The Gut Microbiome in Colorectal Cancer

Hematol Oncol Clin North Am. 2022 May 13:S0889-8588(22)00012-0. doi: 10.1016/j.hoc.2022.03.001. Online ahead of print.ABSTRACTThe gut microbiome is important in human health and disease. Recent studies have begun to elucidate its specific role in colorectal cancer. The gut microbiome seems to play an integral role in colorectal cancer initiation and progression, and oncologic drug metabolism and toxicity. This review examines the associations between the gut microbiome and colorectal cancer initiation, progression, and oncologic drug metabolism, highlighting proposed mechanisms and landmark publications in this field. It also discusses potential methods of modulating the gut microbiome, underscoring the gaps in current understanding, and ends with a clinically relevant overview of microbiome research considerations and study design.PMID:35577712 | DOI:10.1016/j.hoc.2022.03.001
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Source Type: research