Agrimol B alleviates cisplatin-induced acute kidney injury by activating the Sirt1/Nrf2 signaling pathway in mice
Acta Biochim Biophys Sin (Shanghai). 2024 Feb 26. doi: 10.3724/abbs.2023285. Online ahead of print.ABSTRACTCisplatin (CDDP) is a widely used chemotherapeutic agent that has remarkable antineoplastic effects. However, CDDP can cause severe acute kidney injury (AKI), which limits its clinical application. Agrimol B is the main active ingredient found in Agrimonia pilosa Ledeb and has a variety of pharmacological activities. The effect of agrimol B on CDDP-induced renal toxicity has not been determined. To investigate whether agrimol B has a protective effect against CDDP-induced AKI, we first identify Sirtuin 1 (Sirt1) as a ...
Source: Acta Biochimica et Biophysica Sinica - February 26, 2024 Category: Biochemistry Authors: Jiarui Tang Longhui Li Zhijian Chen Cuiting Liao Kai Hu Yongqiang Yang Jiayi Huang Li Tang Li Zhang Longjiang Li Source Type: research
Agrimol B alleviates cisplatin-induced acute kidney injury by activating the Sirt1/Nrf2 signaling pathway in mice
Acta Biochim Biophys Sin (Shanghai). 2024 Feb 26. doi: 10.3724/abbs.2023285. Online ahead of print.ABSTRACTCisplatin (CDDP) is a widely used chemotherapeutic agent that has remarkable antineoplastic effects. However, CDDP can cause severe acute kidney injury (AKI), which limits its clinical application. Agrimol B is the main active ingredient found in Agrimonia pilosa Ledeb and has a variety of pharmacological activities. The effect of agrimol B on CDDP-induced renal toxicity has not been determined. To investigate whether agrimol B has a protective effect against CDDP-induced AKI, we first identify Sirtuin 1 (Sirt1) as a ...
Source: Acta Biochimica et Biophysica Sinica - February 26, 2024 Category: Biochemistry Authors: Jiarui Tang Longhui Li Zhijian Chen Cuiting Liao Kai Hu Yongqiang Yang Jiayi Huang Li Tang Li Zhang Longjiang Li Source Type: research
Agrimol B alleviates cisplatin-induced acute kidney injury by activating the Sirt1/Nrf2 signaling pathway in mice
Acta Biochim Biophys Sin (Shanghai). 2024 Feb 26. doi: 10.3724/abbs.2023285. Online ahead of print.ABSTRACTCisplatin (CDDP) is a widely used chemotherapeutic agent that has remarkable antineoplastic effects. However, CDDP can cause severe acute kidney injury (AKI), which limits its clinical application. Agrimol B is the main active ingredient found in Agrimonia pilosa Ledeb and has a variety of pharmacological activities. The effect of agrimol B on CDDP-induced renal toxicity has not been determined. To investigate whether agrimol B has a protective effect against CDDP-induced AKI, we first identify Sirtuin 1 (Sirt1) as a ...
Source: Acta Biochimica et Biophysica Sinica - February 26, 2024 Category: Biochemistry Authors: Jiarui Tang Longhui Li Zhijian Chen Cuiting Liao Kai Hu Yongqiang Yang Jiayi Huang Li Tang Li Zhang Longjiang Li Source Type: research
Molecules, Vol. 29, Pages 283: Anti-Inflammatory Flavonoids from Agrimonia pilosa Ledeb: Focusing on Activity-Guided Isolation
-Hwa Kang
To elucidate the anti-inflammatory properties and constituents of Agrimonia pilosa Ledeb. (A. pilosa), a comprehensive investigation was conducted employing activity-guided isolation. The anti-inflammatory effects were evaluated through an in vitro nitric oxide (NO) assay on lipopolysaccharide (LPS)-treated RAW 264.7 macrophage cells. Seven bio-active compounds with anti-inflammatory properties were successfully isolated from the butanol fraction and identified as follows: quercetin-7-O-β-d-rhamnoside (1), apigenin-7-O-β-d-glucopyranoside (2), kaempferol-7-O-β-d-glucopyr...
