-related factors including anemia, hypoalbuminemia, and poor glycemic control. (Source: International Journal of Diabetes in Developing Countries)
Source: International Journal of Diabetes in Developing Countries - April 15, 2024 Category: Endocrinology Source Type: research
< i > Ginkgo biloba < /i > attenuated detrimental inflammatory and oxidative events due to < i > Trypanosoma brucei rhodesiense < /i > in mice treated with melarsoprol
ConclusionUtilization of GB as an adjuvant therapy may ameliorate detrimental effects caused by T.b.r infection and MelB toxicity during late stage HAT. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 15, 2024 Category: Tropical Medicine Authors: Janet Khatenje Wendo Source Type: research
Factors influencing adherence to iron drop supplementation in infants aged 6 to 24 months: a systematic review of observational studies
This study aims to examine the factors associated with noncompliance (such as non-utilization or inconsistent usage) of iron drop supplementation among infants between 6 and 24 months old.Online databases (PubMed, Scopus and SID) were searched to retrieve relevant articles published from inception up to July 2023. Among the 2,177 articles detected, after removing duplicate and irrelevant titles, 21 cross-sectional studies that met the authors’ inclusion criteria were included. Screening for articles and data extraction were conducted separately by two researchers.The findings suggest that some factors related to mother...
Source: Nutrition and Food Science - April 14, 2024 Category: Nutrition Authors: Maryam Hasanzadeh Fereshteh Kalantari Hadi Emamat Hamid Ghalandari Hadith Tangestani Source Type: research
The boon and bane of nitrous oxide
Eur Arch Psychiatry Clin Neurosci. 2024 Apr 13. doi: 10.1007/s00406-024-01801-3. Online ahead of print.ABSTRACTNitrous oxide (N2O) has been known since the end of the eighteenth century. Today, N2O plays a huge role as a greenhouse gas and an ozone-depleting stratospheric molecule. The main sources of anthropogenic N2O emissions are agriculture, fuel combustion, wastewater treatment, and various industrial processes. By contrast, the contribution of medical N2O to the greenhouse effect appears to be small. The recreational and medical uses of N2O gradually diverged over time. N2O has analgesic and anesthetic effects, makin...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 13, 2024 Category: Psychiatry Authors: Golo Kronenberg Georgios Schoretsanitis Erich Seifritz Sebastian Olbrich Source Type: research
Neuropsychiatric disorder as early clinical presentation of marantic endocarditis in patient with newly diagnosed poorly differentiated esophago ‐gastric junction adenocarcinoma: A case report
Transesophageal cardiac echocolor-Doppler: large package of endocardial vegetations encompassing the posterior mitral leaflet, especially at P2-P3 level; similar lesions also at the free edge of the anterior mitral flap in A2. Key Clinical MessageNeuropsychiatric symptoms, depression, and progressive mental confusion should not be overlooked as onset symptoms of multiple cerebral ischemic lesions due to cardiac embolization. Comprehensive clinical evaluation due to progressive anemia led to the diagnosis of poorly differentiated adenocarcinoma of the esophagogastric junction as cause of embolizing nonbacterial mitral endoc...
Source: Clinical Case Reports - April 13, 2024 Category: General Medicine Authors: Filomena Ferrentino,
Sara Campana,
Marco Torri,
Carlo Rostagno Tags: CASE REPORT Source Type: research
The boon and bane of nitrous oxide
AbstractNitrous oxide (N2O) has been known since the end of the eighteenth century. Today, N2O plays a huge role as a greenhouse gas and an ozone-depleting stratospheric molecule. The main sources of anthropogenic N2O emissions are agriculture, fuel combustion, wastewater treatment, and various industrial processes. By contrast, the contribution of medical N2O to the greenhouse effect appears to be small. The recreational and medical uses of N2O gradually diverged over time. N2O has analgesic and anesthetic effects, making it widely used in modern dentistry and surgery. New research has also begun studying N2O ’s antidep...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 13, 2024 Category: Neuroscience Source Type: research
Troponin Elevation in Patients Undergoing Percutaneous Hepatic Perfusion for Metastatic Uveal Melanoma
CONCLUSION: Percutaneous Hepatic Perfusion is safe and associated with a transient, asymptomatic troponin elevation peri-operatively without major adverse cardiac events at 90 days. The observed troponin elevation is likely secondary to coronary demand-supply mismatch related to procedural hemodynamic shifts, hypotension, and anemia.PMID:38605434 | DOI:10.1177/10732748241246898 (Source: Cancer Control)
Source: Cancer Control - April 12, 2024 Category: Cancer & Oncology Authors: Sanjay Chandrasekhar Matthew Perez Zurain Niaz Jahanzaib Ekram Neelam Lal Sarah Koly Biwei Cao Jonathan S Zager Mohammed Alomar Source Type: research
Collage of cases and brief review of the laboratory diagnosis and molecular testing in autoimmune haemolytic anaemia
J Family Med Prim Care. 2024 Feb;13(2):409-416. doi: 10.4103/jfmpc.jfmpc_2131_22. Epub 2024 Mar 6.ABSTRACTAutoimmune haemolytic anaemia (AIHA) is an acquired heterogenous clinical entity with variable presentations like acute haemolysis or mild, chronic haemolysis compounded with acute exacerbation in winters or fatal uncompensated haemolysis. A step-wise approach to the diagnosis and characterisation of AIHA should be undertaken, firstly the diagnosis of haemolysis followed by the establishment of immune nature with the aid of direct agglutination tests (DAT). Simultaneously the other causes of immune haemolysis need to b...
