PharmaMemory: an interactive, animated web application for learning autonomic physiology and pharmacology
Discussion PharmaMemory utilizes challenged recall, visual stimulation, and interactive learning to provide users with a multifaceted learning tool. Preliminary data suggest that students find this method of learning beneficial. Further studies are needed to assess PharmaMemory compared to more traditional learning methods such as PowerPoint or text-based learning. Additionally, further research is needed to quantitatively assess reduction in cognitive load.PMID:38545642 | DOI:10.1152/advan.00214.2022 (Source: Adv Data)
Source: Adv Data - March 28, 2024 Category: Epidemiology Authors: Timothy Rosencrans Ryan Jones Daniel Griffin India Loyd Anna Grady Mary Moon Frederick Miller Source Type: research

Utilizing a Medical School Outreach Program to Help High School Students Explore the Impact of Food Security and Ultra-Processed Foods on Health Risks
Adv Physiol Educ. 2024 Mar 28. doi: 10.1152/advan.00115.2023. Online ahead of print.ABSTRACTWe offered an enrichment program for high school students with the theme "The Environment, Health, and You" during the Summer of 2022 and the Spring of 2023. We developed several educational modules for high school students that provided them with an opportunity to learn and explore the foundations of physiological systems, nutrient needs to maintain health, and the impact that environmental factors can have on them. The modules included videos, discussion boards, games, readings, and labs. These modules were integrated into the fir...
Source: Advances in Physiology Education - March 28, 2024 Category: Physiology Authors: Kyeorda Kemp Brianne Lewis Akshata R Naik Virginia E Uhley Source Type: research

PharmaMemory: an interactive, animated web application for learning autonomic physiology and pharmacology
Discussion PharmaMemory utilizes challenged recall, visual stimulation, and interactive learning to provide users with a multifaceted learning tool. Preliminary data suggest that students find this method of learning beneficial. Further studies are needed to assess PharmaMemory compared to more traditional learning methods such as PowerPoint or text-based learning. Additionally, further research is needed to quantitatively assess reduction in cognitive load.PMID:38545642 | DOI:10.1152/advan.00214.2022 (Source: Advances in Physiology Education)
Source: Advances in Physiology Education - March 28, 2024 Category: Physiology Authors: Timothy Rosencrans Ryan Jones Daniel Griffin India Loyd Anna Grady Mary Moon Frederick Miller Source Type: research

Impact of bias field correction on 0.35 T pelvic MR images: evaluation on generative adversarial network-based OARs ’ auto-segmentation and visual grading assessment
ConclusionThe bias field correction did not improve the anatomy visualization from a clinical point of view and the OARs’ auto-segmentation outputs generated by the GAN. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 28, 2024 Category: Cancer & Oncology Source Type: research

Endovascular treatment of intracranial internal carotid artery bifurcation region aneurysms
Intracranial internal carotid artery (ICA) bifurcation region aneurysms are uncommon. When treatment is necessary for ICA, endovascular treatment (EVT) can be a useful option. Due to the complexity of these aneurysms and the variability of EVT techniques, EVT for ICA bifurcation aneurysms is challenging. Currently, it is necessary to perform a review to explore this issue further. In this review, the following issues were discussed: the anatomy of the ICA bifurcation region; the classification, natural history and EVT status of ICA bifurcation region aneurysms; the technique used for identifying ICA bifurcation region aneu...
Source: Frontiers in Neurology - March 28, 2024 Category: Neurology Source Type: research

3D isotropic MRI of ankle: review of literature with comparison to 2D MRI
This article reviews the recent technical developments in the domain 3D MRI, compares imaging with 3D versus 2D sequences, and demonstrates the use-case scenarios with interesting cases, and benefits of 3D MRI in evaluating various ankle joint components and their lesions. (Source: Skeletal Radiology)
Source: Skeletal Radiology - March 27, 2024 Category: Radiology Source Type: research

Early and Long-Term Clinical Outcomes of Ductal Stenting Versus Surgical Aortopulmonary Shunt Among Young Infants with Duct-Dependent Pulmonary Circulation
AbstractSurgical aortopulmonary shunting (SAPS) and ductal stenting (DS) are the main palliations in infants with cyanotic congenital heart diseases (CHD). We aimed to study the safety and efficacy of DS and to compare it with SAPS as a palliative procedure in infants with CHD and duct-dependent pulmonary circulation. Retrospective institutional clinical data review of consecutive infants aged  <  3 months who underwent DS or SAPS over 5 years. The primary outcome was procedural success which was defined as event-free survival (mortality, need for re-intervention, procedural failure) at 30 days post-procedure. Th...
Source: Pediatric Cardiology - March 27, 2024 Category: Cardiology Source Type: research

Impact of Abnormal Potassium on Arrhythmia Risk During Pediatric Digoxin Therapy
AbstractDigoxin is used in children with heart failure and tachyarrhythmia. Its use in patients with single ventricle anatomy has increased following evidence of improved interstage survival after the Norwood procedure. Digoxin has a narrow therapeutic window and may alter serum potassium balance, inducing arrhythmias. We hypothesized digoxin use in the setting of abnormal serum potassium levels is associated with arrhythmias. We reviewed all patients  ≤ 18 years who received digoxin while admitted at our institution from 2014 to 2021. Admissions <  2 nights were excluded. We compared patients with a hemodyna...
Source: Pediatric Cardiology - March 27, 2024 Category: Cardiology Source Type: research

