Altered Microbial Transcription in Long-term Proton Pump Inhibitor Use: Findings From a United States Cohort Study
Proton pump inhibitors (PPIs) are commonly prescribed to reduce gastric hydrochloric acid to treat disorders related to acid exposure, including gastroesophageal reflux disease (GERD) and peptic ulcer disease.1 Although PPIs are often prescribed for long-term use and generally considered safe, their functional impact on the gut microbiome, which may have implications for long-term health, is not fully understood. Their mechanism of action may exert evolutionary pressure on gut microbial communities through altered host immunity, increased gastric pH, and disruption of the gastric acid barrier. (Source: Gastroenterology)
Source: Gastroenterology - March 21, 2024 Category: Gastroenterology Authors: Hanseul Kim, Etienne Nzabarushimana, Curtis Huttenhower, Andrew T. Chan, Long H. Nguyen Tags: Research Letter Source Type: research
Laryngeal Dysfunction Manifesting as Chronic Refractory Cough and Dyspnea Laryngeal Physiology in Respiratory Health and Disease
Chest. 2024 Mar 18:S0012-3692(24)00396-9. doi: 10.1016/j.chest.2024.03.026. Online ahead of print.ABSTRACTTOPIC IMPORTANCE: Laryngeal dysfunction as a cause of chronic refractory cough (CRC) and episodic dyspnea is often missed which results in unnecessary testing and delays in diagnosis. Understanding laryngeal roles in breathing and airway protection can help to appreciate the propensity to laryngeal dysfunction with aging, chronic lung disease and sleep apnea.REVIEW FINDINGS: The human larynx is a complex muscular structure that undertakes multiple roles of breathing, vocalization, coughing and swallowing. To undertake ...
Source: Chest - March 20, 2024 Category: Respiratory Medicine Authors: Krishna M Sundar Amanda Stark Michael J Morris Source Type: research
Causal relationship between irritability and asthma: a bidirectional two-sample Mendelian randomization study
CONCLUSION: The causal relationship between irritability and asthma was analyzed through MR analysis. Irritability increased the risk of asthma. GERD might play an important mediating role in this relationship.PMID:38506573 | DOI:10.1080/15257770.2024.2330594 (Source: Nucleosides, Nucleotides and Nucleic Acids)
Source: Nucleosides, Nucleotides and Nucleic Acids - March 20, 2024 Category: Biochemistry Authors: Xiaoying Lu Xu Hu Ling Wang Source Type: research
