Oral Psoriasis Therapies
Oral psoriasis therapies include both older traditional immunosuppressants, such as methotrexate, cyclosporine, and acitretin, as well as newer, more targeted agents, such as apremilast, deucravacitinib, and oral interleukin-23 receptor antagonists. Patients may prefer oral therapies to injectable therapies based on the route of administration. Both older and newer oral psoriasis therapies can be utilized effectively in the treatment of psoriasis. Here, we will review oral agents used in the treatment of psoriasis as well as provide commentary on their role in our current, evolving psoriasis treatment paradigm. (Source: Dermatologic Clinics)
Source: Dermatologic Clinics - April 3, 2024 Category: Dermatology Authors: JaBreia James, Tracey Otto, Julia Gao, Martina L. Porter Source Type: research

Successful treatment of generalized pustular psoriasis with guselkumab
Conclusions: Our results support the evidence that guselkumab could provide an effective therapeutic approach in the treatment of GPP.PMID:38522861 | DOI:10.1080/09546634.2024.2331807 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 24, 2024 Category: Dermatology Authors: Martina Part Source Type: research

Successful Treatment of Refractory Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome with Baricitinib, a Janus Kinase Inhibitor
Clin Cosmet Investig Dermatol. 2024 Mar 4;17:529-537. doi: 10.2147/CCID.S446468. eCollection 2024.ABSTRACTSynovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome, a rare immune-mediated inflammatory disease, poses diagnostic and therapeutic challenges owing to its multi-system involvement, high heterogeneity, and lack of specific laboratory tests. Additionally, lacking evidence-based treatment recommendations, with the primary approach focusing on symptomatic relief. Herein, we report the case of a 32-year-old Chinese woman who presented with recurrent, generalized multiple osteoarticular pain lasting over...
Source: Clinical, Cosmetic and Investigational Dermatology - March 11, 2024 Category: Dermatology Authors: Jianqiu Yang Chunyu Yuan Shengru Zhou Zhicheng Teng Min Li Source Type: research

Oral Psoriasis —An Overlooked Entity: Current Paradigms and Future Perspectives
AbstractPurpose of ReviewPsoriasis is a chronic, genetically determined, scaly, and inflammatory disease of the skin. Pathogenesis is multi-factorial, involving dysregulated inflammation and genetic associations. Cutaneous lesions are characterized as thick, erythematous, all-around defined plaques covered with a silvery white scale. Commonly affected areas include the elbows, knees, sacral area, and scalp. One of the factors that may result in the appearance of psoriatic lesions may be the oral cavity lesions. Aim of the present article was to review the effects of psoriasis on oral cavity, histopathological investigation...
Source: Current Dermatology Reports - March 2, 2024 Category: Dermatology Source Type: research

Acitretin Treatment Improves a Case of Severe Generalized Epidermodysplasia Verruciformis
A man in his 20s had a 15-year history of generalized hyperkeratotic wart –like plaques. Small warty papules appeared first on his hands in childhood and gradually spread over his body, merging into many large hyperkeratotic plaques and ridges during several years (Supplemental Figure 1, available online at http://www.mayoclinicproceedings.org). The fingernails and toe nails took on a coral or dendritic shape (Figure 1). Hand and foot function and quality of life were significantly impaired. The remainder of his family has no history of similar conditions. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 1, 2024 Category: Internal Medicine Authors: Jun-Cheng Liu, Si-Tan Dong, Dong-Mei Shi Tags: Medical image Source Type: research

Successful treatment of acrodermatitis continua of Hallopeau coexisting with generalized pustular psoriasis with spesolimab: a case report
We report an Asian patient with a 16-year-history of GPP and ACH with marked pustulosis on the nail bed and onychodystrophy. He received conventional systemic regimen acitretin, cyclosporine and biologics adalimumab and secukinumab, but experienced relapse for skin lesions and refractory for nail lesions. He was then treated with a single dose of spesolimab in combination with secukinumab, which resulted in skin clearance and nearly complete resolution of nail lesions over a 32-week period. Our observation suggests that spesolimab should be considered for the treatment of ACH, especially in the patients with intractable na...
Source: Frontiers in Immunology - February 23, 2024 Category: Allergy & Immunology Source Type: research

[[Translated article]]Progressive Kinking of the Hair and Pili Torti Secondary to Acitretin
Actas Dermosifiliogr. 2024 Feb 6:S0001-7310(24)00085-1. doi: 10.1016/j.ad.2023.01.029. Online ahead of print.NO ABSTRACTPMID:38331171 | DOI:10.1016/j.ad.2023.01.029 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - February 8, 2024 Category: Dermatology Authors: M Ballesteros-Redondo L Fern ández-Domper E Montesinos-Villaescusa Source Type: research

Resolution of Pityriasis rubra pilaris induced ectropion with oral dexamethasone. A case report
Orbit. 2024 Feb 6:1-3. doi: 10.1080/01676830.2024.2311657. Online ahead of print.ABSTRACTAn 82-year-old male presented with generalised Pityriasis rubra pilaris (PRP) managed initially by dermatology team. The patient did not respond to first- and second-line treatment, including oral acitretin, steroid creams, and methotrexate, and developed bilateral cicatricial ectropion, for which he was referred to oculoplastic team for surgical management. A head injury resulting in subacute subdural haematoma, managed with a week course of low dose oral dexamethasone, resulted in the improvement of his skin condition and complete re...
Source: Orbit - February 6, 2024 Category: Opthalmology Authors: Ourania Fydanaki Haytham Rezq Anastasios E Sepetis Varajini Joganathan Source Type: research

Efficacy of alitretinoin in the treatment of Darier disease: a case report
We report the case of a female patient with Darier disease that was unsuccessfully treated with acitretin and isotretinoin but showed significant improvement with alitretinoin. Previous reports on the efficacy of alitretinoin in Darier disease are reviewed.PMID:38126103 (Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica)
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - December 21, 2023 Category: Dermatology Authors: Andreja Pagon Mateja Dolenc Volj č Source Type: research