Quantitation of Plasma Renin Activity in Plasma Using Liquid Chromatography & ndash;Tandem Mass Spectrometry (LC-MS/MS)
We describe a semi-automated and simple method for the accurate and precise measurement of PRA from 500 & mu;L of plasma (250 & mu;L if blank subtraction is omitted, as discussed) using a liquid chromatography and tandem mass spectrometry (LC-MS/MS) method for angiotensin I (AngI) in 96-well format. After a 3 h AngI generation step at 37 & deg;C in buffering conditions at pH 6, the reaction is quenched with 10 % formic acid containing AngI internal standard. Sample preparation then proceeds with offline solid phase extraction, two wash steps, and methanol elution followed by injection into the LC-MS/MS system. ...
Source: Springer protocols feed by Imaging/Radiology - January 8, 2016 Category: Radiology Source Type: news

FDA takes action against Vermont dairy farm for illegally administering drugs to cattle
Today, the U.S. Department of Justice entered a consent decree of permanent injunction in the District of Vermont against the Correia Family Limited Partnership, doing business as Wynsum Holsteins, a dairy farm located in West Addison, Vermont, and its partners, Anthony Correia, Barbara Correia and Stephen Correia. The decree accompanies a complaint filed at the request of the U.S. Food and Drug Administration. (Source: Food and Drug Administration)
Source: Food and Drug Administration - December 15, 2015 Category: American Health Source Type: news

ACTH testing may be ‘misleading’ in identifying adrenal insufficiency
Both low-dose and high-dose adrenocorticotropic hormone stimulation tests have similar diagnostic accuracy in identifying adrenal insufficiency; however, the tests have limitations and cannot necessarily rule out the condition, according to research in The Journal of Clinical Endocrinology & Metabolism. Healio (Source: Society for Endocrinology)
Source: Society for Endocrinology - December 15, 2015 Category: Endocrinology Source Type: news

Cosyntropin may help diagnose adrenal insufficiency
The diagnosis of adrenal insufficiency may be made using the serum free cortisol response to cosyntropin as an alternative to serum total cortisol, according to recent findings reported in The Journal of Clinical Endocrinology and Metabolism. Healio (Source: Society for Endocrinology)
Source: Society for Endocrinology - December 14, 2015 Category: Endocrinology Source Type: news

Quantitation of Plasma Renin Activity in Plasma Using Liquid Chromatography–Tandem Mass Spectrometry (LC-MS/MS)
We describe a semi-automated and simple method for the accurate and precise measurement of PRA from 500 μL of plasma (250 μL if blank subtraction is omitted, as discussed) using a liquid chromatography and tandem mass spectrometry (LC-MS/MS) method for angiotensin I (AngI) in 96-well format. After a 3 h AngI generation step at 37 °C in buffering conditions at pH 6, the reaction is quenched with 10 % formic acid containing AngI internal standard. Sample preparation then proceeds with offline solid phase extraction, two wash steps, and methanol elution followed by injection into the LC-MS/MS system. Quantitation is...
Source: Springer protocols feed by Imaging/Radiology - November 27, 2015 Category: Radiology Source Type: news

Blanket forts, healthy hearts and life: What our families are thankful for
When parents and children first arrive at our front door — no matter why or from where they come — they forever become part of our extended family. On this Thanksgiving, just like the 47 million others who are traveling to see loved ones, we too packed up the car and drove to visit 11 of the families who have stayed with us at Boston Children’s over the years. We wanted to find out what they were most thankful for and what makes this season special to them. Thank you to the families of Ella S., Julian, Ella D., Addison, Callum, Nora, Avery, Jace, Molly, Charlotte, Murphy and Robbie for welcoming us i...
Source: Thrive, Children's Hospital Boston - November 26, 2015 Category: Pediatrics Authors: Jenny Fernandez Tags: All posts Thanksgving Source Type: news

