St. John ’ s Wort: A Hidden Danger For Hypertension?
Conclusion: Navigating The Use Of St. John’s Wort Amidst Hypertension
While St. John’s Wort is generally safe for most people, it may pose challenges for individuals managing high blood pressure, especially those on specific medications, such as calcium blockers.
Reflecting on Trista Best’s wisdom, informed decision-making and regular healthcare consultations are key to safely traversing the landscape of supplements.
As we continually unearth the potentials of these natural remedies, balancing their benefits and risks is fundamental to our health journey.
This in-depth understanding helps ensur...
Source: The EMT Spot - June 14, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
Fight Aging! Newsletter, June 12th 2023
In this study, we investigated the effect of NXP032 on neurovascular stabilization through the changes of PECAM-1, PDGFR-β, ZO-1, laminin, and glial cells involved in maintaining the integrity of the blood-brain barrier (BBB) in aged mice. NXP032 was orally administered daily for 8 weeks. Compared to young mice and NXP032-treated mice, 20-month-old mice displayed cognitive impairments in Y-maze and passive avoidance tests. NXP032 treatment contributed to reducing the BBB damage by attenuating the fragmentation of microvessels and reducing PDGFR-β, ZO-1, and laminin expression, thereby mitigating astrocytes and microglia ...
Source: Fight Aging! - June 11, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent Cells Appear Involved in Graft-Versus-Host Disease
Now that increasing attention is given to senescent cells in the biology of aging, their involvement in a wide range of conditions has been uncovered. The transient creation of senescent cells is a part of wound healing, a process that is harmed by the growing burden of lingering senescent cells that occurs with advancing age, and the inability of the aged immune system to remove these cells in a timely fashion. Given the role in wound healing, is perhaps not surprising to find senescent cells involved in graft-versus-host disease following surgical transplantation of tissue. Senolytic therapies may prove to be useful here...
Source: Fight Aging! - June 9, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Steroids And The Heart: A Revealing Study On Long-Term Risks
Conclusion: A Heartfelt Wake-Up Call
These pioneering studies serve as a stark reminder that every choice has consequences – and when it comes to anabolic steroids, those consequences can be heart-wrenching.
The results underscore the urgency of prioritizing health over fleeting performance gains.
As we step forward, awaiting more insights from larger studies, remember – your health is an invaluable asset, one that deserves more than temporary boosts.
Making conscious, informed choices today can shield your heart from undue harm tomorrow.
References
American Heart Association: Steroids, Other A...
Source: The EMT Spot - May 15, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
Optum Store Opting Out of Direct-to-Consumer Pharmacy Biz
Last November [2022], I blogged (see my post athttps://blog.sstrumello.com/2022/11/cigna-express-scripts-by-insiderx.html for reference) how Cigna ' s Express Scripts was discontinuing the company ' s cash-pay mail order pharmacy by InsideRx (the coupon website/app is owned by Express Scripts). Well, now rival United Healthcare ' s OptumRx is doing the same, effectively shutting down its Optum Store. Have a look at this notice:I know it ' s impossible to read, but the first paragraph reads:" We ' re sad to say that starting June 1st, 2023, you will no longer be able to fill prescriptions through the Optum Store except...
Source: Scott's Web Log - May 2, 2023 Category: Endocrinology Tags: 2023 Diabetes Mine Express Scripts by InsideRx Healthline Optum Optum Store OptumRx RVO Health LLC United Healthcare Source Type: blogs
Fight Aging! Newsletter, May 1st 2023
In conclusion, frailty progression accelerates in males with one LTCs and females with two LTCs or more. Health providers should be aware of planning a suitable intervention once the elderly have two or more health conditions.
Plasma Transfer Lowers Epigenetic Age and Mortality in Rats
https://www.fightaging.org/archives/2023/04/plasma-transfer-lowers-epigenetic-age-and-mortality-in-rats/
Plasma transfer from young to old individuals has produced mixed results in animals and little to no benefit in humans where assessed rigorously. These studies were driven by the hypothesis that young plasma contains m...
Source: Fight Aging! - April 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cellular Senescence in Aging Skin
In one sense, the accumulation of senescent cells with age is the same story in every tissue. These cells secrete pro-inflammatory, disruptive signaling that actively degrades tissue structure and function. The targeted destruction of lingering senescent cells produces aspects of rapid rejuvenation in aged mice. In another sense, every tissue is different and senescence in that tissue likely worthy of at least some degree of distinct study, perhaps leading to optimized therapies for clearance of senescent cells on a tissue by tissue basis, for example. Here, find a review that looks at cellular senescence in the context of...
Source: Fight Aging! - April 25, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 20th 2023
This study also provides the potential for de novo generation of complex organs in vivo.
