A case of spontaneous coronary artery dissection that later turned out to be Takayasu arteritis
J Cardiol Cases. 2024 Jan 16;29(4):186-189. doi: 10.1016/j.jccase.2023.12.009. eCollection 2024 Apr.ABSTRACTSpontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndrome (ACS), which typically occurs in women at low risk of atherosclerosis. We herein report a case of SCAD in a 57-year-old man who later developed Takayasu arteritis. The patient presented to our hospital complaining of chest pain and was diagnosed with unstable angina. Emergent coronary angiography was performed, and optical coherence tomography revealed that ACS was caused by SCAD. The patient was treated medically without further...
Source: Atherosclerosis - April 22, 2024 Category: Cardiology Authors: Takahiro Tezuka Hiroyoshi Mori Hiroki Nishiwaki Yosuke Takei Natsuki Taira Ayumi Omura Daisuke Wada Hiromoto Sone Kazuma Tashiro Tokutada Sato Yoshitaka Iso Mio Ebato Hiroshi Suzuki Source Type: research
Serum IL-6 level trajectory for predicting the effectiveness and safety of tocilizumab in the treatment of refractory Takayasu arteritis
CONCLUSIONS: The change of IL-6 levels after TCZ treatment for 6 months compared to the baseline can predict the overall treatment response at 12 months, 24 months and sustained improvement.PMID:38643043 | DOI:10.1016/j.ejim.2024.04.004 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - April 20, 2024 Category: Internal Medicine Authors: Xiaochuan Sun Chenglong Fang Shangyi Jin Jing Li Yunjiao Yang Xiaofeng Zeng Xinping Tian Source Type: research
A Case of Adult-onset Still's Disease (AOSD) with Gastrointestinal Lesions
Intern Med. 2024 Apr 16. doi: 10.2169/internalmedicine.3412-23. Online ahead of print.ABSTRACTA 51-year-old woman with fever was admitted to our hospital. A computed tomography (CT) scan showed thickened colonic walls. Colonoscopy revealed erosion in the ileum and colon. Adult-onset Still's disease (AOSD) was diagnosed due to a subsequent sore throat and skin rash. Following AOSD treatment, methylprednisolone pulse therapy, followed by prednisolone and cyclosporine, was initiated. Despite achieving a temporary improvement, relapse occurred with fever, abdominal pain, with worsening CT and endoscopic findings. The reappeara...
Source: Internal Medicine - April 17, 2024 Category: Internal Medicine Authors: Takahito Harada Yoshikazu Hirata Hayato Kawamura Yuki Yamamoto Yuka Kobayashi Daisuke Kumai Akihisa Adachi Yoshihito Nagura Hirokazu Ikeuchi Noriyuki Hayashi Hiroki Takada Satoshi Sobue Megumi Yoshida Source Type: research
Activation of the IL-6/STAT3 pathway contributes to the pathogenesis of membranous nephropathy and is a target for Mahuang Fuzi and Shenzhuo Decoction (MFSD) to repair podocyte damage
CONCLUSION: The IL-6/STAT3 signaling pathway is activated in podocytes of experimental membranous nephropathy. MFSD alleviates podocyte damage by inhibiting the IL-6/STAT3 pathway.PMID:38626520 | DOI:10.1016/j.biopha.2024.116583 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 16, 2024 Category: Drugs & Pharmacology Authors: Qihan Zhao Haoran Dai Hanxue Jiang Naiqian Zhang Fanyu Hou Yang Zheng Yu Gao Wenbin Liu Zhendong Feng Yuehong Hu Xinyue Tang Hongliang Rui Baoli Liu Source Type: research
Cancers, Vol. 16, Pages 1512: Outcome of Tocilizumab Treatment in Febrile Neutropenic Children with Severe Sepsis/Septic Shock in a Single-Center Retrospective Case Series
Conclusions: Administration of tocilizumab reduced mortality of severe sepsis/septic shock in children with febrile neutropenia. However, it warrants confirmation with a larger number of patients and a longer follow-up. (Source: Cancers)
Source: Cancers - April 16, 2024 Category: Cancer & Oncology Authors: Shih-Hsiang Chen Tsung-Yen Chang Yi-Lun Wang En-Pei Lee Jainn-Jim Lin Yi-Wen Hsiao Tang-Her Jaing Chao-Ping Yang Iou-Jih Hung Tags: Article Source Type: research
Efficacy of tocilizumab in patients with moderate-to-severe corticosteroid-resistant thyroid eye disease: a prospective study
ConclusionTCZ can treat active moderate-to-severe TED, showing high drug compliance and reasonable response to inflammation and extraocular motility abnormality. (Source: International Ophthalmology)
