Effects of acute insecticide exposure on neuronal activity in vitro in rat cortical cultures
Neurotoxicology. 2024 Apr 8:S0161-813X(24)00035-4. doi: 10.1016/j.neuro.2024.04.004. Online ahead of print.ABSTRACTExposure to pesticides, such as carbamates, organophosphates, organochlorines and pyrethroids, has been linked to various health problems, including neurotoxicity. Although most in vivo studies use only male rodents, some studies have shown in vivo sex-specific effects after acute exposure. Since in vivo studies are costly and require a large number of animals, in vitro assays that take sex-specific effects into account are urgently needed. We therefore assessed the acute effects of exposure to different carba...
Source: Neurotoxicology - April 10, 2024 Category: Neurology Authors: Lennart V J van Melis Anneloes M Peerdeman Eva H W Huiberts Regina G D M van Kleef Aart de Groot Remco H S Westerink Source Type: research
GPR39-mediated ERK1/2 signaling reduces permethrin-induced proliferation of estrogen receptor α-negative cells
The objective of this study was to determine the impact of the pyrethroid insecticide permethrin on the growth of estrogen receptor negative breast cancer cells MDA-MB-231. Using tandem mass spectrometric techniques, the effect of permethrin on cellular protein expression was investigated, and gene ontology and pathway function enrichment analyses were performed on the deregulated proteins. Finally, molecular docking simulations of permethrin with the candidate target protein was performed and the functionality of the protein was confirmed through gene knockdown experiments. Our findings demonstrate that exposure to 10-40 ...
Source: Ecotoxicology and Environmental Safety - April 10, 2024 Category: Environmental Health Authors: Ming-Hui Shi Yi Yan Xi Niu Jia-Fu Wang Sheng Li Source Type: research
Effects of acute insecticide exposure on neuronal activity in vitro in rat cortical cultures
Neurotoxicology. 2024 Apr 9;102:58-67. doi: 10.1016/j.neuro.2024.04.004. Online ahead of print.ABSTRACTExposure to pesticides, such as carbamates, organophosphates, organochlorines and pyrethroids, has been linked to various health problems, including neurotoxicity. Although most in vivo studies use only male rodents, some studies have shown in vivo sex-specific effects after acute exposure. Since in vivo studies are costly and require a large number of animals, in vitro assays that take sex-specific effects into account are urgently needed. We therefore assessed the acute effects of exposure to different carbamates (metho...
Source: Neurotoxicology - April 10, 2024 Category: Neurology Authors: Lennart V J van Melis Anneloes M Peerdeman Eva H W Huiberts Regina G D M van Kleef Aart de Groot Remco H S Westerink Source Type: research
GPR39-mediated ERK1/2 signaling reduces permethrin-induced proliferation of estrogen receptor α-negative cells
The objective of this study was to determine the impact of the pyrethroid insecticide permethrin on the growth of estrogen receptor negative breast cancer cells MDA-MB-231. Using tandem mass spectrometric techniques, the effect of permethrin on cellular protein expression was investigated, and gene ontology and pathway function enrichment analyses were performed on the deregulated proteins. Finally, molecular docking simulations of permethrin with the candidate target protein was performed and the functionality of the protein was confirmed through gene knockdown experiments. Our findings demonstrate that exposure to 10-40 ...
Source: Ecotoxicology and Environmental Safety - April 10, 2024 Category: Environmental Health Authors: Ming-Hui Shi Yi Yan Xi Niu Jia-Fu Wang Sheng Li Source Type: research
Effects of acute insecticide exposure on neuronal activity in vitro in rat cortical cultures
Neurotoxicology. 2024 Apr 9;102:58-67. doi: 10.1016/j.neuro.2024.04.004. Online ahead of print.ABSTRACTExposure to pesticides, such as carbamates, organophosphates, organochlorines and pyrethroids, has been linked to various health problems, including neurotoxicity. Although most in vivo studies use only male rodents, some studies have shown in vivo sex-specific effects after acute exposure. Since in vivo studies are costly and require a large number of animals, in vitro assays that take sex-specific effects into account are urgently needed. We therefore assessed the acute effects of exposure to different carbamates (metho...
