Thiolation of Arabinoxylan and Its Application in the Fabrication of pH.
Authors: Ijaz H, Tulain UR, Azam F, Qureshi J Abstract Current research work conducted to synthesize Thiol modifiedarabinoxylan and its application in fabrication of hydrogel. Thioglycolic acid was esterified with arabinoxylan to prepare Thiolatedarabinoxylan. Appearance of peak at 2533.34cm-1 in FTIR and thiol content showed successful thiolation. pH dependent Thiolatedarabinoxylan/acrylic acid(TAX/AA) hydrogels of perindopril erbumine was prepared via free-radical co-polymerization. Perindopril erbumine (PE) was employed as model drug. Different bathes with different feed ratio of TAX, AA and MBA were prepared an...
Source: Drug Development and Industrial Pharmacy - January 16, 2019 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

The Influence of Microneedles on the Percutaneous Penetration of Selected Antihypertensive Agents: Diltiazem Hydrochloride and Perindopril Erbumine.
Abstract It is well documented in the scientific literature that high blood pressure can lead to cardiovascular disease. Untreated hypertension has clinical consequences such as coronary artery disease, stroke or kidney failure. Diltiazem hydrochloride (DH), a calcium-channel blocker, and perindopril erbumine (PE), an inhibitor of the angiotensin converting enzyme are used for the management of hypertension. This project will examine the effect of microneedle rollers on the transport of DH and PE across pig ear skin. The use of the transcutaneous route of administration reduces and in sometimes eliminates the trau...
Source: Current Drug Delivery - July 30, 2018 Category: Drugs & Pharmacology Authors: Luu E, Ita KB, Morra MJ, Popova IE Tags: Curr Drug Deliv Source Type: research

Perindopril Arginine and Amlodipine Besylate for Hypertension: A Safety Evaluation.
Authors: Elliott WJ, Bistrika EA Abstract INTRODUCTION: Controlling blood pressure is a global health priority; single-pill antihypertensive combinations may improve adherence, persistence, and outcomes. Areas Covered: A novel combination of perindopril arginine and amlodipine besylate was recently approved. A systematic review of the literature revealed its most common adverse effects as: peripheral edema (depending on the dose of amlodipine, but attenuated by perindopril), cough, dizziness and hypotension. Dose-dependent hyperkalemia, impairment of renal function (especially in renovascular hypertension), angioed...
Source: Expert Opinion on Drug Safety - October 28, 2017 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

Abstract P100: Bioavailability of Arginine versus Erbumine Formulations of Perindopril in Healthy Subjects [Session Title: Onsite Poster Competition I With Reception]
Perindopril is an angiotensin converting-enzyme inhibitor with a proven track record in cardiovascular clinical trials. Traditionally formulated as the t-butyl amine (“erbumine”) salt, perindopril’s arginine salt has been FDA-approved in combination with amlodipine besylate. The arginine salt has the advantage of being more stable at higher temperatures or humidity.To demonstrate bioequivalence (using the standard FDA definition of 90% confidence intervals that are within 80-125% of the values seen with the reference product), the bioavailability of the two perindopril formulations was compared. After scr...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Andrew Bishop Tags: Poster Abstract Presentations Source Type: research

Efficacy and Safety of Perindopril Arginine + Amlodipine in Hypertension
To study the efficacy and safety of a new combination of perindopril arginine and amlodipine besylate, 837 subjects were enrolled in a three-arm, prospective, 59-center, randomized clinical trial. For 42 days, subjects (average seated blood pressure [BP] 158±12/101±5 mm Hg, age 52±10 years, 52% male, 34% black, 20% diabetic) received amlodipine/perindopril arginine (10/14 mg/d), perindopril erbumine 16 mg/d, or amlodipine 10 mg/d. Goal BP was
Source: Journal of the American Society of Hypertension - January 29, 2015 Category: Cardiology Authors: William J. Elliott, Jennifer Whitmore, Jeffrey D. Feldstein, George L. Bakris Source Type: research

Transdermal delivery of Angiotensin Converting Enzyme Inhibitors.
Abstract The Angiotensin Converting Enzyme (ACE) inhibitor class of drugs has been in clinical use since the 1970's for the management of all grades of heart failure, hypertension, diabetic nephropathy and prophylaxis of cardiovascular events. Because of the advantages associated with transdermal delivery compared with oral delivery many researchers have investigated the skin as a portal for administration of ACE inhibitors. This review summarises the various studies reported in the literature describing the development and evaluation of transdermal formulations of ACE inhibitors. Captopril, enalapril maleate, lis...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 20, 2014 Category: Drugs & Pharmacology Authors: Helal F, Lane ME Tags: Eur J Pharm Biopharm Source Type: research