Molecules, Vol. 21, Pages 564: Agrimonia eupatoria L. and Cynara cardunculus L. Water Infusions: Comparison of Anti-Diabetic Activities
Diabetes mellitus (DM) is frequently diagnosed at a time when patients already suffer from several cardiovascular complications. Our previously published data (Molecules 201520 (11): 20538-50) on the anti-oxidative properties of Agrimonia eupatoria L. (AE) and Cynara cardunculus L. (CC) prompted us to extend the available evidence on their possible protective activities on selected DM-related parameters in a streptozotocin-induced DM rat model and in a series of in vitro experiments. Male rats were divided into four groups: control group, untreated diabetic group, AE and CC treated diabetic groups. During a five-week perio...
Source: Molecules - April 27, 2016 Category: Chemistry Authors: Anika KuczmannováAndrea BalažováEva RačanskáMiroslava KameníkováSilvia FialováJaroslav MajerníkMilan NagyPeter GálPavel Mučaji Tags: Article Source Type: research
Agrimonolide from Agrimonia pilosa suppresses inflammatory responses through down-regulation of COX-2/iNOS and inactivation of NF-κB in lipopolysaccharide-stimulated macrophages
Conclusion The present study suggested that agrimonolide exerted anti- inflammatory activity, at least in part, via suppressing LPS-induced activation of JAK-STATs and p38 MAPKs signaling pathway. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - April 25, 2016 Category: Drugs & Pharmacology Source Type: research
Extracts of Agrimonia eupatoria L. as sources of biologically active compounds and evaluation of their antioxidant, antimicrobial, and antibiofilm activities
In this study, we determined the concentration of total phenols, flavonoids, tannins, and proanthocyanidins in the water, diethyl ether, acetone, and ethanol extracts of Agrimonia eupatoria L. We also investigated the antioxidant activity of these extracts using two methods [2,2-diphenyl-1-picrylhydrazyl (DPPH) and reducing power] and their in vitro antimicrobial (antibacterial and antifungal) activity on some selected species of bacteria and fungi. In addition, the effects of the acetone and water extracts on the inhibition of biofilm formation of Proteus mirabilis and Pseudomonas aeruginosa were investigated using the c...
Source: Journal of Food and Drug Analysis - April 25, 2016 Category: Food Science Source Type: research
A New Triterpenoid from the Aerial Parts of Agrimonia pilosa.
Authors: Ma JH, Jiang QH, Chen Y, Nie XF, Yao T, Ding LQ, Zhao F, Chen LX, Feng Q
Abstract
(1S,3R,17R,18R,19R,20R,22R)-1,3,19,22-tetrahydroxy-28-norurs-12-en-2-one (1), along with 5 known triterpenoids (2-6), were isolated from the aerial parts of Agrimonia pilosa Ledeb. Their structures were established based on extensive spectroscopic and MS analysis. The absolute configuration of compound 1 was deduced by circular dichroism (CD). Compound 1 was the first example of a 28-norursene backbone isolated from the genus Agrimonia. Compounds 2-6 were tested for anti-inflammatory activities against RAW 264.7 macr...
Source: Natural Product Communications - February 19, 2016 Category: Biochemistry Tags: Nat Prod Commun Source Type: research
Agrimonia pilosa Ledeb., Cinnamomum cassia Blume, and Lonicera japonica Thunb. protect against cognitive dysfunction and energy and glucose dysregulation by reducing neuroinflammation and hippocampal insulin resistance in β-amyloid-infused rats
10.1080/1028415X.2015.1135572 < br/ > Sunmin Park (Source: Nutritional Neuroscience)
Source: Nutritional Neuroscience - February 4, 2016 Category: Nutrition Authors: Sunmin Park Suna Kang Da Sol Kim Bo Rerum Moon Source Type: research
Effects of the Four-Herb Compound ANBP on Wound Healing Promotion in Diabetic Mice
In this study, we first used the ultralow temperature preparation method to produce mixed superfine powder from Agrimonia pilosa (A), Nelumbo nucifera (N), Boswellia carteri (B), and Pollen typhae (P), named as ANBP. Applying ANBP on 40 streptozotocin (STZ)-induced diabetic C57BL/6 mice (4-6 weeks, 20 ± 2 g), we observed that the wound healing process was accelerated and the wound healing time was shortened (14 days, P < .05). Pathological observation using hematoxylin–eosin staining indicated that inflammatory cells were reduced (P < .05) while the thickness of granulation tissue and length of epithelia...
Source: The International Journal of Lower Extremity Wounds - December 17, 2015 Category: Surgery Authors: Hou, Q., He, W.-J., Chen, L., Hao, H.-J., Liu, J.-J., Dong, L., Tong, C., Li, M.-R., Zhou, Z.-Z., Han, W.-D., Fu, X.-B. Tags: Basic and Experimental Research Source Type: research
Molecules, Vol. 20, Pages 20538-20550: Agrimonia eupatoria L. and Cynara cardunculus L. Water Infusions: Phenolic Profile and Comparison of Antioxidant Activities
In conclusion, our results provide evidence that the A. eupatoria extract may be a valuable source of polyphenols to be studied for the future development of supplements useful in the prevention of diseases linked to oxidative stress. (Source: Molecules)
Source: Molecules - November 18, 2015 Category: Chemistry Authors: Anika KuczmannováPeter GálLenka VarinskáJakub TremlIvan KováčMartin NovotnýTomáš VasilenkoStefano Dall’AcquaMilan NagyPavel Mučaji Tags: Article Source Type: research
Inhibitory Effect of Agrimonia Pilosa Leaf Extract on the UV‐Induced Photoaging‐Related Ion Channel, ORAI1, and the Enzymes Tyrosinase and Elastase
Abstract
Agrimonia pilosa Ledeb. has received considerable attention as a natural product for its applications in cosmetics owing to its anti‐skin wrinkling and whitening effects. The ORAI1 ion channel is known to be involved in UV‐induced photoaging. Additionally, tyrosinase and elastase are key enzymes in the process of wrinkle formation and pigmentation. We determined that A. pilosa leaf extract and its fractions (dichloromethane, ethyl acetate and n‐butanol) inhibit this channel and associated key enzymes. Whole‐cell patch‐clamp experiments demonstrated that the ethyl acetate fraction had a potent inhibit...
