Drug repurposing for the treatment of patients infected with SARS-CoV-2
AbstractThis paper presents a systematic analysis of the possibility of repurposing commercial drugs through Molecular Docking and Quantitative Structure and Activity Relationship (QSAR) explorations for the treatment of patients infected with the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). To do this, we checked the chances of inhibiting the main protease (Mpro) of SARS-CoV-2, the cyclo-oxygenase-2 (COX-2) enzyme, and the spike viral protein by commercial drugs. The molecular structures of the ligands were obtained from the DrugBank database. All ligand molecular structures were previously optimised usin...
Source: Network Modeling Analysis in Health Informatics and Bioinformatics - April 4, 2024 Category: Bioinformatics Source Type: research
Molecules, Vol. 29, Pages 1480: Monitoring Pharmaceuticals and Personal Care Products in Healthcare Effluent Wastewater Samples and the Effectiveness of Drug Removal in Wastewater Treatment Plants Using the UHPLC-MS/MS Method
This study reveals the prevalence of several different drugs; mean concentrations of 702 μg L−1 of iomeprol, 48.8 μg L−1 of iopromide, 29.9 μg L−1 of gabapentin, 42.0 μg L−1 of caffeine and 82.5 μg L−1 of paracetamol were present. An analysis of 20 samples from ten WWTPs revealed different removal efficiencies for different analytes. Paracetamol was present in the inflow samples of all ten WWTPs and its removal efficiency was 100%. Analytes such as caffeine, ketoprofen, naproxen or atenolol showed hi...
Source: Molecules - March 27, 2024 Category: Chemistry Authors: Lucia Molnarova Tatana Halesova Daniela Tomesova Marta Vaclavikova Zuzana Bosakova Tags: Article Source Type: research
Exploring the potential of SrTi < sub > 0.7 < /sub > Fe < sub > 0.3 < /sub > O < sub > 3 < /sub > perovskite/chitosan nanosheets for the development of a label-free electrochemical sensing assay for determination of naproxen in human plasma samples
Anal Biochem. 2024 Mar 24:115513. doi: 10.1016/j.ab.2024.115513. Online ahead of print.ABSTRACTNaproxen is a nonsteroidal anti-inflammatory drug used to treat nonrheumatic inflammation, migraine, and gout. Therefore, the determination of naproxen in pharmaceutical and biological samples is of particular importance. In the present work, SrTi0.7Fe0.3O3 perovskite/Chitosan nanosheets were used to modify the surface of a glassy carbon electrode (GCE) for highly sensitive determination of naproxen. To ensure the successful synthesis of the perovskite nanosheets, morphological studies including scanning electron microscopy (SEM)...
Source: Analytical Biochemistry - March 26, 2024 Category: Biochemistry Authors: Roghayeh Mahmoudi-Maleki Mir Reza Majidi Hessamaddin Sohrabi Elham Mahmoudi Homa Fooladvand Ali Coruh Aligholi Niaei Source Type: research
Exploring the potential of SrTi < sub > 0.7 < /sub > Fe < sub > 0.3 < /sub > O < sub > 3 < /sub > perovskite/chitosan nanosheets for the development of a label-free electrochemical sensing assay for determination of naproxen in human plasma samples
Anal Biochem. 2024 Mar 24:115513. doi: 10.1016/j.ab.2024.115513. Online ahead of print.ABSTRACTNaproxen is a nonsteroidal anti-inflammatory drug used to treat nonrheumatic inflammation, migraine, and gout. Therefore, the determination of naproxen in pharmaceutical and biological samples is of particular importance. In the present work, SrTi0.7Fe0.3O3 perovskite/Chitosan nanosheets were used to modify the surface of a glassy carbon electrode (GCE) for highly sensitive determination of naproxen. To ensure the successful synthesis of the perovskite nanosheets, morphological studies including scanning electron microscopy (SEM)...
Source: Analytical Biochemistry - March 26, 2024 Category: Biochemistry Authors: Roghayeh Mahmoudi-Maleki Mir Reza Majidi Hessamaddin Sohrabi Elham Mahmoudi Homa Fooladvand Ali Coruh Aligholi Niaei Source Type: research
Exploring the potential of SrTi < sub > 0.7 < /sub > Fe < sub > 0.3 < /sub > O < sub > 3 < /sub > perovskite/chitosan nanosheets for the development of a label-free electrochemical sensing assay for determination of naproxen in human plasma samples
Anal Biochem. 2024 Mar 24:115513. doi: 10.1016/j.ab.2024.115513. Online ahead of print.ABSTRACTNaproxen is a nonsteroidal anti-inflammatory drug used to treat nonrheumatic inflammation, migraine, and gout. Therefore, the determination of naproxen in pharmaceutical and biological samples is of particular importance. In the present work, SrTi0.7Fe0.3O3 perovskite/Chitosan nanosheets were used to modify the surface of a glassy carbon electrode (GCE) for highly sensitive determination of naproxen. To ensure the successful synthesis of the perovskite nanosheets, morphological studies including scanning electron microscopy (SEM)...
