The effects of acamprosate on prefrontal cortical function are mimicked by CaCl2 and they are influenced by the history of alcohol exposure
Neuropharmacology. 2022 Apr 14;212:109062. doi: 10.1016/j.neuropharm.2022.109062. Online ahead of print.ABSTRACTAlcohol use disorder is associated with functional changes in the medial prefrontal cortex (mPFC), which include altered glutamatergic transmission and deficits in executive functions that contribute to relapse. Acamprosate (calcium-bis N-acetylhomotaurinate) reduces alcohol craving and relapse, effects that are thought to be mediated by acamprosate's ability to ameliorate alcohol-induced dysregulation of glutamatergic signaling. Treatment with acamprosate and its active moiety calcium (CaCl2) both improve defici...
Source: Neuropharmacology - April 17, 2022 Category: Drugs & Pharmacology Authors: Patrick R Melugin Fei Wu Crystal Munoz Aarron Phensy Grishma Pradhan Yi Luo Abraham Nofal Rohan Manepalli Sven Kroener Source Type: research
The effects of acamprosate on prefrontal cortical function are mimicked by CaCl2 and they are influenced by the history of alcohol exposure
Neuropharmacology. 2022 Apr 14;212:109062. doi: 10.1016/j.neuropharm.2022.109062. Online ahead of print.ABSTRACTAlcohol use disorder is associated with functional changes in the medial prefrontal cortex (mPFC), which include altered glutamatergic transmission and deficits in executive functions that contribute to relapse. Acamprosate (calcium-bis N-acetylhomotaurinate) reduces alcohol craving and relapse, effects that are thought to be mediated by acamprosate's ability to ameliorate alcohol-induced dysregulation of glutamatergic signaling. Treatment with acamprosate and its active moiety calcium (CaCl2) both improve defici...
Source: Neuropharmacology - April 17, 2022 Category: Drugs & Pharmacology Authors: Patrick R Melugin Fei Wu Crystal Munoz Aarron Phensy Grishma Pradhan Yi Luo Abraham Nofal Rohan Manepalli Sven Kroener Source Type: research
The effects of acamprosate on prefrontal cortical function are mimicked by CaCl2 and they are influenced by the history of alcohol exposure
Neuropharmacology. 2022 Apr 14;212:109062. doi: 10.1016/j.neuropharm.2022.109062. Online ahead of print.ABSTRACTAlcohol use disorder is associated with functional changes in the medial prefrontal cortex (mPFC), which include altered glutamatergic transmission and deficits in executive functions that contribute to relapse. Acamprosate (calcium-bis N-acetylhomotaurinate) reduces alcohol craving and relapse, effects that are thought to be mediated by acamprosate's ability to ameliorate alcohol-induced dysregulation of glutamatergic signaling. Treatment with acamprosate and its active moiety calcium (CaCl2) both improve defici...
Source: Neuropharmacology - April 17, 2022 Category: Drugs & Pharmacology Authors: Patrick R Melugin Fei Wu Crystal Munoz Aarron Phensy Grishma Pradhan Yi Luo Abraham Nofal Rohan Manepalli Sven Kroener Source Type: research
The effects of acamprosate on prefrontal cortical function are mimicked by CaCl2 and they are influenced by the history of alcohol exposure
Neuropharmacology. 2022 Apr 14:109062. doi: 10.1016/j.neuropharm.2022.109062. Online ahead of print.ABSTRACTAlcohol use disorder is associated with functional changes in the medial prefrontal cortex (mPFC), which include altered glutamatergic transmission and deficits in executive functions that contribute to relapse. Acamprosate (calcium-bis N-acetylhomotaurinate) reduces alcohol craving and relapse, effects that are thought to be mediated by acamprosate's ability to ameliorate alcohol-induced dysregulation of glutamatergic signaling. Treatment with acamprosate and its active moiety calcium (CaCl2) both improve deficits i...
