Development of Pulmonary Alveolar Proteinosis in a Patient With Adult-Onset Still Disease Treated With Tocilizumab
We report a patient with systemic adult-onset Still disease (AOSD) who developed anti-granulocyte-macrophage colony-stimulating factor (GM-CSF)-positive pulmonary alveolar proteinosis (PAP) while using tocilizumab (TCZ), diagnosed by milky white bronchoalveolar lavage fluid (BALF; Figure 1). To our knowledge, this is the first case of PAP in AOSD.PMID:35970533 | DOI:10.3899/jrheum.220128 (Source: J Rheumatol)
Source: J Rheumatol - August 15, 2022 Category: Rheumatology Authors: Yuhei Ito Hiroki Nakahara Ayako Nakajima Source Type: research

Can Patients with Controlled Rheumatoid Arthritis Taper Methotrexate from Targeted Therapy and Sustain Remission? A Systematic Review and Meta-analysis
CONCLUSION: Patients with controlled RA may taper MTX from targeted therapy with a 10% reduction in ability to sustain remission, for up to 18 months. Longer follow-up studies with attention to radiographic, functional and patient-reported outcomes are needed. The risk of disease worsening should be discussed with the patient with careful follow-up and prompt retreatment of disease worsening.PMID:35970524 | DOI:10.3899/jrheum.220152 (Source: J Rheumatol)
Source: J Rheumatol - August 15, 2022 Category: Rheumatology Authors: Charis F Meng Diviya A Rajesh Deanna P Jannat-Khah Bridget Jivanelli Vivian Bykerk Source Type: research

Cancer-associated fibroblast-like fibroblasts in vocal fold leukoplakia suppress CD8 < sup > + < /sup > T cell functions by inducing IL-6 autocrine loop and interacting with Th17 cells
Cancer Lett. 2022 Aug 9:215839. doi: 10.1016/j.canlet.2022.215839. Online ahead of print.ABSTRACTThe characteristics of fibroblast cells in head and neck precancerous lesion and its ability to secrete inflammatory cytokines and affect CD8+T cell functions remain unclear. Herein, we reported the existence of fibroblasts in human-derived vocal fold leukoplakia (VFL) with positive staining of fibroblast activation protein (FAP) and α-smooth muscle actin (α-SMA). The fibroblasts from VFL and cancer-associated fibroblasts (CAFs) from head and neck squamous cell carcinoma (HNSCC) displayed similar cellular functions and robust...
Source: Cancer Control - August 12, 2022 Category: Cancer & Oncology Authors: Yi Fang Min Chen Guangfei Li Yue Yang Peijie He Jian Chen Lei Cheng Haitao Wu Source Type: research

118 Acute disseminated encephalomyelitis associated with SARS-CoV-2 vaccine in multiple sclerosis: a case report
Conclusions A number of SARS-CoV-2 vaccines have now been associated with ADEM, but this risk still appears very low in comparison with risks of SARS-CoV-2 infection. This is the first reported case of ADEM in a patient with multiple sclerosis after SARS-CoV-2 vaccination. Literature suggests increased risk of multiple sclerosis exacerbations commonly after SARS-CoV-2 infection. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - August 12, 2022 Category: Neurosurgery Authors: Evans, M., Hanbury, G., Lim, E., Dixon, L., Singh-Curry, V., Nicholas, R. Tags: Poster presentations Source Type: research

063 The role of Monoclonal antibodies in contrasting cases of NORSE
1. A 42-year-old female developed status ten days following admission for alcohol-related liver disease. MRI brain showed symmetrical medial temporal high signal. No cause was identified. Though the convulsive seizures settled, focal seizures persisted. A second MRI showed extensive multi- lobar signal change, presumed inflammatory in nature. Pulsed methylprednisolone and plasma exchange were ineffective. Tocilizumab was administered ten weeks following onset of seizures. Sequential MRIs showed resolution of inflammatory changes. The patient was discharged to rehabilitation- Modified Rankin Score 3. 2. A 79-year-old female...
Source: Journal of Neurology, Neurosurgery and Psychiatry - August 12, 2022 Category: Neurosurgery Authors: Samarasekera, S., Lightning, T. Tags: Poster presentations Source Type: research

More evidences on which biologic and which pathway is key in severe-critical COVID-19 pneumonia
I read with great interest the paper by Della Torre et al on the effects of sarilumab in severe acute respiratory syndrome coronavirus 2 severe-critical pneumonia. They show that sarilumab treated and standard of care (SOC) treated patients present a mortality rate which is statistically not different (n 28 SARI=7% vs n 28 SOC=18%; p=NS).1 These data confirm previous data from the same group; when analysing patients treated with tocilizumab, they showed no statistically significant differences (n 33 SOC=33%, mortality vs tocilizumab (TOCI) n 32=16%, p=NS).2 These data seem to suggest that interleukin (IL)-6 is not the main...
Source: Annals of the Rheumatic Diseases - August 11, 2022 Category: Rheumatology Authors: Ferraccioli, G. Tags: ARD, COVID-19 Correspondence Source Type: research

