Gastrointestinal dysfunction in the valproic acid induced model of social deficit in rats
Auton Neurosci. 2024 Feb 29;253:103161. doi: 10.1016/j.autneu.2024.103161. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) has increased in incidence over the past several decades, and is associated with a range of co-morbidities including gastrointestinal (GI) dysfunctions including gastroesophageal reflux, abdominal pain, bloating, constipation and/or diarrhea. Several animal models have been used that replicate several aspects of ASD but no single model has been able to replicate the entire disease pathophysiology. In humans, prenatal exposure to valproic acid (VPA) has been identified as a significant risk...
Source: Autonomic Neuroscience - March 10, 2024 Category: Neuroscience Authors: Ashley N Varley Kirsteen N Browning Source Type: research

Gastrointestinal dysfunction in the valproic acid induced model of social deficit in rats
Auton Neurosci. 2024 Feb 29;253:103161. doi: 10.1016/j.autneu.2024.103161. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) has increased in incidence over the past several decades, and is associated with a range of co-morbidities including gastrointestinal (GI) dysfunctions including gastroesophageal reflux, abdominal pain, bloating, constipation and/or diarrhea. Several animal models have been used that replicate several aspects of ASD but no single model has been able to replicate the entire disease pathophysiology. In humans, prenatal exposure to valproic acid (VPA) has been identified as a significant risk...
Source: Autonomic Neuroscience - March 10, 2024 Category: Neuroscience Authors: Ashley N Varley Kirsteen N Browning Source Type: research

Blockade of aryl hydrocarbon receptor restricts omeprazole-induced chronic kidney disease
We described the process of renal injury after exposure to OME in mice; the early renal injury markers were increased in renal tubular epithelial cells (RTECs). And after long-term OME treatment, the OME-induced CKD mice model was established. Herein, aryl hydrocarbon receptor (AHR) translocation appeared after exposure to OME in HK-2 cells. Then for both in vivo and in vitro, we found that Ahr-knockout (KO) and AHR small interfering RNA (siRNA) substantially alleviated the OME-induced renal function impairment and tubular cell damage. Furthermore, our data demonstrate that antagonists of AHR and CYP1A1 could attenuate OME...
Source: Journal of Molecular Medicine - March 8, 2024 Category: Molecular Biology Source Type: research

Design, synthesis, α-amylase and glucose diffusion inhibition, and molecular docking studies of new indenopyrazolones bearing benzothiazole derivatives
Bioorg Med Chem Lett. 2024 Mar 5:129692. doi: 10.1016/j.bmcl.2024.129692. Online ahead of print.ABSTRACTAn eco-friendly facile synthesis of a series of twenty 1-(4/6-substitutedbenzo[d]thiazol-2-yl)-3-(phenyl/substitutedphenyl)indeno[1,2-c]pyrazol-4(1H)-ones 7a-t was achieved by the reaction of 2-(benzoyl/substitutedbenzoyl)-(1H)-indene-1,3(2H)-dione 3a-t and 2-hydrazinyl-4/6-substitutedbenzo[d]thiazole 6a-t in presence of freshly dried ethanol and glacial acetic acid under reflux conditions in good yields. The newly synthesized derivatives were well characterized using different physical and spectral techniques (FTIR, 1H ...
Source: Bioorganic and Medicinal Chemistry Letters - March 7, 2024 Category: Chemistry Authors: Ravinder Punia Satbir Mor Suchita Sindhu Deepak Kumar Priyanku Pradip Das Deepak Kumar Jindal Ashwani Kumar Rajni Mohil Komal Jakhar Source Type: research

Blockade of aryl hydrocarbon receptor restricts omeprazole-induced chronic kidney disease
We described the process of renal injury after exposure to OME in mice; the early renal injury markers were increased in renal tubular epithelial cells (RTECs). And after long-term OME treatment, the OME-induced CKD mice model was established. Herein, aryl hydrocarbon receptor (AHR) translocation appeared after exposure to OME in HK-2 cells. Then for both in vivo and in vitro, we found that Ahr-knockout (KO) and AHR small interfering RNA (siRNA) substantially alleviated the OME-induced renal function impairment and tubular cell damage. Furthermore, our data demonstrate that antagonists of AHR and CYP1A1 could attenuate OME...
Source: Molecular Medicine - March 7, 2024 Category: Molecular Biology Authors: Nan Sun Yimeng Zhang Lin Ding Xin An Fang Bai Yanjiang Yang Kuipeng Yu Jiahui Fan Lei Liu Huimin Yang Xiangdong Yang Source Type: research

