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A review on environmental monitoring of water organic pollutants identified by EU guidelines
Publication date: 15 February 2018 Source:Journal of Hazardous Materials, Volume 344 Author(s): João C.G. Sousa, Ana R. Ribeiro, Marta O. Barbosa, M. Fernando R. Pereira, Adrián M.T. Silva The contamination of fresh water is a global concern. The huge impact of natural and anthropogenic organic substances that are constantly released into the environment, demands a better knowledge of the chemical status of Earth’s surface water. Water quality monitoring studies have been performed targeting different substances and/or classes of substances, in different regions of the world, using different types of s...
Source: Journal of Hazardous Materials - October 14, 2017 Category: Environmental Health Source Type: research

Meloxicam and risk of myocardial infarction: a population-based nested case –control study
This study warrants cautious use of this increasingly popular drug. (Source: Rheumatology International)
Source: Rheumatology International - October 13, 2017 Category: Rheumatology Source Type: research

Naproxen gel probably has no important benefit in minimizing pain after orthodontic separator placement.
Authors: Brignardello-Petersen R PMID: 28987485 [PubMed - as supplied by publisher] (Source: Journal of the American Dental Association)
Source: Journal of the American Dental Association - October 12, 2017 Category: Dentistry Tags: J Am Dent Assoc Source Type: research

An Intraplantar Hypertonic Saline Assay in Mice for Rapid Screening of Analgesics.
CONCLUSIONS: The i.pl. HS assay is easily performed, rapidly detects standard analgesics, and produces minimal animal suffering without tissue damage. We propose this assay as a useful addition to the armamentarium of existing preclinical analgesic screens. PMID: 28991111 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - October 5, 2017 Category: Anesthesiology Authors: Asiri YI, Fung T, Schwarz SKW, Asseri KA, Welch ID, Schuppli CA, Barr AM, Wall RA, Puil E, MacLeod BA Tags: Anesth Analg Source Type: research

Molecules, Vol. 22, Pages 1661: In Vitro Evaluation of Third Generation PAMAM Dendrimer Conjugates
quo;Emanuele The present study compares the use of high generation G3 and low generation G0 Polyamidoamine (PAMAM) dendrimers as drug carriers of naproxen (NAP), a poorly water soluble drug. Naproxen was conjugated to G3 in different ratios and to G0 in a 1:1 ratio via a diethylene glycol linker. A lauroyl chain (L), a lipophilic permeability enhancer, was attached to G3 and G0 prodrugs. The G3 and G0 conjugates were more hydrophilic than naproxen as evaluated by the measurement of partitioning between 1-octanol and a phosphate buffer at pH 7.4 and pH 1.2. The unmodified surface PAMAM-NAP conjugates showed significant ...
Source: Molecules - October 4, 2017 Category: Chemistry Authors: Mohammad Najlah Sally Freeman Mouhamad Khoder David Attwood Antony D ’Emanuele Tags: Article Source Type: research

Intensive vaginal dilation using adjuvant treatments in women with Mayer ‐Rokitansky‐Kuster‐Hauser syndrome: retrospective cohort study
AimsTo evaluate the effect of adjuvants during intensive vaginal dilator therapy for functional and anatomical neovagina creation in women with Mayer‐Rokitansky‐Kuster‐Hauser syndrome (MRKH). MethodsThis retrospective cohort study included 75 women with MRKH undergoing intensive vaginal dilator treatment between 2000 and 2014. One specialist nurse performed non‐surgical vaginal dilation aided by adjuvants, during inpatient admissions for several dilation sessions per day. Following discharge, women continued dilation at home and were advised to attend fortnightly follow‐up appointments. ResultsOutcomes from 68 wo...
Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology - September 28, 2017 Category: OBGYN Authors: Ashradha Ketheeswaran, Jennifer Morrisey, Jason Abbott, Michael Bennett, Jan Dudley, Rebecca Deans Tags: Original Article Source Type: research

Assessment of gemfibrozil persistence in river water alone and in co-presence of naproxen
Publication date: January 2018 Source:Microchemical Journal, Volume 136 Author(s): P. Grenni, L. Patrolecco, N. Ademollo, M. Di Lenola, A. Barra Caracciolo Gemfibrozil is a pharmaceutical commonly found in the aquatic compartment and its presence together with a mixture of several other biologically-active drugs raises concern about the possible long-term adverse effects on biota chronically exposed. Most research focus on its effect/degradation in wastewater treatment plant, while few investigations take into account its persistence in receiving aquatic ecosystems and its effects on natural microbial communities. In this...
Source: Microchemical Journal - September 28, 2017 Category: Chemistry Source Type: research

