Hb Westport [ β121 (GH4) Glu & gt;Asp; HBB: c.366A & gt;C]: A novel β-globin variant interfering with HbA1c measurement

CONCLUSIONS: Hb Westport is a novel β-globin variant that interferes with HbA1c measurement by Bio-Rad D-100 cation exchange HPLC, giving a falsely elevated result. This was clinically significant for our subject because the erroneously elevated HbA1c value was above the diabetes diagnostic threshold. Alternative methods for diabetes assessment should be considered in subjects with Hb Westport.PMID:35580651 | DOI:10.1016/j.clinbiochem.2022.05.003

Source: Clinical Biochemistry - May 17, 2022 Category: Biochemistry Authors: Jordyn A Moore Bobby V Li Darrell Wang Becca Chan Richard I King Chris M Florkowski Source Type: research