Outcome of peroral endoscopic myotomy in children with achalasia
ConclusionPOEM is a safe, effective, and durable treatment for achalasia in children. However, GER is a potential concern and should be evaluated in prospective studies before adopting POEM for the management of achalasia in children. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - October 17, 2019 Category: Surgery Source Type: research

Reduction in Hospitalizations for Esophageal Reflux in a Decade with Minimal Increases in Other Functional and Motor Disorders
AbstractBackgroundFunctional and motility disorders (FMDs) are common conditions that cause significant morbidity and economic loss. A comprehensive analysis of these disorders and their impact has not been done in an inpatient setting.AimsWe seek to evaluate adult hospitalization trends for FMDs in the USA.MethodsThe National Inpatient Sample between 2005 and 2014 was analyzed. Poisson regression was used to assess hospitalization trends for FMDs referenced to non-FMD hospitalizations. Linear regression was used to assess cost per hospitalization and length of stay (LOS). All models were adjusted for age, sex, primary ins...
Source: Digestive Diseases and Sciences - October 16, 2019 Category: Gastroenterology Source Type: research

Esophageal High-Resolution Manometry Can Unravel the Mechanisms by Which Different Bariatric Techniques Produce Different Reflux Exposures
AbstractIntroductionBariatric surgery is increasingly performed. Since there are numerous surgical techniques, the effects of these on the esophageal function are still poorly understood. We aimed at assessing the effect of different techniques on esophagogastric junction (EGJ), esophageal peristalsis and reflux exposure using high-resolution manometry (HRM), and impedance-pH monitoring (MII-pH).MethodsAll obese patients underwent symptomatic questionnaires, endoscopy, HRM, and MII-pH before and 1  year after surgery. Esophageal function and EGJ were classified according to Chicago Classification V. 3.0. Intragastric ...
Source: Journal of Gastrointestinal Surgery - October 16, 2019 Category: Surgery Source Type: research

Obstructive Sleep Apnea in Children With Autism
Conclusions:The absence of demographic or clinical predictors of OSA supports using general indications for PSG in children with ASD.Citation:Tomkies A, Johnson RF, Shah G, Caraballo M, Evans P, Mitchell RB. Obstructive sleep apnea in children with autism.J Clin Sleep Med. 2019;15(10):1469–1476. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - October 15, 2019 Category: Sleep Medicine Source Type: research

Clinical outcomes of gastroesophageal reflux disease-related chronic cough following antireflux fundoplication
ConclusionsAntireflux surgery, although less predictable, is effective for the treatment of gastroesophageal reflux disease-related chronic cough. (Source: Esophagus)
Source: Esophagus - October 15, 2019 Category: Gastroenterology Source Type: research

Statins and gastroesophageal reflux disease: A meta-analysis
Conclusions: The current meta-analysis found that the risk of GERD was numerically lower among statin users although the pooled result did not reach statistical significance. Therefore, more studies are still needed to further clarify this potential benefit of statins. (Source: Journal of Postgraduate Medicine)
Source: Journal of Postgraduate Medicine - October 14, 2019 Category: Internal Medicine Authors: K Wijarnpreecha P Panjawatanan L Leelasinjaroen P Ungprasert Source Type: research

Post-reflux swallow-induced peristaltic wave index and mean nocturnal baseline impedance predict PPI response in GERD patients with extra esophageal symptoms
Mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave (PSPW) index are able to increase the diagnostic yield of impedance-pH and are associated to proton pump inhibitor (PPI) response. Few data concerning these variables in patients with extra-esophageal symptoms (EES) are available. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 14, 2019 Category: Gastroenterology Authors: Mentore Ribolsi, Michele Pier Luca Guarino, Alessandro Tullio, Michele Cicala Tags: Alimentary Tract Source Type: research

