The 1 μg Synacthen stimulation test in the diagnosis of secondary adrenal insufficiency in patients with Rathke's cleft cyst and empty sella syndrome
CONCLUSIONS: The incidence of SAI in the general patient population with empty sella syndrome and Rathke's cleft cysts is low. The 1 μg Synacthen test seems to be a valuable tool in the diagnosis of SAI among patients with RCC and PESS. Further studies are necessary to determine the sensitivity and specificity of the 1 μg Synacthen test with the standardization of test protocol and considering the cortisol level at the 20-minute timepoint. PESS patients report dizziness and apathy more frequently than RCC patients, which does not result from the disturbance of the hypothalamic-pituitary-adrenal axis, but probably from th...
Source: Endokrynologia Polska - December 30, 2023 Category: Endocrinology Authors: El żbieta Andrysiak-Mamos Karol Piotr Sagan Łukasz Zwarzany Wojciech Poncyljusz Anhelli Syrenicz Source Type: research

The 1 μg Synacthen stimulation test in the diagnosis of secondary adrenal insufficiency in patients with Rathke's cleft cyst and empty sella syndrome
CONCLUSIONS: The incidence of SAI in the general patient population with empty sella syndrome and Rathke's cleft cysts is low. The 1 μg Synacthen test seems to be a valuable tool in the diagnosis of SAI among patients with RCC and PESS. Further studies are necessary to determine the sensitivity and specificity of the 1 μg Synacthen test with the standardization of test protocol and considering the cortisol level at the 20-minute timepoint. PESS patients report dizziness and apathy more frequently than RCC patients, which does not result from the disturbance of the hypothalamic-pituitary-adrenal axis, but probably from th...
Source: Endokrynologia Polska - December 30, 2023 Category: Endocrinology Authors: El żbieta Andrysiak-Mamos Karol Piotr Sagan Łukasz Zwarzany Wojciech Poncyljusz Anhelli Syrenicz Source Type: research

The 1 μg Synacthen stimulation test in the diagnosis of secondary adrenal insufficiency in patients with Rathke's cleft cyst and empty sella syndrome
CONCLUSIONS: The incidence of SAI in the general patient population with empty sella syndrome and Rathke's cleft cysts is low. The 1 μg Synacthen test seems to be a valuable tool in the diagnosis of SAI among patients with RCC and PESS. Further studies are necessary to determine the sensitivity and specificity of the 1 μg Synacthen test with the standardization of test protocol and considering the cortisol level at the 20-minute timepoint. PESS patients report dizziness and apathy more frequently than RCC patients, which does not result from the disturbance of the hypothalamic-pituitary-adrenal axis, but probably from th...
Source: Endokrynologia Polska - December 30, 2023 Category: Endocrinology Authors: El żbieta Andrysiak-Mamos Karol Piotr Sagan Łukasz Zwarzany Wojciech Poncyljusz Anhelli Syrenicz Source Type: research

The 1 μg Synacthen stimulation test in the diagnosis of secondary adrenal insufficiency in patients with Rathke's cleft cyst and empty sella syndrome
CONCLUSIONS: The incidence of SAI in the general patient population with empty sella syndrome and Rathke's cleft cysts is low. The 1 μg Synacthen test seems to be a valuable tool in the diagnosis of SAI among patients with RCC and PESS. Further studies are necessary to determine the sensitivity and specificity of the 1 μg Synacthen test with the standardization of test protocol and considering the cortisol level at the 20-minute timepoint. PESS patients report dizziness and apathy more frequently than RCC patients, which does not result from the disturbance of the hypothalamic-pituitary-adrenal axis, but probably from th...
Source: Endokrynologia Polska - December 30, 2023 Category: Endocrinology Authors: El żbieta Andrysiak-Mamos Karol Piotr Sagan Łukasz Zwarzany Wojciech Poncyljusz Anhelli Syrenicz Source Type: research

The 1 μg Synacthen stimulation test in the diagnosis of secondary adrenal insufficiency in patients with Rathke's cleft cyst and empty sella syndrome
CONCLUSIONS: The incidence of SAI in the general patient population with empty sella syndrome and Rathke's cleft cysts is low. The 1 μg Synacthen test seems to be a valuable tool in the diagnosis of SAI among patients with RCC and PESS. Further studies are necessary to determine the sensitivity and specificity of the 1 μg Synacthen test with the standardization of test protocol and considering the cortisol level at the 20-minute timepoint. PESS patients report dizziness and apathy more frequently than RCC patients, which does not result from the disturbance of the hypothalamic-pituitary-adrenal axis, but probably from th...
Source: Endokrynologia Polska - December 30, 2023 Category: Endocrinology Authors: El żbieta Andrysiak-Mamos Karol Piotr Sagan Łukasz Zwarzany Wojciech Poncyljusz Anhelli Syrenicz Source Type: research