Response to: 'More evidences on which biologic and which pathway is key in severe-critical COVID-19 pneumonia by Ferraccioli
We thank Prof Ferraccioli for his positive comments on our open-label trials with sarilumab, tocilizumab, anakinra and mavrilimumab in patients with severe hyperinflamed COVID-191–4 and for remarking the unprecedented opportunity offered by our studies to better understand the relative contribution of different targetable inflammatory pathways to the pathogenesis of severe COVID-19.5 The study designs we adopted should be definitely interpreted in light of the scientific data that progressively became available and of the course of the pandemic wave that struck Northern Italy and our Institution. Between 24 February ...
Source: Annals of the Rheumatic Diseases - August 11, 2022 Category: Rheumatology Authors: Della-Torre, E., Campochiaro, C., Cavalli, G., De Luca, G., Ciceri, F., Zangrillo, A., Dagna, L. Tags: ARD, COVID-19 Correspondence response Source Type: research

Treatment of patients with inflammatory rheumatic diseases with rituximab should be carefully considered during the SARS-CoV-2/COVID-19 pandemic. Response to: 'Persistence of rT-PCR-SARS-CoV-2 infection and delayed serological response, as a possible effect of rituximab according to the hypothesis of Schulze-Koops et al by Benucci et al
We thank Dr Benucci et al for their comments1 on our report on fatalities of patients with inflammatory rheumatic diseases (IRDs) treated with rituximab (RTX) during the SARS-CoV-2/COVID-19 pandemic.2 The authors present a case of COVID-19 in a patient with myositis treated with RTX, who required assisted ventilation and eventually recovered after intensive care including invasive ventilation and medication with remdesivir, dexamethason and tocilizumab. While emphasising the potential of RTX to lead to severe courses of COVID-19, a particularly interesting aspect of the report is the complete absence of antibodies to SARS-...
Source: Annals of the Rheumatic Diseases - August 11, 2022 Category: Rheumatology Authors: Schulze-Koops, H., Krueger, K., Vallbracht, I. V., Hasseli, R., Skapenko, A. Tags: ARD, COVID-19 Correspondence response Source Type: research

Clinical Profile and Outcome of Coronavirus Disease-2019 Pneumonia in Kidney Transplant Recipients: A Single-center Study from Western India
Saudi J Kidney Dis Transpl. 2021 Nov-Dec;32(6):1679-1688. doi: 10.4103/1319-2442.352429.ABSTRACTCoronavirus disease-2019 (COVID-19) has become a public health concern and global threat with high morbidity and mortality among kidney transplant recipients. However, risk factors and manifestations in this group of patients remain poorly understood. We aimed to study the clinical characteristics, laboratory parameters, and disease course of kidney transplant recipients with COVID-19 pneumonia. We enrolled 35 kidney transplant patients with COVID-19 pneumonia from March 2020 to November 2020 and studied their clinical records, ...
Source: Saudi Journal of Kidney Diseases and Transplantation - August 10, 2022 Category: Urology & Nephrology Authors: Mital Dipakkumar Parikh Maulin Kamalkumar Shah Jekishan Jayeshbhai Hirapara Bhalendu Vaishnav Samir Patel Abhishek M Prajapati Dhaval Prajapati Rachit J Patel Source Type: research

Clinical Profile and Outcome of Coronavirus Disease-2019 Pneumonia in Kidney Transplant Recipients: A Single-center Study from Western India
Saudi J Kidney Dis Transpl. 2021 Nov-Dec;32(6):1679-1688. doi: 10.4103/1319-2442.352429.ABSTRACTCoronavirus disease-2019 (COVID-19) has become a public health concern and global threat with high morbidity and mortality among kidney transplant recipients. However, risk factors and manifestations in this group of patients remain poorly understood. We aimed to study the clinical characteristics, laboratory parameters, and disease course of kidney transplant recipients with COVID-19 pneumonia. We enrolled 35 kidney transplant patients with COVID-19 pneumonia from March 2020 to November 2020 and studied their clinical records, ...
Source: Saudi Journal of Kidney Diseases and Transplantation - August 10, 2022 Category: Urology & Nephrology Authors: Mital Dipakkumar Parikh Maulin Kamalkumar Shah Jekishan Jayeshbhai Hirapara Bhalendu Vaishnav Samir Patel Abhishek M Prajapati Dhaval Prajapati Rachit J Patel Source Type: research