Source: Neuropharmacology - April 17, 2022 Category: Drugs & Pharmacology Authors: Patrick R Melugin Fei Wu Crystal Munoz Aarron Phensy Grishma Pradhan Yi Luo Abraham Nofal Rohan Manepalli Sven Kroener Source Type: research
A Convenient, Scalable Process for the Preparation and Purification of Calcium Acamprosate
Synthesis DOI: 10.1055/s-0040-1707399 Calcium acamprosate (Campral, N-acetylhomotaurine calcium salt) is a well-established drug for the treatment of alcohol dependence. Its preparation is generally based on a three-step process with some remarkable drawbacks. To avoid these flaws, we have developed a direct, scalable, one-pot procedure for the preparation of calcium acamprosate entailing the nucleophilic opening of readily available 1,3-propanesultone with potassium acetamide (from acetamide and potassium tert-butoxide) in N,N-dimethylformamide solution, followed by in situ cation exchange by addition of calcium chloride ...
Source: Synthesis - May 24, 2020 Category: Chemistry Authors: Cavarischia, Claudia Comely, Alex Écija, Marta Iacoangeli, Tommaso Past ó, Mireia Silvestri, Lavinia Furlotti, Guido Tags: psp Source Type: research
Effects of Oral Calcium Dosage and Timing on Ethanol-induced Sensitization of Locomotion in DBA/2 Mice.
Abstract
Ethanol (EtOH) dosage, frequency, and paired associative learning affect the risk of alcoholism. Recently, Spanagel et al. reported that acamprosate calcium (Acam Ca) prescribed for alcoholism exerts an anti-relapse effect via Ca. Ca is contained in foods, sometimes consumed with alcohol. Therefore, we investigated the association among oral Ca ingestion, EtOH-induced locomotor sensitization, and plasma Ca levels on how to consume Ca for moderate drinking. We used DBA/2 CrSlc mice, and CaCl2 as water-soluble Ca salts. For pre-administration, elemental Ca (50, 75, 100, or 150 mg/kg, p.o.) or water ...
Source: Biological and Pharmaceutical Bulletin - May 16, 2018 Category: Drugs & Pharmacology Authors: Shimizu C, Mitani Y, Tsuchiya Y, Nabeshima T Tags: Biol Pharm Bull Source Type: research
Factors Affecting Ethanol-induced Conditioned Place Preference and Locomotor Sensitization in Mice.
Abstract
The rewarding effects of alcohol can lead to progressively heavier and more frequent drinking. Since studies of reward have mainly focused on responses to higher alcohol doses, the relations between reward and moderate/sustained alcohol exposure remain unknown. Our objective was to evaluate factors affecting the reward value of low alcohol doses and risk factors for increasing alcohol doses due to reward progression caused by alcohol exposure patterns. We thus performed conditioned place preference (CPP) and ethanol (EtOH)-induced locomotor sensitization tests in mice. Low-dose EtOH (0.5 or 1 g/kg...
Source: Biological and Pharmaceutical Bulletin - September 16, 2015 Category: Drugs & Pharmacology Authors: Shimizu C, Oki Y, Mitani Y, Nakamura T, Nabeshima T Tags: Biol Pharm Bull Source Type: research
Pharmacokinetics and Bioequivalence Evaluation of Acamprosate Calcium Tablets in Healthy Chinese Volunteers.
CONCLUSIONS: Similar pharmacokinetic results of acamprosate calcium tablets in healthy Chinese volunteers were found as those in Caucasic population. In all three stages, the two formulations met the regulatory criteria for bioequivalence. Chictr.org identifier: ChiCTR-TTRCC-14004853.
PMID: 26360834 [PubMed - as supplied by publisher] (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - September 7, 2015 Category: Drugs & Pharmacology Authors: Luo Z, Shen Y, Liang M, Miao J, Mei Y, Wang Y, Qin Y Tags: Eur J Pharm Sci Source Type: research
Waltham biotech begins trial in hopes of a new use for alcoholism drug
A drug approved for use in treating alcohol dependence may find a new life helping lessen the side effects of antipsychotics and other medications, thanks to a relatively new Waltham, Mass.-based biotech firm.
Privately-held Synchroneuron recently started a mid-stage trial of a reformulated version of a drug marketed under the name of Campral in the U.S. by Forest Laboratories. The trial will test the drug’s effectiveness in 90 patients around the world suffering from tardive dyskinesia, a condition… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - February 24, 2014 Category: Pharmaceuticals Authors: Don Seiffert Source Type: research
