Fenbendazole and its synthetic analog interfere with HeLa cells' proliferation and energy metabolism via inducing oxidative stress and modulating MEK3/6-p38-MAPK pathway

In conclusion, fenbendazole and analog 6 have multiple targets and strong anti-tumor effects on HeLa cells in vitro and in vivo. The optimized analog 6 could inhibit the viability of HeLa cells with lower toxicity than normal human cells, promising to be developed as an antitumor active compound.PMID:35569513 | DOI:10.1016/j.cbi.2022.109983

Source: Chemico-Biological Interactions - May 15, 2022 Category: Molecular Biology Authors: Yi Peng Jie Pan Fengting Ou Wenchao Wang Haihong Hu Lu Chen Su Zeng Kui Zeng Lushan Yu Source Type: research