High-resolution three ‑dimensional contrast‑enhanced magnetic resonance venography in children: comparison of gadofosveset trisodium with ferumoxytol
ConclusionFerumoxytol produces more uniform and stable enhancement throughout the entire venous circulation in children than gadofosveset, offering a wider time window for optimal image acquisition. FE-MRV offers a near-ideal approach to high-resolution venography in children at all levels of anatomical complexity. (Source: Pediatric Radiology)
Source: Pediatric Radiology - December 22, 2021 Category: Radiology Source Type: research
Creating three dimensional models of the right ventricular outflow tract: influence of contrast, sequence, operator, and threshold
AbstractThe use of 3D printed models of the right ventricular outflow tract (RVOT) for surgical and interventional planning is growing and often requires image segmentation of cardiac magnetic resonance (CMR) images. Segmentation results may vary based on contrast, image sequence, signal threshold chosen by the operator, and manual post-processing. The purpose of this study was to determine potential biases and post-processing errors in image segmentation to enable informed decisions. Models of the RVOT and pulmonary arteries from twelve patients who had contrast enhanced CMR angiography with gadopentetate dimeglumine (GPD...
Source: The International Journal of Cardiovascular Imaging - June 14, 2019 Category: Radiology Source Type: research
Magnetic resonance angiography imaging of pulmonary embolism using agents with blood pool properties as an alternative to computed tomography to avoid radiation exposure
ConclusionsThis single-center, preliminary study using contrast agents with blood pool properties to perform a relatively rapid combined MRA-MRV exam to image for PE and above knee DVT shows potential as an alternative imaging choice to CTPA. Further large-scale, multicentre studies are warranted. (Source: European Journal of Radiology)
Source: European Journal of Radiology - February 12, 2019 Category: Radiology Source Type: research
Gadofosveset-enhanced lung magnetic resonance imaging to detect ongoing vascular leak in pulmonary fibrosis
Vascular leak is a cardinal response to tissue injury [1, 2]. When dysregulated, vascular leak has been shown to contribute to the development of pulmonary fibrosis in the bleomycin mouse model [3]. Specifically targeting vascular endothelial growth factor, initially described as vascular permeability factor [4] and a key mediator regulating capillary permeability, attenuates the development of pulmonary fibrosis in vivo [5]. Gadofosveset (Ablavar; Lantheus Medical Imaging Inc., North Billerica, MA, USA) is a US Food and Drug Administration-approved, gadolinium-based, albumin-binding contrast agent. Gadofosveset has been u...
Source: European Respiratory Journal - May 17, 2018 Category: Respiratory Medicine Authors: Montesi, S. B., Rao, R., Liang, L. L., Goulart, H. E., Sharma, A., Digumarthy, S. R., Shea, B. S., Seethamraju, R. T., Caravan, P., Tager, A. M. Tags: Original Articles: Research letters Source Type: research
Frequency and Severity of Acute Allergic-Like Reactions to Intravenously Administered Gadolinium-Based Contrast Media in Children
Conclusion
Allergic-like reactions to GBCM in children are rare. Gadoterate meglumine has a reaction frequency that does not significantly differ from other GBCMs. During the transition from gadopentetate dimeglumine to gadoterate meglumine, an increase in the frequency of reported allergic-like reactions was observed, likely reflective of the Weber effect. (Source: Investigative Radiology)
Source: Investigative Radiology - April 5, 2018 Category: Radiology Tags: Original Articles Source Type: research
Myocardial T1 mapping and determination of partition coefficients at 3 tesla: comparison between gadobenate dimeglumine and gadofosveset trisodium
Conclusion: Myocardial T1 times did not differ significantly between gadobenate and gadofosveset. At typical clinical doses of the contrast agents, partition coefficients were significantly lower for the intravascular contrast agent than for the extravascular agent.Resumo Objetivo: Avaliar o efeito da utiliza ção de um agente de contraste intravascular baseado em gadolínio quelado a albumina (gadofosveset) no tempo T1 e no coeficiente de partição do miocárdio, quando comparado com um agente de contraste extravascular baseado no gadolínio não quelado a albumina (gadobenato). Materiais e Métodos: Os participantes...
Source: Radiologia Brasileira - March 12, 2018 Category: Radiology Source Type: research
Nuclear magnetic relaxation dispersion of murine tissue for development of T1 (R1) dispersion contrast imaging
This study quantified the spin–lattice relaxation rate (R1) dispersion of murine tissues from 0.24 mT to 3 T. A combination of ex vivo and in vivo spin–lattice relaxation rate measurements were acquired for murine tissue. Selected brain, liver, kidney, muscle, and fat tissues were excised and R1 dispersion profiles were acquired from 0.24 mT to 1.0 T at 37 °C, using a fast field‐cycling MR (FFC‐MR) relaxometer. In vivo R1 dispersion profiles of mice were acquired from 1.26 T to 1.74 T at 37 °C, using FFC‐MRI on a 1.5 T scanner outfitted with a field‐cycling insert electromagnet to dynamically control B...
