Challenges and pitfalls in the management of endocrine toxicities from immune checkpoint inhibitors: a case presentation of synchronous thyrotoxicosis and primary adrenal insufficiency in a melanoma patient
CONCLUSIONS: The simultaneous occurrence of adrenal and thyroid autoimmune diseases, resembling autoimmune polyendocrine syndrome type 2, may occur as a rare but serious side effect of ICI treatment. It often presents with abrupt onset and rapid evolution towards polyglandular insufficiency. Physicians should be aware of the potential association of two or more endocrine disorders and careful monitoring of endocrine function is needed during ICI therapy.PMID:38421588 | DOI:10.1007/s42000-024-00535-0 (Source: Hormones)
Source: Hormones - February 29, 2024 Category: Endocrinology Authors: Calogera Claudia Spagnolo Irene Campo Alfredo Campenn ì Davide Cardile Salvatore Cannav ò Nicola Silvestris Mariacarmela Santarpia Rosaria Maddalena Ruggeri Source Type: research

Immune Checkpoint Inhibitors for Kidney and Bladder Cancer: Adrenotoxic Consequences
Adrenal insufficiency (AI) is a described potential treatment toxicity with immune checkpoint inhibitors (ICIs). The presenting symptoms of AI are often non-specific and common symptoms of metastatic cancer. They include fatigue, loss of appetite, weight loss, nausea, abdominal pain, and muscle pain.1 This often leads to a delay in diagnosis until patients are hospitalized with an adrenal crisis.2 Of note, AI may occur due to a primary autoimmune response as well as secondary to pituitary failure or hypophysitis/hypopituitarism. (Source: Urology)
Source: Urology - February 29, 2024 Category: Urology & Nephrology Authors: Kiera Liblik, Jessica Caterini Queen, Naji J. Touma Source Type: research

Neglected Adrenal Hypoplasia Congenita in Two Siblings with Novel Genetic Mutations in NR0B1 Gene and Notable Clinical Course: A Case Report
CONCLUSION: The diagnosis of CAH in case of low levels of 17- OHP, testosterone, and LH, as well as central hypogonadotropic hypogonadism, should be studied, and further investigations are mandatory to evaluate other subtypes of PAI, especially AHC.PMID:38409716 | DOI:10.2174/0118715303285405240202092244 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 27, 2024 Category: Drugs & Pharmacology Authors: Shayesteh Khalili Anahita Zakeri Farzad Hadaegh Seyed Saeed Tamehri Zadeh Source Type: research

Neglected Adrenal Hypoplasia Congenita in Two Siblings with Novel Genetic Mutations in NR0B1 Gene and Notable Clinical Course: A Case Report
CONCLUSION: The diagnosis of CAH in case of low levels of 17- OHP, testosterone, and LH, as well as central hypogonadotropic hypogonadism, should be studied, and further investigations are mandatory to evaluate other subtypes of PAI, especially AHC.PMID:38409716 | DOI:10.2174/0118715303285405240202092244 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 27, 2024 Category: Endocrinology Authors: Shayesteh Khalili Anahita Zakeri Farzad Hadaegh Seyed Saeed Tamehri Zadeh Source Type: research

Neglected Adrenal Hypoplasia Congenita in Two Siblings with Novel Genetic Mutations in NR0B1 Gene and Notable Clinical Course: A Case Report
CONCLUSION: The diagnosis of CAH in case of low levels of 17- OHP, testosterone, and LH, as well as central hypogonadotropic hypogonadism, should be studied, and further investigations are mandatory to evaluate other subtypes of PAI, especially AHC.PMID:38409716 | DOI:10.2174/0118715303285405240202092244 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - February 27, 2024 Category: Drugs & Pharmacology Authors: Shayesteh Khalili Anahita Zakeri Farzad Hadaegh Seyed Saeed Tamehri Zadeh Source Type: research

Diagnosis and management of secondary adrenal crisis
Rev Endocr Metab Disord. 2024 Feb 27. doi: 10.1007/s11154-024-09877-x. Online ahead of print.ABSTRACTAdrenal crisis (AC) is a life threatening acute adrenal insufficiency (AI) episode which can occur in patients with primary AI but also secondary AI (SAI), tertiary AI (TAI) and iatrogenic AI (IAI). In SAI, TAI and IAI, AC may develop when the HPA axis is unable to mount an adequate glucocorticoid response to severe stress due to pituitary or hypothalamic disruption. It manifests as an acute deterioration in multi-organ homeostasis that, if untreated, leads to shock and death. Despite the availability of effective preventiv...
Source: ENDOCR REV - February 27, 2024 Category: Endocrinology Authors: Luciana Martel-Duguech Jonathan Poirier Isabelle Bourdeau Andr é Lacroix Source Type: research

Diagnosis and management of secondary adrenal crisis
Rev Endocr Metab Disord. 2024 Feb 27. doi: 10.1007/s11154-024-09877-x. Online ahead of print.ABSTRACTAdrenal crisis (AC) is a life threatening acute adrenal insufficiency (AI) episode which can occur in patients with primary AI but also secondary AI (SAI), tertiary AI (TAI) and iatrogenic AI (IAI). In SAI, TAI and IAI, AC may develop when the HPA axis is unable to mount an adequate glucocorticoid response to severe stress due to pituitary or hypothalamic disruption. It manifests as an acute deterioration in multi-organ homeostasis that, if untreated, leads to shock and death. Despite the availability of effective preventiv...
Source: ENDOCR REV - February 27, 2024 Category: Endocrinology Authors: Luciana Martel-Duguech Jonathan Poirier Isabelle Bourdeau Andr é Lacroix Source Type: research

Opioid-induced adrenal insufficiency: diagnostic and management considerations
The dramatic rise in opioid use over the last two decades has led to a surge in their harmful health effects. Lesser known among clinicians is the impact of opioids on the endocrine system, especially with regard to cortisol. Opioids can suppress the hypothalamus-pituitary-adrenal (HPA) axis and may result in clinically significant adrenal insufficiency, especially in those treated at higher doses and for a longer time. A high clinical suspicion is necessary in this population for early diagnosis of opioid-induced adrenal insufficiency (OAI). Diagnosis of OAI is challenging, as the symptoms are often vague and overlap with...
Source: Frontiers in Endocrinology - February 27, 2024 Category: Endocrinology Source Type: research

Diagnosis and management of secondary adrenal crisis
AbstractAdrenal crisis (AC) is a life threatening acute adrenal insufficiency (AI) episode which can occur in patients with primary AI but also secondary AI (SAI), tertiary AI (TAI) and iatrogenic AI (IAI). In SAI, TAI and IAI, AC may develop when the HPA axis is unable to mount an adequate glucocorticoid response to severe stress due to pituitary or hypothalamic disruption. It manifests as an acute deterioration in multi-organ homeostasis that, if untreated, leads to shock and death. Despite the availability of effective preventive strategies, its prevalence is increasing in patients with SAI, TAI and IAI due to more freq...
Source: Reviews in Endocrine and Metabolic Disorders - February 27, 2024 Category: Endocrinology Source Type: research