Associations between the severity of reflux esophagitis in children and changes in oxidative stress, serum inflammation, vasoactive intestinal peptide and motilin.
Authors: Deng Y, Pan L, Qian W Abstract Changes in the levels of serum oxidative stress indexes, gastrointestinal hormones and inflammatory factors in children with different severity of reflux esophagitis (RE) were detected. Sixty child patients diagnosed with gastroesophageal reflux disease (GERD) via gastroscopy were selected and divided into non-erosive reflux disease group (NERD group, n=12) and RE group (n=48) according to whether there was esophageal mucosal injury. In RE group, the patients were further divided into grade I RE group (n=15), grade II RE group (n=18) and grade III RE group (n=15) based on the...
Source: Experimental and Therapeutic Medicine - October 12, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Peroral endoscopic myotomy for esophageal motility disorders
ConclusionsPOEM can be a new option for the treatment of esophageal movement disorders, but large sample, multi-center, long-term study reports are needed, and it promotes the development of NOTES technology. (Source: Esophagus)
Source: Esophagus - October 12, 2019 Category: Gastroenterology Source Type: research

Personal, academic and stress correlates of gastroesophageal Reflux Disease among college students in southwestern Saudi Arabia: A cross-section study
ConclusionGERD is a prevalent problem among college students in southwestern Saudi Arabia as it affects about one third of the students. Considering high prevalence of GERD, associated daily life impacts, young age of the studied subject and the risk of future complications, this condition could represent a challenging health and economic problem. The risk of GERD is higher among; males, smokers, former smokers, non-health care colleges students and subjects exposed to high perceived stress. (Source: Annals of Medicine and Surgery)
Source: Annals of Medicine and Surgery - October 11, 2019 Category: General Medicine Source Type: research

Phase 4 Study in Patients From Asia With Gastroesophageal Reflux Disease Treated With Dexlansoprazole.
Conclusions: In Asian patients with GERD, treatment with dexlansoprazole modified-release indicates a favorable efficacy and safety profile in relieving heartburn and acid regurgitation symptoms. PMID: 31597230 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 11, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

4D spatiotemporal evolution of liquid spray using kilohertz-rate x-ray computed tomography
Four-dimensional (x,y,z,t) x-ray computed tomography was demonstrated in an optically complex spray using an imaging system consisting of ... (Source: Optics Letters)
Source: Optics Letters - October 10, 2019 Category: Physics Authors: B. R. Halls N. Rahman M. N. Slipchenko J. W. James A. McMaster M. D. A. Ligthfoot J. R. Gord T. R. Meyer Source Type: research

Regarding epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux
We read with interest the recent article by Perotin et al. [1], which investigated epithelial dysregulation in obese severe asthma patients with gastro-oesophageal reflux. The researchers found that bronchial epithelial gene expression, sampled by airway brushing, identified an endotype defined by epithelial dysregulation associated with obesity, gastro-oesophageal reflux and use of proton pump inhibitors (OGP cluster). Relative to non-asthmatic healthy controls, pathway signature analysis indicated that the wingless tail (WNT)/β-catenin pathway was the top epithelial pathway dysregulated in the OGP cluster. The clust...
Source: European Respiratory Journal - October 10, 2019 Category: Respiratory Medicine Authors: Ward, C., Kharaba, Z. J. Tags: Original Articles: Correspondence Source Type: research

Regarding epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux
We thank C. Ward and Z.J. Kharaba for their interesting comments on the OGP endotype of severe asthma that we recently described [1]. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 10, 2019 Category: Respiratory Medicine Authors: Perotin, J.-M., Djukanovic, R., Davies, D. E. Tags: Original Articles: Correspondence Source Type: research

Chronic Obstructive Pulmonary Disease and the Risk of Esophagitis, Barrett’s Esophagus, and Esophageal Adenocarcinoma: A Primary Care Case-Control Study
Background: Chronic gastroesophageal reflux predisposes to the development of esophageal adenocarcinoma (EAC). Asthma and medication to treat it are associated with gastroesophageal reflux and EAC. We studied subjects with chronic obstructive pulmonary disease (COPD) to examine the relationship between COPD and medication used to treat it, and the risk of reflux esophagitis, Barrett’s esophagus, and EAC. Methods: A case-control study from the UK General Practice Research Database was conducted. Cases were aged 50 or above with a diagnosis of COPD and were matched with controls without a diagnosis of COPD by age,...
Source: Journal of Clinical Gastroenterology - October 9, 2019 Category: Gastroenterology Tags: ONLINE ARTICLES: Original Articles Source Type: research

Association of Vitamin D and Parathyroid Hormone With Barrett’s Esophagus
Conclusions: Contrary to our hypothesis, we found an inverse association between serum PTH and Barrett’s esophagus. Validation of the finding and the mechanism of that association deserves further study. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - October 9, 2019 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

