Keap1-Nrf2/ARE signal pathway activated by butylphthalide in the treatment of ischemic stroke

CONCLUSION: The butylphthalide can effectively improve the clinical efficacy of acute ischemic stroke, and promote patients' neurological function and activities of daily living. The mechanism may be that butylphthalide improves the CVR of patients, enhances the establishment of collateral compensatory vessels, and changes the expression of the Keap1-Nrf2/ARE signaling pathway, thereby exerting the neuroprotective effect. Clinically, butylphthalide may have good safety in adjuvant therapy of acute ischemic stroke.PMID:35559381 | PMC:PMC9091106
Source: American Journal of Translational Research - Category: Research Authors: Source Type: research