The role of nursing care in the type 2 diabetes treatment associated with chronic liver diseases
Conclusions
Outcomes from the type 2 diabetes treatment paralleling of CLD were presented. Treatment of type 2 diabetes with pioglitazone hydrochloride, gliclazide, sitagliptin, liraglutide and exenatide was proven effective. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - December 2, 2021 Category: Gastroenterology Tags: Original articles: Hepatology Source Type: research
A scalable and sensitive steatosis chip with long-term perfusion of in situ differentiated HepaRG organoids
Biomaterials. 2021 Jun 1;275:120904. doi: 10.1016/j.biomaterials.2021.120904. Online ahead of print.ABSTRACTNonalcoholic fatty liver disease (NAFLD) is a significant liver disease without approved therapy, lacking human NAFLD models to aid drug development. Existing models are either under-performing or too complex to allow robust drug screening. Here we have developed a 100-well drug testing platform with improved HepaRG organoids formed with uniform size distribution, and differentiated in situ in a perfusion microfluidic device, SteatoChip, to recapitulate major NAFLD features. Compared with the pre-differentiated spher...
Source: Biomaterials - June 13, 2021 Category: Materials Science Authors: Yao Teng Zixuan Zhao Farah Tasnim Xiaozhong Huang Hanry Yu Source Type: research
A scalable and sensitive steatosis chip with long-term perfusion of in situ differentiated HepaRG organoids
Biomaterials. 2021 Jun 1;275:120904. doi: 10.1016/j.biomaterials.2021.120904. Online ahead of print.ABSTRACTNonalcoholic fatty liver disease (NAFLD) is a significant liver disease without approved therapy, lacking human NAFLD models to aid drug development. Existing models are either under-performing or too complex to allow robust drug screening. Here we have developed a 100-well drug testing platform with improved HepaRG organoids formed with uniform size distribution, and differentiated in situ in a perfusion microfluidic device, SteatoChip, to recapitulate major NAFLD features. Compared with the pre-differentiated spher...
Source: Biomaterials - June 13, 2021 Category: Materials Science Authors: Yao Teng Zixuan Zhao Farah Tasnim Xiaozhong Huang Hanry Yu Source Type: research
Positive Effect on MS With Treatment of Metabolic Syndrome
In this study, 20 patients receiving metformin hydrochloride and 10 receiving pioglitazone hydrochloride had significantly fewer new or enlarging T2 lesions or gadolinium-enhancing lesions confirmed by brain magnetic resonance imaging after about 2 years of treatment compared with a control group of 20 patients with MS and metabolic syndrome who did not receive metformin or pioglitazone. (Source: JAMA Neurology)
Source: JAMA Neurology - March 7, 2016 Category: Neurology Source Type: research
Analysis of Drugs Illegally Added into Chinese Traditional Patent Medicine Using Surface-enhanced Raman Scattering.
In this report, a surface-enhanced Raman scattering (SERS) analysis method for five kinds of illegally added drugs (rosiglitazone maleate, phenformin hydrochloride, metformin hydrochloride, pioglitazone hydrochloride and sibutramine hydrochloride) in Chinese traditional patent medicine (CTPM) has been demonstrated, including simultaneous detections of drug mixtures with CTPM. Silver colloidal, prepared by a sodium citrate reaction, was used as a SERS substrate. The optimum pH condition for each drug has also been explored because of its combined effect on protonation, surface charge, repulsion of an analyte and nanoparticl...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - October 12, 2013 Category: Chemistry Authors: Zhang Y, Huang X, Liu W, Cheng Z, Chen C, Yin L Tags: Anal Sci Source Type: research
