Ruscogenin alleviates deep venous thrombosis and pulmonary embolism induced by inferior vena cava stenosis inhibiting MEK/ERK/Egr-1/TF signaling pathway in mice

CONCLUSION: IVCS model contributed to the development of DVT and PE in mice and was associated with increased inflammation. RUS showed therapeutic effects by inhibiting inflammation as well as suppressing the activation of MEK/ERK/Egr-1/TF signaling pathway.PMID:35619253 | DOI:10.2174/1381612828666220526120515

Source: Current Pharmaceutical Design - May 27, 2022 Category: Drugs & Pharmacology Authors: Yujie Dai Qianliu Zhou Yuankai Liu Xiaojun Chen Fang Li Boyang Yu Yuanyuan Zhang Junping Kou Source Type: research