Utah Mechanic Critically Burned in Shop Fire
A South Salt Lake mechanic remained in critical condition Tuesday, the day after he was burned in a gasoline fire at his shop. South Salt Lake Deputy Fire Chief Terry Addison said the man was working on vehicle on a lift about 3 p.m. Monday when fuel leaked and pooled around his feet. Fumes from the gasoline were ignited by a nearby space heater, engulfing the mechanic in flames. Firefighters and paramedics rushed to the shop, at 166 E. 3825 South, doused the flames and rendered first aid to the victim before rushing him to the hospital. Addison said the man, whose identity was not released, suffered burns of varying de...
Source: JEMS Patient Care - November 5, 2015 Category: Emergency Medicine Tags: General News Burns & Soft Tissue Trauma Source Type: news

11 Hospitalized by Carbon Monoxide Leak
Authorities in Villa Park believe a furnace was the source of a carbon monoxide leak that sickened 11 people in a home early Sunday morning. Villa Park Fire Department Lt. Chris Gilliland said an ambulance was called to the single-family home on the 200 block of West Division Street at 8:57 a.m. for a report of a 15-year-old with a headache. Crews that arrived found 10 others in the home between the ages of 6 and 61 suffering from carbon monoxide poisoning, according to a news release. All 11 were taken to local hospitals and have since been released, officials said. At the house's entrance, the level of carbon monoxide...
Source: JEMS Patient Care - October 20, 2015 Category: Emergency Medicine Tags: News Toxicology Hazmat General News Source Type: news

11 Hospitalized by Carbon Monoxide Leak
Authorities in Villa Park believe a furnace was the source of a carbon monoxide leak that sickened 11 people in a home early Sunday morning. Villa Park Fire Department Lt. Chris Gilliland said an ambulance was called to the single-family home on the 200 block of West Division Street at 8:57 a.m. for a report of a 15-year-old with a headache. Crews that arrived found 10 others in the home between the ages of 6 and 61 suffering from carbon monoxide poisoning, according to a news release. All 11 were taken to local hospitals and have since been released, officials said. At the house's entrance, the level of carbon monoxide...
Source: JEMS Operations - October 20, 2015 Category: Emergency Medicine Tags: News Toxicology Hazmat General News Source Type: news

5 Things Your Pet Insurance Policy Should Cover
Currently, there are over a dozen companies in the U.S. and Canada offering pet insurance, and if you've tried sorting out the differences between them, like many pet owners, you probably wound up more confused than when you started. As is the case with insurance of any kind, pet health care coverage is a wonderful thing to have if you need it -- and providing there are no big surprises when you submit a claim for reimbursement. Here's the scenario you want to avoid: You faithfully pay your monthly premium for years and enjoy peace of mind knowing your pet's health care will be paid for in the event of an expensive illne...
Source: Healthy Living - The Huffington Post - October 1, 2015 Category: Consumer Health News Source Type: news

Graduated driver license compliant teens involved in fatal motor vehicle crashes - Pressley JC, Addison D, Dawson P, Nelson SS.
BACKGROUND: Significant reductions in motor vehicle injury mortality have been reported for teen drivers after passage of graduated driver licensing (GDL), seat belt, and no tolerance alcohol and drug laws. Despite this, teen drivers remain a vulnerable po... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - August 29, 2015 Category: Global & Universal Tags: Age: Adolescents Source Type: news

Here are Inc.'s 168 fastest growing companies in Dallas-Fort Worth
North Texas is more than well-represented on this year's Inc. 5000 list of fastest-growing private companies. The 168 companies that call DFW home represent the full spectrum of our diverse economy – ranging from energy powerhouse Bridger with its $4 billion in annual revenue to business consulting company Bond Group with its $2 million in annual revenue. You can see the full Inc. 5000 list here. The top ranked Texas company is Nerium International, an Addison firm that develops and distributes… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - August 18, 2015 Category: Biotechnology Authors: Paul O'Donnell Source Type: news