Source: International Ophthalmology - April 16, 2024 Category: Opthalmology Source Type: research
Efficacy of tocilizumab in patients with moderate-to-severe corticosteroid-resistant thyroid eye disease: a prospective study
CONCLUSION: TCZ can treat active moderate-to-severe TED, showing high drug compliance and reasonable response to inflammation and extraocular motility abnormality.PMID:38622479 | DOI:10.1007/s10792-024-03117-6 (Source: Herpes)
Source: Herpes - April 15, 2024 Category: Infectious Diseases Authors: Chaeyeon Lee Ji Woong Park Yoon-Duck Kim Kyung In Woo Source Type: research
Interleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis
AbstractDamage of the endothelial glycocalyx (eGC) plays a central role in the development of vascular hyperpermeability and organ damage during systemic inflammation. However, the specific signalling pathways for eGC damage remain poorly defined. Aim of this study was to combine sublingual video-microscopy, plasma proteomics and live cell imaging to uncover further pathways of eGC damage in patients with coronavirus disease 2019 (COVID-19) or bacterial sepsis. This secondary analysis of the prospective multicenter MICROCODE study included 22 patients with COVID-19 and 43 patients with bacterial sepsis admitted to intermed...
Source: Angiogenesis - April 10, 2024 Category: Molecular Biology Source Type: research
Current and emerging pharmacotherapies for cytokine release syndrome, neurotoxicity, and hemophagocytic lymphohistiocytosis-like syndrome due to CAR T cell therapy
Expert Opin Pharmacother. 2024 Apr 8. doi: 10.1080/14656566.2024.2340738. Online ahead of print.ABSTRACTINTRODUCTION: Chimeric antigen receptor (CAR) T cells have revolutionized treatment of multiple hematologic malignancies. Engineered cellular therapies now offer similar hope to transform management of solid tumors and autoimmune disease. However, toxicities can be serious and often require hospitalization.AREAS COVERED: We review the two chief toxicities of CAR T therapy, cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), and the rarer immune effector cell-associated hemo...
Source: Expert Opinion on Pharmacotherapy - April 8, 2024 Category: Drugs & Pharmacology Authors: Zandra E Walton Matthew J Frigault Marcela V Maus Source Type: research
Pharmacokinetics of Monoclonal Antibodies Throughout Pregnancy: A Systematic Literature Review
ConclusionAvailable information suggests that the anatomical and physiological changes throughout pregnancy may have meaningful effects on the PK of mAbs. For most mAbs (not IFX), modestly higher dosing (per mg) maybe needed during pregnancy to sustain a similar serum exposure compared to pre-pregnancy. (Source: Clinical Pharmacokinetics)
Source: Clinical Pharmacokinetics - April 7, 2024 Category: Drugs & Pharmacology Source Type: research
Therapeutic management of fibrosis in systemic sclerosis patients - an analysis from the Swiss EUSTAR cohort
CONCLUSION: Overall, in Switzerland, a wide range of medications is prescribed for systemic sclerosis patients. This includes modern, targeted treatments for which randomised controlled clinical trial have been recently reported.PMID:38579324 | DOI:10.57187/s.3630 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Kevin Windirsch Suzana Jordan Mike Oliver Becker Cosimo Bruni Rucsandra Dobrota Muriel Elhai Ion-Alexandru Garaiman Carmen-Marina Mihai Michele Iudici Paul Hasler Camillo Ribi Britta Maurer Armando Gabrielli Anna-Maria Hoffmann-Vold Oliver Distler Source Type: research
Therapeutic management of fibrosis in systemic sclerosis patients - an analysis from the Swiss EUSTAR cohort
CONCLUSION: Overall, in Switzerland, a wide range of medications is prescribed for systemic sclerosis patients. This includes modern, targeted treatments for which randomised controlled clinical trial have been recently reported.PMID:38579324 | DOI:10.57187/s.3630 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Kevin Windirsch Suzana Jordan Mike Oliver Becker Cosimo Bruni Rucsandra Dobrota Muriel Elhai Ion-Alexandru Garaiman Carmen-Marina Mihai Michele Iudici Paul Hasler Camillo Ribi Britta Maurer Armando Gabrielli Anna-Maria Hoffmann-Vold Oliver Distler Source Type: research
