Complete remission of advanced pancreatic cancer induced by claudin18.2-targeted CAR-T cell therapy: a case report
Pancreatic cancer (PC) is one of the most malignant tumors in digestive system due to its highly invasive and metastatic properties. At present, conventional treatment strategies for PC show the limited clinical efficacy. Therefore, novel effective therapeutic strategies are urgently needed. Here, we report a case of complete remission of advanced PC induced by claudin18.2-targeted CAR-T cell therapy. The patient was a 72-year-old man who was diagnosed with pancreatic ductal adenocarcinoma 2 years ago, and he experienced tumor recurrence and multiple metastases after pancreaticoduodenectomy and multi-line chemotherapies, i...
Source: Frontiers in Immunology - February 29, 2024 Category: Allergy & Immunology Source Type: research

Re-challenge of immune checkpoint inhibitor pembrolizumab with concurrent tocilizumab after prior grade 3 pneumonitis
Ecancermedicalscience. 2023 Dec 8;17:1644. doi: 10.3332/ecancer.2023.1644. eCollection 2023.ABSTRACTImmune checkpoint inhibitors (ICIs) are associated with specific immune-related adverse events (irAEs) which are unique compared to cytotoxic chemotherapy. For life-threatening adverse events including grade 3 or more, permanent discontinuation of the ICIs is recommended, albeit without much robust evidence. Safe re-challenge of ICIs with concurrent immunosuppression has been reported with irAEs like gastrointestinal toxicity and arthritis. Here we present a case of a lady with undifferentiated pleomorphic sarcoma with progr...
Source: Ecancermedicalscience - February 28, 2024 Category: Cancer & Oncology Authors: Chitrakshi Nagpal Sameer Rastogi Shamim A Shamim Sneha Prakash Source Type: research

Prevention of bleomycin-induced pulmonary fibrosis by vaccination with the Tocilizumab mimotope
Volume 20, Issue 1, December 2024 . (Source: Human Vaccines and Immunotherapeutics)
Source: Human Vaccines and Immunotherapeutics - February 27, 2024 Category: Allergy & Immunology Authors: Jin GuoLin YangHaoming SongLi Baia Department of Cardiorespiratory Rehabilitation, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, Chinab Department of Nephrology, Shangh Source Type: research

CCR5/CXCR3 antagonist TAK-779 prevents diffuse alveolar damage of the lung in the murine model of the acute respiratory distress syndrome
Discussion: Our pre-clinical data suggest that TAK-779 is more effective than the administration of dexamethasone or the anti-IL6R therapeutic antibody tocilizumab, which brings novel therapeutic modality to TAK-779 and other CCR5 inhibitors for the treatment of virus-induced hyperinflammation syndromes, including COVID-19. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - February 21, 2024 Category: Drugs & Pharmacology Source Type: research

Cost-consequence analysis of tocilizumab versus adalimumab and etanercept among rheumatoid arthritis patients in Saudi Arabia: a single-center study
The study aimed to examine the direct medical cost and impact of tocilizumab (TOZ) versus adalimumab (ADM) and etanercept (ETC) on reducing the levels of two inflammatory markers (e.g., C-reactive protein (CRP... (Source: Cost Effectiveness and Resource Allocation)
Source: Cost Effectiveness and Resource Allocation - February 14, 2024 Category: Health Management Authors: Areej S. Albahdal, Amjad M. Alotaibi, Miteb A. Alanazi, Norah Abanmy, Monira Alwhaibi and Yazed AlRuthia Tags: Research Source Type: research

Optimal time of starting tocilizumab in acute phase of adult-onset Still ’s disease and comparison of its efficacy with that of methotrexate: a case series and a review of the literature
We examined the significance of TCZ in terms of therapeutic efficacy, reduction in glucocorticoid usage, and safety in patients with AOSD.•We compared the therapeutic efficacy of TCZ with that of MTX, which is often used to treat glucocorticoid-resistant AOSD.•TCZ is undoubtedly a valuable treatment option for AOSD, especially when administered at relapse, suggesting both high safety and good efficacy. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - February 12, 2024 Category: Rheumatology Source Type: research