Relative Adrenal Insufficiency in Premature Infants: State of the Art
This article discusses of the development of the hypothalamic-pituitary-adrenal axis during gestation, aspects of what is considered normal function, and the diagnosis and management of the entity of relative adrenal insufficiency in the premature infant. (Source: NeoReviews recent issues)
Source: NeoReviews recent issues - July 31, 2015 Category: Pediatrics Authors: Weiss, M. E., Caldarelli, L., Hageman, J. R., Littlejohn, E. Tags: Pediatric Drug Labeling Update Articles Source Type: news

Trillion Dollar Space Industry Started, and You Missed Out
Planetary Resources Inc. released the first ever spacecraft aimed specifically to test technologies for a near future commercial asteroid mining mission. ASTEROID MINING Asteroids are leftover rocks from the creation of the Solar System 4.5 billion years ago. Because they were formed with the same materials as the rest of the planets and moons, they have big deposits of water, gold, cobalt, iron, manganese, molybdenum, nickel, osmium, palladium, platinum, rhenium, rhodium, ruthenium and tungsten. It is believed that most of these elements, mined on Earth, actually came from ancient impacts of asteroids on our planet's surf...
Source: Science - The Huffington Post - July 28, 2015 Category: Science Source Type: news

Supply problems with Efcortesol used in the management of Adrenal Crisis
The sole UK manufacturer of liquid injectable hydrocortisone – Efcortesol (hydrocortisone sodium phosphate) – has withdrawn supplies pending validation and licensing approvals of its new active ingredient supply. They now give an estimated availability date of September. Alternative forms of liquid injectable steroid, such as dexamethasone, are not advisable for emergency treatment due to their delayed onset. The alternative preparation of injectable hydrocortisone – Solu-Cortef (hydrocortisone sodium succinate) – should be substituted. This should be prescribed as the IV/IM pack, w...
Source: Society for Endocrinology - June 23, 2015 Category: Endocrinology Source Type: news

Solving Addison’s puzzle: Uncovering a congenital heart defect
Addison is a smart, sweet and caring child who brings a smile to everyone she meets. She is known for her hugs and frequently doles them out to anyone and everyone. She loves elephants—and her heart is elephant-sized! However, until last fall, Addison’s heart was causing mysterious and persistent medical issues that prevented her from doing all the things she loves. Unbeknownst to my husband and me, Addison was born with a congenital heart defect. As a baby, Addison thrived but always seemed to have something going on. She had issues with reflux and did not enjoy tummy time or sleeping on her back. Waking sever...
Source: Thrive, Children's Hospital Boston - May 21, 2015 Category: Pediatrics Authors: Kristine Hogan Tags: Heart conditions Our patients’ stories cardiac surgery congenital heart defect congenital heart disease Heart Center Source Type: news

Spike In Dolphin Deaths Directly Tied To Deepwater Horizon Oil Spill, Researchers Say
A dramatic increase in dolphin deaths in the Gulf of Mexico is directly linked to the Deepwater Horizon oil spill, scientists concluded in a report published Wednesday. Following the 2010 explosion on the drilling rig owned by British Petroleum (BP) and the subsequent spill of 4.9 million barrels (205.8 million gallons) of oil into the ocean, scientists have documented 1,281 dead and stranded cetaceans, primarily bottlenose dolphins, along the northern coast of the Gulf of Mexico. In this photo taken May 10, 2015, a dead dolphin washes ashore in the Gulf of Mexico on Grand Isle, Louisiana. In 2011, Louisiana saw 163 do...
Source: Science - The Huffington Post - May 21, 2015 Category: Science Source Type: news