Association of Prenatally Diagnosed Isolated Single Left Superior Vena Cava and Postnatal Development of Coarctation of the Aorta
AbstractTo report the prevalence of coarctation of the aorta (CoA) in fetuses with single left superior vena cava (SL-SVC) and to evaluate changes in echocardiographic measurements. Additionally, to report the prevalence of associated malformations. Retrospective observational study of fetuses diagnosed with SL-SVC between 2012 and 2021 at a tertiary fetal cardiology unit. In fetuses without intracardiac abnormalities, Z-scores of the ventricles, great arteries, and Doppler flow patterns are reported. We identified 47 fetuses with SL-SVC of which 8/47 (17%) had abnormal intracardiac anatomy. One fetus was lost to follow-up...
Source: Pediatric Cardiology - March 27, 2024 Category: Cardiology Source Type: research

Predicting treatment plan approval probability for high-dose-rate brachytherapy of cervical cancer using adversarial deep learning
Phys Med Biol. 2024 Mar 27. doi: 10.1088/1361-6560/ad3880. Online ahead of print.ABSTRACTPredicting the probability of having the plan approved by the physician is important for automatic treatment planning. Driven by the mathematical foundation of deep learning that can use a deep neural network to represent functions accurately and flexibly, we developed a deep-learning framework that learns the probability of plan approval for cervical cancer high-dose-rate brachytherapy (HDRBT).&#xD;Approach: The system consisted of a dose prediction network (DPN) and a plan-approval probability network (PPN). DPN predicts OAR D2cc...
Source: Physics in Medicine and Biology - March 27, 2024 Category: Physics Authors: Yin Gao Yesenia Gonzalez Chika Nwachukwu Kevin Albuquerque Xun Jia Source Type: research

Bachmann Bundle Pacing
For practical reasons, the right atrial appendage (RAA) has remained the preferred site for atrial lead implantation since the introduction of atrial pacing nearly 50 years ago.1 The RAA is easy to locate, the trabeculated anatomy of the RAA allows for stable lead placement for both passive and active fixation leads, and pacing and sensing thresholds are adequate and stable.1 There are three downsides of the RAA as a pacing target, though none of these have altered current practice. For one, the RAA tissue between trabeculae is thin and easily perforated, which is why appendage leads account for half of all lead perforatio...
Source: Heart Rhythm - March 27, 2024 Category: Cardiology Authors: Daniel L. Lustgarten, Nicole Habel, Dami án Sánchez-Quintana, Joseph Winget, Daniel Correa de Sa, Robert Lobel, Nathaniel Thompson, Margaret Infeld, Markus Meyer Source Type: research

Anatomical variations in the superficial venous system of the neck: an image-based study using contrast-enhanced computed tomography
ConclusionThese findings indicate that the AJV has a rightward preference during its course. The course of the FV is diverse and affects the diameter of connected veins. (Source: Surgical and Radiologic Anatomy)
Source: Surgical and Radiologic Anatomy - March 27, 2024 Category: Anatomy Source Type: research

Detailed Assessment of Confounders is Necessary for Valid Interpretation of the Results in Patellofemoral Cartilage Restoration Studies
Cartilage restoration procedures have gained increased traction over the years as a treatment for chondral defects in relatively younger patients. A critical assessment of study populations for confounders is vital in order to interpret results in a valid manner. This is particularly true when assessing outcomes of cartilage restoration procedures in the patellofemoral compartment given substantial heterogeneity amongst patients within study populations. Patients often undergo additional procedures (prior or concomitant), have variable anatomy (malalignment, maltracking, and trochlear dysplasia), and variable chondral defe...
Source: Arthroscopy - Journal of Arthroscopic and Related Surgery - March 27, 2024 Category: Surgery Authors: Christopher A. Schneble Tags: Editorial Commentary Source Type: research

Functionally mediated cranial allometry evidenced in a genus of rock-wallabies
Biol Lett. 2024 Mar;20(3):20240045. doi: 10.1098/rsbl.2024.0045. Epub 2024 Mar 27.ABSTRACTIn assessments of skeletal variation, allometry (disproportionate change of shape with size) is often corrected to examine size-independent variation for hypotheses relating to function. However, size-related trade-offs in functional demands may themselves be an underestimated driver of mammalian cranial diversity. Here, we use geometric morphometrics alongside dental measurements to assess craniodental allometry in the rock-wallaby genus Petrogale (all 17 species, 370 individuals). We identified functional aspects of evolutionary all...
Source: Biology Letters - March 26, 2024 Category: Biology Authors: D Rex Mitchell Sally Potter Mark D B Eldridge Meg Martin Vera Weisbecker Source Type: research

Musculoskeletal and tendinous details of selected anomalies in the locomotor system of anurans
Anat Rec (Hoboken). 2024 Mar 26. doi: 10.1002/ar.25430. Online ahead of print.ABSTRACTPrevious studies on anuran anomalies predominantly examine isolated cases or focus on external and skeletal features. Our study analyzes a comprehensive sample collected from 1991 to 2017, examining the muscle-tendon system in 24 anuran species across adult, juvenile, and metamorphic stages. This extensive sample size allows us to investigate consistent anomaly patterns across different developmental stages and anuran families, exploring potential common developmental or genetic factors. Our detailed anatomical examination, encompassing m...
Source: Anatomical Record - March 26, 2024 Category: Anatomy Authors: M ónica C Soliz Virginia Abdala Source Type: research