[The value of DMSA scintigraphy in the diagnostic evaluation of vesicoureteric reflux].
Abstract In terms of treatment planning, the radiologic phenomenon of vesicoureteric reflux has become less important than its inherent risk of further urinary tract infections and loss of renal function. Whilst radiologic and sonographic voiding cystourethrography continues to be the gold standard in the mere detection of vesicoureteric reflux, dimercaptosuccinic acid scanning is important for risk stratification. Also it serves to confirm renal involvement in uncertain situations with urinary tract infection and fever. In older children, it is the standard in primary diagnostics. Furthermore, it enables the diag...
Source: Aktuelle Urologie - October 9, 2019 Category: Urology & Nephrology Authors: Haid B Tags: Aktuelle Urol Source Type: research

Role of Esophageal Mean Nocturnal Baseline Impedance and Post-reflux Swallow-induced Peristaltic Wave Index in Discriminating Chinese Patients With Heartburn.
Authors: Sun YM, Gao Y, Gao F Abstract Background/Aims: Recently, esophageal mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave (PSPW) index have been proposed, which can increase the diagnostic role of multichannel intraluminal impedance and pH recording (MII/pH) for differentiating patients with heartburn. Therefore, our aim is to investigate the role of esophageal proximal MNBI, distal MNBI, and PSPW index in differentiating Chinese patients with heartburn. Methods: Patients with heartburn from the Beijing Anzhen Hospital, who underwent upper gastrointestinal endoscopy ...
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Esophageal Motor Dysfunctions in Gastroesophageal Reflux Disease and Therapeutic Perspectives.
Authors: Lin S, Li H, Fang X Abstract Gastroesophageal reflux disease (GERD) is a very common disease, and the prevalence in the general population has recently increased. GERD is a chronic relapsing disease associated with motility disorders of the upper gastrointestinal tract. Several factors are implicated in GERD, including hypotensive lower esophageal sphincter, frequent transient lower esophageal sphincter relaxation, esophageal hypersensitivity, reduced resistance of the esophageal mucosa against the refluxed contents, ineffective esophageal motility, abnormal bolus transport, deficits initiating secondary p...
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Mechanism Underlying the Formation of a Cluster of Metabolic Syndrome.
CONCLUSIONS: The paper demonstrates that the autonomic dysfunction of nervous system (on a par with insulin resistance) is the main link in the development of MetS. This provides the basis for including the mentioned states - cardiac autonomic neuropathy, lower urinary tract symptoms and gastroesophageal reflux disease - into the MetS cluster. PMID: 31589129 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 8, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Concurrent Magnetic Sphincter Augmentation and Hiatal Hernia Repair for Refractory GERD Following Laparoscopic Sleeve Gastrectomy
Gastroesophageal reflux disease (GERD) has a reported incidence of between 10 to 20% in western populations with an even higher incidence in populations with obesity (1). The vast majority of patients are managed medically with surgical intervention undertaken in those with recalcitrant GERD. Populations with obesity and recalcitrant GERD who are interested in weight loss surgery have historically undergone Laparoscopic Roux En Y Gastric Bypass (LRYGB). De Goot et al in their 2009 meta-analysis demonstrated improvement in GERD in people with obesity following LRYGB(2). (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 8, 2019 Category: Surgery Authors: Gordian U. Ndubizu, Anthony T. Petrick, Ryan Horsley Source Type: research

Concurrent magnetic sphincter augmentation and hiatal hernia repair for refractory GERD after laparoscopic sleeve gastrectomy
Gastroesophageal reflux disease (GERD) has a reported incidence of between 10% and 20% in Western populations with an even higher incidence in populations with obesity [1]. The vast majority of patients are managed medically with surgical intervention undertaken in those with recalcitrant GERD. Populations with obesity and recalcitrant GERD who are interested in weight loss surgery have historically undergone laparoscopic Roux-en-Y gastric bypass (LRYGB). De Goot et  al. [2], in their 2009 meta-analysis, demonstrated improvement in GERD in people with obesity after LRYGB. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 8, 2019 Category: Surgery Authors: Gordian U. Ndubizu, Anthony T. Petrick, Ryan Horsley Tags: Video case report Source Type: research

