Reassessing synaptic adhesion pathways

Trends Neurosci. 2022 May 13:S0166-2236(22)00078-9. doi: 10.1016/j.tins.2022.04.004. Online ahead of print.ABSTRACTMultiple synaptic adhesion proteins are thought to collectively define the properties of specific synapses and thereby shape the architectures of neural circuits. Growing evidence supports a molecular model in which a set of central hub proteins interacts with a vast number of other proteins to organize multifarious synaptic adhesion pathways. However, several fundamental open questions remain, partly owing to drawbacks in current approaches and interpretations. In this opinion, we provide an overview of synaptic adhesion pathways, underscoring open questions to be addressed in future work, and highlighting approaches for advancing understanding of synaptic adhesion processes.PMID:35577622 | DOI:10.1016/j.tins.2022.04.004

Source: Trends in Neurosciences - May 16, 2022 Category: Neuroscience Authors: Dongseok Lim Dongwook Kim Ji Won Um Jaewon Ko Source Type: research