Levetiracetam+nonsteroidal anti-inflammatory drug binary systems: A contribution to the development of new solid dosage forms
Publication date: 25 November 2017 Source:International Journal of Pharmaceutics, Volume 533, Issue 1 Author(s): Sara M.T. Machado, Ricardo A.E. Castro, Teresa M.R. Maria, João Canotilho, M. Ermelinda S. Eusébio A study has been carried out of binary solid systems made up of the antiepileptic drug levetiracetam, LEV, and a nonsteroidal anti-inflammatory drug, NSAID, capable of managing the inflammation that accompanies epileptic activity. One aim of this research was to identify eutectic mixtures and co-crystals, which are able to impact positively on their biopharmaceutical properties. The NSAIDs studied ar...
Source: International Journal of Pharmaceutics - September 24, 2017 Category: Drugs & Pharmacology Source Type: research

Improving the Drug Release of Naproxen Sodium Tablets by Preparing Granules and Tablets with a Preferred Mixing Ratio of Hydrates.
This study showed that a modified designed fluid bed granulation was not affected by differences in the mixing ratio of hydrates when using different water contents after spraying and at the end with the finished granules. Here, x-ray diffraction combined with Rietveld refinement was used to analyze the ratio of the hydrates and its identity. All granulation batches showed a large amount of Naproxen Sodium Monohydrate (> 87%) and no differences could be observed during tablet compression. Quantities of other hydrates were negligibly small. Furthermore, this study also demonstrated the influence of tablet compression by ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - September 19, 2017 Category: Drugs & Pharmacology Authors: David B, Heiko D, Christian G, Stephan T, Wolfgang F, Karsten M, Peter I Tags: Eur J Pharm Biopharm Source Type: research

Comparing the Safety and Efficacy of Celecoxib for the Treatment of Osteoarthritis in Asian and non-Asian Populations: An Analysis of Data from Two Randomized, Double-blind, Placebo-controlled, Active-comparator Trials
AbstractIntroductionCelecoxib is an effective treatment for pain associated with osteoarthritis. There are differences in patient demographics among ethnic groups, with Asian populations typically smaller in body size. As a consequence, there may be a perception that celecoxib is less effective, or has poorer tolerability in Asian patients.MethodsThis analysis compares data from two multicenter, randomized, double-blind, placebo-controlled, active-comparator trials of celecoxib for the treatment of osteoarthritis of the knee: one study in Asian patients and the other in a mixed population comprised mostly of non-Asian pati...
Source: Pain and Therapy - September 18, 2017 Category: Anesthesiology Source Type: research

Synthesis and evaluation of a novel chiral derivatization reagent for resolution of carboxylic acid enantiomers by RP-HPLC
Publication date: Available online 14 September 2017 Source:Microchemical Journal Author(s): Lu-Ping Li, Mei-Na Jin, Qing Shi, Chun-Yan Xu, Ying-Zi Jiang, Yong-Ill Lee, Jun Zhe Min A novel derivatization reagent, N-[1-Oxo-5-(triphenylphosphonium)pentyl]-(S)-3-aminopyrrolidine (OTPA), with triphenylphosphine (TPP) as a basic structure carrying a permanent positive charge was developed for the enantiomeric separation of chiral carboxylic acids by high-performance liquid chromatography (HPLC). OTPA reacted with the carboxylic acids at 40°C within 90min in the presence of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (ED...
Source: Microchemical Journal - September 14, 2017 Category: Chemistry Source Type: research

Prescription audit of NSAIDs and gastroprotective strategy in elderly in primary care.
CONCLUSIONS: The rational choice of NSAIDs and physicians' adherence to gastroprotective measures was suboptimal in primary care. The choice of NSAIDs and gastroprotective strategy in elderly be guided by the CV and gastrointestinal adverse events likelihood due to the NSAIDs and risk profile of patients for such adverse events. PMID: 28885223 [PubMed - in process] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - September 10, 2017 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Comparison of Clinical Efficacies of Preoperatively Initiated Naproxen Sodium + Codeine Phosphate Combination, Diclofenac Potassium and Benzydamine Hydrochloride over Pain, Edema and Trismus after Extraction of Impacted Lower Third Molar: A Randomized Double-Blind Study
The immediate aim of this study is to compare the clinical efficacies of naproxen sodium + codeine phosphate combination, benzydamine hydrochloride, and diclofenac potassium for pain, edema, and trismus following lower third molar extraction. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - September 7, 2017 Category: ENT & OMF Authors: Levent Cigerim, Cennet Neslihan Eroglu Source Type: research

Comparison of Clinical Efficacies of Preoperatively Initiated Naproxen Sodium –Codeine Phosphate in Combination, Diclofenac Potassium, and Benzydamine Hydrochloride for Pain, Edema, and Trismus After Extraction of Impacted Lower Third Molar: A Randomized Double-Blind Study
The aim of this study was to compare the clinical efficacies of naproxen sodium –codeine phosphate in combination, benzydamine hydrochloride, and diclofenac potassium for pain, edema, and trismus after lower third molar extraction. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - September 7, 2017 Category: ENT & OMF Authors: Levent Cigerim, Cennet Neslihan Eroglu Tags: Dentoalveolar surgery Source Type: research