Source: Neurotoxicology - April 10, 2024 Category: Neurology Authors: Lennart V J van Melis Anneloes M Peerdeman Eva H W Huiberts Regina G D M van Kleef Aart de Groot Remco H S Westerink Source Type: research
Effects of acute insecticide exposure on neuronal activity in vitro in rat cortical cultures
Neurotoxicology. 2024 Apr 9;102:58-67. doi: 10.1016/j.neuro.2024.04.004. Online ahead of print.ABSTRACTExposure to pesticides, such as carbamates, organophosphates, organochlorines and pyrethroids, has been linked to various health problems, including neurotoxicity. Although most in vivo studies use only male rodents, some studies have shown in vivo sex-specific effects after acute exposure. Since in vivo studies are costly and require a large number of animals, in vitro assays that take sex-specific effects into account are urgently needed. We therefore assessed the acute effects of exposure to different carbamates (metho...
Source: Neurotoxicology - April 10, 2024 Category: Neurology Authors: Lennart V J van Melis Anneloes M Peerdeman Eva H W Huiberts Regina G D M van Kleef Aart de Groot Remco H S Westerink Source Type: research
Effects of acute insecticide exposure on neuronal activity in vitro in rat cortical cultures
Neurotoxicology. 2024 Apr 9;102:58-67. doi: 10.1016/j.neuro.2024.04.004. Online ahead of print.ABSTRACTExposure to pesticides, such as carbamates, organophosphates, organochlorines and pyrethroids, has been linked to various health problems, including neurotoxicity. Although most in vivo studies use only male rodents, some studies have shown in vivo sex-specific effects after acute exposure. Since in vivo studies are costly and require a large number of animals, in vitro assays that take sex-specific effects into account are urgently needed. We therefore assessed the acute effects of exposure to different carbamates (metho...
Source: Neurotoxicology - April 10, 2024 Category: Neurology Authors: Lennart V J van Melis Anneloes M Peerdeman Eva H W Huiberts Regina G D M van Kleef Aart de Groot Remco H S Westerink Source Type: research
National survey in Switzerland calls for improved diagnosis and treatment in children with scabies
CONCLUSION: In Switzerland, scabies is a frequent dermatosis in migrant and Swiss children. While accessible, optimal diagnostics are underutilised, and treatment is suboptimal. Permethrin resistance appears to be an increasing problem. Dermatologists regularly use ivermectin off-label in children weighing <15 kg. Treatment studies on ivermectin use in children weighing <15 kg, user-friendly diagnostic tools, new treatment protocols, and child-friendly dosage forms are needed to improve the diagnosis and treatment of children with scabies.PMID:38579328 | DOI:10.57187/smw.2023.40129 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Michael Buettcher Anita K Stebler Martin Theiler Kevin Kobylinski Marc Pfister Source Type: research
National survey in Switzerland calls for improved diagnosis and treatment in children with scabies
CONCLUSION: In Switzerland, scabies is a frequent dermatosis in migrant and Swiss children. While accessible, optimal diagnostics are underutilised, and treatment is suboptimal. Permethrin resistance appears to be an increasing problem. Dermatologists regularly use ivermectin off-label in children weighing <15 kg. Treatment studies on ivermectin use in children weighing <15 kg, user-friendly diagnostic tools, new treatment protocols, and child-friendly dosage forms are needed to improve the diagnosis and treatment of children with scabies.PMID:38579328 | DOI:10.57187/smw.2023.40129 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Michael Buettcher Anita K Stebler Martin Theiler Kevin Kobylinski Marc Pfister Source Type: research
National survey in Switzerland calls for improved diagnosis and treatment in children with scabies
CONCLUSION: In Switzerland, scabies is a frequent dermatosis in migrant and Swiss children. While accessible, optimal diagnostics are underutilised, and treatment is suboptimal. Permethrin resistance appears to be an increasing problem. Dermatologists regularly use ivermectin off-label in children weighing <15 kg. Treatment studies on ivermectin use in children weighing <15 kg, user-friendly diagnostic tools, new treatment protocols, and child-friendly dosage forms are needed to improve the diagnosis and treatment of children with scabies.PMID:38579328 | DOI:10.57187/smw.2023.40129 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Michael Buettcher Anita K Stebler Martin Theiler Kevin Kobylinski Marc Pfister Source Type: research
Placental transcriptome variation associated with season, location, and urinary prenatal pyrethroid metabolites of Thai farm-working women
This study explores the impact of prenatal pyrethroid exposure, as well as factors impacting exposure and effect, on the placental transcriptome, to understand pyrethroid exposures' relationship to placental function. The study of Asian Women and their Offspring's Development and Environmental Exposures (SAWASDEE) recruited pregnant farm-working women from two agricultural districts in the Chiang Mai province of Thailand between 2017 and 2019. This cohort was predominantly exposed to cypermethrin (type II), alongside pyrethroids such as cyfluthrin (type II) and permethrin (type I). In 253 participants, maternal urinary pyr...