Source: Analytical Biochemistry - March 26, 2024 Category: Biochemistry Authors: Roghayeh Mahmoudi-Maleki Mir Reza Majidi Hessamaddin Sohrabi Elham Mahmoudi Homa Fooladvand Ali Coruh Aligholi Niaei Source Type: research
Exploring the potential of SrTi < sub > 0.7 < /sub > Fe < sub > 0.3 < /sub > O < sub > 3 < /sub > perovskite/chitosan nanosheets for the development of a label-free electrochemical sensing assay for determination of naproxen in human plasma samples
Anal Biochem. 2024 Mar 24:115513. doi: 10.1016/j.ab.2024.115513. Online ahead of print.ABSTRACTNaproxen is a nonsteroidal anti-inflammatory drug used to treat nonrheumatic inflammation, migraine, and gout. Therefore, the determination of naproxen in pharmaceutical and biological samples is of particular importance. In the present work, SrTi0.7Fe0.3O3 perovskite/Chitosan nanosheets were used to modify the surface of a glassy carbon electrode (GCE) for highly sensitive determination of naproxen. To ensure the successful synthesis of the perovskite nanosheets, morphological studies including scanning electron microscopy (SEM)...
Source: Analytical Biochemistry - March 26, 2024 Category: Biochemistry Authors: Roghayeh Mahmoudi-Maleki Mir Reza Majidi Hessamaddin Sohrabi Elham Mahmoudi Homa Fooladvand Ali Coruh Aligholi Niaei Source Type: research
Designing Powerful Biindole-Based Inherently Chiral Selectors: Enhancing Enantiodiscrimination by Core Functionalization with Additional Coordination Elements
Chemistry. 2024 Mar 22:e202303530. doi: 10.1002/chem.202303530. Online ahead of print.ABSTRACTAmong inherently chiral selectors of axial stereogenicity, usually resulting in very good enantiodiscrimination performances, the biindole-based family has the additional advantage of very easy functionalization of the two nitrogen atoms with a variety of substituents with desirable properties. Aiming to evaluate the possibility of exploiting such feature to enhance the enantiodiscrimination ability of the archetype structure, a series of three inherently chiral monomers were designed and synthesized, characterised by a 2,2'-biind...
Source: Chemistry - March 22, 2024 Category: Chemistry Authors: Sara Grecchi Giorgia Bonetti Elisa Emanuele Ji ří Ludvík Lucie Kol áčná Alan Li ška Magdal éna Hromadová Serena Arnaboldi Roberto Cirilli Patrizia R Mussini Tiziana Benincori Source Type: research
Designing Powerful Biindole-Based Inherently Chiral Selectors: Enhancing Enantiodiscrimination by Core Functionalization with Additional Coordination Elements
Chemistry. 2024 Mar 22:e202303530. doi: 10.1002/chem.202303530. Online ahead of print.ABSTRACTAmong inherently chiral selectors of axial stereogenicity, usually resulting in very good enantiodiscrimination performances, the biindole-based family has the additional advantage of very easy functionalization of the two nitrogen atoms with a variety of substituents with desirable properties. Aiming to evaluate the possibility of exploiting such feature to enhance the enantiodiscrimination ability of the archetype structure, a series of three inherently chiral monomers were designed and synthesized, characterised by a 2,2'-biind...
Source: Chemistry - March 22, 2024 Category: Chemistry Authors: Sara Grecchi Giorgia Bonetti Elisa Emanuele Ji ří Ludvík Lucie Kol áčná Alan Li ška Magdal éna Hromadová Serena Arnaboldi Roberto Cirilli Patrizia R Mussini Tiziana Benincori Source Type: research
Azathioprine and hydroxychloroquine overdose in Sj ögren’s syndrome patient with hypocalcemia: a case report
ConclusionHydroxychloroquine and azathioprine toxicity are considered rare, but it is likely to increase in frequency given the prevalence and increase in autoimmune diseases and the increasing usage of these drugs in treating such diseases. We found hypocalcemia as the presentation to this patient, which needs further investigation into the probable mechanism. Clinicians need to consider the unique effects of hydroxychloroquine and azathioprine poisoning and initiate appropriate emergency interventions to improve the outcomes in similar patients. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - February 27, 2024 Category: General Medicine Source Type: research
What a pain in the back: a review of current treatment options with a focus on naproxen sodium
J Pharm Pharm Sci. 2024 Feb 7;27:12384. doi: 10.3389/jpps.2024.12384. eCollection 2024.ABSTRACTNon-specific low back pain (LBP) represents a challenging and prevalent condition that is one of the most common symptoms leading to primary care physician visits. While established guidelines recommend prioritizing non-pharmacological approaches as the primary course of action, pharmacological treatments are advised when non-pharmacological approaches are ineffective or based on patient preference. These guidelines recommend non-steroidal anti-inflammatory drugs (NSAIDs) or skeletal muscle relaxers (SMRs) as the first-line pharm...