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Harkiran Arora Shalini Trivedi Pooja Jain Udita Singhal Arunpreet Kaur Aditi Raina Source Type: research
Pre-term labour: A study on evaluation of causes and outcome
CONCLUSION: Pre-maturity is a huge health and financial burden in rural and semi-urban central Gujarat. Pre-mature rupture of membranes, previous MTP, extreme physical activity, and maternal anaemia were the major risk factors linked with pre-term labour. Poor neonatal outcomes like LBW, IUGR, and a low Apgar score were significantly associated with the babies delivered pre-mature in our study.PMID:38605778 | PMC:PMC11006067 | DOI:10.4103/jfmpc.jfmpc_2411_22 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Rumi S Bhattacharjee Riya J Shah Nitin S Raithatha Mamta R Patel Source Type: research
Effect of oral vitamin C administration along with iron supplementation for treating anaemia among adolescent girls - Protocol for systematic review and meta-analysis
CONCLUSIONS: The evidence for role of vitamin C as an adjunct in iron and folic acid for treatment of anemia in adolescent girls will be generated once the systematic review and meta-analysis is completed.PMID:38605774 | PMC:PMC11006035 | DOI:10.4103/jfmpc.jfmpc_660_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Ujwala U Ukey Sarita K Sharma Dhruv S Chitre Paras R Waghmare Aditi J Dabir Rohini Desai Neethubaby Palatty Source Type: research
The 2021 Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) guidelines and the outpatient management: Examining physician adherence and its effects on patient outcome
CONCLUSION: We found no significant difference in the patient outcomes, such as number of exacerbations of COPD and mortality, when comparing the 2021 GOLD guideline adherent versus GOLD guideline non-adherent management of COPD.PMID:38605771 | PMC:PMC11006038 | DOI:10.4103/jfmpc.jfmpc_1397_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Ricardo J Orozco David Rodriguez Krystal Hunter Satyajeet Roy Source Type: research
QL1604 plus paclitaxel-cisplatin/carboplatin in patients with recurrent or metastatic cervical cancer: an open-label, single-arm, phase II trial
CONCLUSION: QL1604 plus paclitaxel-cisplatin/carboplatin showed promising antitumor activity and manageable safety profile as first-line treatment in patients with advanced cervical cancer. Programmed cell death protein 1 inhibitor plus chemotherapy may be a potential treatment option for the patient population who have contraindications or can't tolerate bevacizumab, which needs to be further verified in phase III confirmatory study. Trial RegistrationClinicalTrials.gov Identifier: NCT04864782.PMID:38606822 | DOI:10.3802/jgo.2024.35.e77 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - April 12, 2024 Category: OBGYN Authors: Cheng Fang Yun Zhou Yanling Feng Liping He Jinjin Yu Yuzhi Li Mei Feng Mei Pan Lina Zhao Dihong Tang Xiumin Li Buzhen Tan Ruifang An Xiaohui Zheng Meimei Si Baihui Zhang Lingyan Li Xiaoyan Kang Qi Zhou Jihong Liu Source Type: research
Potential therapeutic options for celiac Disease: An update on Current evidence from Gluten-Free diet to cell therapy
Int Immunopharmacol. 2024 Apr 11;133:112020. doi: 10.1016/j.intimp.2024.112020. Online ahead of print.ABSTRACTCeliac disease (CD) is a chronic autoimmune enteropathy and multifactorial disease caused by inappropriate immune responses to gluten in the small intestine. Weight loss, anemia, osteoporosis, arthritis, and hepatitis are among the extraintestinal manifestations of active CD. Currently, a strict lifelong gluten-free diet (GFD) is the only safe, effective, and available treatment. Despite the social burden, high expenses, and challenges of following a GFD, 2 to 5 percent of patients do not demonstrate clinical or pa...
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Effat Noori Nader Hashemi Delsuz Rezaee Reza Maleki Forough Shams Bahram Kazemi Mojgan Bandepour Fardin Rahimi Source Type: research