Double-Track Electrochemical Green Approach for Simultaneous Dissolution Profiling of Naproxen Sodium and Diphenhydramine Hydrochloride
Publication date: 30 November 2017 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 146 Author(s): Mostafa A. Shehata, Esraa M. Fawaz, Mohamed K.Abd El-Rahman, Ezzat M. Abdel-Moety Acquisition of the dissolution profiles of more than single active ingredient in a multi-analyte pharmaceutical formulation is a mandatory manufacturing practice that is dominated by utilization of the off-line separation-based chromatographic methods. This contribution adopts a new “Double-Track” approach with the ultimate goal of advancing the in-line potentiometric sensors to their most effective applicability for...
Source: Journal of Pharmaceutical and Biomedical Analysis - September 5, 2017 Category: Drugs & Pharmacology Source Type: research

A randomized study to evaluate the analgesic efficacy of a single dose of the TRPV1 antagonist mavatrep in patients with osteoarthritis
Conclusion Overall, mavatrep was associated with a significant reduction in pain, stiffness, and physical function when compared with placebo in patients with knee osteoarthritis. Mavatrep's safety profile was consistent with its mechanism of action as a TRPV1 antagonist. Implications Further studies are required to evaluate whether lower multiple doses of mavatrep can produce analgesic efficacy while minimizing adverse events, as well as the potential for improved patient counselling techniques to reduce the minor thermal burns related to decreased heat perception. Trial Registration: 2009-010961-21 (EudraCT Number). (Sou...
Source: Scandinavian Journal of Pain - August 24, 2017 Category: Anesthesiology Source Type: research

Juvenile systemic sclerosis: experience from a tertiary care center from India
AbstractJuvenile systemic sclerosis (JSSc) is a rare disorder with paucity of information on its treatment and longterm   outcome. Herein, we are sharing our experience with this rare entity. Case records of children, diagnosed to have systemic sclerosis attending Pediatric Rheumatology Clinic at All India Institute of Medical Sciences, New Delhi from January 1998 to June 2016 were reviewed. The demographic, clinica l, laboratory, treatment and outcome details were recorded. Disease outcome was classified arbitrarily as controlled, partly controlled or non-responsive/progressive based on: (A) ability to perform activi...
Source: Rheumatology International - August 22, 2017 Category: Rheumatology Source Type: research

The effects of β- d -mannuronic acid (M2000), as a novel NSAID, on COX1 and COX2 activities and gene expression in ankylosing spondylitis patients and the murine monocyte/macrophage, J774 cell line
AbstractAnkylosing spondylitis (AS) is a debilitating chronic inflammatory disease with genetic predisposition, which is characterized by the involvement of spine and sacroiliac joints. Due to the relatively unsuccessful treatments, we designed β-d-mannuronic (M2000) with the beneficial effects in various experimental models as a novel non-steroidal anti-inflammatory drug (NSAID). The aims of our present study were: first, to compare the therapeutic effects of M2000, as a novel designed NSAID, with naproxen and placebo in Iranian patients with AS during 12  weeks; second, to evaluate the effect of M2000 on gene e...
Source: Inflammopharmacology - August 17, 2017 Category: Drugs & Pharmacology Source Type: research

Artificial neural network for the voltamperometric quantification of diclofenac in presence of other nonsteroidal anti-inflammatory drugs and some commercial excipients
Publication date: Available online 16 August 2017 Source:Journal of Electroanalytical Chemistry Author(s): G.Y. Aguilar-Lira, J.M. Gutiérrez-Salgado, A. Rojas-Hernández, J.A. Rodríguez-Ávila, M.E. Páez-Hernández, G.A. Álvarez-Romero This work presents a methodology for the quantification of diclofenac using differential pulse voltammetry and an artificial neural network model. A carbon paste-multiwalled carbon nanotubes electrode is used as working electrode for obtaining the analytical data. Diclofenac was electrochemically characterized and the voltammetric parameters wer...
Source: Journal of Electroanalytical Chemistry - August 16, 2017 Category: Chemistry Source Type: research

Anisotropic Crystal Growth Inhibition by Polymeric Additives: Impact on Modulation of Naproxen Crystal Shape and Size
Crystal Growth& DesignDOI: 10.1021/acs.cgd.7b00802 (Source: Crystal Growth and Design)
Source: Crystal Growth and Design - August 15, 2017 Category: Chemistry Authors: Sendhil K. Poornachary, Vernissa D. Chia, Yin Yani, Guangjun Han, Pui Shan Chow and Reginald B. H. Tan Source Type: research

