Shifting metabolism to increase lifespan

Trends Endocrinol Metab. 2022 May 18:S1043-2760(22)00087-X. doi: 10.1016/j.tem.2022.05.001. Online ahead of print.ABSTRACTLionaki et al. report that reducing mitochondrial protein import increases Caenorhabditis elegans lifespan, through a metabolic shift that enhances the conversion of glucose into serine. Here, I discuss the promise held by these findings in the framework of therapeutic approaches to metabolic and neurodegenerative diseases.PMID:35597712 | DOI:10.1016/j.tem.2022.05.001

Source: Trends in Endocrinology and Metabolism: TEM - May 21, 2022 Category: Endocrinology Authors: Jo ão Pessoa Source Type: research