Phase 1 Study to Assess the Safety, PK and PD of INBRX-101 in Adults With Alpha-1 Antitrypsin Deficiency
Conditions:   Alpha-1 Antitrypsin Deficiency;   AATD Intervention:   Drug: INBRX-101/rhAAT-Fc Sponsor:   Inhibrx, Inc. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 24, 2019 Category: Research Source Type: clinical trials

The Safety and Efficacy of Alpha-1 Antitrypsin (AAT) for the Prevention of Graft ‑Versus-host Disease (GVHD) in Patients Receiving Hematopoietic Cell Transplant
Condition:   Graft Versus Host Disease Interventions:   Biological: Alpha-1 antitrypsin (AAT);   Biological: Placebo Sponsor:   CSL Behring Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 16, 2019 Category: Research Source Type: clinical trials

Effects of Different Exercise Training Modalities in Alpha-1 Antitrypsin Deficiency Patients
Conditions:   Chronic Obstructive Pulmonary Disease;   Alpha 1-Antitrypsin Deficiency Intervention:   Procedure: Exercise training Sponsor:   Klinikum Berchtesgadener Land der Schön-Kliniken Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 14, 2019 Category: Research Source Type: clinical trials

A Study of ALN-AAT02 in Healthy Participants and Participants With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease
Condition:   ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease Interventions:   Drug: ALN-AAT02;   Drug: Placebo Sponsor:   Alnylam Pharmaceuticals Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 7, 2018 Category: Research Source Type: clinical trials

Alvelestat (MPH996) for the Treatment of ALpha-1 ANTitrypsin Deficiency
Conditions:   Alpha-1 Antitrypsin Deficiency (AATD);   Pi*ZZ, Pi*SZ, or Pi*Null Phenotype;   Emphysema or COPD Interventions:   Drug: Alvelestat (MPH996);   Other: Placebo Sponsors:   University of Alabama at Birmingham;   National Institutes of Health (NIH);   Mereo BioPharma Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 20, 2018 Category: Research Source Type: clinical trials