In high-risk patients with arthritis and previous upper GI bleeding, celecoxib vs naproxen reduced recurrent bleeding.
PMID: 28806798 [PubMed - in process] (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - August 15, 2017 Category: Internal Medicine Authors: Chan N, Weitz J Tags: Ann Intern Med Source Type: research

Supra ‐Additive Interaction of Docosahexaenoic Acid and Naproxen and Gastric Safety on the Formalin Test in Rats
ABSTRACT The aim of this work was to evaluate the effect of docosahexaenoic acid (DHA) on the pharmacokinetics and pharmacodynamics—nociception—of naproxen in rats, as well as to determine the gastric safety resulting from this combination versus naproxen alone. Female Wistar rats were orally administered DHA, naproxen or the DHA‐naproxen mixture at fixed‐ratio combination of 1:3. The antinociceptive effect was evaluated using the formalin test. The gastric injury was determined 3 h after naproxen administration. An isobolographic analysis was performed to characterize the antinociceptive interaction...
Source: Drug Development Research - August 3, 2017 Category: Drugs & Pharmacology Authors: Arlette Guadalupe Arroyo ‐Lira, Fernando Rodríguez‐Ramos, Mario I. Ortiz, Gilberto Castañeda‐Hernández, Aracely Evangelina Chávez‐Piña Tags: Research Article Source Type: research

Contaminants of emerging concern in the open sea waters of the Western Mediterranean.
This study investigates the occurrence of 58 chemicals in the open surface water of the Western Mediterranean Sea for the first time. 70 samples in total were collected in 10 different sampling areas. 3 pesticides, 11 pharmaceuticals and personal care products and 2 artificial sweeteners were detected at sub-ng to ng/L levels. Among them, the herbicide terbuthylazine, the pharmaceuticals caffeine, carbamazepine, naproxen and paracetamol, the antibiotic sulfamethoxazole, the antibacterial triclocarban and the two artificial sweeteners acesulfame and saccharin were detected in all samples. The compound detected at the highes...
Source: Environmental Pollution - August 3, 2017 Category: Environmental Health Authors: Brumovský M, Bečanová J, Kohoutek J, Borghini M, Nizzetto L Tags: Environ Pollut Source Type: research

γ-Polyglutamic acid mediated crosslinking PNIPAAm-based thermo/pH-responsive hydrogels for controlled drug release
Publication date: Available online 2 August 2017 Source:Polymer Degradation and Stability Author(s): Ning Yang, Yue Wang, Qingsong Zhang, Li Chen, Yiping Zhao The most important drawbacks of the thermo sensitive hydrogels based on N-isopropylacrylamide (NIPAAm) are the lack of other responsive groups and these hydrogels are not biodegradable; moreover, chemical cross-linking agents were commonly used in hydrogels formation process. In order to overcome these inconvenience, poly (NIPAAm-co- poly (γ-glutamic acid) - Allyl glycidyl ether) (poly (NIPAAm-co-γ-PGA-AGE)) hydrogels were obtained by cross-linking polym...
Source: Polymer Degradation and Stability - August 2, 2017 Category: Chemistry Source Type: research

Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents.
CONCLUSIONS: We identified only a small number of studies, with insufficient data for analysis.As we could undertake no meta-analysis, we are unable to comment about efficacy or harm from the use of NSAIDs to treat chronic non-cancer pain in children and adolescents. Similarly, we cannot comment on our remaining secondary outcomes: Carer Global Impression of Change; requirement for rescue analgesia; sleep duration and quality; acceptability of treatment; physical functioning; and quality of life.We know from adult randomised controlled trials that some NSAIDs, such as ibuprofen, naproxen, and aspirin, can be effective in c...
Source: Cochrane Database of Systematic Reviews - August 2, 2017 Category: General Medicine Authors: Eccleston C, Cooper TE, Fisher E, Anderson B, Wilkinson NM Tags: Cochrane Database Syst Rev Source Type: research

Coxibs, Traditional NSAIDs, and Cardiovascular Safety Post-PRECISION: What We Thought We Knew Then and What We Think We Know Now.
Abstract The aim of the present review is to analyze how thinking about the cardiovascular safety of nonsteroidal antiinflammatory drugs has evolved during the past two decades, and discuss to what extent the additional information from the Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen study may alter our current mechanistic understanding and/or clinical practice. PMID: 28378879 [PubMed - indexed for MEDLINE] (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - July 28, 2017 Category: Drugs & Pharmacology Authors: Patrono C, Baigent C Tags: Clin Pharmacol Ther Source Type: research