Design, synthesis, α-amylase and glucose diffusion inhibition, and molecular docking studies of new indenopyrazolones bearing benzothiazole derivatives
Bioorg Med Chem Lett. 2024 Mar 5:129692. doi: 10.1016/j.bmcl.2024.129692. Online ahead of print.ABSTRACTAn eco-friendly facile synthesis of a series of twenty 1-(4/6-substitutedbenzo[d]thiazol-2-yl)-3-(phenyl/substitutedphenyl)indeno[1,2-c]pyrazol-4(1H)-ones 7a-t was achieved by the reaction of 2-(benzoyl/substitutedbenzoyl)-(1H)-indene-1,3(2H)-dione 3a-t and 2-hydrazinyl-4/6-substitutedbenzo[d]thiazole 6a-t in presence of freshly dried ethanol and glacial acetic acid under reflux conditions in good yields. The newly synthesized derivatives were well characterized using different physical and spectral techniques (FTIR, 1H ...
Source: Molecular Medicine - March 7, 2024 Category: Molecular Biology Authors: Ravinder Punia Satbir Mor Suchita Sindhu Deepak Kumar Priyanku Pradip Das Deepak Kumar Jindal Ashwani Kumar Rajni Mohil Komal Jakhar Source Type: research

Design, synthesis, α-amylase and glucose diffusion inhibition, and molecular docking studies of new indenopyrazolones bearing benzothiazole derivatives
Bioorg Med Chem Lett. 2024 Mar 5:129692. doi: 10.1016/j.bmcl.2024.129692. Online ahead of print.ABSTRACTAn eco-friendly facile synthesis of a series of twenty 1-(4/6-substitutedbenzo[d]thiazol-2-yl)-3-(phenyl/substitutedphenyl)indeno[1,2-c]pyrazol-4(1H)-ones 7a-t was achieved by the reaction of 2-(benzoyl/substitutedbenzoyl)-(1H)-indene-1,3(2H)-dione 3a-t and 2-hydrazinyl-4/6-substitutedbenzo[d]thiazole 6a-t in presence of freshly dried ethanol and glacial acetic acid under reflux conditions in good yields. The newly synthesized derivatives were well characterized using different physical and spectral techniques (FTIR, 1H ...
Source: Bioorganic and Medicinal Chemistry Letters - March 7, 2024 Category: Chemistry Authors: Ravinder Punia Satbir Mor Suchita Sindhu Deepak Kumar Priyanku Pradip Das Deepak Kumar Jindal Ashwani Kumar Rajni Mohil Komal Jakhar Source Type: research

Design, synthesis, α-amylase and glucose diffusion inhibition, and molecular docking studies of new indenopyrazolones bearing benzothiazole derivatives
Bioorg Med Chem Lett. 2024 Mar 5;103:129692. doi: 10.1016/j.bmcl.2024.129692. Online ahead of print.ABSTRACTAn eco-friendly facile synthesis of a series of twenty 1-(4/6-substitutedbenzo[d]thiazol-2-yl)-3-(phenyl/substitutedphenyl)indeno[1,2-c]pyrazol-4(1H)-ones 7a-t was achieved by the reaction of 2-(benzoyl/substitutedbenzoyl)-(1H)-indene-1,3(2H)-dione 3a-t and 2-hydrazinyl-4/6-substitutedbenzo[d]thiazole 6a-t in presence of freshly dried ethanol and glacial acetic acid under reflux conditions in good yields. The newly synthesized derivatives were well characterized using different physical and spectral techniques (FTIR,...
Source: Bioorganic and Medicinal Chemistry Letters - March 7, 2024 Category: Chemistry Authors: Ravinder Punia Satbir Mor Suchita Sindhu Deepak Kumar Priyanku Pradip Das Deepak Kumar Jindal Ashwani Kumar Rajni Mohil Komal Jakhar Source Type: research

Design, synthesis, α-amylase and glucose diffusion inhibition, and molecular docking studies of new indenopyrazolones bearing benzothiazole derivatives
Bioorg Med Chem Lett. 2024 Mar 5;103:129692. doi: 10.1016/j.bmcl.2024.129692. Online ahead of print.ABSTRACTAn eco-friendly facile synthesis of a series of twenty 1-(4/6-substitutedbenzo[d]thiazol-2-yl)-3-(phenyl/substitutedphenyl)indeno[1,2-c]pyrazol-4(1H)-ones 7a-t was achieved by the reaction of 2-(benzoyl/substitutedbenzoyl)-(1H)-indene-1,3(2H)-dione 3a-t and 2-hydrazinyl-4/6-substitutedbenzo[d]thiazole 6a-t in presence of freshly dried ethanol and glacial acetic acid under reflux conditions in good yields. The newly synthesized derivatives were well characterized using different physical and spectral techniques (FTIR,...
Source: Bioorganic and Medicinal Chemistry Letters - March 7, 2024 Category: Chemistry Authors: Ravinder Punia Satbir Mor Suchita Sindhu Deepak Kumar Priyanku Pradip Das Deepak Kumar Jindal Ashwani Kumar Rajni Mohil Komal Jakhar Source Type: research