Assessing medication use patterns by clinical outcomes severity among inpatients with COVID-19: A retrospective drug utilization study
CONCLUSIONS: The study highlights complex medication regimens in managing severe COVID-19, underscoring specific drug patterns associated with critical health outcomes. Further research is needed to explore these patterns.PMID:38340395 | DOI:10.1016/j.biopha.2024.116242 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 10, 2024 Category: Drugs & Pharmacology Authors: Renato Ferreira-da-Silva Priscila Maranh ão Cl áudia Camila Dias Jo ão Miguel Alves L ígia Pires Manuela Morato Jorge Junqueira Pol ónia In ês Ribeiro-Vaz Source Type: research

Systemic inflammation relates to neuroaxonal damage associated with long-term cognitive dysfunction in COVID-19 patients
DISCUSSION: Prolonged systemic inflammation in critically ill COVID-19 patients is related to neuroaxonal damage and subsequent long-term cognitive impairment. Moreover, our findings suggest that plasma NfL concentrations during ICU stay may possess prognostic value in predicting future long-term cognitive impairment in patients that survived severe COVID-19.PMID:38336025 | DOI:10.1016/j.bbi.2024.02.002 (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - February 9, 2024 Category: Neurology Authors: H B Duindam D Mengel M Kox J C G öpfert R P C Kessels M Synofzik P Pickkers W F Abdo Source Type: research

Clinical characteristics and treatment outcomes among the hospitalized elderly patients with COVID-19 during the late pandemic phase in central Taiwan
CONCLUSIONS: In the later stages of the pandemic, with widespread vaccination and advancements in COVID-19 treatments, outcomes for hospitalized elderly and oldest-old patients with COVID-19 have improved. The influence of age on in-hospital mortality has diminished, while comorbidities such as ESRD, cirrhosis, solid tumours, and hematologic malignancies have been associated with mortality.PMID:38326193 | DOI:10.1016/j.jmii.2024.01.006 (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - February 7, 2024 Category: Microbiology Authors: Chieh-Lung Chen Chi-Kang Teng Wei-Cheng Chen Shinn-Jye Liang Chih-Yen Tu Hong-Mo Shih Wan-Ju Cheng Yu-Chao Lin Po-Ren Hsueh Source Type: research

Inetetamab combined with pyrotinib and chemotherapy in the treatment of breast cancer brain metastasis: A case report
CONCLUSION: Inetetamab combined with small molecule TKI drugs, chemotherapy and radiation may be an effective regimen for maintaining stable disease in patients with BCBM.PMID:38322469 | PMC:PMC10841958 | DOI:10.12998/wjcc.v12.i3.575 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - February 7, 2024 Category: Cancer & Oncology Authors: Qing-Qing Dou Ting-Ting Sun Guo-Qiang Wang Wei-Bing Tong Source Type: research

Inetetamab combined with pyrotinib and chemotherapy in the treatment of breast cancer brain metastasis: A case report
CONCLUSION: Inetetamab combined with small molecule TKI drugs, chemotherapy and radiation may be an effective regimen for maintaining stable disease in patients with BCBM.PMID:38322469 | PMC:PMC10841958 | DOI:10.12998/wjcc.v12.i3.575 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - February 7, 2024 Category: Cancer & Oncology Authors: Qing-Qing Dou Ting-Ting Sun Guo-Qiang Wang Wei-Bing Tong Source Type: research

Relationship between earlier introduction of tocilizumab and glucocorticoid-sparing effects on the acute phase of adult-onset Still's disease
Scand J Rheumatol. 2024 Feb 5:1-4. doi: 10.1080/03009742.2024.2310358. Online ahead of print.NO ABSTRACTPMID:38314790 | DOI:10.1080/03009742.2024.2310358 (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - February 5, 2024 Category: Rheumatology Authors: R Yoshihara H Tsuchiya H Shoda K Fujio Source Type: research

Factors affecting prognosis and mortality in severe covid-19 pneumonia patients
Acta Clin Croat. 2023 Apr;62(1):106-114. doi: 10.20471/acc.2023.62.01.13.ABSTRACTFatality rate in coronavirus disease 2019 (COVID-19) cases has been reported to be 3.4% worldwide. The aim of this study was to evaluate the factors that determine prognosis and mortality in severe COVID-19 pneumonia patients. Eighty adult patients with severe COVID-19 pneumonia hospitalized and monitored at Izzet Baysal State Hospital (Bolu, Turkey) between August and November 2020 were included in this retrospective single-center study. Demographic and laboratory data, severity of radiological involvement, comorbidities, agents used in treat...
Source: Acta Clinica Croatica - February 2, 2024 Category: General Medicine Authors: Emine Af şin Muhammed Emin Demirkol Source Type: research