The 1 μg Synacthen stimulation test in the diagnosis of secondary adrenal insufficiency in patients with Rathke's cleft cyst and empty sella syndrome
CONCLUSIONS: The incidence of SAI in the general patient population with empty sella syndrome and Rathke's cleft cysts is low. The 1 μg Synacthen test seems to be a valuable tool in the diagnosis of SAI among patients with RCC and PESS. Further studies are necessary to determine the sensitivity and specificity of the 1 μg Synacthen test with the standardization of test protocol and considering the cortisol level at the 20-minute timepoint. PESS patients report dizziness and apathy more frequently than RCC patients, which does not result from the disturbance of the hypothalamic-pituitary-adrenal axis, but probably from th...
Source: Endokrynologia Polska - December 30, 2023 Category: Endocrinology Authors: El żbieta Andrysiak-Mamos Karol Piotr Sagan Łukasz Zwarzany Wojciech Poncyljusz Anhelli Syrenicz Source Type: research

Evaluation of psoriasis patients with long-term topical corticosteroids for their risk of developing adrenal insufficiency, Cushing's syndrome and osteoporosis
CONCLUSIONS: Our study is the first study that we know of that investigated these three side effects. We have shown that the development of CS, adrenal insufficiency and osteoporosis in patients who use topical steroids for a long time depends on the weekly TCS dosage and the risk increases when it exceeds the threshold of 50 grams per week. therefore, our recommendation would be to avoid long-term use of superpotent steroids and to choose from the medium-potent group if it is to be used.PMID:38156462 | DOI:10.1080/09546634.2023.2298880 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - December 29, 2023 Category: Dermatology Authors: Betul Erdem Muzeyyen Gonul Ilknur Ozturk Unsal Seyda Ozdemir Sahingoz Source Type: research

Comparison of clinical characteristics of a pediatric cohort with combined pituitary hormone deficiency caused by mutation of the PROP1 gene or of other origins
CONCLUSION: Patients with the PROP1 mutations present a clinical picture significantly different from that of other forms of congenital hypopituitarism. Certain specific clinical results may lead to the successful identification of children requiring diagnostics for the PROP1 gene mutation.PMID:38147295 | DOI:10.1007/s42000-023-00510-1 (Source: Hormones)
Source: Hormones - December 26, 2023 Category: Endocrinology Authors: Agata Zygmunt-G órska Ma łgorzata Wójcik None AleksandraGilis-Januszewska Anna Starmach Miros ław Bik-Multanowski Jerzy B Starzyk Source Type: research

Perioperative growth hormone levels as an early predictor of new-onset secondary adrenal insufficiency following transsphenoidal pituitary tumor resection
CONCLUSION: Early morning GH level on POD1 can predict NOSAI with fair accuracy when perioperative stress dose glucocorticoid is administered. Prediction accuracy can be improved by considering CSF leakage, DI, and perioperative changes in GH and PRL in the final regression model.PMID:38148260 | DOI:10.1016/j.asjsur.2023.12.120 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - December 26, 2023 Category: Surgery Authors: Fon-Yih Tsuang Shyang-Rong Shih Ham-Min Tseng Huan-Chih Wang Source Type: research

Comparison of clinical characteristics of a pediatric cohort with combined pituitary hormone deficiency caused by mutation of the PROP1 gene or of other origins
CONCLUSION: Patients with the PROP1 mutations present a clinical picture significantly different from that of other forms of congenital hypopituitarism. Certain specific clinical results may lead to the successful identification of children requiring diagnostics for the PROP1 gene mutation.PMID:38147295 | DOI:10.1007/s42000-023-00510-1 (Source: Hormones)
Source: Hormones - December 26, 2023 Category: Endocrinology Authors: Agata Zygmunt-G órska Ma łgorzata Wójcik None AleksandraGilis-Januszewska Anna Starmach Miros ław Bik-Multanowski Jerzy B Starzyk Source Type: research

Perioperative growth hormone levels as an early predictor of new-onset secondary adrenal insufficiency following transsphenoidal pituitary tumor resection
CONCLUSION: Early morning GH level on POD1 can predict NOSAI with fair accuracy when perioperative stress dose glucocorticoid is administered. Prediction accuracy can be improved by considering CSF leakage, DI, and perioperative changes in GH and PRL in the final regression model.PMID:38148260 | DOI:10.1016/j.asjsur.2023.12.120 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - December 26, 2023 Category: Surgery Authors: Fon-Yih Tsuang Shyang-Rong Shih Ham-Min Tseng Huan-Chih Wang Source Type: research

Detecting the interferences in adrenocorticotropic hormone measurement - three cases reinforcing the efficiency of the complementary clinical and laboratory audit
Biochem Med (Zagreb). 2024 Feb 15;34(1):010802. doi: 10.11613/BM.2024.010802. Epub 2023 Dec 15.ABSTRACTAccurate measurement of adrenocorticotropic hormone (ACTH) is crucial in the evaluation of pituitary and adrenal disorders. Although great progress has been achieved in ACTH measurement with immunometric assays, interference may occur and adversely affect the clinical management. The report contributes to compiling the evidence on the clinical challenges with the management of the interferences in the ACTH measurement by presenting three cases: two with clinically overt hypercortisolism and discrepant ACTH concentrations ...
Source: Biochemia Medica - December 21, 2023 Category: Biochemistry Authors: Tugba Barlas Mehmet Muhittin Yalcin Zakir Osmanov Ozlem Gulbahar Alev Eroglu Altinova Mujde Akturk Mehmet Ayhan Karakoc Ilhan Yetkin Fusun Balos Toruner Source Type: research