Postoperative hypothalamic-pituitary dysfunction and long-term hormone replacement in patients with childhood-onset craniopharyngioma
ConclusionThis study is a large-sample systematic postoperative endocrine function evaluation of patients with childhood-onset CP. Due to the high prevalence of post-operative hypothalamic-pituitary dysfunction, patients with CP usually require long-term multiple hormone substitution therapy. Individualized management and accurate hormone replacement dosage for postoperative childhood-onset CP patients are of great importance. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - November 6, 2023 Category: Endocrinology Source Type: research

Diagnostic performance of an automated immunoassay for salivary cortisol
Ann Endocrinol (Paris). 2023 Nov 3:S0003-4266(23)00715-1. doi: 10.1016/j.ando.2023.10.007. Online ahead of print.ABSTRACTAutomated immunoanalysis (AI) is an interesting alternative for measuring salivary cortisol, as the gold-standard HPLC-MS/MS method is not yet readily available. The aim of this study was to evaluate the diagnostic performance of salivary cortisol immunoassay on the iSYS immunoanalyzer in adrenal dynamic tests. Cortisol was measured on iSYS and on HPLC-MS/MS in saliva samples collected after 1mg-dexamethasone suppression test (DST) in 115 patients suspected of Cushing syndrome, and during Synacthen® sti...
Source: Annales d'Endocrinologie - November 5, 2023 Category: Endocrinology Authors: Christelle Laguillier Morizot Fid éline Bonnet Serrano Marie-Cl émence Leguy Mili ça Simeonovic Catherine See Corinne Zientek Mickael Soussan Lucas Bouys J érôme Bertherat Jean Guibourdenche Source Type: research

Diagnostic performance of an automated immunoassay for salivary cortisol
Ann Endocrinol (Paris). 2023 Nov 3:S0003-4266(23)00715-1. doi: 10.1016/j.ando.2023.10.007. Online ahead of print.ABSTRACTAutomated immunoanalysis (AI) is an interesting alternative for measuring salivary cortisol, as the gold-standard HPLC-MS/MS method is not yet readily available. The aim of this study was to evaluate the diagnostic performance of salivary cortisol immunoassay on the iSYS immunoanalyzer in adrenal dynamic tests. Cortisol was measured on iSYS and on HPLC-MS/MS in saliva samples collected after 1mg-dexamethasone suppression test (DST) in 115 patients suspected of Cushing syndrome, and during Synacthen® sti...
Source: Annales d'Endocrinologie - November 5, 2023 Category: Endocrinology Authors: Christelle Laguillier Morizot Fid éline Bonnet Serrano Marie-Cl émence Leguy Mili ça Simeonovic Catherine See Corinne Zientek Mickael Soussan Lucas Bouys J érôme Bertherat Jean Guibourdenche Source Type: research

Diagnostic performance of an automated immunoassay for salivary cortisol
Ann Endocrinol (Paris). 2023 Nov 3:S0003-4266(23)00715-1. doi: 10.1016/j.ando.2023.10.007. Online ahead of print.ABSTRACTAutomated immunoanalysis (AI) is an interesting alternative for measuring salivary cortisol, as the gold-standard HPLC-MS/MS method is not yet readily available. The aim of this study was to evaluate the diagnostic performance of salivary cortisol immunoassay on the iSYS immunoanalyzer in adrenal dynamic tests. Cortisol was measured on iSYS and on HPLC-MS/MS in saliva samples collected after 1mg-dexamethasone suppression test (DST) in 115 patients suspected of Cushing syndrome, and during Synacthen® sti...
Source: Annales d'Endocrinologie - November 5, 2023 Category: Endocrinology Authors: Christelle Laguillier Morizot Fid éline Bonnet Serrano Marie-Cl émence Leguy Mili ça Simeonovic Catherine See Corinne Zientek Mickael Soussan Lucas Bouys J érôme Bertherat Jean Guibourdenche Source Type: research