How Do You Treat Adrenal Crisis?
Discussion Septo-optic dysplasia (SOD) is a disorder of midline prosencephalic development early in gestation. It causes agenesis of the septum pellucidum and/or thinning or absence of the corpus callosum and pituitary hormone deficiencies. It has an incidence of 1:10,000 live births. Most cases appear to be due to a combination of genetic and environmental factors but there are rare familial cases which are most often autosomal recessive. The phenotype is variable and diagnosis can occur at birth with more severe problems or later with milder ones. Patients must have at least 2 of 3 problems for diagnosis including uni- ...
Source: PediatricEducation.org - May 4, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Management of adrenal crisis
Adrenal crisis (AC) is a life-threatening emergency that may occur in patients with chronic adrenal insufficiency (AI). Due to the rarity of AI, physicians are often unfamiliar with the correct emergency treatment of AC. However, objective data supporting this assumption are lacking. Hahner et al. conducted a prospective study to assess the current management of AC with a special focus on the time needed for initiation of parenteral glucocorticoid treatment in a well characterised cohort of patients with chronic AI and compared the results with expert opinion on optimal time targets and time limits in AC. Their data demo...
Source: Society for Endocrinology - April 27, 2015 Category: Endocrinology Source Type: news

​Lahey Hospital CEO eyeing community hospitals for potential expansion
Lahey Health has been on an expansion spree for the last several years, and according to the CEO of the health system’s biggest institution, the hospital's next acquisition might be a community hospital. The organization was founded from a merger, with the formerly known Lahey Clinic growing beyond its footprint in Burlington, Lexington and Peabody to include Northeast Health System's Beverly Hospital and Addison Gilbert Hospital. In July, the company finalized the acquisition of Winchester Hospital. Rumors… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - April 24, 2015 Category: American Health Authors: Jessica Bartlett Source Type: news

Merseyside woman who thought she was allergic to gin and tonic told symptoms are CANCER
Eve Addison, from Merseyside, was suffering from Hodgkin Lymphoma - cancer of the lymphatic system. It can cause lumps in the neck which become painful after drinking alcohol. (Source: the Mail online | Health)
Source: the Mail online | Health - April 10, 2015 Category: Consumer Health News Source Type: news

Opioid EndocrinopathyOpioid Endocrinopathy
Are opioids adverse effects more of a "pain" than you realized? Learn how opioids may be associated with hypogonadism, adrenal insufficiency, and other endocrine disorders. Endocrine Practice (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 3, 2015 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

Select Medical to buy Concentra for $1B
Select Medical Corp. has entered into a deal to buy Concentra for $1.055 billion, in a deal that will combine two national competitors of physical-therapy services. Both companies have a strong local presence. Concentra, based in Addison, Texas, is a national health care company that operates urgent care centers and provides occupation medicine, physical therapy, primary care and wellness programs. A subsidiary of Humana Inc. (NYSE: HUM), the company operates more than 300 medical centers in 38… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - March 23, 2015 Category: Pharmaceuticals Authors: John George Source Type: news

I Wish I'd Known Then What I Know Now
Dear Addison, Five years ago today, we met you for the very first time. Your body was broken. Your cry was weak. Your grasp was nonexistent. Your muscle tone was low. I will never forget bending over your bed in the NICU isolation room with my mind full of questions. I didn't know how to be a mother, let alone to a baby who was so sick. I didn't know how to love a baby, let alone a baby with Down syndrome. I wish I could say that after 20 weeks of pregnancy worrying about that call from the genetics counselor informing us that "your daughter has Trisomy 21," I held you and all worries fled. I wish I cou...
Source: Healthy Living - The Huffington Post - February 23, 2015 Category: Consumer Health News Source Type: news

High rates of adrenal crisis seen in patients with chronic insufficiency
A prospective study carried out by researchers at the University of Wuerzburg has found that adrenal crisis occurs in a large proportion of patients with chronic adrenal insufficiency, even if they are educated about managing the disease; the study was published this week in The Journal of Clinical Endocrinology & Metabolism. Healio   (Source: Society for Endocrinology)
Source: Society for Endocrinology - December 10, 2014 Category: Endocrinology Source Type: news