T Cells May Play a Role in the Brain Inflammation Characteristic of Neurodegenerative Conditions
https://www.fightaging.org/archives/2023/03/t-cells-may-play-a-role-in-the-brain-inflammation-characteristic-of-neurodegenerative-conditions/
Alzheimer's disease, and other forms of neurodegenerative condition, are characterized by chronic inflammation in brain tissue. Unresolved inflammatory signaling is disruptive of tissue structure and function. Here, researchers provide evidence for T cells to become involved in thi...
Source: Fight Aging! - March 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reprogramming Skin Cells with a Novel Transcription Factor Combination Aids Wound Healing
This study also provides the potential for de novo generation of complex organs in vivo.
Link: https://doi.org/10.1101/2023.03.05.531138 (Source: Fight Aging!)
Source: Fight Aging! - March 17, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 23rd 2023
This study explored the association between tap drinking water and longevity in Cilento, Italy, to understand whether trace elements in local drinking water may have an influence on old, nonagenarian, and centenarian people and promote their health and longevity.
Data on population and water sources were collected through the National Demographic Statistics, the Cilento Municipal Archives, and the Cilento Integrated Water Service. Ordinary least squares (OLS) regression and a geographically weight regression (GWR) model were used to study the spatial relationship between the explanatory and outcome variables of long...
Source: Fight Aging! - January 22, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
More on the Work of the Longevity Escape Velocity Foundation
The Longevity Escape Velocity Foundation (LEVF) is initially working to assess combinations of approaches to the treatment of aging, to assess the degree to which mouse life span is affected. Aging consists of many distinct mechanisms, and comprehensive rejuvenation will require a diverse package of therapies. Yet the research and development community undertakes little work on combined treatments. Here, the Lifespan.io team talks to Aubrey de Grey about some of the details of the work presently under way.
We are obviously very excited about LEVF's robust mouse rejuvenation (RMR) project. Could you walk our reader...
Source: Fight Aging! - January 18, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Want your skin to look better? Then consider your mental health. [PODCAST]
“Stigma surrounding mental illness often prevents patients from seeking the mental health care they need, delaying care and prolonging suffering. Fear, embarrassment, and impaired quality of life are a reality for many patients suffering from skin disorders like severe cases of psoriasis, hair loss, or acne. In these cases, assistance from a dermatologist who bridgesRead more …Want your skin to look better? Then consider your mental health. [PODCAST] originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - June 25, 2022 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/post-author/the-podcast-by-kevinmd" rel="tag" data-wpel-link="internal" > The Podcast by KevinMD < /a > < /span > Tags: Podcast Dermatology Psychiatry Source Type: blogs
The Reckoning: What Happens to Digital Health After COVID?
By JEFF GOLDSMITH and ERIC LARSEN
It has been a rough year so far for digital health. After an astonishing $45 billion poured into new digital health companies in 2020 and 2021, and an early 2021 peak in market valuations of publicly-traded digital health providers, valuations and multiples have collapsed. Once high-flying Teladoc, which traded at an eye-watering 42x revenues and commanded a $45 billion market capitalization, is now trading around 2.7X at about $5.7 billion. AmWell, the next largest telehealth player, has seen its stock drop more 90% from its high.
Nor is the evaporation in market value is co...
Source: The Health Care Blog - May 9, 2022 Category: Consumer Health News Authors: matthew holt Tags: Health Tech digital health Digital health investing Eric Larsen Healthcare bubble Jeff Goldsmith Source Type: blogs
BREAKING: Thirty Madison and Nurx Merge, CEO Steve Gutentag Takes Us Inside
By JESSICA DaMASSA, WTF HEALTH
Thirty Madison and Nurx are merging and here’s what Steve Gutentag, CEO of Thirty Madison and the soon-to-be-combined entity, is saying about the deal!
This is a merger of two well-funded, direct-to-consumer, virtual-care-plus-pharmacy startups that deliver specialty and expert care and prescription drugs to a combined 750,000 active patients, with or without insurance. To-date, Nurx has raised a total $110 million, and Thirty Madison closed a Series C in June 2021 that brought their total funding to $210 million with a then-valuation of over $1 billion.
Thirty Madison currently ...
Source: The Health Care Blog - February 9, 2022 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Tech WTF Health Jessica DaMassa mental health care Nurx Steve Gutentag thirty madison virtual care Source Type: blogs
Nanotherapy for Immunosuppression May Lead to Diabetes Treatment
Researchers at Northwestern University developed a nanoparticle delivery system for a common immunosuppressant drug that increases the potential of pancreatic islet transplantation as a viable long-term treatment for Type I diabetes. The technology targets the drug to act on the antigen presenting cells of the immune system, rather than T cells. This results in a more selective immunosuppression with fewer side-effects and better long-term viability for transplanted islets, which are typically attacked and destroyed by the immune system. The researchers hope that the technology could pave the way for islet transplantation ...
Source: Medgadget - January 20, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Nanomedicine diabetes northwestern Source Type: blogs