Diagnostic performance of an automated immunoassay for salivary cortisol
Ann Endocrinol (Paris). 2023 Nov 3:S0003-4266(23)00715-1. doi: 10.1016/j.ando.2023.10.007. Online ahead of print.ABSTRACTAutomated immunoanalysis (AI) is an interesting alternative for measuring salivary cortisol, as the gold-standard HPLC-MS/MS method is not yet readily available. The aim of this study was to evaluate the diagnostic performance of salivary cortisol immunoassay on the iSYS immunoanalyzer in adrenal dynamic tests. Cortisol was measured on iSYS and on HPLC-MS/MS in saliva samples collected after 1mg-dexamethasone suppression test (DST) in 115 patients suspected of Cushing syndrome, and during Synacthen® sti...
Source: Annales d'Endocrinologie - November 5, 2023 Category: Endocrinology Authors: Christelle Laguillier Morizot Fid éline Bonnet Serrano Marie-Cl émence Leguy Mili ça Simeonovic Catherine See Corinne Zientek Mickael Soussan Lucas Bouys J érôme Bertherat Jean Guibourdenche Source Type: research

Diagnostic performance of an automated immunoassay for salivary cortisol
Ann Endocrinol (Paris). 2023 Nov 3:S0003-4266(23)00715-1. doi: 10.1016/j.ando.2023.10.007. Online ahead of print.ABSTRACTAutomated immunoanalysis (AI) is an interesting alternative for measuring salivary cortisol, as the gold-standard HPLC-MS/MS method is not yet readily available. The aim of this study was to evaluate the diagnostic performance of salivary cortisol immunoassay on the iSYS immunoanalyzer in adrenal dynamic tests. Cortisol was measured on iSYS and on HPLC-MS/MS in saliva samples collected after 1mg-dexamethasone suppression test (DST) in 115 patients suspected of Cushing syndrome, and during Synacthen® sti...
Source: Annales d'Endocrinologie - November 5, 2023 Category: Endocrinology Authors: Christelle Laguillier Morizot Fid éline Bonnet Serrano Marie-Cl émence Leguy Mili ça Simeonovic Catherine See Corinne Zientek Mickael Soussan Lucas Bouys J érôme Bertherat Jean Guibourdenche Source Type: research

Diagnostic performance of an automated immunoassay for salivary cortisol
Ann Endocrinol (Paris). 2023 Nov 3:S0003-4266(23)00715-1. doi: 10.1016/j.ando.2023.10.007. Online ahead of print.ABSTRACTAutomated immunoanalysis (AI) is an interesting alternative for measuring salivary cortisol, as the gold-standard HPLC-MS/MS method is not yet readily available. The aim of this study was to evaluate the diagnostic performance of salivary cortisol immunoassay on the iSYS immunoanalyzer in adrenal dynamic tests. Cortisol was measured on iSYS and on HPLC-MS/MS in saliva samples collected after 1mg-dexamethasone suppression test (DST) in 115 patients suspected of Cushing syndrome, and during Synacthen® sti...
Source: Annales d'Endocrinologie - November 5, 2023 Category: Endocrinology Authors: Christelle Laguillier Morizot Fid éline Bonnet Serrano Marie-Cl émence Leguy Mili ça Simeonovic Catherine See Corinne Zientek Mickael Soussan Lucas Bouys J érôme Bertherat Jean Guibourdenche Source Type: research

Factors underlying a disproportionate increase in hospital admissions for adrenal insufficiency in women aged 20-29 years
We examined data on acute non-surgical hospitalisations for AI/AC from New South Wales, Australia, to determine relevant factors that may have contributed to this increase. Data were analysed to ascertain associations between various comorbid psychosocial issues, identified by relevant ICD-10-AM codes in each record, and ACs. From 2005 to 2021. There were 877 admissions for an acute non-surgical illness in this age group. The average admission rate for females [63.5/million/year] was almost twice that for males [34.0/million/year] (p<0.01), as was the average female AC admission rate [14.7/million/year] relative to that...
Source: Frontiers in Endocrinology - November 3, 2023 Category: Endocrinology Source Type: research

On Primary Adrenal Insufficiency with Normal Concentrations of Cortisol – Early Manifestation of Addison’s Disease
Horm Metab Res DOI: 10.1055/a-2180-7108Primary adrenal insufficiency (AI) is an endocrine disorder in which hormones of the adrenal cortex are produced to an insufficient extent. Since receptors for adrenal steroids have a wide distribution, initial symptoms may be nonspecific. In particular, the lack of glucocorticoids can quickly lead to a life-threatening adrenal crisis. Therefore, current guidelines suggest applying a low threshold for testing and to rule out AI not before serum cortisol concentrations are higher than 500 nmol/l (18 μg/dl). To ease ...
Source: Hormone and Metabolic Research - November 2, 2023 Category: Endocrinology Authors: W äscher, Hanna Knauerhase, Andreas Klar, Bettina Postrach, Till Weber, Marc-Andr é Willenberg, Holger Sven Tags: Original Article: Endocrine Care Source Type: research

