Design, Synthesis and Activity Study of Pyridine Derivatives as Highly Effective and Selective TYK2 Inhibitors

Biomed Res Int. 2022 May 9;2022:6383893. doi: 10.1155/2022/6383893. eCollection 2022.ABSTRACTDue to the high homology of the ATP sites of the JAK family, the development of selective inhibitors for a certain JAK isoform is extremely challenging. Our strategy to achieve high selectivity for TYK2 relies on targeting the TYK2 pseudokinase (JH2) domain. Based on the clinical compound BMS-986165, through structure-activity relationship studies, a class of acyl compounds with excellent TYK2 inhibitory activity and selectivity to other subtypes of the JAK family was discovered.PMID:35586808 | PMC:PMC9110192 | DOI:10.1155/2022/6383893

Source: Biomed Res - May 19, 2022 Category: Research Authors: Chaoying Cheng Mengguang Zhou Panpan Zhang Wenjian Qian Lei Chen Guorong Chen Source Type: research