CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency
A wide range of human diseases result from haploinsufficiency, where the function of one of the two gene copies is lost. Here, we targeted the remaining functional copy of a haploinsufficient gene using CRISPR-mediated activation (CRISPRa) in Sim1 and Mc4r heterozygous mouse models to rescue their obesity phenotype. Transgenic-based CRISPRa targeting of the Sim1 promoter or its distant hypothalamic enhancer up-regulated its expression from the endogenous functional allele in a tissue-specific manner, rescuing the obesity phenotype in Sim1 heterozygous mice. To evaluate the therapeutic potential of CRISPRa, we injected CRIS...
Source: ScienceNOW - January 17, 2019 Category: Science Authors: Matharu, N., Rattanasopha, S., Tamura, S., Maliskova, L., Wang, Y., Bernard, A., Hardin, A., Eckalbar, W. L., Vaisse, C., Ahituv, N. Tags: Genetics, Medicine, Diseases, Online Only r-articles Source Type: news
University Of Maryland confirms 40 adenovirus cases
One student at the university has been hospitalized with the illness (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - December 22, 2018 Category: Consumer Health News Source Type: news
QuickStats: Percentage of Adults Aged 20-64 Years With a Blood Cholesterol Check by a Health Professional During the Past 12 Months, by Poverty Status --- National Health Interview Survey, 2012 and 2017
The percentage of adults aged 20-64 who had a blood cholesterol check by a health professional in the past 12 months increased from 58.0% in 2012 to 65.5% in 2017. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - December 6, 2018 Category: American Health Tags: Adenovirus Infection Avian Influenza Cancer Cholesterol MMWR Morbidity & Mortality Weekly Report Salmonella Secondhand Smoke Uterine Cancer Zoonotic diseases Source Type: news
Notes from the Field: An Outbreak of Salmonella Agbeni Infections Linked to Turtle Exposure --- United States, 2017
In June 2017, PulseNet, the national molecular subtyping network for foodborne disease surveillance, identified 17 Salmonella Agbeni clinical isolates with indistinguishable XbaI enzyme pattern (outbreak strain) by pulsed-field gel electrophoresis. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - December 6, 2018 Category: American Health Tags: Adenovirus Infection Avian Influenza Cancer MMWR Morbidity & Mortality Weekly Report Salmonella Secondhand Smoke Uterine Cancer Zoonotic diseases Source Type: news
Outbreak of Epidemic Keratoconjunctivitis Caused by Human Adenovirus Type D53 in an Eye Care Clinic --- Los Angeles County, 2017
This report details the first documented outbreak of adenovirus D53 epidemic keratoconjunctivitis in the United States. Seventeen epidemic keratoconjunctivitis cases were identified; after the primary case, all cases occurred in eye care clinic patients or their household contacts. Infection prevention lapses were associated with the outbreak, specifically improper ocular equipment disinfection. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - December 6, 2018 Category: American Health Tags: Adenovirus Infection Avian Influenza Cancer MMWR Morbidity & Mortality Weekly Report Secondhand Smoke Uterine Cancer Zoonotic diseases Source Type: news
Health Highlights: Dec. 6, 2018
Here are some of the latest health and medical news developments, compiled by the editors of HealthDay:
Staff at N.J. Facility Where 11 Children Died Did Not Follow Sanitation Procedures
The adenovirus outbreak that infected more than 30 children... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - December 6, 2018 Category: General Medicine Source Type: news
Adenovirus Kills 12 in 2 States, But What Is It?
Adenovirus refers to a cluster of viruses -- more than 50 known strains -- that most commonly infect the respiratory system. Each strain may bring about a different set of symptoms, such as the common cold, sore throat, fever, bronchitis, and pneumonia (Source: WebMD Health)
Source: WebMD Health - December 5, 2018 Category: Consumer Health News Source Type: news
Morning Break: CDC on Tick Watch; Toothpaste and Early Puberty; Adenovirus Mystery
(MedPage Today) -- Health news and commentary from around the Web gathered by the MedPage Today staff (Source: MedPage Today Psychiatry)
Source: MedPage Today Psychiatry - December 4, 2018 Category: Psychiatry Source Type: news
Family speaks out on Maryland student's adenovirus-related death
The parents of a University of Maryland student who died after contracting the adenovirus are speaking out about conditions on campus. Freshman Olivia Paregol died last week after complaining about flu-like symptoms. Jericka Duncan spoke to the parents about what they think contributed to her death. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - November 28, 2018 Category: Consumer Health News Source Type: news
Three more University of Maryland students sickened with adenovirus
Another three University of Maryland students have fallen ill with adenovirus. Now, a total of eight people there have been sickened, including one immunocompromised girl who died last week. (Source: the Mail online | Health)
Source: the Mail online | Health - November 27, 2018 Category: Consumer Health News Source Type: news
Parents of Maryland student who died say health center didn't test for adenovirus
Freshman Olivia Paregol's father also believes mold in her dorm room contributed to her death (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - November 27, 2018 Category: Consumer Health News Source Type: news
Adenovirus death: Father says dorm mold "didn't help" ill daughter
The University of Maryland is trying to calm fears that recent mold problems on campus could be linked to a virus that caused a student's death. Freshman Olivia Paregol, 18, died on Sunday after contracting adenovirus, which typically causes respiratory illness. The university said five more students have illnesses tied to the virus, but insists there's "no consistent connection" to mold. Olivia's father believes the school could have done more. Jericka Duncan reports (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - November 22, 2018 Category: Consumer Health News Source Type: news
Adenovirus death: Father says dorm mold "didn't help" ill daughter
As 5 more students confirmed to have illnesses tied to the virus, University of Maryland insists there's "no consistent connection" to mold problems (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - November 22, 2018 Category: Consumer Health News Source Type: news
U of Maryland Student Dies of Adenovirus-Related Illness
WEDNESDAY, Nov. 21, 2018 -- An 18-year-old University of Maryland student has died from an adenovirus-related illness, and there have been reports of five other cases among students.
Recently, at least 11 children at a New Jersey rehab facility died... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 21, 2018 Category: Pharmaceuticals Source Type: news
College student, 18, dies of adenovirus days before Thanksgiving
Olivia Paregol, an 18-year-old freshman at the University of Maryland died of adenovirus on Sunday after battling Crohn's disease and complications of the virus that has killed several New Jersey kids. (Source: the Mail online | Health)
Source: the Mail online | Health - November 21, 2018 Category: Consumer Health News Source Type: news