Investigation on influence of Wurster coating process parameters for development of delayed release minitablets of Naproxen.
Authors: Shah N, Aware R, Shetty V, Mehta T Abstract The present work aims at studying process parameters affecting coating of minitablets (3 mm in diameter) through Wurster coating process. Minitablets of Naproxen with high drug loading were manufactured using 3 mm multi-tip punches. The release profile of core pellets (published) and minitablets was compared with that of marketed formulation. The core formulation of minitablets was found to show similarity in dissolution profile with marketed formulation and hence was further carried forward for functional coating over it. Wurster processing was imp...
Source: Drug Development and Industrial Pharmacy - July 26, 2017 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

The Risk of Major NSAID Toxicity with Celecoxib, Ibuprofen or Naproxen: a Secondary Analysis of the PRECISION Randomized Controlled Clinical Trial
• Naproxen and ibuprofen at moderate dosages were associated with significantly more major NSAID toxicity events than celecoxib among older adults with arthritis and established coronary artery disease or risk factors.• These risks translate into numbers needed to harm of 135 (95% CI 72-971) for naproxen and 82 (95% CI 53-173) for ibuprofen, both compared with celecoxib. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - July 26, 2017 Category: General Medicine Authors: Daniel H Solomon, M Elaine Husni, Peter A Libby, Neville D Yeomans, AM Lincoff, Thomas F. L üscher, Venu Menon, Danielle M Brennan, Lisa M Wisniewski, Steven E Nissen, Jeffrey S Borer Tags: Clinical Research Study Source Type: research

The Risk of Major NSAID Toxicity with Celecoxib, Ibuprofen, or Naproxen: A Secondary Analysis of the PRECISION Trial
We examined the risk of major nonsteroidal anti-inflammatory drug toxicity in the PRECISION trial. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - July 26, 2017 Category: General Medicine Authors: Daniel H. Solomon, M. Elaine Husni, Peter A. Libby, Neville D. Yeomans, A. Michael Lincoff, Thomas F. L ϋscher, Venu Menon, Danielle M. Brennan, Lisa M. Wisniewski, Steven E. Nissen, Jeffrey S. Borer Tags: Clinical Research Study Source Type: research

An evaluation of myeloperoxidase-mediated bio-activation of NSAIDs in promyelocytic leukemia (HL-60) cells for potential cytotoxic selectivity.
In this study, we have investigated the acute bio-activation of NSAIDs and their metabolites via myeloperoxidase (MPO), a highly-expressed peroxidase enzyme in acute myeloid leukemia. As bio-activation involves the formation of reactive metabolites, we hypothesized that NSAIDs which produced reactive metabolites would be correlated with leukemia cell toxicity. We tested the enzymatic peroxidation of three NSAIDs, namely diclofenac, indomethacin, and naproxen in comparison with their hepatic metabolites, 4'- hydroxydiclofenac (4'-OHD), 5-hydroxydiclofenac (5-OHD), O-desmethyl-N-deschlorobenzoylindomethacin (DMBI), O-desmeth...
Source: Toxicology Letters - July 25, 2017 Category: Toxicology Authors: Morgan AGM, Babu D, Michail K, Siraki AG Tags: Toxicol Lett Source Type: research

Improvement of the surface hydrophilic properties of naproxen particles with addition of hydroxypropylmethyl cellulose and sodium dodecyl sulphate: In vitro and in vivo studies
In this study, a new surface-modified naproxen was developed to enhance brain concentration in acute migraine treatment. Fast-dissolving naproxen granules were made by mixing hydroxypropylmethylcellulose (HPMC) sodium dodecyl sulphate (SDS) and sodium croscarmellose with micronized naproxen particles. The aim of this study was to evaluate the effect of adding proportions of SDS to the HPMC film caused changes in the polymer chains of the HPMC, producing a new hydrophilic HPMC-SDS structure. These formulations with different HPMC/SDS ratios were characterised using electron microscopy (SEM), powder X-ray diffraction (PXRD),...
Source: International Journal of Pharmaceutics - July 20, 2017 Category: Drugs & Pharmacology Source Type: research

Use of multicriteria decision analysis for assessing the benefit and risk of over ‐the‐counter analgesics
ConclusionsMulticriteria decision analysis enabled participants to evaluate the OTC analgesics against a range of favourable and unfavourable effects in a group setting that enabled all issues to be openly aired and debated. The model was easily communicated and understood by the peer reviewers, so the model should be comprehensible to physicians, pharmacists and other health professionals. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 13, 2017 Category: Drugs & Pharmacology Authors: Andrew Moore, Anne Crossley, Bernard Ng, Lawrence Phillips, Özgür Sancak, K.D. Rainsford Tags: Research Paper Source Type: research