Source: Pain Physician - February 22, 2024 Category: Anesthesiology Authors: Steven M Weisman Giovanni Ciavarra Grant Cooper Source Type: research
What a pain in the … back: a review of current treatment options with a focus on naproxen sodium
J Pharm Pharm Sci. 2024 Feb 7;27:12384. doi: 10.3389/jpps.2024.12384. eCollection 2024.ABSTRACTNon-specific low back pain (LBP) represents a challenging and prevalent condition that is one of the most common symptoms leading to primary care physician visits. While established guidelines recommend prioritizing non-pharmacological approaches as the primary course of action, pharmacological treatments are advised when non-pharmacological approaches are ineffective or based on patient preference. These guidelines recommend non-steroidal anti-inflammatory drugs (NSAIDs) or skeletal muscle relaxers (SMRs) as the first-line pharm...
Source: J Pharm Pharm Sci - February 22, 2024 Category: Drugs & Pharmacology Authors: Steven M Weisman Giovanni Ciavarra Grant Cooper Source Type: research
What a pain in the … back: a review of current treatment options with a focus on naproxen sodium
J Pharm Pharm Sci. 2024 Feb 7;27:12384. doi: 10.3389/jpps.2024.12384. eCollection 2024.ABSTRACTNon-specific low back pain (LBP) represents a challenging and prevalent condition that is one of the most common symptoms leading to primary care physician visits. While established guidelines recommend prioritizing non-pharmacological approaches as the primary course of action, pharmacological treatments are advised when non-pharmacological approaches are ineffective or based on patient preference. These guidelines recommend non-steroidal anti-inflammatory drugs (NSAIDs) or skeletal muscle relaxers (SMRs) as the first-line pharm...
Source: Journal of Pharmacy and Pharmaceutical Sciences - February 22, 2024 Category: Drugs & Pharmacology Authors: Steven M Weisman Giovanni Ciavarra Grant Cooper Source Type: research
What a pain in the back: a review of current treatment options with a focus on naproxen sodium
J Pharm Pharm Sci. 2024 Feb 7;27:12384. doi: 10.3389/jpps.2024.12384. eCollection 2024.ABSTRACTNon-specific low back pain (LBP) represents a challenging and prevalent condition that is one of the most common symptoms leading to primary care physician visits. While established guidelines recommend prioritizing non-pharmacological approaches as the primary course of action, pharmacological treatments are advised when non-pharmacological approaches are ineffective or based on patient preference. These guidelines recommend non-steroidal anti-inflammatory drugs (NSAIDs) or skeletal muscle relaxers (SMRs) as the first-line pharm...
Source: Pain Physician - February 22, 2024 Category: Anesthesiology Authors: Steven M Weisman Giovanni Ciavarra Grant Cooper Source Type: research
What a pain in the … back: a review of current treatment options with a focus on naproxen sodium
J Pharm Pharm Sci. 2024 Feb 7;27:12384. doi: 10.3389/jpps.2024.12384. eCollection 2024.ABSTRACTNon-specific low back pain (LBP) represents a challenging and prevalent condition that is one of the most common symptoms leading to primary care physician visits. While established guidelines recommend prioritizing non-pharmacological approaches as the primary course of action, pharmacological treatments are advised when non-pharmacological approaches are ineffective or based on patient preference. These guidelines recommend non-steroidal anti-inflammatory drugs (NSAIDs) or skeletal muscle relaxers (SMRs) as the first-line pharm...
Source: J Pharm Pharm Sci - February 22, 2024 Category: Drugs & Pharmacology Authors: Steven M Weisman Giovanni Ciavarra Grant Cooper Source Type: research
What a pain in the … back: a review of current treatment options with a focus on naproxen sodium
J Pharm Pharm Sci. 2024 Feb 7;27:12384. doi: 10.3389/jpps.2024.12384. eCollection 2024.ABSTRACTNon-specific low back pain (LBP) represents a challenging and prevalent condition that is one of the most common symptoms leading to primary care physician visits. While established guidelines recommend prioritizing non-pharmacological approaches as the primary course of action, pharmacological treatments are advised when non-pharmacological approaches are ineffective or based on patient preference. These guidelines recommend non-steroidal anti-inflammatory drugs (NSAIDs) or skeletal muscle relaxers (SMRs) as the first-line pharm...
Source: Journal of Pharmacy and Pharmaceutical Sciences - February 22, 2024 Category: Drugs & Pharmacology Authors: Steven M Weisman Giovanni Ciavarra Grant Cooper Source Type: research
