Mammary fibromatosis (desmoid tumor) in a dog: cytological, pathological, and immunohistochemistry studies

Abstract In the present study, we describe an ill-defined firm mass in the mammary tissue in an 8-year-old terrier dog. Fine-needle aspiration (FNA) cytology showed a moderate cellularity with numerous bland bare nuclei and proliferating fibroblasts in a bloody background. Occasional clusters of spindle cells also were present. Histopathologically, a proliferation of spindle cells without atypia forming or interlacing fascicles was observed. A variable amount of collagen was seen in the background. There was no evidence of mitotic figures. Immunohistochemical analysis presented that the neoplastic cells expressed vimentin and smooth muscle actin (SMA) but did not stain for cytokeratin, S-100 protein, and CD 34. Based on cytology, histopathology, and immunohistochemical findings, the present tumor was diagnosed as mammary fibromatosis. Although fibromatosis has been reported rarely in the veterinary literature, it could be considered in differential diagnosis list of any spindle cell lesions in the breast. Histopathological examination in conjunction with the judicious use of immunohistochemistry (IHC) is required in order to reach a correct diagnosis.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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This article describes a case of a 41-year-old male, a chronic smoker with an actively bleeding, ulcerated, solitary, firm lesion on the lateral border of the tongue which had bled thrice before. A differential diagnosis of pyogenic granuloma, haemangioma, fibroma, nerve sheath tumour, salivary gland tumour and malignancy was made and surgically excised. Histopathology of the excised specimen revealed a well-circumscribed lesion with spindle-shaped cells arranged in interlacing fascicles and with the help of immunohistochemical markers confirmed it to be a PEN. DISCUSSION: To our knowledge, this is the first descriptio...
Source: Malaysian Journal of Pathology - Category: Pathology Tags: Malays J Pathol Source Type: research
;n ES Abstract A peripheral (gingival) fibroma, a gingival cyst and hyperplastic gingivitis occurred simultaneously in a man with metastatic medullary thyroid carcinoma (MCT). The gingival growths and hyperplasia appeared to be related to poor oral hygiene rather than to the MTC. Despite the patient's improved oral hygiene, the hyperplastic gingivitis and peripheral fibroma recurred, and a new peripheral fibroma and gingival cyst developed, which prompted reconsideration of a link with the MTC. MTC cells secrete calcitonin (CT), procalcitonin (ProCT) and growth factors; the patient's serum CT and ProCT were severa...
Source: Biotechnic and Histochemistry - Category: Research Authors: Tags: Biotech Histochem Source Type: research
Metaplastic breast carcinoma (MPBC) represents 0.2-5% of all breast cancers and is typically very aggressive, with worse clinical outcomes than triple negative invasive breast cancers (TNBC)[1,2]. It is comprised of ductal, squamous, and/or chondroid, and spindle elements, with squamous cell carcinoma being the most frequent histological subtype. The World Health Organization (WHO) further divides metaplastic breast cancer into several subgroups: low-grade adenosquamous carcinoma, fibromatosis-like metaplastic carcinoma, squamous cell carcinoma, spindle cell carcinoma, metaplastic carcinoma with mesenchymal differentiation...
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: Tumour Review Source Type: research
Source: Journal of Dentistry for Children - Category: Dentistry Authors: Tags: Case Reports Source Type: research
We report a case of PTC-DTF with infiltration of the mesenchymal component of tumor into perithyroidal muscle and early recurrence of desmoid after thyroidectomy, an outcome previously not reported.Presentation of caseA 20-year-old man underwent left hemithyroidectomy for a thyroid nodule. Pathology demonstrated a 4.2 cm tumor with PTC-DTF with the PTC comprising
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
PMID: 31403969 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
CONCLUSION: More in-depth knowledge is required for many sarcomas to link their genetic alterations to tumorigenesis in order to develop efficient personalised treatment strategies. Clinical trial designs need to be adapted to evaluate new therapeutic strategies in these ultra-rare tumours and their various sub-types more efficaciously. PMID: 31396640 [PubMed - as supplied by publisher]
Source: Der Orthopade - Category: Orthopaedics Authors: Tags: Orthopade Source Type: research
We report a localized form of juvenile hyaline fibromatosis, a rare disease with several cases reported in the worldwide literature. A 23-year-old man presented with multiple tumors, joint contractures, and osteolytic bone lesions, but without gingival hyperplasia in one year of follow-up. Although, the onset of this condition is commonly in early childhood with progression, his unusual clinical presentation began at eight years of age with late progression in adolescence.
Source: Dermatology Online Journal - Category: Dermatology Source Type: research
AbstractSurgical treatment of cardiac fibroma is rare in patients with left ventricular noncompaction (LVNC). Although several case reports regarding cardiac fibroma have been published, resection in a patient with LVNC has not been described. Here, we describe the surgical treatment of left ventricular fibroma in a child with LVNC. We resected a cardiac fibroma in a 10 ‐year‐old boy with LVNC to control ventricular arrhythmia. Partial resection with careful tumor dissection was performed to avoid endocardial damage and entering the ventricular cavity. The postoperative course was uneventful, and the patient remains as...
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: CASE REPORT Source Type: research
We report a case of 41-year-old male who suffered short of breath for 3 years, and lower limbs edema for 2 years. Diagnoses: Transthoracic echocardiogram (TTE) and cardiac magnetic resonance (CMR) showed a large amount of pericardial effusion and confirmed a mass of 18 × 14 mm on the superior vena cava near the outer edge of right atrium. The patient was first diagnosed as pleural mesothelioma. Surgery was performed to relieve the symptoms and confirm diagnoses. However, during surgery, we found the right atrium is apparently thicken with rough and uneven surface. Histology of right atrium mass indicated it ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
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