Antagonism of histamine H < sub > 3 < /sub > receptor promotes angiogenesis following focal cerebral ischemia

In conclusion, this study demonstrates that H3R antagonism promotes angiogenesis after cerebral ischemia, which is independent of activation of histaminergic neurons, but related to the H3R on vascular endothelial cells and its interaction with Annexin A2. Thus, H3R antagonists might be promising drug candidates to improve angiogenesis and neurological recovery after ischemic stroke.PMID:35581293 | DOI:10.1038/s41401-022-00916-4
Source: Acta Pharmacologica Sinica - Category: Drugs & Pharmacology Authors: Source Type: research