Source: Molecules - January 5, 2024 Category: Chemistry Authors: Mijin Park Dahye Ryu Jwayeong Cho Kang-Mo Ku Young-Hwa Kang Tags: Article Source Type: research
Formulation optimization and evaluation of oromucosal in situ gel loaded with silver nanoparticles prepared by green biosynthesis
This study offers a promising dosage form for local treatment of oral diseases.PMID:38142949 | DOI:10.1016/j.ejps.2023.106683 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - December 24, 2023 Category: Drugs & Pharmacology Authors: Simona Roha ľová Tom áš Wolaschka Ľudmila Balážová Katar ína Paulovičová Jana T óthová Sylvie Pavlokov á Martin Stahorsk ý Jan Gajdziok Source Type: research
Formulation optimization and evaluation of oromucosal in situ gel loaded with silver nanoparticles prepared by green biosynthesis
This study offers a promising dosage form for local treatment of oral diseases.PMID:38142949 | DOI:10.1016/j.ejps.2023.106683 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - December 24, 2023 Category: Drugs & Pharmacology Authors: Simona Roha ľová Tom áš Wolaschka Ľudmila Balážová Katar ína Paulovičová Jana T óthová Sylvie Pavlokov á Martin Stahorsk ý Jan Gajdziok Source Type: research
Formulation optimization and evaluation of oromucosal in situ gel loaded with silver nanoparticles prepared by green biosynthesis
This study offers a promising dosage form for local treatment of oral diseases.PMID:38142949 | DOI:10.1016/j.ejps.2023.106683 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - December 24, 2023 Category: Drugs & Pharmacology Authors: Simona Roha ľová Tom áš Wolaschka Ľudmila Balážová Katar ína Paulovičová Jana T óthová Sylvie Pavlokov á Martin Stahorsk ý Jan Gajdziok Source Type: research
Flavonoid compound from Agrimonia pilosa Ledeb improves adipose insulin resistance by alleviating oxidative stress and inflammation
Researches and practice of traditional Chinese medicine indicated that Agrimonia pilosa Ledeb could improve insulin resistance (IR) and treat type 2 diabetes (T2DM). To reveal its underling mechanisms, we isolate... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - September 14, 2023 Category: Complementary Medicine Authors: Tingwang Guo, Yun Pan, Lin Yang, Gang Chen, Jia Deng and Liancai Zhu Tags: Research Source Type: research
Molecules, Vol. 28, Pages 1019: Effect of Agrimonia eupatoria L. and Origanum vulgare L. Leaf, Flower, Stem, and Root Extracts on the Survival of Pseudomonas aeruginosa
Ryšlavá
Pseudomonas aeruginosa is one of the most antibiotic multi-resistant bacteria, causing chronic pulmonary disease and leading to respiratory failure and even mortality. Thus, there has been an ever-increasing search for novel and preferably natural antimicrobial compounds. Agrimonia eupatoria L. and Origanum vulgare L. shoots are commonly used as teas or alcoholic tinctures for their human health-promoting and antibacterial properties. Here, we explored the antimicrobial effects of all plant parts, i.e., leaf, flower, stem, and root extracts, prepared in water or in 60% ethanol, against P. aeruginosa. The impa...
Source: Molecules - January 19, 2023 Category: Chemistry Authors: Kate řina Bělonožníková Eli ška Sladkovská Daniel Kavan Veronika H ýsková Petr Hodek Daniel Šmíd Helena Ry šlavá Tags: Article Source Type: research
Molecules, Vol. 28, Pages 713: Quantification and Validation of an HPLC Method for Low Concentrations of Apigenin-7-O-Glucuronide in Agrimonia pilosa Aqueous Ethanol Extract Topical Cream by Liquid & ndash;Liquid Extraction
In this study, we aimed to develop and validate a pretreatment method for separating and analyzing the small amounts of biomarkers contained in topical cream formulations. Analyzing semisolid formulations that contain low concentrations of active ingredients is difficult. Cream formulations containing an aqueous ethanol extract of 0.1% Agrimonia pilosa is an example. Approximately 0.0013% of apigenin-7-O-glucuronide(A7OG) was contained as a biomarker in the cream. To determine the A7OG content present in the cream formulation, liquid–liquid extraction using dichlormethane was applied. In addition, the volume ...
