Aspergillus mediastinitis following post-immunotherapy lobectomy for oligometastatic lung

We report the case of a 50-year-old woman with metastatic lung adenocarcinoma who responded remarkably well to immunotherapy and underwent upper right lobectomy. Three weeks after hospital discharge, she was readmitted for severe dyspnea due to mainstem bronchus compression by mediastinal mass. Histological analysis of transbronchial needle aspiration revealed A. fumigatus. After six months of voriconazole regimen, her symptoms improved with the regression of bronchial compression. Postoperative progression of pseudo-tumoral mass in patients treated with long-term immunotherapy may be related to opportunistic infectious disease and requires investigation.PMID:35570033 | DOI:10.1016/j.rmr.2022.04.002
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Authors: Source Type: research