Genetic and phenotypic spectrum of non-21-hydroxylase-deficiency primary adrenal insufficiency in childhood: data from 111 Chinese patients
Conclusions STAR and NR0B1 were the most frequently mutated genes in patients with non-21OHD PAI. Age of onset and clinical characteristics were dependent on aetiology. Combining clinical features and molecular tests facilitates accurate diagnosis. (Source: Journal of Medical Genetics)
Source: Journal of Medical Genetics - December 21, 2023 Category: Genetics & Stem Cells Authors: Duan, Y., Zheng, W., Xia, Y., Zhang, H., Liang, L., Wang, R., Yang, Y., Zhang, K., Lu, D., Sun, Y., Han, L., Yu, Y., Gu, X., Sun, Y., Xiao, B., Qiu, W. Tags: Diagnostics Source Type: research

Bilateral adrenal infarction and insufficiency associated with antiphospholipid syndrome and surgery: a case report
ConclusionsThe timing of postoperative anticoagulant therapy initiation remains controversial. Therefore, adrenal insufficiency due to adrenal infarction should be monitored while anticoagulant therapy is discontinued in patients with antiphospholipid syndrome. (Source: International Journal of Emergency Medicine)
Source: International Journal of Emergency Medicine - December 21, 2023 Category: Emergency Medicine Source Type: research

Prolonged adrenal insufficiency following discontinuation of Osilodrostat treatment for intense hypercortisolism
We report two additional cases of persistent prolonged adrenal insufficiency after discontinuation of osilodrostat treatment for intense hypercortisolism due to Cushing's disease and ectopic ACTH syndrome. In addition, we show for that adrenal insufficiency in these patients was associated with low/normal 11-deoxycortisol concentrations despite high plasma ACTH concentrations. These results suggest that CYP11B1 is not the only target of osilodrostat and that, in vivo, osilodrostat has other prolonged and strong inhibitory effect on adrenal steroidogenesis upstream of CYP11B1. Knowledge of this remnant effect is important f...
Source: European Journal of Endocrinology - December 20, 2023 Category: Endocrinology Authors: A Ferriere S Salenave M Puerto J Young A Tabarin Source Type: research

Case report: A case of fulminant type 1 diabetes mellitus after COVID-19 vaccination during treatment of advanced gastric cancer: pitfall in managing immune-related adverse events
The occurrence of fulminant type 1 diabetes mellitus as an adverse event during cancer immunotherapy has been previously reported. However, little is known about the causal relationship between the coronavirus disease 2019 (COVID-19) vaccination and fulminant type 1 diabetes mellitus. A 60-year-old man with advanced gastric cancer, receiving S-1 + oxaliplatin and nivolumab therapy, followed by nab-paclitaxel + ramucirumab as a second-line treatment, with steroid supplementation for complications of hypopituitarism-induced hypoadrenocorticism, was administered a COVID-19 vaccine after three cycles of nab-paclitaxel + ramuci...
Source: Frontiers in Oncology - December 20, 2023 Category: Cancer & Oncology Source Type: research

Diagnosis and management of adrenal incidentaloma: use of clinical judgment and evidence in dialog with the patient
AbstractThe prevalence of adrenal incidentaloma (AI) in imaging studies, including those of the adrenal glands, is estimated to be 1 –5%. Essential factors for the proper management of AI include a correct diagnosis, adequate surgical skills, appropriate perioperative management, and sound dialogue with the patient. Aside from the possibility of overdiagnosis, patients with apparent signs or symptoms attributable to adrenal hor mone excess have reasonable indications for surgery. At the same time, milder patients may be candidates for active surveillance without intervention. Even individuals with nonfunctioning AI may b...
Source: Surgery Today - December 13, 2023 Category: Surgery Source Type: research

Clinical characteristics and outcomes of patients with primary liver cancer and immune checkpoint inhibitor-associated adrenal insufficiency: A retrospective cohort study
CONCLUSION: The current study demonstrated that PLC patients undergoing ICIs therapy and developing AI after ICIs treatment had favorable survival outcomes compared to those without irAEs.PMID:38064811 | DOI:10.1016/j.intimp.2023.111337 (Source: International Immunopharmacology)
Source: International Immunopharmacology - December 8, 2023 Category: Allergy & Immunology Authors: Qingqing Cai Wei Wu Ranyi Li Xiaoyu Li Qing Xu Lin Zhao Qianzhou Lv Source Type: research

Erratum to "Iatrogenic Adrenal Insufficiency Following Post COVID-19 Organizing Pneumonia" [Archivos de Bronconeumologia 59 (2023) 63-65]
Arch Bronconeumol. 2023 Nov 25:S0300-2896(23)00373-3. doi: 10.1016/j.arbres.2023.11.007. Online ahead of print.NO ABSTRACTPMID:38040573 | DOI:10.1016/j.arbres.2023.11.007 (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - December 1, 2023 Category: Respiratory Medicine Authors: Esther Palones Elena Curto Anna Pelegr í Marina Arilla Ingrid Solanes Astrid Crespo-Lessmann Source Type: research

Erratum to "Iatrogenic Adrenal Insufficiency Following Post COVID-19 Organizing Pneumonia" [Archivos de Bronconeumologia 59 (2023) 63-65]
Arch Bronconeumol. 2023 Nov 25:S0300-2896(23)00373-3. doi: 10.1016/j.arbres.2023.11.007. Online ahead of print.NO ABSTRACTPMID:38040573 | DOI:10.1016/j.arbres.2023.11.007 (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - December 1, 2023 Category: Respiratory Medicine Authors: Esther Palones Elena Curto Anna Pelegr í Marina Arilla Ingrid Solanes Astrid Crespo-Lessmann Source Type: research

Harnessing the power of nutritional antioxidants against adrenal hormone imbalance-associated oxidative stress
In conclusion, harnessing the power of nutritional antioxidants has the potential to help with oxidative stress caused by an imbalance in adrenal hormones. This could lead to new research and therapeutic interventions. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - November 30, 2023 Category: Endocrinology Source Type: research

Glucocorticoid Withdrawal Symptoms and Quality of Life in Patients with Systemic Lupus Erythematosus
CONCLUSION: SLE patients with previous GCS exposure could experience AI and withdrawal symptoms such as sleep disturbance and depression during discontinuation of low-dose GCS. Fatigue, depression, and poor sleeper were significantly associated with poor SLEQoL.PMID:38023806 | PMC:PMC10656199 | DOI:10.1155/2023/5750791 (Source: International Journal of Rheumatology)
Source: International Journal of Rheumatology - November 29, 2023 Category: Rheumatology Authors: Matee Karoonkatima Pongthorn Narongroeknawin Sumapa Chaiamnuay Paijit Asavatanabodee Rattapol Pakchotanon Source Type: research