Deciphering key genes involved in cisplatin resistance in kidney renal clear cell carcinoma through a combined < em > in silico < /em > and < em > in vitro < /em > approach
Oncol Res. 2023 Sep 15;31(6):899-916. doi: 10.32604/or.2023.030760. eCollection 2023.ABSTRACTThe low survival rate of Kidney renal clear cell carcinoma (KIRC) patients is largely attributed to cisplatin resistance. Rather than focusing solely on individual proteins, exploring protein-protein interactions could offer greater insight into drug resistance. To this end, a series of in silico and in vitro experiments were conducted to identify hub genes in the intricate network of cisplatin resistance-related genes in KIRC chemotherapy. The genes involved in cisplatin resistance across KIRC were retrieved from the National Cent...
Source: Cell Research - September 25, 2023 Category: Cytology Authors: Muneeba Malik Mamoona Maqbool Tooba Nisar Tazeem Akhter Javed Ahmed Ujan Alanood S Algarni Fakhria A Al Joufi Sultan Shafi K Alanazi Mohammad Hadi Almotared Mounir M Salem Bekhit Muhammad Jamil Source Type: research

Deciphering key genes involved in cisplatin resistance in kidney renal clear cell carcinoma through a combined < em > in silico < /em > and < em > in vitro < /em > approach
Oncol Res. 2023 Sep 15;31(6):899-916. doi: 10.32604/or.2023.030760. eCollection 2023.ABSTRACTThe low survival rate of Kidney renal clear cell carcinoma (KIRC) patients is largely attributed to cisplatin resistance. Rather than focusing solely on individual proteins, exploring protein-protein interactions could offer greater insight into drug resistance. To this end, a series of in silico and in vitro experiments were conducted to identify hub genes in the intricate network of cisplatin resistance-related genes in KIRC chemotherapy. The genes involved in cisplatin resistance across KIRC were retrieved from the National Cent...
Source: Oncology Research - September 25, 2023 Category: Cancer & Oncology Authors: Muneeba Malik Mamoona Maqbool Tooba Nisar Tazeem Akhter Javed Ahmed Ujan Alanood S Algarni Fakhria A Al Joufi Sultan Shafi K Alanazi Mohammad Hadi Almotared Mounir M Salem Bekhit Muhammad Jamil Source Type: research