Gratitude for the Other 364 Days of the Year
There are few healthy habits with more immediate results than gratitude. This is why English author Joseph Addison declared, "There is not a more pleasing exercise of the mind." Unlike other virtues, he said, gratitude offers "natural gratification" as the "duty is sufficiently rewarded by the performance." Likewise, there are few healthy habits with more reverberating effects. Unlike eating broccoli or meditating, expressing appreciation is discernibly beneficial for both the practitioner and recipient. Both research and thought leaders agree. A growing body of data shows that people who cu...
Source: Healthy Living - The Huffington Post - December 4, 2014 Category: Consumer Health News Source Type: news

How my dog sniffed out breast cancer and saved my life
Five years ago, Dr Claire Guest's labrador Daisy discovered a lump in her owner's breast. Now, Dr Guest has founded Medical Detection Dogs - one of the Telegraph's Christmas charities (Source: Telegraph Health)
Source: Telegraph Health - November 20, 2014 Category: Consumer Health News Tags: Telegraph Christmas Appeal Addison's disease Medical Detection Dogs breast cancer diabetes prostate cancer Source Type: news

Adrenal insufficiency - 2014 Lancet review
Adrenal insufficiency is the deficient production or action of glucocorticoids, with or without deficiency also in mineralocorticoids and adrenal androgens. It is a life-threatening disorder that can result from:- primary adrenal failure- secondary adrenal disease due to impairment of the hypothalamic—pituitary axis Prompt diagnosis and management are essential. The clinical manifestations of primary adrenal insufficiency result from deficiency of all adrenocortical hormones, but they can also include signs of other concurrent autoimmune conditions. In secondary or tertiary adrenal insufficiency, the clinical picture...
Source: Clinical Cases and Images - November 12, 2014 Category: Journals (General) Tags: Endocrinology Lancet Source Type: news

Evaluation of adrenal function in critically ill children
The activation of the hypothalamic-pituitary-adrenal axis in response to critical illness and the resulting release of cortisol from the adrenal cortex are essential to stress adaptation and maintenance of cardiovascular homeostasis. However, there is no consensus on adequate adrenal response to critical illness.   Balbão et al., conducted  a prospective study  to evaluate adrenal function in critically ill children compared with a control group of healthy children by measuring  salivary cortisol and serum total cortisol at baseline and after ACTH stimulation test. Another ...
Source: Society for Endocrinology - October 21, 2014 Category: Endocrinology Source Type: news

When lethargy can be fatal
A condition usually considered psychological might indicate Addison's disease, says Dr James LeFanu (Source: Telegraph Health)
Source: Telegraph Health - September 8, 2014 Category: Consumer Health News Source Type: news

When lethargy can be fatal
A condition usually considered psychological might indicate Addison's disease, says Dr James LeFanu (Source: The Telegraph : Health Advice)
Source: The Telegraph : Health Advice - September 8, 2014 Category: Consumer Health News Source Type: news

5ɑ-reductase and adrenal insufficiency
Patients with critical illness or hepatic failure exhibit impaired cortisol response to ACTH, or ‘relative adrenal insufficiency’. The mechanism could be that elevated bile acids inhibit inactivation of cortisol in liver by 5α-reductases, leading to downregulation of the hypothalamic–pituitary–adrenal axis and adrenocortical atrophy. Livingstone and colleagues investigated the consequences of 5α-reductase type 1 deficiency in mice. Their results confirm that impaired peripheral clearance of glucocorticoids can cause ‘relative adrenal insufficiency&rs...
Source: Society for Endocrinology - August 29, 2014 Category: Endocrinology Source Type: news

Hip but not thigh intramuscular adipose tissue is associated with poor balance and increased temporal gait variability in older adults - Addison O, Young P, Inacio M, Bair WN, Prettyman MG, Beamer BA, Ryan AS, Rogers MW.
BACKGROUND: Intramuscular adipose tissue (IMAT) of the lower extremity is a strong negative predictor of mobility function. Variability in temporal gait factors is another important predictor of mobility function. The purpose of this study was to examine t... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - July 18, 2014 Category: Global & Universal Tags: Age: Elder Adults Source Type: news