Source: Environmental Pollution - March 30, 2024 Category: Environmental Health Authors: Yewei Wang Karen Hermetz Amber Burt Elizabeth M Kennedy Corina Lesseur Parinya Panuwet Nancy Fiedler Tippawan Prapamontol Panrapee Suttiwan Warangkana Naksen Dana Boyd Barr Ke Hao Jia Chen Carmen J Marsit Source Type: research
Placental transcriptome variation associated with season, location, and urinary prenatal pyrethroid metabolites of Thai farm-working women
This study explores the impact of prenatal pyrethroid exposure, as well as factors impacting exposure and effect, on the placental transcriptome, to understand pyrethroid exposures' relationship to placental function. The study of Asian Women and their Offspring's Development and Environmental Exposures (SAWASDEE) recruited pregnant farm-working women from two agricultural districts in the Chiang Mai province of Thailand between 2017 and 2019. This cohort was predominantly exposed to cypermethrin (type II), alongside pyrethroids such as cyfluthrin (type II) and permethrin (type I). In 253 participants, maternal urinary pyr...
Source: Environmental Pollution - March 30, 2024 Category: Environmental Health Authors: Yewei Wang Karen Hermetz Amber Burt Elizabeth M Kennedy Corina Lesseur Parinya Panuwet Nancy Fiedler Tippawan Prapamontol Panrapee Suttiwan Warangkana Naksen Dana Boyd Barr Ke Hao Jia Chen Carmen J Marsit Source Type: research
Scabies in infants and children – a narrative review
AbstractScabies is a human ectoparasitosis caused by Sarcoptes scabei var. hominis. World-wide around 300 million patients are affected. Infants and children have the highest incidence rates. Poverty and overcrowding are social factors contributing to a higher risk of transmission and treatment failure. The leading symptom of the infestation is itch. Complications are bacterial infections that are res ponsible for mortality. Diagnosis is clinical. Non-invasive imaging technologies like dermoscopy can be used. Polymerase chain reaction (PCR) is less sensitive and specific than microscopy of skin scrapings. Treatment of ch...
Source: European Journal of Pediatrics - March 27, 2024 Category: Pediatrics Source Type: research
Glucocorticoid hormones in relation to environmental exposure to bisphenols and multiclass pesticides among middle aged-women: Results from hair analysis
Environ Pollut. 2024 Mar 22:123839. doi: 10.1016/j.envpol.2024.123839. Online ahead of print.ABSTRACTBisphenols and pesticides have been shown to alter circulating glucocorticoids levels in animals, but there is limited human data. Moreover, measurements from biological fluids may not be able to reflect long-term status of non-persistent pollutants and glucocorticoids due to the high variability in their levels. Using hair analysis, we examined the associations between glucocorticoid hormones and environmental exposure to multi-class organic pollutants among a healthy female population aged 25-45 years old. Concentrations ...
Source: Environmental Pollution - March 24, 2024 Category: Environmental Health Authors: Feng-Jiao Peng Paul Palazzi Sakina Mezzache Emilie Adelin Nasrine Bourokba Philippe Bastien Brice M R Appenzeller Source Type: research
Glucocorticoid hormones in relation to environmental exposure to bisphenols and multiclass pesticides among middle aged-women: Results from hair analysis
Environ Pollut. 2024 Mar 22:123839. doi: 10.1016/j.envpol.2024.123839. Online ahead of print.ABSTRACTBisphenols and pesticides have been shown to alter circulating glucocorticoids levels in animals, but there is limited human data. Moreover, measurements from biological fluids may not be able to reflect long-term status of non-persistent pollutants and glucocorticoids due to the high variability in their levels. Using hair analysis, we examined the associations between glucocorticoid hormones and environmental exposure to multi-class organic pollutants among a healthy female population aged 25-45 years old. Concentrations ...
Source: Environmental Pollution - March 24, 2024 Category: Environmental Health Authors: Feng-Jiao Peng Paul Palazzi Sakina Mezzache Emilie Adelin Nasrine Bourokba Philippe Bastien Brice M R Appenzeller Source Type: research
