Anti-TLR4 IgG2 prevents acetaminophen-induced acute liver injury through the Toll-like receptor 4/MAPKs signaling pathway in mice

CONCLUSION: The results clearly suggest that the underlying molecular mechanisms in the hepatoprotection of anti-TLR4 IgG2 in APAP-induced hepatotoxicity may be due to its anti-oxidation, anti-apoptosis, and anti-inflammation effects through inhibition of the TLR4/MAPKs signaling axis.PMID:35578873 | DOI:10.2174/1566524022666220516141728

Source: Molecular Medicine - May 17, 2022 Category: Molecular Biology Authors: Chuanxia Yao Maorong Wang Jin Zhu Yiwen Wang DanDan Gong Tian Feng Yaqiong Zhang Chunhui Wang Source Type: research