Therapeutic Options for Early Cancer of the Esophagogastric Junction
Publication date: Available online 6 October 2019Source: Cirugía Española (English Edition)Author(s): Félix Junquera, Sonia Fernández-Ananín, Carmen BalaguéAbstractEarly-stage (T1) esophagogastric junction cancer continues to represent 2%–3% of all cases. Adenocarcinoma is the most frequent and important type, the main risk factors for which are gastroesophageal reflux and Barrett's esophagus with dysplasia.Patients with mucosal (T1a) or submucosal (T1b) involvement initially require a thorough digestive endoscopy, and narrow-band imaging can improve visualization. Endoscopic...
Source: Cirugia Espanola - October 7, 2019 Category: Surgery Source Type: research

Prevalence and characterization of chronic rhinosinusitis in patients with non ‒cystic fibrosis bronchiectasis at a tertiary care center in the United States
BackgroundChronic rhinosinusitis (CRS) is associated with bronchiectasis; however, this relationship has not been well studied in the United States (US) population. In this work we aimed to determine the prevalence of CRS among patients with bronchiectasis affiliated with a US tertiary medical center and identify which comorbid diseases are associated with the presence of CRS in patients with bronchiectasis.MethodsThis was a retrospective cohort study in which data were obtained from a large database warehouse at a tertiary care center. Patients with bronchiectasis were identified from 2007 to 2017 using diagnosis codes fr...
Source: International Forum of Allergy and Rhinology - October 7, 2019 Category: Allergy & Immunology Authors: Shaan N. Somani, Jason H. Kwah, Chen Yeh, David B. Conley, Leslie C. Grammer, Robert C. Kern, Michelle Prickett, Robert P. Schleimer, Stephanie S. Smith, Whitney W. Stevens, Bruce K. Tan, Kevin C. Welch, Anju T. Peters Tags: ORIGINAL ARTICLE Source Type: research

Botox Injection into the Lower Esophageal Sphincter Induces Hiatal Paralysis and Gastroesophageal Reflux.
CONCLUSION: ISIB, in addition to decreasing LES pressure, paralyzes the esophageal hiatus (crural diaphragm) and induces GER. PMID: 31589467 [PubMed - as supplied by publisher] (Source: American Journal of Physiology. Gastrointestinal and Liver Physiology)
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - October 7, 2019 Category: Physiology Authors: Kumar D, Zifan A, Mittal RK Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Esophagitis After Bariatric Surgery: Large Cross-sectional Assessment of an Endoscopic Database
ConclusionEE is more prevalent after SG compared with RYGB in a pre-bariatric surgery cohort with GERD. SG is associated with significant esophageal physiologic changes conducive to GERD and its clinical consequences. (Source: Obesity Surgery)
Source: Obesity Surgery - October 4, 2019 Category: Surgery Source Type: research

Clinical, Endoscopic, and Histologic Findings at the Distal Esophagus and Stomach Before and Late (10.5  Years) After Laparoscopic Sleeve Gastrectomy: Results of a Prospective Study with 93% Follow-Up
ConclusionsPatients submitted to LSG showed a significant and progressive increase in the presence of “de novo” GERD. Also, an increased duodenogastric reflux was seen through an open and immobile pylorus. Therefore, based on these results, it seems like LSG is a “pro-reflux” surgical procedure, which should be continuously evaluated late after surgery. (Source: Obesity Surgery)
Source: Obesity Surgery - October 3, 2019 Category: Surgery Source Type: research

Isorhamnetin alleviates esophageal mucosal injury in a chronic model of reflux esophagitis.
In conclusion, isorhamnetin attenuated esophageal mucosal injury in rats with chronic RE, possibly by suppressing formation of cytokines and infiltration of inflammatory cells, inhibiting p38 and NFκB pathways, and enhancing HO-1 activity. PMID: 31586635 [PubMed - as supplied by publisher] (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - October 3, 2019 Category: Drugs & Pharmacology Authors: Liu G, Jiang C, Li D, Yao L, Lin Y, Guo B, Qiu J, Wang W, Wang W Tags: Eur J Pharmacol Source Type: research

Barrett's esophagus: "All diseases are divine and all are human".
In conclusion, BE may have two different presentations: environmental ("human", reflux) or sporadic BE, which is the most common form, and genetic ("divine", inherited) or familiar BE, less common but with a greater risk for malignancy. As they might be two different diseases, surveillance programs and treatments should also be different. PMID: 31566411 [PubMed - as supplied by publisher] (Source: Revista Espanola de Enfermedades Digestivas)
Source: Revista Espanola de Enfermedades Digestivas - October 2, 2019 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