Source: Molecules - January 11, 2023 Category: Chemistry Authors: Jin Seok Lee Yu Ran Nam Hyun Jong Kim Woo Kyung Kim Tags: Article Source Type: research
Molecules, Vol. 28, Pages 158: Therapeutic Potential of Flavonoids and Tannins in Management of Oral Infectious Diseases & mdash;A Review
Molecules, Vol. 28, Pages 158: Therapeutic Potential of Flavonoids and Tannins in Management of Oral Infectious Diseases—A Review
Molecules doi: 10.3390/molecules28010158
Authors:
Ján Kováč
Lívia Slobodníková
Eva Trajčíková
Katarína Rendeková
Pavel Mučaji
Alice Sychrová
Silvia Bittner Fialová
Medicinal plants are rich sources of valuable molecules with various profitable biological effects, including antimicrobial activity. The advantages of herbal products are their effectiveness, relative safety based on research or extended traditional use, and accessibility without prescripti...
Source: Molecules - December 24, 2022 Category: Chemistry Authors: J án Kováč L ívia Slobodníková Eva Traj číková Katar ína Rendeková Pavel Mu čaji Alice Sychrov á Silvia Bittner Fialov á Tags: Review Source Type: research
Agrimol B inhibits colon carcinoma progression by blocking mitochondrial function through the PGC-1 α/NRF1/TFAM signaling pathway
ConclusionsOur findings demonstrated that Agr regulates the expression of PGC-1α, thereby inducing mitochondrial dysfunction and promoting tumor cell apoptosis. This work highlights the potential of Agr as a promising therapeutic candidate in CRC. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - December 14, 2022 Category: Cancer & Oncology Source Type: research
Essential oils of four wild plants inhibit the blood seeking behaviour of female Aedes aegytpi
Exp Parasitol. 2022 Nov 11:108424. doi: 10.1016/j.exppara.2022.108424. Online ahead of print.ABSTRACTAedes aegypti (Diptera: Culicidae) mosquito is an important vector of many disease-causing pathogens. An effective way to escape from these mosquito-borne diseases is to prevent mosquito bites. In the current study, essential oils of Lepidium pinnatifidum, Mentha longifolia, Origanum vulgare, and Agrimonia eupatoria were evaluated for their repellent potential against Ae. aegypti females. Essential oils were extracted using steam distillation from freshly collected aerial parts of the plants and tested against 4-5 day old f...
Source: Experimental Parasitology - November 14, 2022 Category: Parasitology Authors: Sajid Iqbal Fawad Ahmed Khan Abdullah Haris Raimondas Mozuratis Muhammad Binyameen Muhammad Azeem Source Type: research
Essential oils of four wild plants inhibit the blood seeking behaviour of female Aedes aegytpi
Exp Parasitol. 2022 Nov 11:108424. doi: 10.1016/j.exppara.2022.108424. Online ahead of print.ABSTRACTAedes aegypti (Diptera: Culicidae) mosquito is an important vector of many disease-causing pathogens. An effective way to escape from these mosquito-borne diseases is to prevent mosquito bites. In the current study, essential oils of Lepidium pinnatifidum, Mentha longifolia, Origanum vulgare, and Agrimonia eupatoria were evaluated for their repellent potential against Ae. aegypti females. Essential oils were extracted using steam distillation from freshly collected aerial parts of the plants and tested against 4-5 day old f...
Source: Experimental Parasitology - November 14, 2022 Category: Parasitology Authors: Sajid Iqbal Fawad Ahmed Khan Abdullah Haris Raimondas Mozuratis Muhammad Binyameen Muhammad Azeem Source Type: research
Molecules, Vol. 27, Pages 7597: Nutritional and Polyphenolic Composition of Agrimonia procera Wallr. from Experimental Cultivation with Different Levels of Nitrogen Fertilization
osmala
Plants of the genus Agrimonia, including fragrant agrimony Agrimonia procera Wallr., mainly used as pharmaceutical raw material, perfectly fit into the current trends in nutrition and food technology that are searching for organic raw materials with high contents of bioactive compounds, such as dietary polyphenols and fiber. The aim of the research was to determine the nutritional and polyphenolic composition of fragrant agrimony Agrimonia procera Wallr. from experimental cultivation with varying levels of nitrogen fertilization in the nitrate, ammonium, or amide forms. In the experimental cultivation of fragran...
Source: Molecules - November 5, 2022 Category: Chemistry Authors: El żbieta Karlińska Olga Kaczorowska Beata Romanowska Monika Kosmala Tags: Article Source Type: research
