Inhibition of epithelial SHH signaling exerts a dual protective effect against inflammation and epithelial-mesenchymal transition in inflammatory bowel disease

This study demonstrated that the inhibition of SHH signaling by small molecule might have therapeutic benefit in IBD, and provided compelling experimental evidence that SHH signaling inhibitors can impose anti-inflammatory effects in intestinal epithelial cells while preserving their epithelial characteristics by restricting the induction of EMT.PMID:35569705 | DOI:10.1016/j.tiv.2022.105382
Source: Toxicology in Vitro - Category: Toxicology Authors: Source Type: research