Genetics Home Reference: autoimmune Addison disease
http://ghr.nlm.nih.gov/condition/autoimmune-addison-disease (Source: NLM General Announcements)
Source: NLM General Announcements - July 1, 2014 Category: Databases & Libraries Source Type: news

Thursday consumer health tips
Autism spectrum disorder Post-traumatic stress disorder (PTSD) Salt craving: A symptom of Addison's disease? Brain aneurysm Vitamin B-12: Can it improve memory in Alzheimer's? (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - June 26, 2014 Category: Databases & Libraries Source Type: news

As pediatric cancer survivors, mother and daughter share unique bond
This story originally appeared on Insight, Dana-Farber’s blog.  Jessica Tierney never thought she’d experience a harder moment than learning she had cancer at age 15 – until her 7-year-old daughter, Emma, was diagnosed with acute lymphocytic leukemia (ALL) last October. Emma is undergoing treatment at Boston Children’s Hospital and Dana-Farber’s Jimmy Fund Clinic, just as Jessica did in 1991. “Emma already knew I had once been really sick, so I told her, ‘Look at me. I was treated a long time ago, and the medicine is even better now,” Jessica Tierney recalls of hearing h...
Source: Thrive, Children's Hospital Boston - June 23, 2014 Category: Pediatrics Authors: Guest Blogger Tags: All posts Cancer Dana-Farber/Boston Children's Cancer and Blood Disorders Center our patients' stories Source Type: news

Teenager has Addison's disease where organs shut down if she gets too excited
Hannah Bowness-Major, 13, from Cheshire, has Addison's disease, which means her adrenal glands do not produce enough of the hormone cortisol. (Source: the Mail online | Health)
Source: the Mail online | Health - June 13, 2014 Category: Consumer Health News Source Type: news

Salt craving: A symptom of Addison's disease?
  (Source: MayoClinic.com - Ask a Specialist)
Source: MayoClinic.com - Ask a Specialist - May 30, 2014 Category: Consumer Health News Source Type: news

Wednesday's pick of the day
Today sees our two nurses' sessions, as well as two more Plenary Lectures together with a further satellite symposia New insights in the management of adrenal insufficiency and the importance of circadian rhythm, sponsored by ViraPharma Make sure you're up and about for our first ever Society for Endocrinology Journal Awards. Five authors of winning papers from the Society's five official journals will present their work from  8am in room 1C. We're also looking forward to our second Education Workshop:  Practical publishing advice at 9.30, room 3B in which seven speakers will guide you t...
Source: Society for Endocrinology - March 26, 2014 Category: Endocrinology Source Type: news

This week's new live comedy
Nine Lessons And Carols For Godless People | Mae Martin | British Radio new comedy awards 2013 finalNine Lessons And Carols For Godless People, LondonThe news that Robin Ince is calling time on his annual secular celebration of Christmas was greeted with a loud clap of thunder, and the veil of the temple was rent in twain. In fact, the dismay among faithful attendees of Nine Lessons And Carols For Godless People is a testament to how securely the event has been established in the comedy calendar. For six years now, Ince has brought a cohort of luminaries from the worlds of comedy, music and popular science together to prov...
Source: Guardian Unlimited Science - December 7, 2013 Category: Science Authors: James Kettle Tags: The Guardian Josie Long Comedy Culture Brian Cox Stage Alan Carr Editorial Source Type: news

Comfort eating now classified by doctors as 'psychiatric condition' that needs treatment
When life gets stressful, do you find yourself reaching for the biscuit tin, or for a large bag of crisps? So do Hayley Bennett (left) and Keith Addison. (Source: the Mail online | Health)
Source: the Mail online | Health - October 29, 2013 Category: Consumer Health News Source Type: news

Boy who could be killed by argument: Morgan Taylor's body could shut down in stressful event
Four-year-old Morgan Taylor, from Burnley, has adrenal insufficiency which means his body does not produce the stress hormone cortisol. (Source: the Mail online | Health)
Source: the Mail online | Health - October 8, 2013 Category: Consumer Health News Source Type: news