CSACI position statement: Newer generation H1-antihistamines are safer than first-generation H1-antihistamines and should be the first-line antihistamines for the treatment of allergic rhinitis and urticaria
Oral H1-antihistamines (AHs) are the most commonly used therapy to treat allergic rhinitis and chronic urticaria. Older, first-generation AHs (e.g. diphenhydramine, hydroxyzine) have significant and common side e... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - October 1, 2019 Category: Allergy & Immunology Authors: Michael N. Fein, David A. Fischer, Andrew W. O ’Keefe and Gord L. Sussman Tags: Review Source Type: research

Effects of Laparoscopic Sleeve Gastrectomy on Quality of Life Related to Gastroesophageal Reflux Disease
Journal of Laparoendoscopic&Advanced Surgical Techniques, Ahead of Print. (Source: Journal of Laparoendoscopic)
Source: Journal of Laparoendoscopic - October 1, 2019 Category: Surgery Authors: Andrea Balla Silvia Quaresima Livia Palmieri Ardit Seitaj Annamaria Pronio Danilo Badiali Abe Fingerhut Pietro Ursi Alessandro M. Paganini Source Type: research

Effects of Laparoscopic Sleeve Gastrectomy on Quality of Life Related to Gastroesophageal Reflux Disease
Journal of Laparoendoscopic&Advanced Surgical Techniques, Ahead of Print. (Source: Journal of Laparoendoscopic and Advanced Surgical Techniques)
Source: Journal of Laparoendoscopic and Advanced Surgical Techniques - October 1, 2019 Category: Surgery Authors: Andrea Balla Silvia Quaresima Livia Palmieri Ardit Seitaj Annamaria Pronio Danilo Badiali Abe Fingerhut Pietro Ursi Alessandro M. Paganini Source Type: research

Thickened Feedings for Infants with Gastroesophageal Reflux.
PMID: 31573169 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - October 1, 2019 Category: Primary Care Authors: Finck A, Morris L Tags: Am Fam Physician Source Type: research

Is there any relation between connective tissue growth factor and scar tissue in vesicoureteral reflux?
Ş Abstract Gültekin ND, Benzer M, Tekin-Neijmann Ş. Is there any relation between connective tissue growth factor and scar tissue in vesicoureteral reflux. Turk J Pediatr 2019; 61: 71-78. Vesicoureteral reflux (VUR) is the most common uropathy in childhood which leads to increased frequency of urinary tract infection (UTI) and renal scarring. Connective tissue growth factor (CTGF) plays an important role in the development of glomerular and tubulointerstitial fibrosis in progressive kidney diseases. The aim of this study was to investigate the relation between urinary CTGF and renal damage resulted from VU...
Source: The Turkish Journal of Pediatrics - September 29, 2019 Category: Pediatrics Authors: Gültekin ND, Benzer M, Tekin-Neijmann Ş Tags: Turk J Pediatr Source Type: research

Cough presentation in primary care and the identification of chronic cough: a need for diagnostic clarity?
Conclusions: The prevalence of CC was lower than reported in previous studies. People with possible CC had higher rates of underlying conditions associated with CC. These observations may suggest poor recognition and/or under-recording of CC in primary care. PMID: 31558053 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 29, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Changing etiological frequency of chronic cough in a tertiary hospital in Shanghai, China.
This study aimed to investigate the changing etiological frequency of chronic cough in a tertiary hospital in Shanghai, China, and to explore the clinical significance. Methods: Medical records of 1,311 patients with chronic cough who visit our hospital between January 2009 and December 2016 were retrospectively reviewed. The etiologies of chronic cough were identified according to a standardized step-by-step diagnostic protocol and the changes in the etiological frequency of chronic cough over the years were using the Chi-squared (χ2) test. Results: Cough variant asthma (CVA) (449/1,311, 34.2%), gastroesophage...
Source: Journal of Thoracic Disease - September 28, 2019 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

The “Silk Road”: A Novel Method for Inserting Transpyloric Feeding Tubes in Low Resource Settings
Transpyloric tube (TPT) feeding is used in a multitude of conditions including gastroesophageal reflux disease. We here describe a new simple method to insert TPTs. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - September 28, 2019 Category: Surgery Authors: Mahmood Kaddah, Naser El-mefleh, Muhammad Eyad Ba'Ath Tags: Case Series Source Type: research