IJERPH, Vol. 14, Pages 739: Development of a New Microextraction Fiber Combined to On-Line Sample Stacking Capillary Electrophoresis UV Detection for Acidic Drugs Determination in Real Water Samples
A new analytical method coupling a (off-line) solid-phase microextraction with an on-line capillary electrophoresis (CE) sample enrichment technique was developed for the analysis of ketoprofen, naproxen and clofibric acid from water samples, which are known as contaminants of emerging concern in aquatic environments. New solid-phase microextraction fibers based on physical coupling of chromatographic supports onto epoxy glue coated needle were studied for the off-line preconcentration of these micropollutants. Identification and quantification of such acidic drugs were done by capillary zone electrophoresis (CZE) using ul...
Source: International Journal of Environmental Research and Public Health - July 7, 2017 Category: Environmental Health Authors: Maria Espina-Benitez Lilia Araujo Avismelsi Prieto Alberto Naval ón Jos é Vílchez Paola Valera Ana Zambrano Vincent Dugas Tags: Article Source Type: research

Rapid screening of non-steroidal anti-inflammatory drugs illegally added in anti-rheumatic herbal supplements and herbal remedies by portable ion mobility spectrometry
Publication date: 25 October 2017 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 145 Author(s): Mengjiao Li, Haiyan Ma, Jinglin Gao, Lina Zhang, Xinyu Wang, Di Liu, Jing Bian, Ye Jiang In this work, for the first time, a high-performance ion mobility spectrometry with electrospray ionization (ESI-HPIMS) method has been employed as a rapid screening tool for the detection of acetaminophen, ibuprofen, naproxen, diclofenac sodium and indomethacin illegally added in anti-rheumatic herbal supplements and herbal remedies. Samples were dissolved and filtered through a 0.45μm microporous membrane, then the fi...
Source: Journal of Pharmaceutical and Biomedical Analysis - June 28, 2017 Category: Drugs & Pharmacology Source Type: research

Cancer Stem Cell and Bulk Cancer Cell Active Copper(II) Complexes with Vanillin Schiff Base Derivatives and Naproxen.
Abstract Four copper(II) complexes, 1-4 containing regioisomeric vanillin Schiff base derivatives ((E)-5/4/3/2-methoxy-2-(((2-(methylthio)ethyl)imino)methyl)phenol) and the nonsteroidal anti-inflammatory drug (NSAID), naproxen, were synthesised and characterised. All complexes effectively cleave DNA in cell-free systems, with 4 displaying the highest nuclease activity. DNA binding studies suggest that 4 binds to DNA via the grooves prior to inducing oxidative DNA cleavage. Three of the complexes (1, 3, and 4) indiscriminately kill cancer stem cell (CSC)-enriched cells (HMLER-shEcad) and bulk cancer cells (HMLER) a...
Source: Chemistry - June 28, 2017 Category: Chemistry Authors: Lu C, Eskandari A, Cressey P, Suntharalingam K Tags: Chemistry Source Type: research

A novel enantioseparation approach based on liposome electrokinetic capillary chromatography
In this study, we proposed a brand-new LEKC chiral separation approach using liposomes comprised of phosphatidylcholine (PC) and cholesterol as pseudo-stationary phase and sulfobutyl ether-β-cyclodextrin (SBE-β-CD) as chiral selector. Compared with the single CD system and CD-SDS-MEKC system, this LEKC method presented an obviously preferable enantioseparation of four model drugs (naproxen, warfarin, ketoprofen and amlodipine). In this new established system, all the enantiomers represented baseline separations with the resolution and selectivity respectively achieving 1.584/1.067 (for naproxen), 2.226/1.045 (for...
Source: Journal of Pharmaceutical and Biomedical Analysis - June 27, 2017 Category: Drugs & Pharmacology Source Type: research

The Cardiovascular Pharmacology of Nonsteroidal Anti-Inflammatory Drugs
Publication date: Available online 23 June 2017 Source:Trends in Pharmacological Sciences Author(s): Tilo Grosser, Emanuela Ricciotti, Garret A. FitzGerald The principal molecular mechanisms underlying the cardiovascular (CV) and renal adverse effects of nonsteroidal anti-inflammatory drugs (NSAIDs), such as myocardial infarction and hypertension, are understood in more detail than most side effects of drugs. Less is known, however, about differences in the CV safety profile between chemically distinct NSAIDs and their relative predisposition to complications. In review article, we discuss how heterogeneity in the pharmac...
Source: Trends in Pharmacological Sciences - June 24, 2017 Category: Drugs & Pharmacology Source Type: research

Synergism between Naproxen and Rutin in a Mouse Model of Visceral Pain
ABSTRACT The aim of the present study was to evaluate the antinociceptive interaction between naproxen and the glycoside flavonoid, rutin in the acetic acid‐induced writhing test in mice. Naproxen (5, 20, 50, and 100 mg/kg p.o.) or rutin (10, 25, 50, and 100mg/kg p.o.) were administered 60 min before the intraperitoneal administration with acetic acid. The dose‐response curve of each individual compound and the experimental effective dose 50 (ED50) value were obtained to determinate different proportions of the combinations between the two compounds (naproxen‐rutin 1:1, 3:1, and 3:1) in the writhing test. The ...
Source: Drug Development Research - June 22, 2017 Category: Drugs & Pharmacology Authors: Angel Josabad Alonso ‐Castro, Joceline Estefanía Rangel‐Velázquez, Mario A. Isiordia‐Espinoza, Luis Enrique Villanueva‐Solís, Othoniel H. Aragon‐Martinez, Juan Ramón Zapata‐Morales Tags: Research Article Source Type: research

