Colorectal Cancer in Younger Adults

Hematol Oncol Clin North Am. 2022 May 13:S0889-8588(22)00005-3. doi: 10.1016/j.hoc.2022.02.005. Online ahead of print.ABSTRACTContrary to decreasing incidence rate of colorectal cancer (CRC) in older adults, incidence rates have nearly doubled in younger adults (age <50 years) in the United States since the early 1990s. A similar increase has been observed across the globe. Despite overall population trends in aging, about 15% of CRCs will be diagnosed in younger adults by 2030. The mechanisms and factors contributing to early-onset CRC (EOCRC) remain puzzling, especially because most young adults diagnosed with CRC have no known risk factors or predisposing conditions, such as family history of CRC or polyps or a hereditary syndrome (eg, Lynch syndrome, polyposis). In this up-to-date review, we discuss the current knowledge of EOCRC, including epidemiology, risk factors, clinical and molecular features, treatment and survival, and recognition and screening strategies.PMID:35577711 | DOI:10.1016/j.hoc.2022.02.005
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Source Type: research