Antagonism of histamine H < sub > 3 < /sub > receptor promotes angiogenesis following focal cerebral ischemia
In conclusion, this study demonstrates that H3R antagonism promotes angiogenesis after cerebral ischemia, which is independent of activation of histaminergic neurons, but related to the H3R on vascular endothelial cells and its interaction with Annexin A2. Thus, H3R antagonists might be promising drug candidates to improve angiogenesis and neurological recovery after ischemic stroke.PMID:35581293 | DOI:10.1038/s41401-022-00916-4
Source: Acta Pharmacologica Sinica - Category: Drugs & Pharmacology Authors: Li-Shi Fan You-Chao Chen Ru-Jia Liao Yan-Yan Zhao Xiang-Nan Zhang Zhong Chen Lei Jiang Wei-Wei Hu Source Type: research