Temperature-Controlled Bidirectional Enantioselectivity in Asymmetric Hydrogenation Reactions Utilizing Stereodynamic Iridium Complexes
Synthesis DOI: 10.1055/s-0036-1588861 Stereochemically flexible 2,2(-bis(diphenylphosphino)biphenyl (BIPHEP) ligands were modified with chiral α-substituted carboxylic acid auxiliaries in the 3- and 3′-position. The resulting central-to-axial chirality transfer to the stereochemically flexible chiral axis of the BIPHEP­ core was investigated as well as complexation of these diastereomeric ligands to iridium(I). Solid-state structures of both ligand diastereomers and a diastereomerically pure iridium(I) BIPHEP complex were obtained. Thermal equilibration of the resulting iridium(I) complexes was studied to i...
Source: Synthesis - June 20, 2017 Category: Chemistry Authors: Siebert, Max Storch, Golo Rominger, Frank Trapp, Oliver Tags: paper Source Type: research

Amphiphilic naproxen prodrugs: differential scanning calorimetry study on their interaction with phospholipid bilayers
ConclusionsVariation of LAA portion can modulate the naproxen prodrugs affinity towards the biological membrane as well as towards the lipophilic carrier. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 16, 2017 Category: Drugs & Pharmacology Authors: Maria Chiara Giuffrida, Rosario Pignatello, Francesco Castelli, Maria Grazia Sarpietro Tags: Research Paper Source Type: research

NSAIDs relieve osteoarthritis (OA) pain, but cardiovascular safety in question even for diclofenac, ibuprofen, naproxen, and celecoxib: what are the alternatives?
Publication date: July 2017 Source:Scandinavian Journal of Pain, Volume 16 Author(s): Harald Breivik (Source: Scandinavian Journal of Pain)
Source: Scandinavian Journal of Pain - June 15, 2017 Category: Anesthesiology Source Type: research

In-hospital use of non-steroidal anti-inflammatory drugs in patients with  heart failure in academic centers in the United States.
In-hospital use of non-steroidal anti-inflammatory drugs in patients with heart failure in academic centers in the United States. Int J Risk Saf Med. 2016;28(4):181-188 Authors: Alvarez PA, Nguyen DT, Schutt R, Ganduglia C, Estep JD, Graviss EA, Putney D Abstract BACKGROUND: Non-steroidal anti-inflammatory drugs are considered potentially harmful for patients with heart failure. OBJECTIVE: To determine the prevalence of in-hospital NSAID use, their type, associated diagnosis and impact in clinical outcomes among patients with a diagnosis of heart failure. METHODS: The University ...
Source: International Journal of Risk and Safety in Medicine - June 9, 2017 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Desorption of micropollutant from spent carbon filters used for water purifier.
In this study, to examine the accumulated micropollutants in the spent carbon filter used in the water purifier, first, the method to desorb micropollutant from the activated carbon was developed and optimized. Then, using this optimized desorption conditions, we examined which micropollutants exist in spent carbon filters collected from houses in different regions in Korea where water purifiers were used. A total of 11 micropollutants (caffeine (CFF), acetaminophen (ACT), sulfamethazine (SMA), sulfamethoxazole (SMZ), metoprolol (MTP), carbamazepine (CBM), naproxen (NPX), bisphenol-A (BPA), ibuprofen (IBU), diclofenac (DCF...
Source: Environmental Science and Pollution Research International - June 9, 2017 Category: Environmental Health Authors: Kwon DS, Tak SY, Lee JE, Kim MK, Lee YH, Han DW, Kang S, Zoh KD Tags: Environ Sci Pollut Res Int Source Type: research

WITHDRAWN: Celecoxib for rheumatoid arthritis.
CONCLUSIONS: For an individual with RA the potential benefits of celecoxib need to be balanced against the uncertainty that the short-term reduced incidence of upper GI complications are maintained in the long-term and its increased cost in comparison to traditional NSAIDs. PMID: 28598564 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - June 9, 2017 Category: General Medicine Authors: Garner SE, Fidan D, Frankish RR, Judd M, Shea B, Towheed T, Tugwell P, Wells GA Tags: Cochrane Database Syst Rev Source Type: research