Value of Exhaled Nitric Oxide and FEF25-75 in Identifying Factors Associated With Chronic Cough in Allergic Rhinitis.
CONCLUSIONS: NAEB, CVA, and UACS are common causes of chronic cough in patients with AR. FeNO can first be used to discriminate patients with CVA/NAEB, then FEF25-75 (or combined with FeNO) can further discriminate patients with CVA from those with CVA/NAEB. PMID: 31552718 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - September 27, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Contribution of magnetic resonance imaging to the management of esophageal diseases: A systematic review
ConclusionMR Esophagography might become a non-invasive, non-irradiating technique of choice following diagnostic esophagogastroduodenoscopy for the assessment of esophageal diseases. (Source: European Journal of Radiology)
Source: European Journal of Radiology - September 27, 2019 Category: Radiology Source Type: research

Does acid reflux precipitate ischaemia in subjects with acute coronary syndrome?
CONCLUSIONS: Although GORD is common in subjects with ACS, we have not been able to show that GORD may serve as a trigger for ischaemia in these subjects. PMID: 31591635 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - September 27, 2019 Category: Cardiology Authors: George SK, Tlou B, Ponnusamy S, Naidoo DP Tags: Cardiovasc J Afr Source Type: research

Statement for gastroesophageal reflux disease after peroral endoscopic myotomy from an international multicenter experience
AbstractIt has been 10  years since peroral endoscopic myotomy (POEM) was reported for the first time, and POEM has currently become the standard treatment for achalasia and related disorders globally because it is less invasive and has a higher curative effect than conventional therapeutic methods. However, there are li mited studies comparing the long-term outcomes of POEM with those of conventional therapeutic methods, particularly in the occurrence of gastroesophageal reflux disease (GERD) after therapy. With this background, we held a consensus meeting to discuss the pathophysiology and management of GERD after P...
Source: Esophagus - September 26, 2019 Category: Gastroenterology Source Type: research

Is the stomach a way to one's heart? Gastric autonomic activity and AF susceptibility in gastroesophageal reflux disease
Journal of Cardiovascular Electrophysiology, EarlyView. (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - September 25, 2019 Category: Cardiology Authors: Varun Malik, Dennis H Lau, Dominik Linz, Melissa E. Middeldorp, Prashanthan Sanders Tags: EDITORIAL – INVITED Source Type: research

An Apparent Large Pericardial Effusion: A Consequence of Dual Antiplatelet Therapy or an Entirely Different Diagnosis?
A 71-YEAR-OLD, 67 kg, 170 cm man presented to the authors ’ institution for evaluation of atypical chest pain of 6 months duration. The patient described his chest discomfort as relatively mild. It seldomly persisted for more than a few seconds; was confined to the left chest without radiation; and was not related to activity, position, or breathing. He denied dysphagia, odynophagia, and symptoms of gastroesophageal reflux disease. The patient had a history of chronic atrial fibrillation and peripheral vascular disease for which he received chronic dual antiplatelet therapy (apixaban and clopidogrel). (Source: Journa...
Source: Journal of Cardiothoracic and Vascular Anesthesia - September 24, 2019 Category: Anesthesiology Authors: Paul S. Pagel, Hana T. Millen, Trevor S. Peterson, Sweeta D. Gandhi, Nicole L. Lohr, G. Hossein Almassi Tags: Diagnostic Dilemma Source Type: research

4-Carboxyphenylboronic acid-decorated, redox-sensitive rod-shaped nano-micelles fabricated through co-assembling strategy for active targeting and synergistic co-delivery of camptothecin and gemcitabine.
Abstract To achieve redox-controlled and tumor active targeting synergistic self-delivery of camptothecin and gemcitabine, redox-sensitive rod-shaped nano-micelles are fabricated through co-assembling between camptothecin-disulfide bond-PEG2000-4-carboxyphenylboronic acid and camptothecin-disulfide bond-gemcitabine conjugate. Most of all, for multidrug resistant cancer cell line MCF-7/ADR which is more resistant against CPT, increasing content of CPT in the formulation is favorable for synergistic effect of CPT and GEM drug combination. Benefiting from simple co-assembling strategy, it is easy and convenient to ad...
Source: European Journal of Pharmaceutics and Biopharmaceutics - September 24, 2019 Category: Drugs & Pharmacology Authors: Xu Y, Huang Y, Lu W, Liu S, Xiao Y, Yu J Tags: Eur J Pharm Biopharm Source Type: research