Addison's disease patient resources from the ADSHG
The Addison's Disease Self Help Group (ADSHG) has extended its resources for patients by publishing its 2004-2012 series of medical lectures free-to-view online at http://www.addisons.org.uk/topics/2011/09/0041.html. The most recent lecture was delivered by Professor Richard Ross (Sheffield) on new therapy developments. The ADSHG has also introduced a one-stop web shop for print packs of its medical literature. Resources available at cost-price include a 'Hospital folder' (comprising nurse leaflets, surgical guidelines, steroid alert stickers, emer...
Source: Society for Endocrinology - August 8, 2013 Category: Endocrinology Source Type: news

Balint Group Process (Richard B Addison PhD)
Introduction to Balint Group Process for first time participants, a review for those who have participated, and a resource for those who are introducing Balint to their residents/students. (Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded)
Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded - May 20, 2013 Category: Primary Care Source Type: news

What Is the Best Approach to Tailoring Hydrocortisone Dose?What Is the Best Approach to Tailoring Hydrocortisone Dose?
Do you consider circadian rhythm when dosing hydrocortisone for patients with adrenal insufficiency? Clinical Endocrinology (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - May 3, 2013 Category: Endocrinology Tags: Diabetes & Endocrinology Journal Article Source Type: news

Predictive Factors of Adrenal InsufficiencyPredictive Factors of Adrenal Insufficiency
What is the strongest predictor for potential adrenal failure? BMC Endocrine Disorders (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 28, 2013 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

What Causes Hypercalcemia?
Discussion Calcium homeostasis is regulated by mechanisms involving the absorption from the gastrointestinal tract, bone deposition and resorption, and renal excretion. To review Vitamin D homeostasis click here. Serum calcium is found in three forms: free (47%), protein bound (43%) and diffusable calcium complexes (10%). The protein binding proteins are albumin (80%) and globulin (20%). The free calcium is the most important biologically. Acidosis also increases free calcium and alkalosis decreases free calcium. Problems associated with hypercalcemia include nausea, emesis, abdominal pain, constipation, polyuria, dehydra...
Source: PediatricEducation.org - March 25, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news

Opioids can cause endocrine dysfunction
3 out of 5 stars The Effect of Opioid Therapy on Endocrine Function. Brennan MJ. Am J Med 2013 Mar;126:S12-S18. Abstract In recent months, TPR has discussed recent medical literature detailing various averse effects of chronic opioid therapy, including narcotic bowel syndrome and opioid-induced hyperalgesia, Additional adverse effects include sedation, immune suppression, and worsening sleep apnea. This well done review article provides a helpful outline of yet another complication: depressed endocrine function. The author notes that opioids affect 2 endocrine pathways. The first pathway is the hyp...
Source: The Poison Review - February 26, 2013 Category: Toxicology Authors: Leon Tags: Medical adrenal endocrine function gonads hypothalamus narcotics opiates opioids ovaries pituitary testes Source Type: news

Tired and listless? You may need more stress hormone
Kaye Occleston was diagnosed with a potentially fatal disorder called adrenal insufficiency, 12 years after she became ill. (Source: the Mail online | Health)
Source: the Mail online | Health - February 19, 2013 Category: Consumer Health News Source Type: news

Hysterectomy After Childbirth – Laura’s Story
My name is Laura Boot-Handford and I recently turned 30. I grew up in the beautiful town Lewes, East Sussex. I met my Husband there whilst at college. We both went to University in Leicester and settled in Northampton nearby once we had finished. We bought our first house and two cats. We got married and soon thought about starting a family of our own.I was 27 when we had our first son, Harry. I had a consultant led pregnancy as I have Addisons, although I rarely saw the consultant.  I started to get high blood pressure and traces of protein in my urine which was indicating the onset of pre eclampsia so the registrar ...
Source: The Hysterectomy Association - February 13, 2013 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Post Birth Your Stories childbirth postpartum haemorrhage Womb transplant Source Type: news