Celecoxib for rheumatoid arthritis.
CONCLUSIONS: Celecoxib may improve clinical symptoms, alleviate pain and contribute to little or no difference in physical function compared with placebo. Celecoxib was associated with fewer numbers of participant withdrawals. Results for incidence of gastroduodenal ulcers (≥ 3 mm) and short-term serious adverse events were uncertain; however, there were few reported events for either.Celecoxib may slightly improve clinical symptoms compared with tNSAIDs. Results for reduced pain and improved physical function were uncertain. Particpants taking celecoxib had lower incidence of gastroduodenal ulcers (≥ 3 mm) and there...
Source: Cochrane Database of Systematic Reviews - June 9, 2017 Category: General Medicine Authors: Fidahic M, Jelicic Kadic A, Radic M, Puljak L Tags: Cochrane Database Syst Rev Source Type: research

Studies on binary mixtures of Pluronic P123 and twin tailed 1-Butyl-3-methyl-imidazolium Aerosol OT - Aggregation behavior and impact on Naproxen and Rifampicin partitioning
Publication date: September 2017 Source:Journal of Molecular Liquids, Volume 241 Author(s): Parvaiz Ahmad Bhat, Oyais Ahmad Chat, Aijaz Ahmad Dar Pluronic P123, 1-Butyl-3-methyl-imidazolium Aerosol OT ([Bmim][AOT]) and their binary mixtures at varied mole fractions have been investigated for micellization and rheological properties. The composition of the mixed micelles has been estimated on the basis of Clint, Gibbs adsorption, and Rubingh theories. The mixed micellar systems exhibited synergism for all the investigated mole fraction ranges with more pronounced synergism at intermediate mole fractions of [Bmim][AOT]. The...
Source: Journal of Molecular Liquids - June 7, 2017 Category: Molecular Biology Source Type: research

Evaluation of Cardiovascular Risk Associated with SKI306X Use in Patients with Osteoarthritis and Rheumatoid Arthritis
Conclusions Evaluation of the cardiovascular safety of the anti-inflammatory analgesic herbal medicine SKI306X revealed that it did not differ from that of naproxen, which is known to have low cardiovascular risk. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - June 7, 2017 Category: Drugs & Pharmacology Source Type: research

Inhibition of Methotrexate Uptake via Organic Anion Transporters OAT1 and OAT3 by Glucuronides of Nonsteroidal Anti-inflammatory Drugs.
In this study, [(3)H]MTX uptake was observed by using human OAT1 and OAT3-overexpressing HEK293 cells in the presence or absence of NSAIDs-Glu. All examined NSAIDs-Glu exhibited concentration-dependent inhibitory effects on MTX uptake via OAT1 and OAT3. Our results indicated that NSAIDs-Glu are more potent (5- to 15-fold) inhibitors of OAT3 than OAT1. Moreover, stereoselective inhibitory effects of NSAIDs-Glu on OATs-mediated MTX uptake were not observed, unlike on MRPs-mediated transport. These findings suggest that inhibition of OAT1 and OAT3-mediated renal uptake of MTX by plasma NSAIDs-Glu may be one of the competitive...
Source: Biological and Pharmaceutical Bulletin - June 3, 2017 Category: Drugs & Pharmacology Authors: Iwaki M, Shimada H, Irino Y, Take M, Egashira S Tags: Biol Pharm Bull Source Type: research

Multi-responsive polypeptide hydrogels derived from N-carboxyanhydride terpolymerizations for delivery of nonsteroidal anti-inflammatory drugs
Org. Biomol. Chem., 2017, Advance Article DOI: 10.1039/C7OB00931C, PaperJingwei Fan, Richen Li, Hai Wang, Xun He, Tan P. Nguyen, Rachel A. Letteri, Jiong Zou, Karen L. Wooley Multi-responsive polypeptide-based hydrogels exhibited thermo-, mechano-, and enzyme-responsive properties, enabling performance as a delivery system for encapsulation and release of naproxen. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - June 2, 2017 Category: Molecular Biology Authors: Jingwei Fan Source Type: research

Nonsteroidal anti-inflammatory drugs and cardiovascular safety - translating pharmacological data into clinical readouts.
Authors: Tacconelli S, Bruno A, Grande R, Ballerini P, Patrignani P Abstract INTRODUCTION: The pharmacological management of pain includes the use of nonsteroidal anti-inflammatory drugs(NSAIDs). They comprise traditional(t) NSAIDs and selective cyclooxygenase(COX)-2 inhibitors (named coxibs). The analgesic and anti-inflammatory effects of NSAIDs are dependent on the extent and duration of COX-2 inhibition in the spinal cord and inflammatory sites. However, the simultaneous inhibition of COX-2 in the vasculature translates into a prothrombotic phenotype and promotes hypertension and heart failure. Areas covered. Th...
Source: Expert Opinion on Drug Safety - June 2, 2017 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research