Source: NMR in Biomedicine - October 18, 2017 Category: Radiology Authors: Yonathan T. Araya, Francisco Mart ínez‐Santiesteban, William B. Handler, Chad T. Harris, Blaine A. Chronik, Timothy J. Scholl Tags: RESEARCH ARTICLE Source Type: research
4D flow image quality with blood pool contrast: a comparison of gadofosveset trisodium and ferumoxytol
AbstractTo evaluate the effect of MRI blood pool contrast agent on 4D flow image quality and ventricular volume measurements. Adult patients referred for clinical cardiac MRI (n = 22) were imaged with 4D flow. Patients with renal failure (n = 10) received ferumoxytol, and the remainder (n = 12) received gadofosveset trisodium. Image quality was assessed with (1) signal-to-noise ratio (SNR); (2) contrast-to-noise ratio (CNR); and (3) 5-point Likert scale based o n endocardial border definition (1 = none; 2 = partial but unable to visualize; 3 = able to roughly estimate; 4 = visible for most of t...
Source: The International Journal of Cardiovascular Imaging - September 8, 2017 Category: Radiology Source Type: research
Survey of gadolinium-based contrast agent utilization among the members of the Society for Pediatric Radiology: a Quality and Safety Committee report
ConclusionSurvey results demonstrate that GBCAs are administered judiciously in children, yet there is an opportunity to improve their utilization with the goal of reducing potential future adverse effects. (Source: Pediatric Radiology)
Source: Pediatric Radiology - March 9, 2017 Category: Radiology Source Type: research
Validation of Blood Volume Fraction Quantification with 3D Gradient Echo Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Porcine Skeletal Muscle
by Stefan Hindel, Anika S öhner, Marc Maaß, Wolfgang Sauerwein, Dorothe Möllmann, Hideo Andreas Baba, Martin Kramer, Lutz Lüdemann
The purpose of this study was to assess the accuracy of fractional blood volume (vb) estimates in low-perfused and low-vascularized tissue using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). The results of different MRI methods were compared with histology to evaluate the accuracy of these methods under clinical conditions.vb was estimated by DCE-MRI using a 3D gradient echo sequence with k-space undersampling in five muscle groups in the hind leg of 9 female pigs. Two ga...
Source: PLoS One - January 30, 2017 Category: Biomedical Science Authors: Stefan Hindel Source Type: research
Correlation between quantitative and semiquantitative parameters in DCE-MRI with a blood pool agent in rectal cancer: can semiquantitative parameters be used as a surrogate for quantitative parameters?
ConclusionThis study shows a strong correlation between quantitative and semiquantitative parameters in DCE-MRI for rectal cancer. Peak enhancement correlates strongly withKtrans and wash-in showed strong correlation withVp andKep. These parameters have been reported to predict tumor aggressiveness and response in rectal cancer. Therefore, semiquantitative analyses might be a surrogate for quantitative analyses. (Source: Abdominal Imaging)
Source: Abdominal Imaging - January 2, 2017 Category: Radiology Source Type: research
Superior Abdominal 4D Flow MRI Data Consistency with Adjusted Preprocessing Workflow and Noncontrast Acquisitions
Conclusions Superior abdominal 4D flow MRI data consistency was obtained by applying eddy current correction before any other data manipulation, using noise masking and velocity anti-aliasing cautiously, and using noncontrast acquisitions. (Source: Academic Radiology)
Source: Academic Radiology - December 8, 2016 Category: Radiology Source Type: research
Combined blood pool and extracellular contrast agents for pediatric and young adult cardiovascular magnetic resonance imaging
ConclusionCardiac MR studies utilizing both extracellular and blood pool contrast agents are feasible and safe and provide excellent-quality LGE and MR angiography images. The use of two contrast agents allows for a comprehensive assessment of both myocardial viability and vascular anatomy during the same exam. (Source: Pediatric Radiology)
Source: Pediatric Radiology - August 29, 2016 Category: Radiology Source Type: research
MRI with ferumoxytol: A single center experience of safety across the age spectrum
ConclusionIn our single‐center experience, no serious AEs occurred with the diagnostic use of ferumoxytol across a wide spectrum of age, renal function, and indications. Because of the limited sample size, firm conclusions cannot be drawn about the generalizability of our results. Thus, vigilance and monitoring are recommended to mitigate potential rare adverse reactions. J. Magn. Reson. Imaging 2016. (Source: Journal of Magnetic Resonance Imaging)
Source: Journal of Magnetic Resonance Imaging - July 31, 2016 Category: Radiology Authors: Kim ‐Lien Nguyen, Takegawa Yoshida, Fei Han, Ihab Ayad, Brian L. Reemtsen, Isidro B. Salusky, Gary M. Satou, Peng Hu, J. Paul Finn Tags: Original Research Source Type: research
Appearance of Focal Liver Lesions Using Contrast-Enhanced Magnetic Resonance Imaging Using Gadofosveset Trisodium, an Intravascular (Blood-Pool) Contrast Agent: A Pictorial Essay
Contrast-enhanced magnetic resonance imaging (MRI) of focal liver lesions is typically performed with either extracellular or hepatobiliary-specific contrast agents. Although intravascular contrast agents are often used in contrast-enhanced ultrasound imaging of focal liver lesions, these agents are not typically used for MR imaging [1]. (Source: Canadian Association of Radiologists Journal)
Source: Canadian Association of Radiologists Journal - June 14, 2016 Category: Radiology Authors: H.M.C. Cheung, C. Law, M. Shoichet, P.J. Karanicolas, N. Coburn, L. Milot Tags: Abdominal Imaging / Imagerie abdominale Source Type: research