A partial form of AIRE deficiency underlies a mild form of autoimmune polyendocrine syndrome type 1
Autoimmune polyendocrine syndrome type 1 (APS-1) is caused by mutations in the autoimmune regulator (AIRE) gene. Most patients present with severe chronic mucocutaneous candidiasis and organ-specific autoimmunity from early childhood, but the clinical picture is highly variable. AIRE is crucial for negative selection of T cells, and scrutiny of different patient mutations has previously highlighted many of its molecular mechanisms. In patients with a milder adult-onset phenotype sharing a mutation in the canonical donor splice site of intron 7 (c.879+1G>A), both the predicted altered splicing pattern with loss of exon 7 (A...
Source: Journal of Clinical Investigation - November 1, 2023 Category: Biomedical Science Authors: Bergithe Eikeland Oftedal, Amund Holte Berger, Øyvind Bruserud, Yael Goldfarb, Andre Sulen, Lars Breivik, Alexander Hellesen, Shifra Ben-Dor, Rebecca Haffner-Krausz, Per M. Knappskog, Stefan Johansson, Anette S.B. Wolff, Eirik Bratland, Jakub Abramson, E Source Type: research

Emergency and perioperative management of adrenal insufficiency in children and young people: British Society for Paediatric Endocrinology and Diabetes consensus guidance
Adrenal insufficiency (AI) is characterised by lack of cortisol production from the adrenal glands. This can be a primary adrenal disorder or secondary to adrenocorticotropic hormone deficiency or suppression from exogenous glucocorticoids. Symptoms of AI in children may initially be non-specific and include growth faltering, lethargy, poor feeding, weight loss, abdominal pain, vomiting and lingering illnesses. AI is treated with replacement doses of hydrocortisone. At times of physiological stress such as illness, trauma or surgery, there is an increased requirement for exogenous glucocorticoids, which if untreated can le...
Source: Archives of Disease in Childhood - October 30, 2023 Category: Pediatrics Authors: Mushtaq, T., Ali, S. R., Boulos, N., Boyle, R., Cheetham, T., Davies, J. H., Elder, C. J., Gan, H.-W., Hindmarsh, P. C., Katugampola, H., Krone, N., Salomon Estebanez, M., Shenoy, S., Tollerfield, S., Wong, S. C., Regan, F., Developed by the Paediatric Ad Tags: Open access Review Source Type: research

Real-life oral corticosteroid sparring effects of biologic treatment on eosinophilic asthma, five years of follow-up
Conclusion: Our study shows that biologic treatment effectively reduces the need for daily OCS in patients with severe asthma with a further reduction in the number of patients using daily OCS even after 5 years. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Peshbahar, S., Bjerrum, A. S. Tags: Airway pharmacology and treatment Source Type: research

Tapering courses of oral corticosteroids after hospital admission due to asthma exacerbation
Conclusion: Clinicians often prescribe tapering OCS outside of guideline recommendations. Tapering OCS was not associated with increased time to next exacerbation. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Russell, R., Ray, M., Yaqub, H., Murphy, A. Tags: Airway pharmacology and treatment Source Type: research

Use of short synacthen testing to detect iatrogenic adrenal insufficiency among severe asthma patients
Conclusion: Over 40% of our cohort had AI diagnosed after SST. Higher daily mOCS dose appears to increase risk but symptoms of AI, or absence thereof, were not predictive of AI; systematic screening for all patients with OCS exposure sufficient for biologics is prudent. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Fyles, F., Joplin, H., Nuttall, A., Watkins, L., Burhan, H. Tags: Airway pharmacology and treatment Source Type: research

Success of an oral corticosteroid withdrawal pathway for severe asthma patients on biologics
Conclusion: Our pathway facilitated successful withdrawal of mOCS in 85% of patients with cortisol ≥25 nmol/L on 3mg Prednisolone, with no adverse events. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Russell, R., Boddy, C., Bell, M., Hampson, E., Parnell, L., Naveed, S., Meeran, K., Siddiqui, S., Bradding, P. Tags: Airway pharmacology and treatment Source Type: research