Clinical Profile and Outcome of Coronavirus Disease-2019 Pneumonia in Kidney Transplant Recipients: A Single-center Study from Western India
Saudi J Kidney Dis Transpl. 2021 Nov-Dec;32(6):1679-1688. doi: 10.4103/1319-2442.352429.ABSTRACTCoronavirus disease-2019 (COVID-19) has become a public health concern and global threat with high morbidity and mortality among kidney transplant recipients. However, risk factors and manifestations in this group of patients remain poorly understood. We aimed to study the clinical characteristics, laboratory parameters, and disease course of kidney transplant recipients with COVID-19 pneumonia. We enrolled 35 kidney transplant patients with COVID-19 pneumonia from March 2020 to November 2020 and studied their clinical records, ...
Source: Saudi Journal of Kidney Diseases and Transplantation - August 10, 2022 Category: Urology & Nephrology Authors: Mital Dipakkumar Parikh Maulin Kamalkumar Shah Jekishan Jayeshbhai Hirapara Bhalendu Vaishnav Samir Patel Abhishek M Prajapati Dhaval Prajapati Rachit J Patel Source Type: research

Clinical Profile and Outcome of Coronavirus Disease-2019 Pneumonia in Kidney Transplant Recipients: A Single-center Study from Western India
Saudi J Kidney Dis Transpl. 2021 Nov-Dec;32(6):1679-1688. doi: 10.4103/1319-2442.352429.ABSTRACTCoronavirus disease-2019 (COVID-19) has become a public health concern and global threat with high morbidity and mortality among kidney transplant recipients. However, risk factors and manifestations in this group of patients remain poorly understood. We aimed to study the clinical characteristics, laboratory parameters, and disease course of kidney transplant recipients with COVID-19 pneumonia. We enrolled 35 kidney transplant patients with COVID-19 pneumonia from March 2020 to November 2020 and studied their clinical records, ...
Source: Saudi Journal of Kidney Diseases and Transplantation - August 10, 2022 Category: Urology & Nephrology Authors: Mital Dipakkumar Parikh Maulin Kamalkumar Shah Jekishan Jayeshbhai Hirapara Bhalendu Vaishnav Samir Patel Abhishek M Prajapati Dhaval Prajapati Rachit J Patel Source Type: research

Clinical Profile and Outcome of Coronavirus Disease-2019 Pneumonia in Kidney Transplant Recipients: A Single-center Study from Western India
Saudi J Kidney Dis Transpl. 2021 Nov-Dec;32(6):1679-1688. doi: 10.4103/1319-2442.352429.ABSTRACTCoronavirus disease-2019 (COVID-19) has become a public health concern and global threat with high morbidity and mortality among kidney transplant recipients. However, risk factors and manifestations in this group of patients remain poorly understood. We aimed to study the clinical characteristics, laboratory parameters, and disease course of kidney transplant recipients with COVID-19 pneumonia. We enrolled 35 kidney transplant patients with COVID-19 pneumonia from March 2020 to November 2020 and studied their clinical records, ...
Source: Saudi Journal of Kidney Diseases and Transplantation - August 10, 2022 Category: Urology & Nephrology Authors: Mital Dipakkumar Parikh Maulin Kamalkumar Shah Jekishan Jayeshbhai Hirapara Bhalendu Vaishnav Samir Patel Abhishek M Prajapati Dhaval Prajapati Rachit J Patel Source Type: research

Effect of interleukin-6 receptor antagonists in critically ill adult patients with COVID-19 pneumonia: two randomised controlled trials of the CORIMUNO-19 Collaborative Group
Conclusion In critically ill patients with COVID-19, anti-IL-6 receptors did not significantly increase the number of patients alive without any NIV or MV by day 14. (Source: European Respiratory Journal)
Source: European Respiratory Journal - August 10, 2022 Category: Respiratory Medicine Authors: Hermine, O., Mariette, X., Porcher, R., Resche-Rigon, M., Tharaux, P.-L., Ravaud, P., on behalf of the CORIMUNO-19 Collaborative Group Tags: Respiratory infections and tuberculosis Original Articles: Respiratory infection and COVID-19 Source Type: research

Evolving nonvasodilator treatment options for pulmonary arterial hypertension
Purpose of review With the establishment of vasodilator therapy as a mainstay of treatment for pulmonary arterial hypertension (PAH), new therapeutic approaches are needed to prevent the development of the vasculopathy associated with this disease. Many studies are currently underway to investigate nonvasodilator treatment options. Recent findings Modulation of bone morphogenic protein receptor type 2 (BMPR2) signaling with sotatercept showed promising results in phase 2 studies. Rituximab, an anti-CD20 monoclonal antibody, showed some signal for beneficial effect in patients with scleroderma-associated PAH. Stu...
Source: Current Opinion in Pulmonary Medicine - August 9, 2022 Category: Respiratory Medicine Tags: DISORDERS OF THE PULMONARY CIRCULATION: Edited by Christopher King and Oksana A. Shlobin Source Type: research