Effect of Bladder Distension on Dosimetry of Organs at Risk During Intracavitary Cervical HDR Brachytherapy Using Dose-Volume and Dose-Surface Histograms

High dose rate (HDR) intracavitary brachytherapy has become common practice in the treatment and management of cervical cancer. During HDR brachytherapy of the cervix, the main organs at risk (OAR) for radiation exposure are the bladder, rectum, sigmoid colon and small bowel. Irradiation of these organs can lead to a number of late complications following radiation therapy. For a treatment plan to be exceptionally effective, it requires both deliverance of desired prescription dose to the target organ but also a minimization of dose distribution to the OAR.
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research

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CONCLUSION: The lifetime attributable risk of cancer incidence and mortality due to radiation exposure is not trivial. Therefore efforts should be made to reduce patient doses while maintaining image quality. PMID: 32871427 [PubMed - indexed for MEDLINE]
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Clin Imaging Source Type: research
CONCLUSION: LncRNA CASC15 has the potential to become a new therapeutic target or marker for a variety of tumors. PMID: 32962611 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
Conditions:   Malignant Neoplasm;   Malignant Neoplasm of Rectum;   Malignant Neoplasm of Anus;   Malignant Neoplasm of Urinary Bladder;   Malignant Neoplasm of Cervix;   Malignant Neoplasm of Ovary;   Malignant Neoplasm of Prostate;   Malignant Neoplasm of Large Intestine;   M alignant Neoplasm of Colon;   Gynecologic Cancer Intervention:   Biological: Capsules containing either dietary fiber or placebo Sponsors:   Sahlgrensk...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractObjectivesTetrandrine, a natural bisbenzylisoquinoline alkaloid, possesses promising anticancer activities on diverse tumours. This review provides systematically organized information on cancers of tetrandrinein vivo andin vitro, discuss the related molecular mechanisms and put forward some new insights for the future investigations.Key findingsAnticancer activities of tetrandrine have been reported comprehensively, including lung cancer, colon cancer, bladder cancer, prostate cancer, ovarian cancer, gastric cancer, breast cancer, pancreatic cancer, cervical cancer and liver cancer. The potential molecular mechani...
Source: Journal of Pharmacy and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Review Source Type: research
In this report, a group of experts of the Spanish Society of Medical Oncology (SEOM), the Spanish Society of Medical Radiology (SERAM), and Spanish Society of Nuclear Medicine and Molecular Imaging (SEMNIM) provide an up-to-date review and a consensus guide on these issues. PMID: 32623581 [PubMed - as supplied by publisher]
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Tags: Clin Transl Oncol Source Type: research
CONCLUSION: We found that 1-in-11 cancer survivors developed a SPC. Given the increasing number of cancer survivors and the importance of SPC as a cause of cancer death, there is a need for increased screening for and prevention of SPC. PMID: 32356175 [PubMed - indexed for MEDLINE]
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Tags: J Cancer Res Clin Oncol Source Type: research
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Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Abstract BACKGROUND: Carcinoma cervix is amongst the leading causes of mortality and morbidity in women population worldwide. High-dose-rate intracavitary brachytherapy (HDR-ICBT) post external beam radiation therapy (EBRT) is the standard of care in managing locally advanced stage cervical cancer patients. HDR-ICBT is generally performed under general anaesthesia (GA) in operation theatre (OT), but due to logistic reasons, sometimes, it becomes difficult to accommodate all patients under GA. Since prolonged overall treatment time (OTT) makes the results inferior, taking patients in day care setup under procedural...
Source: J Egypt Natl Canc In... - Category: Cancer & Oncology Authors: Tags: J Egypt Natl Canc Inst Source Type: research
CONCLUSIONS: The first results of treatment with the Axxent eBT device are promising, as no recurrences have been observed and toxicity is very low. eBT is a good alternative for treating cervical cancer in centers without access to conventional HDR. PMID: 31183970 [PubMed - as supplied by publisher]
Source: Journal of Applied Clinical Medical Physics - Category: Physics Authors: Tags: J Appl Clin Med Phys Source Type: research
Abstract Over the past century, definitive management of unresectable cervical cancer has evolved and currently employs high-dose radiation treatment with teletherapy and intracavitary brachytherapy (ICBT) components, combined with concurrent chemotherapy. Reflecting high disease prevalence among developing nations, the International Federation of Gynecology and Obstetrics (FIGO) staging of cervical cancer relies on clinical assessment, with limited radiographic studies. However, multiple clinicopathologic analyses describe suboptimal correlation between clinical examination findings and pathologic stage. Over the...
Source: Journal of Radiation Oncology - Category: Cancer & Oncology Source Type: research
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