Laryngotracheal Stenosis Management: A 16-Year Experience.
Abstract In recent years, it has become increasingly apparent that the laryngotracheal stenosis (LTS) cohort comprises distinct etiological subgroups; however, treatment of the disease remains heterogeneous with limited research to date assessing predictors of treatment outcome. We aim to assess clinical and surgical predictors of endoscopic treatment outcome for LTS, as well as to further characterize the disease population. A retrospective chart review of adult patients with LTS presenting over a 16-year period was conducted. Seventy-five patients were identified and subdivided into 4 etiologic subgroups: iatrog...
Source: Ear, Nose and Throat Journal - September 23, 2019 Category: ENT & OMF Authors: Woliansky J, Paddle P, Phyland D Tags: Ear Nose Throat J Source Type: research

Chinese Medicine JQ Granule Combined with Half-dose Omeprazole for Nonerosive Reflux Disease: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial Study Protocol
This study will evaluate in a large, independent, randomized controlled trial (RCT) the comparative effectiveness of a specific type of Chinese herbal granule with half-dose PPI and full-dose PPI in managing nonerosive reflux disease.Methods and analysisThis trial will be a multicenter, randomized, double-blind, placebo-controlled RCT. A total of 204 participants will be enrolled and randomized (1:1) to each group: herb granules plus 10 mg omeprazole plus 10 mg dummy omeprazole; and dummy herb granules plus 20 mg omeprazole. The efficacy measures will be the changes in scores in the Gastroesophageal Re...
Source: European Journal of Integrative Medicine - September 22, 2019 Category: Complementary Medicine Source Type: research

Review article: Contribution of magnetic resonance imaging to the management of esophageal diseases: a systematic review
ConclusionMR Esophagography might become a non-invasive, non-irradiating technique of choice following diagnostic esophagogastroduodenoscopy for the assessment of esophageal diseases. (Source: European Journal of Radiology)
Source: European Journal of Radiology - September 22, 2019 Category: Radiology Source Type: research

Eosinophilic esophagitis in children: current knowledge to open new horizons.
Authors: Alterio T, Cardile S, Trayers C, Valenti S, Loddo I, Mardare R, Mosca A, Nobili V Abstract Eosinophilic Esophagitis (EoE) is a chronic immune/antigen-mediated condition which is also driven by genetic and environmental factors. It has been deeply investigated over the last years and its incidence is widely increasing in childhood. Although atopic diseases are closely linked with EoE, it does not recognize a classical IgE-mediate immune pathogenesis but it is rather a T helper type 2 inflammatory process. Familial clustering supports genetic predisposition in EoE and recent advances in understanding the gen...
Source: Scandinavian Journal of Gastroenterology - September 21, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Reflux esophagitis, functional and non-functional
Publication date: Available online 17 September 2019Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Serhat BorAbstractThe pathogenesis of gastroesophageal reflux disease has been explained by acid-peptic model. However, related with the progress of the diagnostic modalities, another phenotypical group of patients were defined and called “functional disorders of the esophagus”. These patients are important because diagnosis is particularly difficult, co-morbid disorders especially psychiatric diseases are common, proton pump inhibitor response is low, and surgical results are very poor. ...
Source: Best Practice and Research Clinical Gastroenterology - September 21, 2019 Category: Gastroenterology Source Type: research

Management of Gastroesophageal Reflux Disease in the Elderly Patient
AbstractGastroesophageal reflux disease (GERD) is an especially common disorder in the elderly population. Its presentation in this population is often different  from that in younger patients. A greater proportion of patients experience atypical GERD symptoms rather than heartburn or regurgitation, increasing the likelihood the diagnosis will be missed or overlooked. Elderly patients more commonly present with severe erosive esophagitis and GERD complicati ons compared with younger patients, and thus may require more aggressive therapy. While diagnostic work-up and management of GERD in elderly patients is similar to...
Source: Drugs and Aging - September 21, 2019 Category: Geriatrics Source Type: research