Design, synthesis, α-amylase and glucose diffusion inhibition, and molecular docking studies of new indenopyrazolones bearing benzothiazole derivatives
Bioorg Med Chem Lett. 2024 Mar 5;103:129692. doi: 10.1016/j.bmcl.2024.129692. Online ahead of print.ABSTRACTAn eco-friendly facile synthesis of a series of twenty 1-(4/6-substitutedbenzo[d]thiazol-2-yl)-3-(phenyl/substitutedphenyl)indeno[1,2-c]pyrazol-4(1H)-ones 7a-t was achieved by the reaction of 2-(benzoyl/substitutedbenzoyl)-(1H)-indene-1,3(2H)-dione 3a-t and 2-hydrazinyl-4/6-substitutedbenzo[d]thiazole 6a-t in presence of freshly dried ethanol and glacial acetic acid under reflux conditions in good yields. The newly synthesized derivatives were well characterized using different physical and spectral techniques (FTIR,...
Source: Bioorganic and Medicinal Chemistry Letters - March 7, 2024 Category: Chemistry Authors: Ravinder Punia Satbir Mor Suchita Sindhu Deepak Kumar Priyanku Pradip Das Deepak Kumar Jindal Ashwani Kumar Rajni Mohil Komal Jakhar Source Type: research

10-year follow-up results of the European Achalasia Trial: a multicentre randomised controlled trial comparing pneumatic dilation with laparoscopic Heller myotomy
Conclusions PD and LHM are equally effective even after 10 years of follow-up with limited risk to develop gastro-oesophageal reflux. Based on these data, we conclude that PD and LHM can both be proposed as initial treatment of achalasia. (Source: Gut)
Source: Gut - March 7, 2024 Category: Gastroenterology Authors: Boeckxstaens, G., Elsen, S., Belmans, A., Annese, V., Bredenoord, A. J., Busch, O. R., Costantini, M., Fumagalli, U., Smout, A. J. P. M., Tack, J., Vanuytsel, T., Zaninotto, G., Salvador, R. Tags: Gut Oesophagus Source Type: research

A Mendelian randomization analysis identifies causal association between sarcopenia and gastroesophageal reflux disease
In conclusion, this MR analysis supported the causal association between sarcopenia-related traits and GERD.PMID:38446595 | DOI:10.18632/aging.205627 (Source: Aging)
Source: Aging - March 6, 2024 Category: Biomedical Science Authors: Renwang Hu Can Liu Dan Li Source Type: research

Are night-time respiratory symptoms assessed by asthma control test affected by comorbidities?
CONCLUSIONS: These results confirm and extend previous findings showing that there is a higher likelihood that underlying unknown sleep disturbances worsen asthma control, suggesting that a more comprehensive assessment is necessary to clarify the cause of nocturnal symptoms in asthma.PMID:38446620 | DOI:10.1080/02770903.2024.2327036 (Source: Journal of Asthma)
Source: Journal of Asthma - March 6, 2024 Category: Respiratory Medicine Authors: Alida Benfante Alessandra Tomasello Chiara Caponetto Salvatore Battaglia Nicola Scichilone Source Type: research

A Mendelian randomization analysis identifies causal association between sarcopenia and gastroesophageal reflux disease
In conclusion, this MR analysis supported the causal association between sarcopenia-related traits and GERD.PMID:38446595 | DOI:10.18632/aging.205627 (Source: Aging)
Source: Aging - March 6, 2024 Category: Biomedical Science Authors: Renwang Hu Can Liu Dan Li Source Type: research

Are night-time respiratory symptoms assessed by asthma control test affected by comorbidities?
CONCLUSIONS: These results confirm and extend previous findings showing that there is a higher likelihood that underlying unknown sleep disturbances worsen asthma control, suggesting that a more comprehensive assessment is necessary to clarify the cause of nocturnal symptoms in asthma.PMID:38446620 | DOI:10.1080/02770903.2024.2327036 (Source: Journal of Asthma)
Source: Journal of Asthma - March 6, 2024 Category: Respiratory Medicine Authors: Alida Benfante Alessandra Tomasello Chiara Caponetto Salvatore Battaglia Nicola Scichilone Source Type: research