Source: Journal of Food Biochemistry - October 1, 2015 Category: Food Science Authors: You‐Jin Chang, Dong‐Ung Lee, Joo Hyun Nam, Woo Kyung Kim Tags: Full Article Source Type: research
Dandelion (Taraxacum officinale) and Agrimony (Agrimonia eupatoria) as Indicators of Geogenic Contamination of Flysch Soils in Eastern Slovakia.
Abstract
Contents of potentially toxic elements Fe, Mn, Cr, Ni, Co, V, Cu, and Mo were determined in common dandelion (Taraxacum officinale) and agrimony (Agrimonia eupatoria) to show their usefulness as bioindicators of geogenic soil pollution. Both plants were collected on geochemically anomalous soils developed on flysch sedimentary rocks (Paleogene) of Eastern Slovakia, which also are composed of weathered detritus of some ultramafic rocks. Generally, contents of the investigated association of potentially toxic elements are highly increased in these "serpentine"-like soils. Elevated concentrations wer...
Source: Archives of Environmental Contamination and Toxicology - August 9, 2015 Category: Environmental Health Authors: Čurlík J, Kolesár M, Ďurža O, Hiller E Tags: Arch Environ Contam Toxicol Source Type: research
Anticholinesterase, antioxidant activity and phytochemical investigation into aqueous extracts from five species of Agrimonia genus.
Abstract
Aqueous extracts of aerial flowering parts of five Agrimonia species (Rosaceae): Agrimonia coreana Nakai, Agrimonia japonica (Miq.) Koidz, Agrimonia procera Wallr., Agrimonia eupatoria L. and Agrimonia leucantha Kunze were investigated on their antioxidant activity, measured using five different methods; the best was the extract from A. procera with IC50 values from 6 to 29 μg/mL. All the extracts displayed inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) at the tested concentration of 100 μg/mL. We found the highest inhibition of cholinesterase in the extract of A. ...
Source: Natural Product Research - August 3, 2015 Category: Biochemistry Authors: Kubínová R, Švajdlenka E, Jankovská D Tags: Nat Prod Res Source Type: research
Protein tyrosine phosphatase 1B (PTP1B) inhibitory activity and glucosidase inhibitory activity of compounds isolated from Agrimonia pilosa
Pharmaceutical Biology, Ahead of Print. (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - June 18, 2015 Category: Drugs & Pharmacology Tags: article Source Type: research
The phytochemical investigation of Agrimonia eupatoria L. and Agrimonia procera Wallr. as valid sources of Agrimoniae herba—The pharmacopoeial plant material
Publication date: 10 October 2015 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 114 Author(s): Sebastian Granica , Holger Kluge , Gert Horn , Adam Matkowski , Anna K. Kiss The agrimony herb is a traditional plant drug, which is commonly used as a mildly astringent agent. According to European Pharmacopoeia, the only source of this plant drug is Agrimonia eupatoria. By contrast the German Commission E pharmacopoeial monograph used to allow Agrimonia procera to be used as a second valid source of Agrimoniae herba. Several studies have been conducted on the phytochemical composition of common agrim...
Source: Journal of Pharmaceutical and Biomedical Analysis - June 17, 2015 Category: Drugs & Pharmacology Source Type: research
Determination of antioxidative properties of herbal extracts: Agrimonia herba, Cynare folium, and Ligustri folium.
Authors: Topolska D, Valachova K, Nagy M, Soltes L
Abstract
OBJECTIVES: Hyaluronan (HA) molecules were exposed to free radical-mediated degradation performed by the reaction mixture Cu(II) and ascorbate, the so-called Weissberger biogenic oxidative system, which mimics the situation of acute inflammation. To achieve protection of HA from degradation, herbal extracts such as Agrimonia herba, Cynare folium, and Ligustri folium were selected.
METHODS: Time- and dose- dependent changes of dynamic viscosity of the HA solutions in the presence and absence of the herbal extracts were recorded by rotationa...
Source: Neuroendocrinology Letters - June 4, 2015 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research
P1-25-3 * inhibition of rectal cancer growth by a new herbal extract combinations(fuo-c4) in vivo
Conclusion: The study demonstrated that FUO-C4 could inhibit tumor growth and angiogenesis, induce apoptosis and decrease microvessel density in CT26 rectal cancer model, especially with acceptable toxicity. (Source: Annals of Oncology)
Source: Annals of Oncology - October 19, 2014 Category: Cancer & Oncology Authors: Li, X., Li, J., Tian, Y., Zhang, L., Liu, H., Li, Z., Yin, W. Tags: Poster Session (Poster presentations categorized by each organ) Source Type: research
